Paper Talk

淼淼Elva
  • 0.0 (0)
  • 科學
  • 每星期更新

Sharing research articles, tracking the latest developments

  1. 9小時前

    499-Redox and Ferroptosis Resistance in Airway Inflammation

    Pathogenic ILC2 and Th2 cells require cystine for glutathione synthesis to survive and expand. This redox balance, maintained by GPX4 and TXNRD1, prevents ferroptosis and enables lipid metabolism. Targeting these antioxidant systems mitigates airway inflammation.References: Wientjens C, Doverman M, Zurkovic J, et al. Tolerance to ferroptosis facilitates lipid metabolism and pathogenic type 2 immunity in allergic airway inflammation[J]. Immunity, 2025.

    17 分鐘

  2. 9小時前

    498-Enhancer Landscapes of Microglial Plasticity

    PAMs are yolk sac-derived microglia that regulate myelinogenesis. They exhibit plasticity, transitioning from a reactive state to homeostasis, then switching to DAM or WAM states during injury or aging. Epigenomic profiling identifies specific enhancers and TFs like ATF4 as key regulators.References: Hamagami N, Kapadia D, Barclay K M, et al. State-specific enhancer landscapes govern microglial plasticity[J]. Immunity, 2026.

    18 分鐘

  3. 10小時前

    497-hPSC-Derived Immune Cells for Cancer Immunotherapy

    Human pluripotent stem cells (hPSCs) provide a scalable, genetic platform for cancer immunotherapy. By engineering iPSCs to create "off-the-shelf" CAR-NK, CAR-T, and CAR-macrophage cells, researchers can enhance anti-tumor activity while reducing immune rejection and toxicity.References: Human pluripotent stem cell-derived innate and adaptive immune cells for cancer immunotherapyShah, Zahir et al.Cell Stem Cell, Volume 0, Issue 0

    19 分鐘

  4. 1日前

    496-Vascularized Human Retinal Organoids

    Researchers developed vascularized human retinal organoids using a novel bioengineered platform. By integrating endothelial cells, the model reduces hypoxia and enhances RGC survival. These organoids exhibit mature light-driven responses, serving as a tool for vision research.References: Sharma K, Habibey R, Ribeiro M M, et al. Retinal ganglion cell survival and functional maturation in transiently vascularized human retinal organoids[J]. Cell Stem Cell, 2026.

    19 分鐘

  5. 1日前

    495-Vitamin B6 Enhances Antitumor Immunity

    Vitamin B6 and its active form PLP promote tumor regression by preserving CD8+ T cell stemness and antitumor function. PLP directly inhibits p70S6K, preventing the phosphorylation and nuclear exclusion of BACH2. This axis sustains stemness genes and enhances immunotherapy efficacy.References: Wu J, Li G, Zhou J, et al. Vitamin B6 preserves the stemness-like phenotypes and antitumor ability of CD8+ T cells[J]. Developmental Cell, 2025.

    15 分鐘

  6. 1日前

    494-Cell Atlas of Human Gonadal Lineage Specification

    This single-cell atlas of 128,000 cells maps human gonad development from 5 to 12 weeks. It identifies coelomic-epithelium-derived progenitors that branch into supporting and steroidogenic lineages. The study also reveals GnRHR signaling's role in testis differentiation.References: Lardenois A, Suglia A, Moore C L, et al. Single-cell exploration of gonadal somatic cell lineage specification during human sex determination[J]. Developmental Cell, 2025.

    16 分鐘

  7. 2日前

    493-Commensal TMCM Lipids Protect the Ocular Surface

    Research shows the commensal bacterium Corynebacterium mastitidis uses the lipid TMCM to trigger protective ocular immunity. TMCM activates IL-17+ γδ T cells through TCR and IL-1R1 signaling. This microbial factor strengthens barrier defenses and prevents bacterial infections.References: Xu X, Rigas Y E, Mattapallil M J, et al. Commensal-derived trehalose monocorynomycolate triggers γδ T cell-driven protective ocular barrier immunity[J]. Immunity, 2025.

    13 分鐘

  8. 2日前

    492-ECS-dependent polytubey block in Arabidopsis

    In Arabidopsis, egg-cell proteins SDN1–3 prevent polyspermy by degrading specific miRNAs (miR833a, miR395a/f, miR827). This turnover ensures the expression of ECS1/2 endopeptidases, which establish a polytubey block post-fertilization to maintain genomic integrity.References: Shen K, Qu M, Zhou X, et al. Degradation of detrimental microRNAs safeguards the fertilized egg cells to establish an ECS-dependent polytubey block in Arabidopsis[J]. Developmental cell, 2025.

    17 分鐘
查看全部 (486)

關於

Sharing research articles, tracking the latest developments

資料

  • 創作者
    淼淼Elva
  • 活躍年份
    2025年 - 2026年
  • 單集
    486
  • 分級
    兒童適宜
  • 版權
    © 淼淼Elva@小宇宙App
  • 節目網站
    Paper Talk

你可能也會喜歡