Genefitletics

Sushant Kumar
  • 5.0 (1)
  • Health & Fitness
  • Every two weeks

This podcast is hosted by biotech entrepreneur Sushant Kumar, Founder & CEO of Genefitletics. Through this exclusive health podcast, he addresses the information asymmetry in the preventive health space. He is currently building Genefitletics, which is a direct-to-customer Biotech company- that studies & analyses activities of single & multicellular microorganisms living on & inside human body to provide precision health interventions in order to eradicate epidemic of chronic diseases, cancer & more.

  1. 4 days ago

    Why do Cancer Cells Ferment? | The Living Algorithm Ep-3

    Is cancer a genetic disease, or a metabolic one?While conventional oncology focuses heavily on the Somatic Mutation Theory, a growing body of research points toward a different paradigm: cancer as a mitochondrial metabolic disease driven by disruptions in bioelectric signalling and cellular bioenergetics.Here is how the metabolic cascade unfolds:The Trigger: Chronic inflammation, environmental toxins, and viral loads create a "perfect storm," damaging mitochondrial structure and impairing oxygen-based ATP production.The Downstream Effect: Corrupted mitochondria begin using oxygen to generate damaging Reactive Oxygen Species (ROS). This ROS damages cellular DNA—meaning genetic mutations may actually be a downstream result of mitochondrial damage, not the root cause.Bioelectric Disruption: Mitochondria regulate calcium signalling and ion channels. When impaired, calcium overload and closed gap junctions cause rogue cells to detach from normal tissue architecture and begin uncontrolled proliferation.The Fermentation Shift: Unable to perform respiration, cancer cells revert to primitive fermentation pathways, fuelling growth using glucose and glutamine.The Defence Shield: Fermenting these fuels produces metabolic waste like lactic acid and succinic acid, which can build a protective shield around tumors, rendering standard chemotherapies less effective.Therapeutic Implications Targeting this metabolic vulnerability through nutritional ketosis—starving cells of fermentable fuels while adopting ketone-supported strategies—presents a compelling adjunct to standard care. Ketones may help bypass corrupted pathways and enhance the therapeutic efficacy of existing treatments.We unpack all of this in Episode 3 of The Living Algorithm:Why cancer cells resort to fermentationHow lactate and succinate create drug resistanceCombining metabolic therapy with standard care to improve outcomes in late-stage cancerWhy Type 2 diabetes elevates cancer risk—and how insulin regulation serves as key prevention🔗 Listen to the full 30-minute episode here.#WarburgEffect #CancerMetabolism #WhyCancerCellsFerment #CancerResearch #Oncology #SciencePodcast #AerobicGlycolysis #CancerBiology

    Why do Cancer Cells Ferment? | The Living Algorithm Ep-3

  2. 6 days ago

    Mitochondria & Bioelectrome | The Living Algorithm Ep 2

    🔋 Your cells have a built-in electrical system—and it might be your body's quietest defense against cancer.When isolated, an individual cell acts on selfish, micro-level biological goals. But when cells bind together in a bioelectric, distributed network, something remarkable happens:They communicate, share a "bioelectric memory," and work together toward whole-body anatomical goals.How does this network keep order? Cells communicate through protein-based gap junctions, maintaining a calm, "hyperpolarized" state (between −70 to −90 mV). In this stable state, cells are far less likely to divide uncontrollably.At the center of this electrical control room are your mitochondria:🟢 Potassium (K⁺) flows OUT: Open K⁺ channels keep the cell's interior negatively charged and stable.🔴 Calcium (Ca²⁺) stays OUT: Closed Ca²⁺ channels block positive charges that trigger rapid cell proliferation.⚡ The ATP Engine: Mitochondria fuel the Sodium-Potassium pump, maintaining the crucial electrostatic balance.So, what actually happens in cancer? When systemic inflammation or environmental stress hits, mitochondria-driven ROS can cause a calcium overload. This shifts the cell's membrane potential from negative to positive, creating an electrostatic barrier that shuts down gap junction communication.Cut off from the network, the cell reverts to its selfish, isolated state—pursuing its own unilateral goals. That is cancer.The research backing this bioelectric perspective is compelling: 🔬 Potassium channels act as tumor suppressors—loss of function is linked to colorectal, GI, and esophageal cancers. 🔬 K⁺–Ca²⁺ dysregulation is widely observed in breast, lung, prostate, and liver cancers. 🔬 Bioelectric therapies targeting K⁺ efflux and Ca²⁺ influx are emerging as exciting new frontiers in oncology.Instead of focusing solely on destroying mutations, what if the future of oncology lies in restoring the cell's bioelectric potential?In Episode 2 of The Living Algorithm, we dive deep into this disruptive, scientifically backed view of cancer and how it could shift the future of prevention and treatment.🎙️ Listen to the full episode here:

    Mitochondria & Bioelectrome | The Living Algorithm Ep 2

  3. 23 Jul

    The Living Algorithm : Ep- 1 | Why Cancer is a metabolic disease?

