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5月22日

An overview of Rome V

In this episode, Lin Chang, MD, and Jan Tack, MD, PhD, discuss the history and evolution of Rome criteria, developing guidelines for multifactorial disorders in Rome V and more. · Lin Chang, MD, and Jan Tack, MD, PhD 1:04 · How has the Rome Foundation evolved over the last ten years? 4:26 · What are the Rome criteria, and why should clinicians care about them? 7:20 · How did these guidelines become the Rome criteria? 10:32 · What is the timeline of developing these criteria? 12:35 · Can you tell us about how the Rome Foundation got to the name "DGBI", and why it makes sense for multifactorial conditions? 22:22 · What are the highlights and most important changes from Rome V? 26:38 · How will this information be disseminated so clinicians can learn about it? 34:22 · What lessons did you learn from the Rome V process? 37:40 · What's next for the Rome Foundation? 40:04 Lin Chang, MD, is professor of medicine and vice chief of the Vatche and Tamar Manoukian Division of Digestive Diseases at David Geffen School of Medicine at UCLA. Jan Tack, MD, PhD, is president of the Rome Foundation. He also serves as professor of medicine at KU Leuven and chief of the division of gastroenterology and hepatology at Leuven University Hospitals. We'd love to hear from you! Send your comments/questions to guttalkpodcast@healio.com. Follow us on X @HealioGastro @sameerkberry @umfoodoc. Disclosures: Chey and Tack report no financial disclosures. Chang reports consulting roles with Ardelyx, Atmo, Eli Lilly & Co., FoodMarble, GSK, Ironwood Pharmaceuticals and Ono Pharmaceutical; speaking fees from Bausch Health; research grants from AnX Robotica and Ironwood; serving on the Rome Foundation Board of Directors; and having unvested stock options with FoodMarble, ModifyHealth, PICO Health and Trellus Health. Reference: · Drossman DA, et al. Gastroenterology. 2026;doi:10.1053.j.gastro.2026.02.014.
27/11/2024

Enhancing Clinical Trial Enrollment with Michel van Harten, MD

In this episode, host Shikha Jain, MD, speaks with Michel van Harten, MD, about creating better information systems for physicians and patients, how shared decision-making can improve drug development and more. • Welcome to another exciting episode of Oncology Overdrive 0:14 • About van Harten 0:20 • The interview 1:00 • What was your journey to becoming a physician and beyond to where you are now? 1:24 • How did you learn the necessary skills to be an exceptional leader in this space? 2:51 • How many years were you a practicing physician for? 3:53 • What does myTomorrows do, and what drew you to this type of work? 4:54 • Where is this service available? 7:19 • Jain and van Harten on the challenges patients face surrounding eligibility for clinical trials. 8:36 • Where do you see this going down the line? 10:05 • Has your company looked into how to these services can impact diversifying clinical trial enrollment? 12:04 • What are some challenges your company has faced? 13:50 • How quickly do you think growth will accelerate in this space? 15:26 • How will this work and resource have major impacts on drug development in a more accelerated way than in the past? 16:11 • From the patient-facing side, have you faced any challenges concerning patients' willingness to be enrolled in clinical trials? 18:22 • What is next for you, and where do you see yourself in twenty years? 19:13 • Do you have any concerns about AI in health care? […] What should we be aware of when utilizing AI in this space? 19:45 • Jain and van Harten on the challenges and setbacks that come from outdated and inaccurate clinical trial databases. 21:35 • If someone could only listen to the last few minutes of this episode, what would you want listeners to take away? 23:50 • How to contact van Harten 24:28 • Thanks for listening 25:17 Michel van Harten, MD, is the CEO of myTomorrows. We'd love to hear from you! Send your comments/questions to Dr. Jain at oncologyoverdrive@healio.com. Follow Healio on X and LinkedIn: @HemOncToday and https://www.linkedin.com/company/hemonctoday/. Follow Dr. Jain on X: @ShikhaJainMD. Michel van Harten can be reached via email michel.vanharten@mytomorrows.com. Disclosures: Jain and van Harten report no relevant financial disclosures.
26/06/2025

