2026

  1. 2 days ago

    Why ‘Normal’ Blood Work Misses Early Diabetes and Heart Risk? | The Living Algorithm Ep-7

    Routine blood tests have been the gold standard for medical investigations for decades. Today, a new wave of shallow tech and copycat digital health platforms are combining these standard blood panels with wearable data, framing it as the ultimate solution for preventive health.Yet, actual clinical outcomes haven't improved—they’ve worsened:Diabetes: Over 250 million Indians live with diabetes, and nearly 150 million remain undiagnosed because standard blood panels still flag them as “normal.”Cardiovascular Disease: Heart disease remains the world's leading killer, while conventional care relies almost entirely on tracking basic cholesterol levels.Kidney Health: Renal dysfunction is routinely caught at advanced stages, relying on reactive eGFR metrics that often lead straight to dialysis.The core issue? We are obsessed with measuring the post-mortem of biochemical processes—spotting abnormal blood biomarkers and immediately masking them with drugs, generic supplements, or cookie-cutter diet plans.Standard blood panels fail to:Identify the molecular drivers causing those abnormal blood values.Detect early inflammatory cascades, cytokine signaling, or cellular stress long before plasma levels shift.Disease manifests at a cellular level decades before it shows up on a blood test, MRI, CT, or DEXA scan.Relying solely on blood work and wearable gadgets without decoding cellular dysfunction will never fix root-cause health. Take Type 2 Diabetes: the system hyper-focuses on suppressing blood glucose and HbA1c, completely ignoring the cellular drivers of hyperinsulinemia. A glucose spike is often just a symptom of underlying inflammation; tracking it via standard labs or continuous glucose monitors (CGMs) won't reverse the condition.In Episode 7 of The Living Algorithm, we dive deep into why basing your health strategy strictly on traditional blood work and basic wearables fails to prevent cardiometabolic disease.

    Why ‘Normal’ Blood Work Misses Early Diabetes and Heart Risk? | The Living Algorithm Ep-7

  2. 27 Aug

    The Fungal Theory of Cancer: Cell Suppression Explained | The Living Algorithm Ep-6

    The dominant somatic mutation theory only explains 2 out of 10 hallmarks of cancer. So why is the conventional oncology model still almost exclusively focused on sequencing DNA and targeting downstream genetic mutations?Otto Warburg showed decades ago that cancer is fundamentally driven by mitochondrial dysfunction. When cellular energy production breaks down, cells revert to an ancient, oxygen-deprived fermentation model. This inefficient energy output floods the environment with lactic acid, shielding cancer cells and fueling further growth.Despite this, mainstream protocols continue to treat genetic mutations—which are downstream epiphenomena—with toxic drugs. The result? Over 2,500 people in India die of cancer every single day.To solve cancer, we must ask what damages the mitochondria in the first place.Enter the Cell Suppression Theory. Driven by pathogen virulence and toxic bi-products, this model explains how mitochondrial damage occurs—and accounts for all 10 hallmarks of cancer.In Episode 6 of The Living Algorithm, we dive deep into:Pathogen Dynamics: The direct role of fungal, bacterial, and viral pathogens in cancer onset.The Vulnerability Loop: How chronic inflammation and the Cell Danger Response enable fungal invasion.Metabolic Defense: How the shift to lactic acid production actively feeds fungal growth and damages cell membranes.Clinical Protocol Shifts: Why oncologists must incorporate microbiome health, mitochondrial integrity, and metabolic therapy into standard care.If you are ready to look beyond outdated paradigms, this 25-minute conversation is essential viewing.#Cancer #Fungi #FungalTheoryOfCancer #CellSuppressionTheory #Mycobiome #CancerResearch #AlternativeHealth #HealthSecrets #DidYouKnow #Science

    The Fungal Theory of Cancer: Cell Suppression Explained | The Living Algorithm Ep-6

  3. 20 Aug

    Can the Gut Microbiome Rescue Failed Immunotherapy | The Living Algorithm Ep-5

    The 5-year therapeutic success rate for cancer in India sits below 11%, with over 100 lives lost to the disease every single hour. While current standard-of-care treatments like chemotherapy and immunotherapy offer breakthroughs for a select subset of patients, they fall short for the vast majority. Why do Immune Checkpoint Inhibitors (ICIs) fail so many? A primary culprit is T-cell exhaustion coupled with mitochondrial dysfunction. Standard immunotherapies struggle when the tumor microenvironment actively disables the host immune response through: Nutrient Competition & Amino Acid Reprogramming: Cancer cells hijack methionine and tryptophan metabolism. By elevating S-adenosylmethionine (SAM), tumor cells alter gene expression to downregulate AMPK, upregulate PD-1 expression, and force CD4+ T-cell exhaustion. Mitochondrial Impairment: Nutrient depletion and toxic fermentation byproducts collapse mitochondrial membrane potential, deplete ATP production, and suppress PGC-1α—disarming the T-cell’s mechanical ability to destroy tumor cells. Persistent Antigen & Metabolite Exposure: Ongoing stress signals suppress T-cell proliferation and strip away effector functions. Overcoming immunotherapy resistance requires looking beyond cell surface receptors to the biochemical signals driving the microenvironment—where the gut microbiome plays a pivotal role. Microbial-derived metabolites and postbiotics hold the key to restoring mitochondrial energetics, reversing T-cell dysfunction, and enhancing PD-1 therapy outcomes. In Episode 5 of The Living Algorithm, we unpack: The root mechanisms behind immunotherapy non-responsiveness The biophysical drivers of T-cell exhaustion How mitochondrial bioenergetics dictate CAR-T and ICI efficacy How targeted gut microbial metabolites can restore T-cell cytotoxicity Listen to the full discussion here:  #CancerResearch #Immunotherapy #Oncology #GutMicrobiome #Immunometabolism #CellularHealth #Biotechnology #PrecisionMedicine #TheLivingAlgorithm #TCellExhaustion #Mitochondria #Metabolomics