    Are we looking at cancer all wrong? Introducing “The Living Algorithm”, a new podcast diving deep into the biology and biochemistry behind the onset and progression of cancer. Every week, we break down science- and evidence-based insights into how our cells go rogue, spread, and—most importantly, what it truly takes to prevent cancer before diagnosis or treatment ever enters the conversation. 🎙️ Episode 1: Demystifying the Myths of Cancer In our inaugural episode, we challenge the conventional narrative that cancer is purely a genetic disease and explore a groundbreaking perspective: Cancer as a mitochondrial metabolic disease. Here is a quick preview of what we cover: The Real Boss of the Cell: The ~5,000 trillion mitochondria in our bodies don't just generate energy—they control the cell cycle, signaling when cells grow, divide, remain quiet, or undergo apoptosis (cell death).The Biological Intelligence Network: Mitochondria act as highly sophisticated communication hubs, processing external inputs to drive our body's adaptive responses.The Breakdown: When chronic inflammation or microbiome disruptors hit, mitochondrial energetics fail. Reactive Oxygen Species (ROS) surge, ion channels freeze, and gap junctions close—isolating the cell from the body’s network.Going Rogue: Cut off from the collective, these detached cells revert to ancient survival mechanisms to grow and proliferate in isolation. If you’re interested in the future of cancer prevention, metabolic health, and cutting-edge therapeutics, this conversation is well worth your time. 🎧 Listen to Episode 1 now:  #CancerResearch #MitochondrialHealth #MetabolicHealth #PreventativeMedicine #Biochemistry #TheLivingAlgorithm #Podcast

    The Living Algorithm : Ep- 1 | Why Cancer is a metabolic disease?

  4. 16 Jun

    The Energetic Physics of Mitochondria- Why Breakdown Here Causes Cancer & Degeneration

    While we are too much focussed on decoding our genome, using wearables to track our health at plasma level & or leveraging DNA-Protein-drug pipeline to manage our post-symptomatic disease conditions, we have missed the key organelle that controls our biology- Mitochondria.Mitochondria is not just a powerhouse of cells as has been thought over decades. Even mitochondria, found in every cell except the red blood cells, is considered to be the motherboard of cells & is a distributed network. It has various receptors which allows it to sense environmental cues, process & integrate information & send signals to nucleus, driving epigenetic modifications & cytokine production that drive cellular adaptations & recalibrations.To understand the energetic processes of mitochondria, we have to understand the application of the laws of physics on human biological systems. Our body has a limited energy budget & is allocated among competing biochemical processes.Cellular stressors could lead to high energy resistance & disrupt the flow of electrons/increase in supply of electrons that could lead to flow back of electrons & production of reactive oxygen species. Mitochondria could also leak out its own DNA that enters the nucleus to communicate stress. This leads to production of cytokines & mitobiokines that drives this communication of stress to other cells as well as body- brain communication. These communication cascades lead to reallocation of energy from expensive growth, maintenance & repair to response to stressors- called as allostatic response, leading to new allostatic state. This persistence allostatic state leads to allostatic overload, systemic dysregulation, breakdown in communication network & onset of disease.From cancer perspective, we need to understand that it is not mutations but disruption in calcium circuits/ion channels & calcium overload that acts as electrostatic barrier to block the gap junction intercellular communication network, making dysfunctional cells detach from the cell collective & pursue its unicellular objectives. Interestingly the ion channels, whose movement drives & controls the biolelectric pattern, the voltage gradient of cells, resides in the mitochondrial inner & outer membrane & is controlled by mitochondrial functions. In effect mitochondria modulates these bioelectric patterns via controlling movement of ion channels, thereby impacting proliferation, differentiation, migration, and apoptosis of cells.In our today’s talk, we discussed how energetic processes of mitochondria drives cellular homeostasis & how breakdown in these processes can lead to organ & systemic dysfunction & onset of degenerative diseases & cancerKnow more at: www.genefitletics.com

  5. 30 Jan

    Why Your Blood Tests & Smartwatch Are LYING to You?

