Acute Myeloid Leukemia — An Interview with Dr Ghayas Issa on the Role of Menin Inhibitors

Featuring an interview with Dr Ghayas Issa, including the following topics:

• Mechanism of action and efficacy of menin inhibitors (0:00)
• Presentation and management of differentiation syndrome (13:31)
• Role of menin inhibitors in other cancers (18:19)
• Case: A woman in her mid 40s with KMT2A-rearranged acute myeloid leukemia (AML) after treatment for breast cancer (20:51)
• Mechanisms of resistance to menin inhibition in AML (26:53)
• Case: A woman in her early 70s with monocytic AML and multiple mutations including NPM1 experienced complete response with ziftomenib (32:31)
• Mechanism of action of menin inhibitors as differentiation agents (38:05)
• Similarities and differences between approved and investigational menin inhibitors under clinical development for the treatment of AML (45:55)
• Dual targeted therapy and other novel treatment approaches under clinical evaluation with menin inhibitors (51:25)
• Other investigational therapeutic strategies in AML (54:39)

CME information and select publications