Openness to Innovation with Don Dizon, MD

In this episode, host Shikha Jain, MD, speaks with Don Dizon, MD, about innovation throughout times of uncertainty in medicine, challenges currently facing physicians and more. • Welcome to another exciting episode of Oncology Overdrive 1:34 • About Dizon 1:44 • The interview 2:27 • How did you decide to become an oncologist and navigate a traditional academic career with many non-traditional "add-ons"? 3:01 • Jain and Dizon on the importance of providing humanity to physicians. 7:19 • Jain and Dizon on finding balance when providing patients with information. 9:03 • Jain and Dizon on federal funding challenges facing oncology advancements. 10:17 • Can you tell us more about transitioning to your new role at Tufts? 12:50 • Jain and Dizon on the growing amount of career shifts in medicine. 17:22 • How do we move forward with these new guardrails up from corporatization? 18:34 • Jain and Dizon on how the age of social media has changed the perception, training and demands of doctors. 24:56 • Dizon and Jain on the power of being able to admit "I don't know." 28:22 • What are some tips that you have for new attendings and people just starting in their careers? 33:54 • Dizon and Jain on the importance of humanizing patients during their care. 38:34 • If someone could only listen to the last few minutes of this episode, what would you want listeners to take away? 44:17 • How to contact Dizon 44:57 • Thanks for listening 45:51 Don Dizon, MD, is a professor of medicine at Tufts University and is the system chief of hematology and oncology for Tufts Medicine. He is also the editor in chief of CA: A Cancer Journal for Clinicians, the flagship journal of the American Cancer Society as well as the vice-chair of membership and accrual at the SWOG Cancer Research Network. We'd love to hear from you! Send your comments/questions to Dr. Jain at oncologyoverdrive@healio.com. Follow Healio on X and LinkedIn: @HemOncToday and https://www.linkedin.com/company/hemonctoday/. Follow Dr. Jain on X: @ShikhaJainMD. Dizon can be reached on Tiktok @drdonsdizon, Instagram @drdonsdizon and LinkedIn. Disclosures: Jain and Dizon report no relevant financial disclosures.
11/09/2025

The Value of Precision Medicine with James Hamrick, MD and Sanjeev Kumar

In this episode, host Shikha Jain, MD, speaks with James Hamrick, MD, and Sanjeev Kumar about the value of biomarker testing and precision oncology, personal journeys with patient advocacy and more. • Welcome to another exciting episode of Oncology Overdrive 1:05 • About Kumar 1:20 • About Hamrick 1:52 • The interview 2:30 • Sanjeev, can you tell us about how you got involved in oncology and immunology? 2:59 • James, how did you get into this space and start working with Caris Life Sciences? 7:15 • Sanjeev, how did your mother's experience unfold, and how did you incorporate your personal knowledge help advocate and navigate throughout the situation? 12:00 • Hamrick and Kumar on the importance of patient advocacy. 17:44 • Jain, Hamrick and Kumar on the impact precision oncology can have on personalized cancer care. 23:57 • How do we make current innovations available to everyone? How can we help advocate for patients in rural areas? 28:33 • Hamrick on how precision oncology helps support decision-making for physicians and community oncologists. 35:13 • Jain, Hamrick and Kumar on the art and practice of medicine. 40:57 • If someone could only listen to the last minute of this episode, what would you want listeners to take away? 41:53 • How to contact Kumar 44:13 • How to contact Hamrick 44:34 • Thanks for listening 45:14 James Hamrick, MD, MPH, is the chairman of the Caris Precision Oncology Alliance™ (Caris POA) at Caris Life Sciences. Sanjeev Kumar is chairman and CEO of the Gallbladder Cancer Foundation, and is a biotech manufacturing leader with a background in immunology from UC Berkeley. We'd love to hear from you! Send your comments/questions to Dr. Jain at oncologyoverdrive@healio.com. Follow Healio on X and LinkedIn: @HemOncToday and https://www.linkedin.com/company/hemonctoday/. Follow Dr. Jain on X: @ShikhaJainMD. Kumar can be reached via email at sanjeevk@gallbladdercancer.org, or at the Gallbladder Cancer Foundation website. Hamrick can be reached at the Caris Life Sciences website. Disclosures: Jain and Kumar report no relevant financial disclosures. Hamrick reports being an employee of Caris Life Sciences and an advisor to Community Oncology Partners LLC.
20/11/2025