    Your blood tests are giving you a map of a city that no longer exists.HDL, LDL, HbA1c — these markers tell you nothing about what's actually driving your health or disease. And pairing them with a wearable doesn't fix the problem. It just makes it louder.In this episode, Sushant & Sakshi explore:-Why conventional biomarkers are dangerously outdated- How mitochondria — ancient bacteria — control your entire cell collective- The bioelectric signalling network that governs your hormones, immunity & more- Why the real focus should be: Environment × Microbiome × MitochondriaIf you're serious about transforming your biology — not just managing numbers — this is the conversation you need to hear.🔔 Subscribe for science-backed health insights that go beyond the surface.more at: www.genefitletics.com/orahyg

    Why Your Blood Tests & Smartwatch Are LYING to You?

  6. 2 Jan

    How to personalise your protein intake?

    We Indians have got obsessed with protein based on a confusing but dubious marketing narrative- “India is a protein deficient nation”. This has led to launch of numerous startups launching protein supplement- Whey protein, plant based protein, protein bars, protein wafers & moreWe have seen a number of influencers promoting high consumption of protein but if protein deficiency is a reality, is high consumption the solution? How about how each of amino acid is metabolised right now .Let us decode this mystery todayWhat are symptoms of protein deficiency?- Fatigue, skin issues, low muscle mass & more. Are low or marginal income individuals who do not have financial liberty to purchase protein supplements, have protein deficiency? The fact is protein is an essential macromolecule & is required for vital cellular & metabolic processes but marketing as an alternative for every single chronic health condition is a blatant lie.Over the last few years, we have been focussed on personalising our food choices to regulate our blood sugar response but we have not bothered to ask this simple question- Why do not we personalise our amino acids? There are 9 essential amino acids that confer different host benefits or trigger production of signalling molecules & metabolites that could either lead to cellular resilience or cellular inflammation.Just a blanket recommendation of consuming some X gram/KG/day does not translate into biochemical interactions that deliver metabolic health & protein synthesis benefits. Most of the recommendations are based on population studies considering every individual as average healthy while our biology is unique & is neither average nor healthy.Therefore protein deficiency is not a standard deficiency & is a function of your unique biology & how your microbiome interacts with each amino acids.When you fall for these marketing narratives & consume protein in excess, without understanding how each of amino acid interacts with your biology or you lack stomach acid to break protein into constituent amino acids, your microbiome may ferment these amino acids into harmful metabolites that could trigger systemic inflammation. For instance, Imdizole propionate, a microbial byproduct of amino acid histamine leads to glucose intolerance, type 2 diabetes & even an early risk factor independent of cholesterol changes.If you have protein deficiency it is not a function of consumption but how each amino acid interacts with your biology including your microbiome. Personalising amino acids based on your cellular biochemistry is key to better protein synthesis, neurotransmitter production, skin health, metabolic health.Our data shows that 69% of our customers have protein fermentation levels as average with 87% found eggs in minimise list. We at Genefitletics measures your cellular biochemistry to determine how each of amino acid is metabolized & deliver personalised biotherapeutics interventions that promote benefits from amino acid metabolism.Know more here: www.genefitletics.com/orahyg#protein #proteinpowder #proteinshake #proteinsnack #protein #proteinpowder #proteinsnack #proteinshake #supplements #supplementfacts #supplementreview #supplement #wheyprotein #wheyisolate #whey #wheyproteinpowder #wheyconcentrate #arginine #bloating #constipation #constipationawareness #larginine #citrulline

    How to personalise your protein intake?

