49 集

Promoting strategies to increase healthspan, well-being, cognitive and physical performance through deeper understandings of biology.

FoundMyFitness Rhonda Patrick, Ph.D.

    • 醫學

Promoting strategies to increase healthspan, well-being, cognitive and physical performance through deeper understandings of biology.

    New Omega-3, sulforaphane research, and more! [Kevin Rose Show]

    New Omega-3, sulforaphane research, and more! [Kevin Rose Show]

    This episode was originally recorded for The Kevin Rose Show. Given some of the unique discussions we had, I had no choice but to ask the great Kevin Rose if he would let me re-post it over here on the FoundMyFitness podcast feed. A request which he graciously obliged.
    In this episode, we discuss...
    00:08:00 - Omega-3 00:27:23 - Metformin 00:50:05 - Sulforaphane 01:06:57 - Magnesium L-Threonate 01:13:44 - Sauna 01:23:48 - New FMF Membership Learn more about the new premium membership.
    Learn more about sauna on our overview page.
    Learn more about metformin on our overview page.
    Learn more about Kevin Rose at his website or on his Twitter @kevinrose. You can also subscribe to either of his two podcasts:
    Kevin Rose Show Foundation by True Ventures

    • 1 小時 36 分鐘
    Is Resveratrol a Longevity Compound?

    Is Resveratrol a Longevity Compound?

    In this episode, Rhonda gives a summary of the science of resveratrol including its effects in animals and humans, mechanisms, and the bottom line on resveratrol supplementation and safety.
    Learn more about resveratrol at our comprehensive overview
    Relevant timepoints...
    00:03:39 - Clinical effects of resveratrol in humans 00:04:10 - Effects on cardiovascular health biomarkers in humans 00:06:54 - Reduction of inflammatory biomarkers in humans 00:08:11 - Improved cognition and memory in clinical studies 00:11:23 - Healthspan improvements in animals 00:12:28 - Induction of longevity genes via xenohormesis 00:16:19 - Contradictory effects on exercise-associated benefits 00:20:34 - Various factors that affect resveratrol bioavailability 00:23:09 - Unintentional effects on drug metabolism Get earlier access with the premium members early access podcast feed, monthly Q&A sessions, an exclusive bi-weekly science digest email, and more! Click here to learn about premium.
    Click here to sign-up for a three issue trial of the bi-monthly science digest.

    • 28 分鐘
    NAD+, Nicotinamide Riboside, and Nicotinamide Mononucleotide with Rhonda Patrick

    NAD+, Nicotinamide Riboside, and Nicotinamide Mononucleotide with Rhonda Patrick

    In this episode, Rhonda describes NAD+ (perhaps one of the most important molecules in the human body), why it is so important for aging, and why it declines with age. She discusses some of the popular NAD+ boosters like nicotinamide riboside and nicotinamide mononucleotide, explains what the animal and human data say, discusses some of the concerns associated with using these boosters, and provides some concluding thoughts.
    Learn more about NAD+ Learn more about nicotinamide riboside Learn more about nicotinamide mononucleotide Learn more about sirtuins Get earlier access with the premium members early access podcast feed, monthly Q&A sessions, an exclusive bi-weekly science digest email, and more! Click here to get started.

    • 35 分鐘
    Dr. David Sinclair on Informational Theory of Aging, Nicotinamide Mononucleotide, Resveratrol & More

    Dr. David Sinclair on Informational Theory of Aging, Nicotinamide Mononucleotide, Resveratrol & More

