Prosthetic Gods

James Hughes and Nir Eisikovits
  • 0.0 (0)
  • Philosophy
  • Twice monthly

Welcome to “Prosthetic Gods,” the podcast where bioethicist James Hughes and philosopher Nir Eisikovits engage in spirited debates on the ethics and politics of emerging technologies. Hughes, a pro-technology transhumanist, and Eisikovits, with his Luddite stance, explore topics from brain-computer interfaces to artificial intelligence. Tune in and explore the promise and perils of technological advancements with us!

  1. 1 day ago

    Killer Robots

    Episode 46 - Killer Robots This week Nir and J discuss the evolving ethical, political, and strategic landscape of autonomous weapons systems, contrasting historical methods of remote warfare (such as landmines and guided missiles) with modern AI-driven autonomy. They debate the necessity of keeping a "human in the loop," weighing consequentialist arguments—such as sparing soldiers' lives, acting faster than human cognition, and potentially reducing collateral damage—against risks like cognitive deskilling, unpredictable AI behavior (illustrated by recent LLM security breaches), and complex accountability gaps. The conversation highlights how the geopolitical arms race, particularly with China, severely limits the practicality of international regulations or unilateral restraint. Ultimately, they question whether human moral judgment can or should be replicated by artificial consciences, concluding that technological determinism and military pressures will likely drive the adoption of fully autonomous systems regardless of ethical hesitations. Iain M. Banks' Culture Series: The discussion concludes with a recommendation of Banks' sci-fi novels, which explore a post-scarcity, utopian society governed by hyper-intelligent, benevolent AIs—a fitting, if idealized, backdrop to modern debates on AI alignment, control, and human irrelevance. Show Notes: NYT on autonomous weapons The Culture Series by Iain M. Banks  “Defining Autonomy: Why Software, Not Drones, Will Decide the Next War” by Kateryna Bondar and Matt Mande   “The Futility of Banning Killer Robots” by Rob Enderle  “The Vulnerability of Autonomous Warfare Systems” by Burak Oktenli  “By Algorithm or Order: Integrating Lethal Autonomous Weapon Systems into Targeting” by Maj. Michael J. Brodka    “Autonomous Ukraine: We Are in a New Era of Warfare” with Michael C. Horowitz and Erin D. Dumbacher  “A legal perspective:  Autonomous weapon systems under international humanitarian law” by Neil Davison   “The End of American Military Dominance? A Conversation” with Paul Scharre      As always, listeners can contact us at prostheticgods@gmail.com with questions, comments, and suggestions for future topics. Credits: Hosted by James Hughes and Nir Eisikovits Music & Production by Jake Burley

  2. 22 Jul

    Right to Try

    Episode 45 - Right to Try This week on Prosthetic Gods, Nir and J discuss patient autonomy and the "right to try". The debate surrounding medical autonomy is intensifying as desperate patients use federal "Right-to-Try" laws and amateur biohackers bypass traditional regulations to create and access unapproved treatments. A booming gray market has emerged for unproven, compounded peptide shots, and RFK’s FDA wants to protect that access. These trends highlight a profound ethical tension between a patient's fundamental right to medical self-determination and the state's paternalistic duty to protect the clinical trial regime - which gives us the data necessary for informed consent - and to guard citizens from harm. Ultimately, regulators and bioethicists argue that without rigorous oversight, vulnerable individuals may fall victim to "snake oil" because true informed consent is impossible when a treatment's risks and efficacy remain largely unknown Show Notes: “No Evidence for Trump’s Right to Try Claim” Eugene Kiely “Right–to-Try Does Not Undermine Clinical Trials” Niklas Anzinger “Survey: Americans Overwhelmingly Back the Right to Try for Individualized Treatments” Goldwater Institute “Final wish denied as Colorado ALS patient's access to experimental drug stalls”  Brian Maass, Colin McIntyre “Peptides, Patient Autonomy, and the Limits of Medical Freedom” Chuck Dinerstein “Survey Shows Peptide Misinformation, Misuse Rising in US” Ashish Rana “What's behind the push to make peptide therapies more readily available” Will Stone   As always, listeners can contact us at prostheticgods@gmail.com with questions, comments, and suggestions for future topics. Credits: Hosted by James Hughes and Nir Eisikovits Music & Production by Jake Burley

