Y Combinator

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Channel • 2 Shows

Technology

Technology

Updated twice weekly
Technology

Technology

Every two weeks

4 DAYS AGO

Replit CEO Amjad Masad: Coding Agents, Autonomy, and the Future of Work

Amjad Masad started Replit to make programming accessible to anyone, anywhere. What began as a tool for learning to code has grown into a platform pushing the limits of AI-assisted software creation and recently surpassed $100M in ARR.On The Breakdown with Tom and Dave, Amjad shares the journey from his early days in Jordan, working on open-source projects, to leading Replit through major pivots from "teach a billion people to code" to "let anyone build software." He discusses the evolving nature of programming, the future of work, and the next generation of human-computer collaboration.

4 days ago

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36 min
3 DAYS AGO

Chelsea Finn: Building Robots That Can Do Anything

Chelsea Finn on June 17th, 2025 at AI Startup School in San Francisco.From MIT through her PhD at Berkeley, where she pioneered meta‑learning methods, and Google Brain, Chelsea Finn has built her career around teaching machines how to learn. Now an Assistant Professor at Stanford and co‑founder of Physical Intelligence, she’s using that foundation to bring learning-driven robotics into messy, real-world environments rather than confined lab setups.In this talk, Chelsea traces the evolution of her team’s work—from early experiments on robotic grasping and vision to today’s ambitious efforts at folding laundry, tidying kitchens, and generalizing across tasks—all without hand-crafted code. Instead, they used scalable foundation models and massive datasets, teaching robots physical common sense as they learn by doing. She shares stories of the rocky setbacks, the surprises hidden in data, and the moment it all clicked: robots equipped with generalizable physical intelligence can indeed adapt and assist in the unpredictable world around us.

3 days ago

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45 min
11 JUL

Aravind Srinivas: The Race to Build the AI Browser of the Future

Aravind Srinivas on June 16, 2025 at AI Startup School in San Francisco.Aravind Srinivas started Perplexity with one goal: to rethink how we search, browse, and interact with information online. In this conversation, he shares the journey from hacking together a natural-language-to-SQL search tool to building a product used by millions around the world.He talks about the big bet on the AI-powered browser, why agents—not just chatbots—are the next step, and how speed, accuracy, and focus help a startup compete against giants. Along the way, he reflects on co-founder dynamics, early technical challenges, and what it takes to keep building when the biggest players in the world are racing alongside you.

11 Jul

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43 min
10 JUL

Andrew Ng: Building Faster with AI

Andrew Ng on June 16, 2025 at AI Startup School in San Francisco.Andrew Ng has helped shape some of the most influential movements in modern AI—from online education to deep learning to AI entrepreneurship. In this talk, he shares what he’s learning now: why execution speed matters more than ever, how agentic workflows are changing what startups can build, and why concreteness beats vagueness when turning ideas into products. He reflects on the rise of AI coding assistants, the shifting bottlenecks in product development, and why, despite faster software, it’s still human judgment and responsibility that will shape what comes next.

10 Jul

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44 min
15 JUL

John Jumper: AlphaFold and the Future of Science

John Jumper on June 16, 2025 at AI Startup School in San Francisco. John Jumper is a physicist-turned-computational biologist who led DeepMind’s AlphaFold team—and earned the 2024 Nobel Prize in Chemistry for solving protein folding, a decades-old scientific challenge. In this talk, he shares how a deep learning breakthrough at CASP14 turned into AlphaFold 1 and then AlphaFold 2, delivering atomic accuracy predictions and revolutionizing biology. He explains the scientific puzzle behind protein folding, the key algorithmic breakthroughs, and the impact of making millions of protein structures accessible to researchers worldwide.

15 Jul

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27 min
8 JUL

How to Spend Your 20s in the AI Era

AI has upended the once "safe" CS career path. New grads are facing unemployment rates twice those of art history majors, and a CS degree is no longer a surefire ticket to wealth. At the same time, small, focused teams are scaling from zero to eight-figure revenue in months. In a special Lightcone Live at AI Startup School, Garry, Diana, Harj, and Jared discuss why it's now more important than ever to focus on building real skills, domain expertise, and agency rather than just chasing credentials.

8 Jul

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39 min
21 JUN

Sam Altman: The Future of OpenAI, ChatGPT's Origins, and Building AI Hardware

A fireside with Sam Altman at AI Startup School in San Francisco.Sam Altman grew up obsessed with technology, broke into the Stanford mainframe as a kid, and dropped out to start his first company before turning 20.In this conversation, he traces the path from early startup struggles to building OpenAI—sharing what he’s learned about ambition, the weight of responsibility, and how to keep building when the whole world is watching. He opens up about the hardest moments of his career, the limits of personal productivity, and why, in the end, it's all still about finding people you like working with and doing something that matters.

21 Jun

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43 min
25 JUN

Satya Nadella: Microsoft's AI Bets, Hyperscaling, Quantum Computing Breakthroughs

A fireside with Satya Nadella on June 17, 2025 at AI Startup School in San Francisco.Satya Nadella started at Microsoft in 1992 as an engineer. Three decades later, he’s now Chairman & CEO, navigating the company through one of the most profound technological shifts yet: the rise of AI.In this conversation, he shares how Microsoft is thinking about this moment— from the infrastructure needed to train frontier models, to the social permission required to use that compute. He draws parallels to the early PC and internet eras, breaks down what makes a great team, and reflects on what he’d build if he were starting his career today.

25 Jun

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40 min
27 JUN

Legendary Consumer VC Predicts The Future Of AI Products

Kirsten Green, founder of Forerunner Ventures, has backed some of the most iconic consumer brands of the past two decades — from Warby Parker to Chime to Dollar Shave Club. In this conversation with Garry, she shares how great products (not marketing tricks) still win, why AI is unlocking a new kind of emotional relationship between consumers and technology, and what founders can learn from the messy creative stage we're in right now. She also breaks down how shifts in distribution, wellness, and digital behavior are reshaping what it means to build for real human needs.

27 Jun

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36 min
23 MAY

AI Apps Are Broken — Here's How To Fix Them

In this episode of The Breakdown, Tom and Dave are joined by fellow YC General Partner Pete Koomen to lay out a new vision for how AI should actually work: not as a chatbot bolted onto legacy software, but as a customizable tool that helps people offload the work they don't want to do. From editable system prompts to agents that act more like collaborators, they dig into what it means to build AI-native software—and why the future belongs to products that let users teach machines how to think.

23 May

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30 min

Make something people want.