Cancer Treatment Innovations with Jason Williams, MD and Nathan Goodyear, MD

In this episode, host Shikha Jain, MD, speaks with Jason Williams, MD, and Nathan Goodyear, MD, about innovations in immunotherapy, the future of cancer care and more. • Welcome to another exciting episode of Oncology Overdrive 1:02 • About Williams 1:12 • About Goodyear 1:56 • The interview 3:08 • Nathan, can you explain the concept of your medical philosophy, Docēre rāphè, and how you integrate it into your practice? 3:29 • Jason, how did you get to where you are today, and how did you end up founding the Williams Cancer Institute? 5:28 • Nathan, as an OB-GYN and lifestyle physician, what was your path to this space and at Williams Cancer Institute? 14:22 • How do you both navigate being creative in the current climate of misinformation from a patient and physician standpoint? 20:17 • Jason, what are the benefits and challenges of practicing in other countries versus in the United States? 26:05 • Discussion on patient education through scientific evidence and innovation. 31:00 • If someone could only listen to the last minute of this episode, what would you want listeners to take away? 33:37 • How to contact Goodyear & Williams 35:42 • Thanks for listening 36:11 Jason Williams, MD, DABR, is a medical doctor, board-certified radiologist and image-guided cancer specialist. As a leader in immunotherapy, he performed the world's first ablation procedure combined with intra-tumoral immunotherapy injections. Dr. Williams serves as the Director of Interventional Oncology and Immunotherapy at the Williams Cancer Institute, which he founded to advance innovative cancer treatments. Nathan Goodyear, MD, MD(H), is an integrative medicine physician, board-certified in obstetrics and gynecology, and a leader in wellness and cancer prevention. He specializes in functional and regenerative medicine, focusing on healing and teaching the body to restore itself. Dr. Goodyear works at the Williams Cancer Institute, pioneering innovative cancer care with a holistic approach. We'd love to hear from you! Send your comments/questions to Dr. Jain at oncologyoverdrive@healio.com. Follow Healio on X and LinkedIn: @HemOncToday and https://www.linkedin.com/company/hemonctoday/. Follow Dr. Jain on X: @ShikhaJainMD. Goodyear and Williams can be reached at williamscancerinstitute.com. Disclosures: Jain, Goodyear and Williams report no relevant financial disclosures.
23/03/2023

Proton Therapy and Radiation Oncology with Isabelle Choi, MD

In this episode, host Shikha Jain, MD, speaks with Isabelle Choi, MD, about the use of proton therapy in radiation oncology, improving accessibility to radiation technology and more. • Welcome to another exciting episode of Oncology Overdrive :14 • About Choi :27 • The interview 2:00 • Can you tell us about your journey to become a radiation oncologist? 2:18 • What is proton therapy, and how does it work? 4:57 • What types of cancer can receive proton therapy? 7:35 • What do you look for to decide if somebody should or should not get proton therapy? 10:41 • What are ways to improve the overall outcomes in toxicity during cancer care that you have found in your research in proton therapy? 13:49 • Do you feel like there is a challenge in the equity space? How do we address that in this field that is needed in many populations, but is often not able to be delivered due to lack of resources? 17:51 • Have you had challenges with patients not understanding what radiation oncology is? … How do you address that concern or mistrust that patients may bring? 23:46 • Jain and Choi on multidisciplinary communication when it comes to supporting patients 27:33 • Jain and Choi on the challenges of making extra time for patient communication in the setup of the current health care system and physician burnout 31:22 • If someone could only listen to the last minute of this episode, what would you want them to take away? 36:15 • How to contact Choi 37:27 • Thanks for listening 38:00 Isabelle Choi, MD, is the director of research and clinical director at the New York Proton Center. She is a radiation oncology attending in the Department of Radiation Oncology at Memorial Sloan Kettering Cancer Center. We'd love to hear from you! Send your comments/questions to Dr. Jain at oncologyoverdrive@healio.com. Follow us on Twitter @HemOncToday and @ShikhaJainMD. Dr. Choi can be reached at www.nyproton.com or on the Memorial Sloan Kettering website. Disclosures: Choi and Jain report no relevant financial disclosures.
29/05/2025