  7. 29/10/2025

    The key to healthy aging- Health Discourse Ep-17

    Cellular resilience & homeostasis is the centre piece of longevity. It is the ability of different branches of our biology to work in synchrony to establish & maintain redox equilibrium.The key driving force of our cellular longevity is mitochondria- the furnace that provides energy currency-ATP to our cells, tissues & organs.While mitochondria efficiently produces ATP in the presence of oxygen via oxidative phosphorylation(OXPHOS), as a part of this energy generation process, free radicals/super oxides are also produced. These superoxides are harmful as they have 3 unpaired electrons. However, our body has an inbuilt mechanism wherein interaction between amino acids, microbiome & cellular environment secretes & influences production of specific antioxidants & enzymes-Superoxide dismutase (SOD), Glutathione, Glutathione peroxidase & Catalase that could travel inside the mitochondria to neutralise these super oxides.The mechanism involves multiple biochemical reactions. Your gut microbiome metabolises specific amino acids- Glutamate, Cysteine & glycine to influence their bioavailability. These amino acids are synthesised into glutathione in cytosol( inside the cells) from where it is transported to mitochondria via specific transporters that allows this negatively charged molecule to pass the inner mitochondrial membrane. The activity of these specific transporter proteins are indirectly influenced by Butyrate(gut microbial metabolites) via its metabolic & epigenetic impacts on cells & mitochondrial health.,Gut microbiome also codes for specific proteins that drive production of Superoxide dismutase. Specific gut microbes could increase the production of SOD via nutritional cooperation. It is important to note that only few antioxidants- SOD, Glutathione can pass the inner mitochondrial membraneInside the mitochondria, SOD with the help of co-factor manganese could convert super oxide into Hydrogen Peroxide(H2O2). Glutathione is oxidised by glutathione peroxidase which converts H2O2 into water, thereby neutralising super oxides. However, if you are deficient in manganese, SOD could partner with iron that could have pro-inflammatory effects & even rust mitochondria. However, when we cross the age of 30 years, our body’s ability to produce these antioxidants reduces & therefore we need exogenous consumption of these antioxidants or their precursors. We also have to make sure that our gut microbiome is balanced & performs beneficial functions to drive the synthesis of SOD & glutathione.Understanding your unique biochemistry & interaction between your gut microbiome & mitochondria is key to promote redox homeostasis. Know more at: www.genefitletics.com/agegorithm Citations https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1328324https://pmc.ncbi.nlm.nih.gov/articles/PMC10216031/

    The key to healthy aging- Health Discourse Ep-17

  8. 23/06/2025

    Can Wearables help you prevent Chronic Disease?

    Health is not about reductionist biology, not about treating every body organ separately. Unfortunately this has been practice till now!If we experience particular symptoms, we head to our healthcare practitioner & get a series of labs done! Our healthcare practitioner recommend some synthetic compounds, pharmaceutical drug or generic nutrition recommendations to inhibit or suppress particular biochemical functions.Why? Because we trust our healthcare practitioner. Has it helped? Not really? The same disease management strategy has been adopted by new age healthtech companies. The mode of healthcare delivery data collection has changed, complementing blood works with wearables- be it smartwatch,CGM or smart rings. The data collection is the same- healthcare delivery. Be it blood sugar response, HRV or sleep.Unfortunately, the thousands of biochemical reactions are not linear & outcome to millions of interactions happening inside our body. Our body is a complex ecosystem. These new toys( wearables driven markers are the outcome of these millions of interactions. Until you could measure all of these interactions & what specific pathways or molecules are causing abnormal levels of these markers, you cannot derive actionable interventions to regulate that metric.For instance, if your so called toy ring may tell your HRV is low but it fails to decode what specific pathway or molecule caused it.Is it low Butyrate ? low GABA? Elevated LPS? Low nitric oxide? High Uric Acid? Or histamine overproduction?Just by knowing your HRV is low does not translate into interventions that can modulate your heart rate variability.Similarly for sleep, If you disrupted sleep patterns, is it gut derived neurotoxins disrupting the HPA axis causing stress & obstructing sleep? Or its Fluoride consumption that is entering the pineal gland & disrupting melatonin production?Unfortunately, none of these toys could elucidate the underlying cause of dysregulated wearable metrics be it sleep, HRV or blood pressure?But yes, the healthtech VC will be sold by the phrase “ Oh we are collecting healthcare data for the Indian population” & a lot of money will be poured into developing & marketing such wearables . After few years, they may think “ Oh these investments turned sour”.You need to focus not on healthcare delivery but molecular data- that can be collected & mined by combining multiple scientific disciplines including biology, biochemistry, mathematics, bioinformatics, physics, engineering, computer science & more. Just some piece of toy laden with sensors can never measure these molecular & cellular interactions.

    Can Wearables help you prevent Chronic Disease?
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About

This podcast is hosted by biotech entrepreneur Sushant Kumar, Founder & CEO of Genefitletics. Through this exclusive health podcast, he addresses the information asymmetry in the preventive health space. He is currently building Genefitletics, which is a direct-to-customer Biotech company- that studies & analyses activities of single & multicellular microorganisms living on & inside human body to provide precision health interventions in order to eradicate epidemic of chronic diseases, cancer & more.

Information

  • Creator
    Sushant Kumar
  • Years Active
    2020 - 2026
  • Episodes
    111
  • Rating
    Explicit
  • Copyright
    © Sushant Kumar
  • Show Website
    Genefitletics