  3. 8 Jul

    Magnificent Humanity: A Conversation with Father Michael Baggot

    Episode 44 - Magnificent Humanity This week, J and Nir talk to Father Michael Baggot about Pope Leo XIV’s recent encyclical, Magnifica Humanitas, which outlines Catholic positions on AI and other emerging technologies. Father Michael Baggot is an Associate Professor of Bioethics at the Vatican’s Pontifical Athenaeum Regina Apostolorum in Rome, a member of the Scholarly Advisory Board for Magisterium AI, and the chief editor of Enhancement Fit for Humanity: Perspectives on Emerging Technologies. Show Notes: MAGNIFICA HUMANITAS  “Pope Leo’s First Encyclical Is a Game Changer,” The Nation  “Pope Leo XIV Against the Market’s Techno-Dehumanization,” Jacobin  “Pope Leo Isn’t Standing Athwart the Singularity” New York Times      As always, listeners can contact us at prostheticgods@gmail.com with questions, comments, and suggestions for future topics. Credits: Hosted by James Hughes and Nir Eisikovits Music & Production by Jake Burley

  4. 24 Jun

    Brain-Computer Interfaces

    Episode 43 - Brain-Computer Interfaces This week on Prosthetic Gods, Nir and J discuss the ethics of brain-computer interfaces. What role do they play in the futurist imagination, and what is the reality of their current use? How quickly will they be available for consumer use, and what ethical issues do they pose? Show Notes: The Philosophy of Brain-Computer Interfaces Conference - UMass Boston - June 5-6, 2026  “Long-term independent use of an intracortical brain–computer interface for speech and cursor control” Nature Medicine “Brain-computer interface trials are taking off” MIT Technology Review “Brain Implant Lets Man With Severe Paralysis Speak in His Own Voice Again” ScienceAlert “How Scientists Are Growing Computers From Human Brain Cells” SingularityHub “China Prepares Tianjin as a Center for Brain-Computer Technology” VOI An introduction to Neal Asher's Polity Universe books      As always, listeners can contact us at prostheticgods@gmail.com with questions, comments, and suggestions for future topics. Credits: Hosted by James Hughes and Nir Eisikovits Music & Production by Jake Burley

  5. 3 Jun

    Live from Cambridge: Existential Risk

    Live from Cambridge: Existential Risk In this special live episode, recorded before an audience at Long Now Boston, Nir and J dig into existential risk. J takes seriously the prospect of catastrophic AI outcomes even absent consciousness or agency in any rich sense, while Nir worries less about civilization-ending scenarios than about a quieter, lowercase existential threat: the erosion of what makes us distinctively human.  Show Notes: Find out more about our hosts, Long Now Boston, here!   The Hollow Men by T.S. Elliot Enshitification by Cory Doctorow The Apology by Plato Cyborgs and Space by Manfred E. Clynes and Nathan S. Kline     As always, listeners can contact us at prostheticgods@gmail.com with questions, comments, and suggestions for future topics. Credits: Hosted by James Hughes and Nir Eisikovits Music & Production by Jake Burley

  6. 20 May

    Who Really Needs Ozempic Anyway?