    Can the Gut Microbiome Rescue Failed Immunotherapy | The Living Algorithm Ep-5

  4. 13 Aug

    How Oral Health & Cancer are Linked | The Living Algorithm Ep-4

    Over 90% of cancer patients suffer from some form of oral disease or infection. This isn't just an alarming statistic—it highlights a critical biological mechanism underlying cancer development.While mainstream healthcare remains hyper-focused on isolated genetic mutations (which yield less than an 11% therapeutic success rate), the oral microbiome is actively driving cellular depolarization, fostering cancer onset, growth, and proliferation.The fundamental issue? We continue to treat oral health as isolated from the rest of the body, overlooking its direct role in systemic disease.Oral health is the bedrock of overall health. Research increasingly demonstrates that oral microbial dysbiosis and bacterial metabolites directly disrupt mitochondrial energy processes—generating excess Reactive Oxygen Species (ROS), damaging DNA/RNA and proteins, and breaking down vital cellular communication networks. This dysbiosis isn't limited to oral cancers; it is tied to head and neck, pancreatic, brain, colon, and breast cancers.In Episode 4 of “The Living Algorithm”, we break down:The Oral Microbiome & Cancer Pathogenesis: How oral bacteria actively drive cancer development.The Periodontal-Systemic Connection: The direct link between gum disease and oncogenesis.Transmembrane Potential Disruptions: How dysbiosis alters cellular voltage and function.Bio-energetics of Damaged Teeth: How compromised teeth disrupt electron flow, bio-currents, and local blood flow to create ideal conditions for cancer growth.The Nitric Oxide Shield: The vital role of oral-derived nitric oxide in cancer prevention.With nearly 90% of the population experiencing some degree of oral disease, addressing these root causes is crucial for long-term prevention.Listen to Episode 4 of "The Living Algorithm" on Spotify, Apple Podcasts, or YouTube.#OralHealth #OralCancer #DentalHealth #CancerAwareness #MouthCancer #OralHygiene #DentalCare #CancerPrevention #HealthTips #dentistry

    How Oral Health & Cancer are Linked | The Living Algorithm Ep-4

  5. 6 Aug

    Why do Cancer Cells Ferment? | The Living Algorithm Ep-3

    Is cancer a genetic disease, or a metabolic one?While conventional oncology focuses heavily on the Somatic Mutation Theory, a growing body of research points toward a different paradigm: cancer as a mitochondrial metabolic disease driven by disruptions in bioelectric signalling and cellular bioenergetics.Here is how the metabolic cascade unfolds:The Trigger: Chronic inflammation, environmental toxins, and viral loads create a "perfect storm," damaging mitochondrial structure and impairing oxygen-based ATP production.The Downstream Effect: Corrupted mitochondria begin using oxygen to generate damaging Reactive Oxygen Species (ROS). This ROS damages cellular DNA—meaning genetic mutations may actually be a downstream result of mitochondrial damage, not the root cause.Bioelectric Disruption: Mitochondria regulate calcium signalling and ion channels. When impaired, calcium overload and closed gap junctions cause rogue cells to detach from normal tissue architecture and begin uncontrolled proliferation.The Fermentation Shift: Unable to perform respiration, cancer cells revert to primitive fermentation pathways, fuelling growth using glucose and glutamine.The Defence Shield: Fermenting these fuels produces metabolic waste like lactic acid and succinic acid, which can build a protective shield around tumors, rendering standard chemotherapies less effective.Therapeutic Implications Targeting this metabolic vulnerability through nutritional ketosis—starving cells of fermentable fuels while adopting ketone-supported strategies—presents a compelling adjunct to standard care. Ketones may help bypass corrupted pathways and enhance the therapeutic efficacy of existing treatments.We unpack all of this in Episode 3 of The Living Algorithm:Why cancer cells resort to fermentationHow lactate and succinate create drug resistanceCombining metabolic therapy with standard care to improve outcomes in late-stage cancerWhy Type 2 diabetes elevates cancer risk—and how insulin regulation serves as key prevention🔗 Listen to the full 30-minute episode here.#WarburgEffect #CancerMetabolism #WhyCancerCellsFerment #CancerResearch #Oncology #SciencePodcast #AerobicGlycolysis #CancerBiology

    Why do Cancer Cells Ferment? | The Living Algorithm Ep-3

  6. 4 Aug

    Mitochondria & Bioelectrome | The Living Algorithm Ep 2

    🔋 Your cells have a built-in electrical system—and it might be your body's quietest defense against cancer.When isolated, an individual cell acts on selfish, micro-level biological goals. But when cells bind together in a bioelectric, distributed network, something remarkable happens:They communicate, share a "bioelectric memory," and work together toward whole-body anatomical goals.How does this network keep order? Cells communicate through protein-based gap junctions, maintaining a calm, "hyperpolarized" state (between −70 to −90 mV). In this stable state, cells are far less likely to divide uncontrollably.At the center of this electrical control room are your mitochondria:🟢 Potassium (K⁺) flows OUT: Open K⁺ channels keep the cell's interior negatively charged and stable.🔴 Calcium (Ca²⁺) stays OUT: Closed Ca²⁺ channels block positive charges that trigger rapid cell proliferation.⚡ The ATP Engine: Mitochondria fuel the Sodium-Potassium pump, maintaining the crucial electrostatic balance.So, what actually happens in cancer? When systemic inflammation or environmental stress hits, mitochondria-driven ROS can cause a calcium overload. This shifts the cell's membrane potential from negative to positive, creating an electrostatic barrier that shuts down gap junction communication.Cut off from the network, the cell reverts to its selfish, isolated state—pursuing its own unilateral goals. That is cancer.The research backing this bioelectric perspective is compelling: 🔬 Potassium channels act as tumor suppressors—loss of function is linked to colorectal, GI, and esophageal cancers. 🔬 K⁺–Ca²⁺ dysregulation is widely observed in breast, lung, prostate, and liver cancers. 🔬 Bioelectric therapies targeting K⁺ efflux and Ca²⁺ influx are emerging as exciting new frontiers in oncology.Instead of focusing solely on destroying mutations, what if the future of oncology lies in restoring the cell's bioelectric potential?In Episode 2 of The Living Algorithm, we dive deep into this disruptive, scientifically backed view of cancer and how it could shift the future of prevention and treatment.🎙️ Listen to the full episode here:

    Mitochondria & Bioelectrome | The Living Algorithm Ep 2

  7. 23 Jul

    The Living Algorithm : Ep- 1 | Why Cancer is a metabolic disease?

    Are we looking at cancer all wrong? Introducing “The Living Algorithm”, a new podcast diving deep into the biology and biochemistry behind the onset and progression of cancer. Every week, we break down science- and evidence-based insights into how our cells go rogue, spread, and—most importantly, what it truly takes to prevent cancer before diagnosis or treatment ever enters the conversation. 🎙️ Episode 1: Demystifying the Myths of Cancer In our inaugural episode, we challenge the conventional narrative that cancer is purely a genetic disease and explore a groundbreaking perspective: Cancer as a mitochondrial metabolic disease. Here is a quick preview of what we cover: The Real Boss of the Cell: The ~5,000 trillion mitochondria in our bodies don't just generate energy—they control the cell cycle, signaling when cells grow, divide, remain quiet, or undergo apoptosis (cell death).The Biological Intelligence Network: Mitochondria act as highly sophisticated communication hubs, processing external inputs to drive our body's adaptive responses.The Breakdown: When chronic inflammation or microbiome disruptors hit, mitochondrial energetics fail. Reactive Oxygen Species (ROS) surge, ion channels freeze, and gap junctions close—isolating the cell from the body’s network.Going Rogue: Cut off from the collective, these detached cells revert to ancient survival mechanisms to grow and proliferate in isolation. If you’re interested in the future of cancer prevention, metabolic health, and cutting-edge therapeutics, this conversation is well worth your time. 🎧 Listen to Episode 1 now:  #CancerResearch #MitochondrialHealth #MetabolicHealth #PreventativeMedicine #Biochemistry #TheLivingAlgorithm #Podcast

    The Living Algorithm : Ep- 1 | Why Cancer is a metabolic disease?

