38 things Python developers should learn in 2025

Python in 2025 is different. Threads really are about to run in parallel, installs finish before your coffee cools, and containers are the default. In this episode, we count down 38 things to learn this year: free-threaded CPython, uv for packaging, Docker and Compose, Kubernetes with Tilt, DuckDB and Arrow, PyScript at the edge, plus MCP for sane AI workflows. Expect practical wins and migration paths. No buzzword bingo, just what pays off in real apps. Join me along with Peter Wang and Calvin Hendrix-Parker for a fun, fast-moving conversation.

Episode sponsors

Seer: AI Debugging, Code TALKPYTHON
Agntcy
Talk Python Courses

Links from the show

Calvin Hendryx-Parker: github.com/calvinhp
Peter on BSky: @wang.social

Free-Threaded Wheels: hugovk.github.io
Tilt: tilt.dev
The Five Demons of Python Packaging That Fuel Our ...: youtube.com
Talos Linux: talos.dev
Docker: Accelerated Container Application Development: docker.com
Scaf - Six Feet Up: sixfeetup.com
BeeWare: beeware.org
PyScript: pyscript.net
Cursor: The best way to code with AI: cursor.com
Cline - AI Coding, Open Source and Uncompromised: cline.bot

Watch this episode on YouTube: youtube.com
Episode #524 deep-dive: talkpython.fm/524
Episode transcripts: talkpython.fm

Theme Song: Developer Rap
🥁 Served in a Flask 🎸: talkpython.fm/flasksong

---== Don't be a stranger ==---
YouTube: youtube.com/@talkpython

Bluesky: @talkpython.fm
Mastodon: @talkpython@fosstodon.org
X.com: @talkpython

Michael on Bluesky: @mkennedy.codes
Michael on Mastodon: @mkennedy@fosstodon.org
Michael on X.com: @mkennedy