    Episode 42 - Who Really Needs Ozempic Anyway? This week on Prosthetic Gods, Nir and J discuss the tradeoffs of GLP1 drugs. Their use has reversed the obesity epidemic and has proven to have myriad medical and psychological benefits. But they also come with risks, and are seen as a technofix replacing the need for diets. Are GLP1s another step to the posthuman body, and is that a good or bad thing? Errata: The first GLP1s were approved by the FDA in 2005, semaglutide/Ozempic in 2017, and oral orforglipron/Foundayo was approved in April 2026. More than two thirds of American adults are overweight or obese by BMI, and 40% are obese. Show Notes: GLP-1s Are a Lot Weirder Than Anyone Thought | The Ezra Klein Show   Ethical Considerations in the Use of Weight Loss Medications  The Ethics of Ozempic and Wegovy WHO issues global guideline on the use of GLP-1 medicines in treating obesity   Review of 64 studies finds GLP1s effective for weight loss for almost all groups  Obesity rate declining in US Hard Fork Podcast Rest is History Podcast   As always, listeners can contact us at prostheticgods@gmail.com with questions, comments, and suggestions for future topics. Credits: Hosted by James Hughes and Nir Eisikovits Music & Production by Jake Burley

  7. 6 May

    Disgust

    Episode 41 - Disgust This week on Prosthetic Gods, Nir and J discuss the role of disgust in morality. Neuroscience suggests that feelings of disgust underlie many moral judgments, especially in the treatment of sexuality. Conservatives have long defended disgust as a source of moral intuition, while liberals seek to minimize it. Can we suppress disgust? Should we? Show Notes: Hiding from Humanity: Disgust, Shame, and the Law by Martha Nussbaum  “The Wisdom of Repugnance,” by Leon Kass  The Righteous Mind by Jonathan Haidt  “Daedalus, or, Science and the Future,” JBS Haldane What We Are Seeking, Cameron Reed Wolfendon Report of the Committee on Homosexual Offenses and Prostitution Jeremy Bentham’s Auto-Icon   As always, listeners can contact us at prostheticgods@gmail.com with questions, comments, and suggestions for future topics. Credits: Hosted by James Hughes and Nir Eisikovits Music & Production by Jake Burley

  8. 22 Apr

    Nicholas Christakis - Technology and Contagion

    Episode 40 - Nicholas Christakis - Technology and Contagion Dr. Nicholas Christakis is the Sterling Professor of Social and Natural Science at Yale University and the Director of the Human Nature Lab. His research sits at the intersection of the social, biological, and computational sciences, exploring how our evolutionary biology and social network structures shape human behavior, health, and society. His groundbreaking work on "social contagion," demonstrates how everything from obesity and smoking to happiness and cooperative behavior spreads through human networks. Most recently, his work has focused on the emergence of "hybrid systems" of humans and machines, examining both the Burkean risks of how AI might degrade our interpersonal social graces and the technoprogressive potential of using "dumb bots" to optimize human coordination.   Show Notes: The Human Nature Lab at Yale University An overview of Dr. Christakis's current research on social networks, computational social science, and the biology of social interactions. Blueprint: The Evolutionary Origins of a Good Society, by Nicholas Christakis. His 2019 book detailing how evolution has biologically pre-wired humans for a "good society" based on love, friendship, and cooperation. Connected: The Surprising Power of Our Social Networks and How They Shape Our Lives, by Nicholas Christakis His 2009 book exploring the "three degrees of influence" rule and how social contagion dictates our behavior. Dr. Christakis on Bluesky - @nachristakis.bsky.social For the Love of Science Vlog     As always, listeners can contact us at prostheticgods@gmail.com with questions, comments, and suggestions for future topics. Credits: Hosted by James Hughes and Nir Eisikovits Music & Production by Jake Burley

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About

Welcome to “Prosthetic Gods,” the podcast where bioethicist James Hughes and philosopher Nir Eisikovits engage in spirited debates on the ethics and politics of emerging technologies. Hughes, a pro-technology transhumanist, and Eisikovits, with his Luddite stance, explore topics from brain-computer interfaces to artificial intelligence. Tune in and explore the promise and perils of technological advancements with us!

Information

  • Creator
    James Hughes and Nir Eisikovits
  • Years Active
    2024 - 2026
  • Episodes
    48
  • Rating
    Explicit
  • Copyright
    © Copyright 2026 All rights reserved.
  • Show Website
    Prosthetic Gods

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