  8. 16 Jun

    The Energetic Physics of Mitochondria- Why Breakdown Here Causes Cancer & Degeneration

    While we are too much focussed on decoding our genome, using wearables to track our health at plasma level & or leveraging DNA-Protein-drug pipeline to manage our post-symptomatic disease conditions, we have missed the key organelle that controls our biology- Mitochondria.Mitochondria is not just a powerhouse of cells as has been thought over decades. Even mitochondria, found in every cell except the red blood cells, is considered to be the motherboard of cells & is a distributed network. It has various receptors which allows it to sense environmental cues, process & integrate information & send signals to nucleus, driving epigenetic modifications & cytokine production that drive cellular adaptations & recalibrations.To understand the energetic processes of mitochondria, we have to understand the application of the laws of physics on human biological systems. Our body has a limited energy budget & is allocated among competing biochemical processes.Cellular stressors could lead to high energy resistance & disrupt the flow of electrons/increase in supply of electrons that could lead to flow back of electrons & production of reactive oxygen species. Mitochondria could also leak out its own DNA that enters the nucleus to communicate stress. This leads to production of cytokines & mitobiokines that drives this communication of stress to other cells as well as body- brain communication. These communication cascades lead to reallocation of energy from expensive growth, maintenance & repair to response to stressors- called as allostatic response, leading to new allostatic state. This persistence allostatic state leads to allostatic overload, systemic dysregulation, breakdown in communication network & onset of disease.From cancer perspective, we need to understand that it is not mutations but disruption in calcium circuits/ion channels & calcium overload that acts as electrostatic barrier to block the gap junction intercellular communication network, making dysfunctional cells detach from the cell collective & pursue its unicellular objectives. Interestingly the ion channels, whose movement drives & controls the biolelectric pattern, the voltage gradient of cells, resides in the mitochondrial inner & outer membrane & is controlled by mitochondrial functions. In effect mitochondria modulates these bioelectric patterns via controlling movement of ion channels, thereby impacting proliferation, differentiation, migration, and apoptosis of cells.In our today’s talk, we discussed how energetic processes of mitochondria drives cellular homeostasis & how breakdown in these processes can lead to organ & systemic dysfunction & onset of degenerative diseases & cancerKnow more at: www.genefitletics.com

  9. 30 Jan

    Why Your Blood Tests & Smartwatch Are LYING to You?

    Your blood tests are giving you a map of a city that no longer exists.HDL, LDL, HbA1c — these markers tell you nothing about what's actually driving your health or disease. And pairing them with a wearable doesn't fix the problem. It just makes it louder.In this episode, Sushant & Sakshi explore:-Why conventional biomarkers are dangerously outdated- How mitochondria — ancient bacteria — control your entire cell collective- The bioelectric signalling network that governs your hormones, immunity & more- Why the real focus should be: Environment × Microbiome × MitochondriaIf you're serious about transforming your biology — not just managing numbers — this is the conversation you need to hear.🔔 Subscribe for science-backed health insights that go beyond the surface.more at: www.genefitletics.com/orahyg

    Why Your Blood Tests & Smartwatch Are LYING to You?

  10. 2 Jan

    How to personalise your protein intake?

    We Indians have got obsessed with protein based on a confusing but dubious marketing narrative- “India is a protein deficient nation”. This has led to launch of numerous startups launching protein supplement- Whey protein, plant based protein, protein bars, protein wafers & moreWe have seen a number of influencers promoting high consumption of protein but if protein deficiency is a reality, is high consumption the solution? How about how each of amino acid is metabolised right now .Let us decode this mystery todayWhat are symptoms of protein deficiency?- Fatigue, skin issues, low muscle mass & more. Are low or marginal income individuals who do not have financial liberty to purchase protein supplements, have protein deficiency? The fact is protein is an essential macromolecule & is required for vital cellular & metabolic processes but marketing as an alternative for every single chronic health condition is a blatant lie.Over the last few years, we have been focussed on personalising our food choices to regulate our blood sugar response but we have not bothered to ask this simple question- Why do not we personalise our amino acids? There are 9 essential amino acids that confer different host benefits or trigger production of signalling molecules & metabolites that could either lead to cellular resilience or cellular inflammation.Just a blanket recommendation of consuming some X gram/KG/day does not translate into biochemical interactions that deliver metabolic health & protein synthesis benefits. Most of the recommendations are based on population studies considering every individual as average healthy while our biology is unique & is neither average nor healthy.Therefore protein deficiency is not a standard deficiency & is a function of your unique biology & how your microbiome interacts with each amino acids.When you fall for these marketing narratives & consume protein in excess, without understanding how each of amino acid interacts with your biology or you lack stomach acid to break protein into constituent amino acids, your microbiome may ferment these amino acids into harmful metabolites that could trigger systemic inflammation. For instance, Imdizole propionate, a microbial byproduct of amino acid histamine leads to glucose intolerance, type 2 diabetes & even an early risk factor independent of cholesterol changes.If you have protein deficiency it is not a function of consumption but how each amino acid interacts with your biology including your microbiome. Personalising amino acids based on your cellular biochemistry is key to better protein synthesis, neurotransmitter production, skin health, metabolic health.Our data shows that 69% of our customers have protein fermentation levels as average with 87% found eggs in minimise list. We at Genefitletics measures your cellular biochemistry to determine how each of amino acid is metabolized & deliver personalised biotherapeutics interventions that promote benefits from amino acid metabolism.Know more here: www.genefitletics.com/orahyg#protein #proteinpowder #proteinshake #proteinsnack #protein #proteinpowder #proteinsnack #proteinshake #supplements #supplementfacts #supplementreview #supplement #wheyprotein #wheyisolate #whey #wheyproteinpowder #wheyconcentrate #arginine #bloating #constipation #constipationawareness #larginine #citrulline

    How to personalise your protein intake?