Scientific Investment in Precision Oncology with Sadie Dobrozsi, MD

In this episode, host Shikha Jain, MD, speaks with Sadie Dobrozsi, MD, about the power of information in personalized oncology care, understanding the impacts of genetic testing and more. • Welcome to another exciting episode of Oncology Overdrive 1:34 • About Dobrozsi 1:39 • The interview 2:03 • What was your path to this field of pediatric oncology, and how did you decide to focus on genetic testing? 2:33 • Can you talk about what it means to use genomics to optimize therapy and tailor precision medicine, and how you implement that in your work? 7:58 • Why is it so important to continue focusing on funding precision medicine as an advancement in cancer care? 10:34 • Can you talk about your work with BRCA research and how treatment and surgeries have evolved with our understanding of it? 14:30 • Jain and Dobrozsi on the importance of shared decision-making in oncology, and how genomics plays a role in that ongoing conversation. 20:18 • How do we navigate difficult conversations with increasingly younger patient populations, and why are we having these conversations more now than ever before? 23:55 • When it comes to genetic testing, how much knowledge is "good knowledge"? 27:05 • If someone could only listen to the last few minutes of this episode, what would you want listeners to take away? 34:31 • How to contact Dobrozsi 35:12 • Thanks for listening 35:39 Sadie Dobrozsi, MD, is a board-certified pediatric oncologist, a nationally recognized leader in complex care delivery, and the medical director of genetic testing and oncology imaging at Evolent, a leading specialty and primary care management company. We'd love to hear from you! Send your comments/questions to Dr. Jain at oncologyoverdrive@healio.com. Follow Healio on X and LinkedIn: @HemOncToday and https://www.linkedin.com/company/hemonctoday/. Follow Dr. Jain on X: @ShikhaJainMD. Dobrozsi can be reached on LinkedIn or via email sdobrozsi@evolent.com. Disclosures: Jain and Dobrozsi report no relevant financial disclosures.
4月28日

Bats, boats, baths, and vasculitis: The story of ultrasound in GCA

In this week's episode we interview Kinanah Yaseen, MD, a rheumatologist from Cleveland Clinic's department of rheumatic and immunologic diseases about using ultrasound for giant cell arteritis. · Intro by Adam J. Brown, MD 0:12 · Dr. Brown's recent patient 1:34 · History of ultrasound and GCA 3:20 · Episode overview 7:05 · History of echolocation; how bats helped us invent ultrasound 8:00 · What is a bat bomb? 14:56 · How the Titanic helped us invent ultrasound 16:48 · Neurologists bring ultrasound to medicine 20:09 · OB/GYN is next to use ultrasound 23:11 · Ultrasound image quality becomes better 26:32 · Ultrasound use in giant cell arteritis 28:44 · Welcome Kinanah Yaseen, MD 33:49 · Using ultrasound in the clinic 34:25 · Can you walk us through an ultrasound of the axillary and vertebral arteries? 37:16 · Can you tell us why we stopped looking for sites to biopsy by finding narrowing of the vessels? 38:19 · Tell us about the halo sign 39:10 · How do you validate your ultrasound skills? 40:20 · If we start a patient on steroids, how useful is an ultrasound? 42:35 · Episode summary 44:20 · Thank you for listening 45:57 We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. Kinanah Yaseen, MD, is a is a staff member of Cleveland Clinic's department of rheumatic and immunologic diseases. References: Friedman, G, et al.Isr J Med Sci. 1988 Kaproth-Joslin K A, et al. Radiographics. 2015 ;doi:10.1148/rg.2015140300 Puéchal X, et al. Lancet. 1995;doi:10.1016/s0140-6736(95)92626-7 Schmidt W A, et al. Lancet. 1995;doi:10.1016/s0140-6736(95)93005-1 Sigel B. Ultrasound Med Biol. 1998;doi:10.1016/s0301-5629(97)00264-0 Editor's Note: This has been updated to include references.
25/09/2025