    David A. Sinclair, PhD, is a professor in the Department of Genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biological Mechanisms of Aging. He is the co-founder of the journal Aging, where he serves as co-chief editor.
    Dr. Sinclair's work focuses on understanding the mechanisms that drive human aging and identifying ways to slow or reverse aging's effects. In particular, he has examined the role of sirtuins in disease and aging, with special emphasis on how sirtuin activity is modulated by compounds produced by the body as well as those consumed in the diet, such as resveratrol. His work has implications for human metabolism, mitochondrial and neurological health, and cancer.
    In this episode, we discuss...
    00:17:59 - How caloric restriction, fasting, and exercise increase levels of a molecule called NAD+ and how this activates sirtuins, a family of genes involved in longevity. 00:21:47 - How NAD+ levels and sirtuin activities decrease with age, and how animal studies suggest that raising cellular NAD+ levels can trick the body into thinking it is younger. 00:23:03 - How resveratrol enhances the binding of sirtuins to NAD+ thus making sirtuins more easily activated for a longer period. 00:27:36 - We also discuss Steve Horvath's epigenetic aging clock, which measures DNA methylation groups, and how they may play a role in widespread gene regulation, including sirtuin genes, and how NAD+ may participate in resetting the clock. 00:31:54 - How the signal that resets the epigenetic clock in mice involves the Yamanaka factors -- a group of four transcription factors that can reprogram an adult cell to become a pluripotent stem cell that can form any cell type. 00:46:48 - How resveratrol is a xenohormetic compound and is produced when grape plants are stressed either in response to fungus or lack of water. 00:55:35 - How a phase 2 clinical trial involving people with Alzheimer's disease showed resveratrol improved cognitive function, improved cerebrospinal fluid amyloid beta levels, lowered markers of activated microglia, and more. 00:58:03 - How both nicotinamide riboside and nicotinamide mononucleotide have been shown to improve cognitive function and brain pathology in mice that have been engineered to get a disease similar to Alzheimer's disease. 01:06:19 - How older mice that were given nicotinamide mononucleotide experienced delayed aging in the liver, muscle, immune cells, eyes, and bones, but those that took a lower dose had improved mitochondrial function and enhanced physical performance. 01:01:22 - How there may be challenges in translating animal studies on nicotinamide riboside and nicotinamide mononucleotide to humans particularly due to the need to determine the dose required to promote health benefits. And so much more! Click here to get this episode's show notes and transcript

    Watch this episode's highlights on the FMF Clips channel
    Get early access with the premium members early access podcast feed, monthly Q&A sessions, an exclusive bi-weekly science digest email, and more! Click here to get started.
    Submit your raw genetic data to get the latest version of the genetic report at foundmyfitness.com/genetics.

    • 1 小時 22 分鐘
    Sauna Use as an Exercise Mimetic for Heart and Healthspan

    Sauna Use as an Exercise Mimetic for Heart and Healthspan

    This podcast is the audio from a presentation Dr. Rhonda Patrick gave on how the sauna may be an exercise mimetic for heat health and healthspan. Sauna use has emerged as a means to increase lifespan and improve overall health, based on compelling data from observational, interventional, and mechanistic studies. Listen in to find out more.
    Click here to get the episode show notes and video.
    Watch the episode with cardiologist and sauna scientist Dr. Jari Laukkanen.
    Did you enjoy this podcast? It was brought to you by people like you!
    Click here to visit our crowdsponsor page where you can learn more about how to support the podcast.

    • 46 分鐘
    Exercise as a Treatment for Depression

    Exercise as a Treatment for Depression

    In this short episode, Dr. Patrick discusses some of the compelling science including observational studies, randomized controlled trials, and human mechanistic studies that suggests exercise is a powerful tool for preventing or managing the symptoms of depression and mental illness. Moreover, she talks about the specific types of exercise and exercise parameters that evidence suggests might be the most helpful for depression.
    This podcast started its life as a video, so make sure to check out the full video or the references and episode notes on the episode page.
    Click here to get this episode's show notes and video.
    Click here to visit the in-depth depression topic page.
    See the full interview with Dr. Charles Raison.
    Did you enjoy this podcast? It was brought to you by people like you!
    Click here to visit our crowdsponsor page where you can learn more about how to support the podcast and access the premium members benefits.

    • 17 分鐘

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