2025

  1. 29/10/2025

    The key to healthy aging- Health Discourse Ep-17

    Cellular resilience & homeostasis is the centre piece of longevity. It is the ability of different branches of our biology to work in synchrony to establish & maintain redox equilibrium.The key driving force of our cellular longevity is mitochondria- the furnace that provides energy currency-ATP to our cells, tissues & organs.While mitochondria efficiently produces ATP in the presence of oxygen via oxidative phosphorylation(OXPHOS), as a part of this energy generation process, free radicals/super oxides are also produced. These superoxides are harmful as they have 3 unpaired electrons. However, our body has an inbuilt mechanism wherein interaction between amino acids, microbiome & cellular environment secretes & influences production of specific antioxidants & enzymes-Superoxide dismutase (SOD), Glutathione, Glutathione peroxidase & Catalase that could travel inside the mitochondria to neutralise these super oxides.The mechanism involves multiple biochemical reactions. Your gut microbiome metabolises specific amino acids- Glutamate, Cysteine & glycine to influence their bioavailability. These amino acids are synthesised into glutathione in cytosol( inside the cells) from where it is transported to mitochondria via specific transporters that allows this negatively charged molecule to pass the inner mitochondrial membrane. The activity of these specific transporter proteins are indirectly influenced by Butyrate(gut microbial metabolites) via its metabolic & epigenetic impacts on cells & mitochondrial health.,Gut microbiome also codes for specific proteins that drive production of Superoxide dismutase. Specific gut microbes could increase the production of SOD via nutritional cooperation. It is important to note that only few antioxidants- SOD, Glutathione can pass the inner mitochondrial membraneInside the mitochondria, SOD with the help of co-factor manganese could convert super oxide into Hydrogen Peroxide(H2O2). Glutathione is oxidised by glutathione peroxidase which converts H2O2 into water, thereby neutralising super oxides. However, if you are deficient in manganese, SOD could partner with iron that could have pro-inflammatory effects & even rust mitochondria. However, when we cross the age of 30 years, our body’s ability to produce these antioxidants reduces & therefore we need exogenous consumption of these antioxidants or their precursors. We also have to make sure that our gut microbiome is balanced & performs beneficial functions to drive the synthesis of SOD & glutathione.Understanding your unique biochemistry & interaction between your gut microbiome & mitochondria is key to promote redox homeostasis. Know more at: www.genefitletics.com/agegorithm Citations https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1328324https://pmc.ncbi.nlm.nih.gov/articles/PMC10216031/

    The key to healthy aging- Health Discourse Ep-17

  2. 23/06/2025

    Can Wearables help you prevent Chronic Disease?

    Health is not about reductionist biology, not about treating every body organ separately. Unfortunately this has been practice till now!If we experience particular symptoms, we head to our healthcare practitioner & get a series of labs done! Our healthcare practitioner recommend some synthetic compounds, pharmaceutical drug or generic nutrition recommendations to inhibit or suppress particular biochemical functions.Why? Because we trust our healthcare practitioner. Has it helped? Not really? The same disease management strategy has been adopted by new age healthtech companies. The mode of healthcare delivery data collection has changed, complementing blood works with wearables- be it smartwatch,CGM or smart rings. The data collection is the same- healthcare delivery. Be it blood sugar response, HRV or sleep.Unfortunately, the thousands of biochemical reactions are not linear & outcome to millions of interactions happening inside our body. Our body is a complex ecosystem. These new toys( wearables driven markers are the outcome of these millions of interactions. Until you could measure all of these interactions & what specific pathways or molecules are causing abnormal levels of these markers, you cannot derive actionable interventions to regulate that metric.For instance, if your so called toy ring may tell your HRV is low but it fails to decode what specific pathway or molecule caused it.Is it low Butyrate ? low GABA? Elevated LPS? Low nitric oxide? High Uric Acid? Or histamine overproduction?Just by knowing your HRV is low does not translate into interventions that can modulate your heart rate variability.Similarly for sleep, If you disrupted sleep patterns, is it gut derived neurotoxins disrupting the HPA axis causing stress & obstructing sleep? Or its Fluoride consumption that is entering the pineal gland & disrupting melatonin production?Unfortunately, none of these toys could elucidate the underlying cause of dysregulated wearable metrics be it sleep, HRV or blood pressure?But yes, the healthtech VC will be sold by the phrase “ Oh we are collecting healthcare data for the Indian population” & a lot of money will be poured into developing & marketing such wearables . After few years, they may think “ Oh these investments turned sour”.You need to focus not on healthcare delivery but molecular data- that can be collected & mined by combining multiple scientific disciplines including biology, biochemistry, mathematics, bioinformatics, physics, engineering, computer science & more. Just some piece of toy laden with sensors can never measure these molecular & cellular interactions.

    Can Wearables help you prevent Chronic Disease?

  3. 10/04/2025

    Are fats good for your health?

    We have spent decades avoiding one of the most essential & vital macromolecule-FATS to our own peril.You may hear these fitness folks propagating fats are bad & causing cardiovascular disease referring to an obsolete & obnoxious paper or theory of Ancel keys who claimed in 1958 that it is fat & cholesterol which causes heart disease.Obviously, these folks do not have even an iota of understanding of how human biochemistry works.Years & decades of FAT hate & removing things such butter, ghee or full fat milk( saturated fats) has not helped reduce the incidence of cardiovascular & metabolic diseases. Infact, the incidence of these diseases has increased manifold!What is the reason?We are living under the false assumption that saturated fats are bad & even some folks are even endorsing that seed oils & polyunsaturated fats are not bad!Let us clear this clutter! The number of double bonds in a particular fatty acid determines how it will interact with our cells!While some saturated fats such as C14-myristic acid & C16-Palmitic acid are worst offenders & specifically C16 is said to trigger release of reactive oxygen & nitrogen species & cause cardiovascular disease, it has now been found that some specific odd chain saturated fatty acids such as Pentadecnoic acid(C15) & heptadecanoic acid(C17) as well even chain saturated fatty acid- Stearic Acid(C18) are actually beneficial for our cellular health. Specifically C15 is now called the holy grail of longevity & plays a key role in activating various receptors that reinstates cellular homeostasis, regulates glucose metabolism, reduces cancer cell proliferation, reduces inflammation & even improves cell membrane stability.Just putting all saturated fats in one bucket is a flawed approach & it is important to understand the chemical structure of each saturated fats & interaction with cells, microbiome, receptors & associated biochemical pathways Our today’s talk breaks this myth & discusses, backed by existing research, each of fats in detailKnow more about how you can improve triglyceride levels at:www.genefitletics.com/orahygCitations https://www.nature.com/articles/s41598-020-64960-yhttps://pubmed.ncbi.nlm.nih.gov/33965456/https://pmc.ncbi.nlm.nih.gov/articles/PMC9241382/

    Are fats good for your health?