Humans at the Center of Health Care with Shakira Grant, MBBS

In this episode, host Shikha Jain, MD, speaks with Shakira Grant, MBBS, about providing patients and physicians with the proper education on AI tools, focusing on marginalized communities and more. • Welcome to another exciting episode of Oncology Overdrive 0:14 • About Grant 0:26 • The interview 2:07 • How did you get to where you are today? 2:38 • Tell me about how you got into the AI space […] What aspects interest you specifically? 4:19 • Can you take me step-by-step through how CROSS works with different health care organizations? 8:05 • How does CROSS address concerns about AI? 10:33 • Do you think AI could widen our disparities if it's taking its prompts from biases in humans? 13:31 • How do we educate people about fixing the challenges presented by AI so that we can use this data more accurately? 16:38 • Where do you see this going? […] What would you view as success in the next ten years? 18:22 • How are you managing the current political climate with this type of work? 21:31 • What do you plan to do next in your own career? 27:42 • If someone could only listen to the last few minutes of this episode, what would you want listeners to take away? 29:25 • How to contact Grant 30:23 • Thanks for listening 31:28 Shakira J. Grant, MBBS, MSCR, is a physician, entrepreneur, and healthcare executive who works at the intersection of clinical medicine, health policy, and artificial intelligence. She is the founder of CROSS Global Research & Strategy, LLC (CROSS), a company dedicated to providing end-to-end solutions that ease the adoption of AI in healthcare. We'd love to hear from you! Send your comments/questions to Dr. Jain at oncologyoverdrive@healio.com. Follow Healio on X and LinkedIn: @HemOncToday and https://www.linkedin.com/company/hemonctoday/. Follow Dr. Jain on X: @ShikhaJainMD. Grant can be reached on LinkedIn or via email drgrant@crosscatalyze.com. Disclosures: Jain and Grant report no relevant financial disclosures.
2月26日

Navigating Health Care on Social Media with Franziska Haydanek, DO

In this episode, host Shikha Jain, MD, speaks with Franziska Haydanek, DO, about building a social media presence, approaching the rise of misinformation online and more. · Welcome to another exciting episode of Oncology Overdrive 0:14 · About Franziska Haydanek, DO 0:25 · The interview 1:09 · Tell us about your journey. How did you get into the OB-GYN space, and later into the digital creation space? 1:31 · What do you do to balance your content creation with your clinical and personal lives? 6:31 · How do you handle attacks and negativity online? 11:19 · How do you continue to put content online despite the rise in negativity and misinformation? […] How do you keep yourself motivated to create content? 12:31 · Do you feel that there has been a shift on social media in recent years? 14:37 · How do you advise patients to navigate the truth online? 16:18 · Jain and Haydanek on ways to combat misinformation. 19:53 · How do we make sure the voices that need to be heard are the ones being amplified? 21:31 · Jain and Haydanek on approaching the ways in which physicians speak to audiences online. 22:47 · How are you seeing the politicization of women's health play out in the spaces you are in? 25:53 · What do we do to try and advocate for changes toward the issues surrounding women's health? 27:01 · Jain and Haydanek on how health care has become political, and what physicians can do to continue advocating for their patients. 29:50 · If someone could only listen to the last minute of this episode, what would you want listeners to take away? 34:44 · How to contact Haydanek 35:50 · Thanks for listening 36:10 Franziska Haydanek, DO, FACOG, is a board-certified OB-GYN practicing full scope obstetrics & gynecology in Rochester, NY. She is also known as Paging Dr. Fran online, working as a medical content creator with over 1.3 million followers. She is a strong advocate for her fellow healthcare workers as well as the patients she serves. We'd love to hear from you! Send your comments/questions to Dr. Jain at oncologyoverdrive@healio.com. Follow Healio on X and LinkedIn: @HemOncToday and https://www.linkedin.com/company/hemonctoday/. Follow Dr. Jain on X: @ShikhaJainMD. Haydanek can be reached across social media @PagingDrFran. Disclosures: Jain and Haydanek report no relevant financial disclosures.

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