  4. 26/03/2025

    Discover your Biological Age Story- Health discourse with Sakshi & Sushant Ep 13

    Aging is the future not because there is a wave of longevity companies measuring your biological age but assessment of biological age at system biology level gives a comprehensive picture of efficiency of your human & microbial cellular functions.Unfortunately, none of the longevity or so-called fitness companies have model & data in place to measure the cellular functions & specific gene expression & molecular pathways that are causing cellular decay.Some may look at telomere testing or DNA methylation while others may look at plasma level of blood investigations to assess the biological ageIt is important to mention that-Telomere testing does not give a comprehensive view of biology at molecular level & is just one aspect of biological age. None of the telomere tests can actually tell how bad your mitochondria is performing or what specific biomarkers is leading to telomere length shortening-DNA methylation just looks at underexpression or no expression of certain genes, lacking a comprehensive view of human biology-Blood tests never focus on human microbiome functions & just look at certain few blood markers, the outcome of that itself suffers from high standard deviation ~ more than 30%. There are multiple structural issues with no focus on the optimality of quantum biomarkers.-None of these biological age clocks are based on Indian specific molecular data.Departure from these flawed models, we measure biological age based on measurement of cellular functions, focussing on -Cellular Proteostasis -Oxidative stress driven DNA damage-Telomere regulation- Systemic Inflammation-Cellular Senescence -Stem Cell Regenerative signalling-Protein Fermentation-Gut & oral microbiome functional pathways-Cellular stress response-including unfolded protein response-Hypoxia induced stress-Metabolic stress-Mitochondrial Biogenesis-Genotoxic Stress-Antioxidant production markersOur model based on deep learning algorithms has been developed from mining 6 billion of molecular & phenotype metadata sets.Our today’s podcast discusses the science behind aging & how we are bringing a data driven revolution in longevity.

    Discover your Biological Age Story- Health discourse with Sakshi & Sushant Ep 13

  5. 11/02/2025

    Metabolic Therapy for Prevention & successful elimination of cancer- Ft. Dr Thomas N Seyfried

    In the year 2022, 1.46 million Indians developed cancer while over 9,00,000 lost their life.65% cancer mortality rate is the biggest cause of concern given that we have so many companies claiming to detect cancer early & number of therapies- radiation, chemo & immunotherapies to kill the tumours.Have you ever wondered why ?We have been stuck in the Dogma that cancer is a genetic disease caused by random genetic mutations while research & evidence has established that cancer is a mitochondria metabolic disease caused by damaged respiration & genetic mutations are downstream effects. Today at our prevent cancer podcast, we invited a special guest & world’s renowned cancer researcher- Dr. Thomas Seyfried. He holds a Ph.D. in Genetics and Biochemistry from the University of Illinois and has a background in neurology.Dr. Seyfried has received numerous awards and honors from various organizations, and he has over 150 peer-reviewed publications. He is also the author of the book "Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer," published in 2012.We discussed in detail on the following-Cancer as a mitochondrial metabolic disease-Why do we not have any solutions for prevention & successful management of cancer?-Why is the somatic mutation theory flawed?-How do cancer cells survive ? -What is cancer cachexia?-How cancer cells fall back on ancient fermentation pathways to proliferate & grow?-What is the origin of metastasis? Role of macrophages in metastatic cancer?-How does standard of care lead to growth of cancer?-Role of inflammatory oncotaxis in malignant cancer?Worth listening to!You can support Dr. Thomas Seyfried in multiple ways:Buy his summary ebook: https://www.cancer-as-a-metabolic-disease.com/summaryebook-purchase-page/Summary book, paperback: https://www.cancer-as-a-metabolic-disease.com/summaryebook-purchase-page/Buy his scientific bookhttps://www.amazon.com/Cancer-Metabolic-Disease-Management-Prevention/dp/0470584920Donate the research directly: https://foundationformetaboliccancertherapies.com/#cancerawareness #cancermedicine #cancerprevention #cancerresearch #chemotherapy #chemotherapie #chemosideeffects #chemotherapysideeffects #cancersurvivor #cancerpatients #cancerpatient #oncology #oncologia #radiationtherapy #radiationoncology #radiationoncologist #cancergenes #dna #genetesting #dnatest #dnadiet #microbiome #cancertest #earlydetectionsaveslives #earlydetection #oralmicrobiome #gutmicrobiome #gutmicrobiometest #oralmicrobiometest #nutritionfacts #nutritiontips #cancerdiet #geneticmutation #metabolictherapy

    Metabolic Therapy for Prevention & successful elimination of cancer- Ft. Dr Thomas N Seyfried

  6. 28/01/2025

    Impact of Oxidative Stress on Longevity #biologicalage #aging #longevitysecrets #longevity

    One of the important factors that directly impacts your longevity & biological age is oxidative stress. Oxidative stress is one of the culprits in the onset of various metabolic diseases & even cancer. What exactly is Oxidative Stress? It is a state of imbalance between pro-oxidant & antioxidant activities. Interaction between your biology with the food you eat, environment you live in , toxins or even exercise could lead to production of reactive oxidative species(ROS) which could lead to mitochondria dysfunction, DNA , lipid & protein damage, causing metabolic diseases & even cancer. However our body has defense mechanisms in place. Our body can produce antioxidant glutathione but it needs help from tiny little bugs living in our gut. Gut microbiomes metabolise non-essential amino acids- glutamate, glycine & cysteine & synthesise into glutathione. The glutathione can be oxidised by the help of a specific enzyme called glutathione peroxidase(Gpx). Again certain gut microbes when active could express certain genes that could code for protein that induces production of this enzyme. Once Glutathione is oxidised, it could donate electrons to neutralise ROS. Gut microbiome has a major role to play in maintaining redox balance. Besides, the role of oral microbiome cannot be ruled out as certain oral microbes stimulate production of nitric oxide via nitrate-nitrite pathways that activate certain signalling pathways in the cells that upregulate enzymes that produce glutathione. In addition, nitric oxide influences availability of cysteine that the gut microbiome can use to synthesise glutathione.As such oral & gut microbiomes work together to make sure that glutathione is produced &, oxidised, that can neutralise ROS. However glutathione contains sulphur containing amino acids & a certain gut &/or oral microbiome could synthesise sulphide in H2S. H2s is a potential toxin that could block complex IV of electron transport chain, disrupt production of butyrate(which is needed for stimulating antioxidant activities), disrupt mucus barrier & interfere with metabolic functions The role of the gut microbiome extends beyond Glutathione. Your gut microbes could metabolise various polyphenols, flavonoids, flavonols, ellagic acid & more & synthesize into beneficial compounds that could promote antioxidant activity & neutralise ROS. Therefore it is important to understand your unique biochemistry rather than assuming that your body will produce Glutathione or any other antioxidant at its even as well as if your gut/oral microbes could transform dietary glutathione into harmful toxin H2S which would have cascading effect on your metabolic health.Know more at: www.genefitletics.com/orahyg Citations https://pmc.ncbi.nlm.nih.gov/articles/PMC10216031/ https://pubmed.ncbi.nlm.nih.gov/17157184 https://pmc.ncbi.nlm.nih.gov/articles/PMC10643359/ https://pmc.ncbi.nlm.nih.gov/articles/PMC4631205 https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1328324/full

    Impact of Oxidative Stress on Longevity #biologicalage #aging #longevitysecrets #longevity

2024

  1. 16/10/2024

    Prevent Cancer Ep.3 - How does #Cancer grows & spreads? #cancerawareness #cancercure #cancermedicine

    90% of cancer deaths are attributed to metastasis. What exactly is metastasis ? In simple words it is the spread of cancer cells from the primary tumour sides to different tissues & distant organs. The process involves local invasion, detach from primary site, enter( intravasate) into circulation/blood stream, evade immune attack, enter other tissues /organs & proliferate/form secondary tumour at distant site. While the world is too much focussed on genetic mutations, the process of metastasis is so complex that it is too much to ask for genetic mutations that occur in random fashion. Most of the cancer cells have limited capacity to spread their wings to other sites inside the body. This is where the role of macrophages- the immune cells comes into picture. Macrophages are genetically programmed to go to the site of injury, heal the wound &/or kill that virus or harmful bacteria. These specialised immune cells cannot recognise the tumour cells & start throwing growth factors & cytokines which are stimulatory towards these cancer cells. Macrophages are fusogenic & they fuse with these tumour cells, making them transit from a respiratory energy metabolism state to fermentation stage. Ultimately these macrophages become rogue & start spreading to different parts of the body as they have free passage to different parts of the body due to their inherent nature & task of repair work. In the episode 3 of “ Prevent Cancer Podcast”, we discuss in detail -What causes metastasis? -Why do cancer cells spread to non-random locations? -Why in spite of having similar biochemical phenotype, stem cells may not express systemic metastasis ? Worth listening. Citation : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597235/ Watch our previous episodes: Episode 1- https://youtu.be/OOReAl0b7QQ Listen on Spotify- https://spotifyanchor-web.app.link/e/6WDSc0UxJNb Episode 2- https://youtu.be/_LEhJXladKM Listen on Spotify- https://spotifyanchor-web.app.link/e/cv0EWXUxJNb Check out what Genefitletics is doing in Cancer: www.genefitletics.com/oraonco #cancerawareness #cancermedicine #cancerprevention #cancerresearch #chemotherapy #chemotherapie #chemosideeffects #chemotherapysideeffects #cancersurvivor #cancerpatients #cancerpatient #oncology #oncologia #radiationtherapy #radiationoncology #radiationoncologist #cancergenes #dna #genetesting #dnatest #dnadiet #microbiome #cancertest #earlydetectionsaveslives #earlydetection #oralmicrobiome #gutmicrobiome #gutmicrobiometest #oralmicrobiometest #nutritionfacts #nutritiontips #cancerdiet #geneticmutation #cancercell #cancerprogression #tumour

    Prevent Cancer Ep.3 - How does #Cancer grows & spreads? #cancerawareness #cancercure #cancermedicine

  2. 10/10/2024

    Decoding difference between #cancercells & Normal Cells- #Cancer #Podcast Ep-2 #cancerawareness

    We all know cancer is nothing but uncontrolled cell growth & division. Mitochondria in every cell controls cell cycle. It is a kill switch. When there is mitochondria dysfunction, this kill switch is gone. The cells starts to proliferate & grow. The question arises what differentiates normal cells from cancer cells? It is how cells generate energy. Normal cells generate energy using aerobic respiration. They, in presence of oxygen via oxidative phosphorylation, generate ATP & releases CO2 & water as a byproduct. During this process, they utilize energy sources - carbohydrates & fats to convert into ATP. However mitochondrial dysfunction results in a situation of respiration insufficiency & cells start to divide & grow( become cancerous). These cancer cells can no longer use oxygen efficiently to generate energy. Rather it resorts to ancient fermentation pathways to grow utilizing substrates such as glucose & glutamine via substrate level phosphorylation. As long as people suffering from cancer keep on consuming a lot of glucose, they are enabling cancer cells to proliferate & grow. Unfortunately, we have not seen any healthcare practitioner/oncologist focussing on precision nutrition to starve cancer while nourishing health cells & adoption a nutritional therapeutics approach to stimulate mitochondria biogenesis. In episode 2 of “ Prevent Cancer Podcast”, we discuss the basic difference between normal cells & cancer cells. Know more about how we early detect oral cancer: www.genefitletics.com/oraonco cancerawareness #cancermedicine #cancerprevention #cancerresearch #chemotherapy #chemotherapie #chemosideeffects #chemotherapysideeffects #cancersurvivor #cancerpatients #cancerpatient #oncology #oncologia #radiationtherapy #radiationoncology #radiationoncologist #cancergenes #dna #genetesting #dnatest #dnadiet #microbiome #cancertest #earlydetectionsaveslives #earlydetection #oralmicrobiome #gutmicrobiome #gutmicrobiometest #oralmicrobiometest #nutritionfacts #nutritiontips #cancerdiet #geneticmutation

    Decoding difference between #cancercells & Normal Cells- #Cancer #Podcast Ep-2 #cancerawareness

  3. 07/10/2024

    Going beyond #somatic #mutation theory- Decoding cause of Cancer #cancerawareness #cancermanagement

    Cancer has been regarded as a genetic disease caused by genetic mutations driven by somatic mutation theory. You would be have influx of number of DNA testing or early cancer detection companies claiming they could detect risk/early cancer onset looking at certain genetic mutations, circulating tumor cells or physical examinations These all are driven by a financial model to make money out of personalized chemo/immuno or radiation therapies irrespective of success of such therapies throwing toxins inside our body. & then we have some new age VC funded startups setting up dialysis like chains to offer these toxin laden therapies. Unfortunately, none of these companies/healthcare institutions have a clear understanding of how cancer manifests & still treat the human body as black box. It has now been found that somatic mutation theory(SMT) is a flawed approach & cancer is a mitochondrial metabolic disease(MMT). In a recent research it was discovered there was absence of genes mutations & chromosomal abnormalities in 73 out of 210 cancer cases by sequencing their biological samples(1) while driver gene mutations, said to be responsible for a number of cancers, was found in normal cells which are non cancerous (2). It has also been found that there exists genomic heterogeneity in different tumor cells which itself makes these targeted therapies sub-optimal & genetic mutations can easily bypass them. So what causes Cancer ? It is damaged respiration( mitochondria dysfunction) followed by compensatory fermentation(4). Yes it is mitochondria dysfunction caused by chronic inflammation, carcinogenic toxins, viruses,  environmental toxins & more which shuts down the kill switch that controls cell cycle. This leads to cell growth & proliferation triggered by ancient fermentation pathways that ferments glucose & glutamine(3).  In order to break this myth that cancer is a genetic disease & understand the molecular mechanism behind cancer onset, we have started  “Prevent Cancer Podcast”  The first episode : What causes cancer ? is live now. (1) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712719/ (2) https://pubmed.ncbi.nlm.nih.gov/30467157/ (3)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493566/ (4) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8467939/ #cancerawareness #cancermedicine #cancerprevention #cancerresearch #chemotherapy #chemotherapie #chemosideeffects #chemotherapysideeffects #cancersurvivor #cancerpatients #cancerpatient #oncology #oncologia #radiationtherapy #radiationoncology #radiationoncologist #cancergenes #dna #genetesting #dnatest #dnadiet #microbiome #cancertest #earlydetectionsaveslives #earlydetection #oralmicrobiome #gutmicrobiome #gutmicrobiometest #oralmicrobiometest  #nutritionfacts #nutritiontips #cancerdiet #geneticmutation #healthpodcast #cancerpodcast

    Going beyond #somatic #mutation theory- Decoding cause of Cancer #cancerawareness #cancermanagement

  4. 27/09/2024

    Groundbreaking truth about Heart disease #worldheartday #hearthealth #cardiovasculardisease

    On the eve of World Heart Day 2024, let us break all myths around onset & progression of cardiovascular disease. Cardiovascular disease is the number one killer globally with no preventative solutions as of now. Most of the #healthcare practitioners & #healthtech companies still blame cholesterol for development of cardiovascular disease while it is a known fact, backed by years of research, that cholesterol does not cause heart disease. In fact cholesterol is one of the essential molecules required for various cellular processes right from maintaining structure, fluidity & integrity of cell membrane, facilitating intracellular signalling including production of nitric oxide. It has also been found that 75% of the people who were hospitalized for heart disease had normal cholesterol levels.Do not blame cholesterol for heart disease. So a question may arise, if cholesterol does not cause heart disease what is the underlying cause of the number one killer globally? What should be measured to evaluate our risk of cardiovascular disease? Should we measure apolipoprotein? Triglycerides ? Today's podcast discusses in detail. We covered the following topic -Cholesterol is not to be blamed for our heart issues - Role of nitric oxide in preventing cardiovascular disease -What causes functional loss of nitric oxide production -Role of oral microbiome in regulating blood pressure -Role of Gut Dysbiosis in elevation of apolipoprotein, triglycerides, VLDL & LDL -How mouth wash & fluoride are connected with increased risk of blood pressure & heart disease. -Why measuring apolipoprotein cannot help you frame a preventative solution for your heart issue. A must listen for everyone, not to be missed! Citations https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682969 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164974/ https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1271001/full#B35 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962737/ https://www.sciencedirect.com/science/article/abs/pii/S156757692300869X https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290464/ https://pubmed.ncbi.nlm.nih.gov/35893593 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214130 https://pubmed.ncbi.nlm.nih.gov/33914709/ #heartdisease #heartattack #heartdiseaseawareness #hearthealth #metabolichealth #type2diabetes #coronaryarterydisease #cardiology #cardiologist #highbloodpressure #lowbloodpressure #hypertensionawareness #hypertension #cardiovasculardisease#heartcondition #healthhack #heartpalpitations #heartconditions #cholesterol #lowcarbdiet #lowcholesterol #highcholesterol #statin #healthtips

    Groundbreaking truth about Heart disease #worldheartday #hearthealth #cardiovasculardisease

  5. 26/09/2024

    Facts you should know about Microbiome Tests #microbiomehealth #microbiometest #guthealth

    Over the last 4-5 years, we have seen a flurry of gut microbiome DNA testing companies, claiming they have an out of box solution to reverse most chronic diseases! I am afraid this is far away from reality! No doubt, Gut microbiome has a vital role to play in overall physiology but these companies have less than optimal approach on two fronts -These companies do not focus on the system biology approach & fail to study other areas of microbiome including oral, skin, vaginal, scalp, immune system, mitochondria, hormonal health, heavy metals, toxins & more. -Driven by their investor/VC funds philosophy, these companies have adopted primitive DNA sequencing tech to make it an FMCG product/service rather than focussing on bringing scientific breakthroughs. These companies focusses on microbial composition & potential & fail to measure the biochemical functions at molecular level, thereby lacking precision, efficacy & accuracy. A complete departure from this linear outdated model, we at Genefitletics have adopted a system biology approach to -Offer system biology + mathematics platform - Measure the biochemical functions of gut & oral microbiome -Measure mitochondrial functions - collect, process & analyze molecular, longitudinal & clinical data to predict onset of various diseases including type 2 diabetes, cardiovascular diseases, chronic kidney disease & halitosis -Machine learnt models to predict glycemic response to 300 plus foods -Construct data driven precision nutrition & therapeutics interventions to rebalance an individuals’s biology -Collect longitudinal data at regular intervals to train our ML model, assess the efficacy of our interventions & revise the recommendations aligned with changes in individual’s biochemistry -now also offer oral cancer early detect test & associated disease prevention interventions Access to platform is now available for a monthly subscription model starting at Rs.2,500( $ 31) a month More details here: www.genefitletics.com #health #gutmicrobiome #gutmicrobiometest #guthealthtips #guthealthforlife #guthealth #typ2diabetes #obesity #thyroid #hashimoto #hypothyroidism #hypothyroidweightloss #hyperthyroidism #autoimmunedisease #autoimmuneawareness #autism #autismawarness #heartcondition #cardiovasculardisease #cardiovascularrisk #dnatesting #dnatest #dnadiet

    Facts you should know about Microbiome Tests #microbiomehealth #microbiometest #guthealth

  6. 27/08/2024

    Cholesterol does not cause Heart Disease #cardiovasculardisease

    Do you know which is the most complex machinery ever made on this planet earth? Yes , it's the human body! Our body is a sack of chemicals & biochemical reactions that need to work in synchrony to keep our body in homeostasis. It needs flow of electrons, voltage & current to keep all biological functions moving. Literally everything is connected- what happens in the mouth, spreads everywhere , what happens in mouth influences the functions your gut microbiome performs, what happens in the gut impacts your brain, heart, hormones & more.  What we eat feeds our microbiome which in turn extracts chemical energy for their survival & as a byproduct releases molecules, chemicals & metabolites that impact our overall health.Still when it comes to metabolic health, we are too obsessed with solving /suppressing our blood sugar response without understanding the biochemistry behind. How many CGM companies actually solve for heart health, kidney health or sexual health?  Actually no one! Oh I forgot , a number of these companies track cholesterol levels assuming cholesterol is root  cause of heart disease. Probably, they have forgotten the basics or do not understand how human biology works. Hard truth for everyone, there is no life without cholesterol- it is synthesized by every cell inside the body & is required for various biochemical processes including producing bile acid, regulating sex hormones, and producing vitamin D.  Since some cells synthesize less than they require while others synthesize in excess, some cells are net exporters while others are net exporters. Therefore cholesterol is transported from one cell to another which needs to be packaged with protein( since cholesterol is not soluble in water) which is referred to as lipoprotein. Cholesterol is packaged with VLDL & LDL & transported to other cells in need. Once the cell utilizes cholesterol, it is transported back via reverse cholesterol transport process.During his process, the liver synthesizes APOA-1 which is released in the bloodstream. The cholesterol moves into APOA-1( made us of 70% HDL) which is transported in liver to perform other cellular processes.  Although some may say we track APOA-1 & APOB-100, the truth is expression of apolipoprotein is regulated /impacted by metabolites secreted by your gut & oral microbiome. Certain metabolites that can impact your LDL production & expression of APOA-1 includes Butyrate, TMAO, Indole Propionic Acid, LPS production, nitric oxide,  p-cresol, PAG & more. Therefore rather than measuring your cholesterol or APOA-1/APOB-100, you should focus on measuring your microbial biochemistry & metabolites secreted by your gut & oral microbiome. Our video discusses this in detail Know more at www.genefitletics.com/orahyg Citations https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2023.1271001/full#B35https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962737/ https://www.sciencedirect.com/science/article/abs/pii/S156757692300869X https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290464/ https://pubmed.ncbi.nlm.nih.gov/35893593/ https://pubmed.ncbi.nlm.nih.gov/33914709/ #heartdisease #heartattack #heartdiseaseawareness #hearthealth #metabolichealth #type2diabetes #coronaryarterydisease #cardiology #cardiologist #highbloodpressure #lowbloodpressure #hypertension

    Cholesterol does not cause Heart Disease #cardiovasculardisease

  7. 09/05/2024

    Can we detect early signs of chronic kidney disease?

    Chronic Kidney Disease is a global health problem. The biggest issue lies in its late diagnosis during the progression of disease. The clinical manifestation & plasma level indications such as eGFR that can indicate kidney health are reduced only at advanced stages of disease development. However the fact is the changes in biology & chemistry at molecular level takes place years before the nitrogenous substances such as urea & creatinine accumulates in the blood. Unfortunately, up till now, we had no models in place to detect the early signs of chronic kidney disease. Even some of the companies are tracking certain vital parameters such as weight monitoring, sleep, water tracking, nutrition & more but these practices are just focussed on managing kidney disease. It is no brainer that increased risk of type 2 diabetes or high blood glucose level could damage blood vessels of kidneys & increase risk /trigger chronic kidney disease. However, research & empirical evidence has now found that functions of oral & gut microbiome have a role to play in early onset of chronic kidney diseases & could be used as early indication & offer preventative solutions -Halitosis(bad breath) via oral microbial metabolites such as oral H2S, ammonia, polyamines & urease pathways is an early sign. -Secretion of gut microbial derived metabolites & uremic toxins such as p-cresol, Indoxyl Sulphate, TMAO & LPS could impact kidney function.High circulatory level of these toxins could lead to oxidative stress. Here comes a very important aspect which is missed by the current healthcare system. Oxidative stress leads to oxidation of certain metals on protein & enzymes, thereby making cells dysfunctional & disrupting nitric oxide. This establishes a clear correlation that chronic kidney disease could increase risk of type 2 diabetes & cardiovascular diseases as well. Our today’s podcast episode discusses this in detail

    Can we detect early signs of chronic kidney disease?

  8. 16/04/2024

    Health Discourse with Sakshi & Sushant- Episode 12

    It has been found that 33% of adult female population suffer from depression, while 1 in 5 men would have this growing mental health issue. Stress is rampant while millions of people deal with dementia & Parkinson's. While there are solution such as drugs & antidepressants to manage these growing mental health conditions, we have not seen any application of science to carve out preventive solution for growing mental health issues. We all know the role of gut microbiome in our brain health via the gut-brain axis. Gut microbes not only produce neurotransmitters but also secrete certain toxic metabolites which could travel to brain & trigger inflammation. But research has now found that the second largest coloniser of microbes in the body- mouth has a vital role to play not only in our oral health but a range of systemic health issues such as type 2 diabetes, heart diseases, arthritis, IBD, colon cancer & more. Improper nutrition & bad oral hygiene could lead to trigger oral microbial dysbiosis which over activates immune response & leads to chronic inflammation. This prolonged inflammation creates a situation of leaky gum which allows certain oral microbes such as streptococcus mutans & P Ginagavalis translocate from mouth into bloodstream & brain where it could secrete toxin metabolites & directly trigger onset & progression of brain health issues such as dementia. Specifically P. Gingivalis could secrete neurotoxic protease-Gingipain which could lead to creation of Amyloid Beta Protein Plague which is associated with dementia. It has also been found that people suffering from Chronic Periodontal disease & also experience neuro inflammation. Besides, Oral microbial dysbiosis is also connected with loss of dopamine production neurons, the hallmark of motor dysfunction & parkinsons disease. Our today’s talk opens pandorabox on oral microbiome- brain health connection. We are the only company in India that analyses oral microbiome functions to translate early pre-disease signals into unique molecular insights & carve our precision nutrition interventions to bring back your body back into homeostasis. More details here :https://genefitletics.com/orahyg/

    Health Discourse with Sakshi & Sushant- Episode 12

  9. 08/04/2024

    Health Discourse with Sakshi & Sushant- Episode 11

    We have become a protein obsessed nation! Have you ever wondered why? We are told we are deficient in protein! But does this apply to everyone? Is the entire adult population protein deficient? What is the basis of the claim ? How do we calculate deficiency? If you are recommended some X grams / kg of body weight to meet your protein requirement, you are misguided. These recommendations are based on population studies which considers you as an average healthy individual & metabolising food/protein in the same way others metabolise? These are wrong claims as our biology is as unique as our fingerprint. We need protein for various cellular processes, brain functioning, energy & more but how much each individual needs & which ones is & should be driven by his/her unique biochemical profile. There are multiple factors at play when it comes to protein consumption & absorption which includes digestive enzymes. Your microbes could tell you if you are digesting protein efficiently via activating certain pathways such as Protein Fermentation & digestive efficiency. If you are not digestive protein efficiently or eating excess protein, it may land up in your large intestine where certain microbes- Proteobacteria interact with amino acid & produce harmful metabolites such as Ammonia, methane, H2S,p-Cresol, Putrescine, PAG, TMAO & more which could range of chronic health conditions including autoimmune disorders, cardiovascular diseases & more. Research has found that excess production of p-cresol could suppress GLP-1 production which is said to cause obesity even typ3 2 diabetes. Even when it comes to type 2 diabetes, do not fall for a high protein diet as a solution for type 2 diabetes.Understand your unique biology- Certain polyphenols such as walnuts, Pomegranate, Strawberry & more when converted by your microbiome into Urolithin A improve your hypoglycemic response & pancreatic B Cell function. Do not fall for these generic recommendations, your biology is unique, you deserve nutrition choices aligned with your biochemical individuality. Our today’s talk deep dives into role of protein in detail

    Health Discourse with Sakshi & Sushant- Episode 11