ISHLT Voices

ISHLT

ISHLT Voices features conversations, studies, and member profiles. Explore advanced heart and lung failure, transplantation, mechanical circulatory support, and pulmonary vascular disease through the eyes of your community. The content of industry-supported ISHLT Voices podcasts are developed entirely by our industry partners. They are not official ISHLT educational programs, and therefore are not eligible for CME under the ISHLT.

Episodes

  1. 26/06/2025

    DQS: The New Evolution of dd-cfDNA Testing and Noninvasive Rejection Monitoring, Presented by Natera

    In this episode of the ISHLT Voices podcast, hosted by Natera, you'll hear transplant cardiologists explore the evolving landscape of post-heart transplant care, zeroing in on the transformative shift from traditional, invasive biopsies to cutting-edge noninvasive molecular diagnostics—particularly cell-free DNA technologies. Brent Lampert, DO Medical Director, Transplant Cardiologist The Ohio State University Wexner Medical Center   Columbus, OH USA     Ajith P. Nair, MD, FACC, FAHA Associate Professor, Medicine—Cardiology Texas Heart Institute at Baylor College of Medicine Houston, TX USA   Drs. Lampert and Nair discuss the clinical promise of tools like Natera's Prospera Heart with Donor Quantity Score (DQS), which not only offer heightened accuracy and earlier detection of graft injury and rejection, but also may empower clinicians to strike a vital balance: preventing rejection without over-immunosuppression. Real-world insights, compelling case examples, and candid discussions about the challenges of biopsy-based monitoring—and how new technology is reshaping decisions, outcomes, and patient peace of mind—make this a must-listen for anyone intrigued by the future of transplantation medicine.   The content of this podcast was developed entirely by our industry partner, Natera. It is not an official educational program of the ISHLT, and therefore is not eligible for CME under the ISHLT. This episode was created for ISHLT Voices and sponsored by Natera.

    37 min
  2. 14/11/2024

    Explore Noninvasive Rejection Monitoring in Single Lung Transplantation; A SLAM Study Overview Presented by Natera

    In this episode of the ISHLT Voices podcast, hosted by Natera, you'll hear a discussion on the need for noninvasive surveillance options for single lung transplantation and the role that the Prospera Lung donor derived cell free DNA (dd-cfDNA) test can play. There are inherent, increased risks and challenges associated with management of single lung transplantation over double lung. Monitoring through invasive transbronchial biopsy procedures (TBBx) is often not the best option for these high-risk, frail patients. In this podcast, notable transplant pulmonologists Drs. Rosenheck and Arunachalam highlight the need in the single lung population for noninvasive surveillance options. The Prospera Lung donor derived cell free DNA (dd-cfDNA) test has been validated in single and double lung transplants with emerging data in support of clinical utility. The expert speakers also discuss the recently published data in support of dd-cfDNA usage in the single lung transplant population from the SLAM study.   Justin Rosenheck, DO Assistant Professor of Internal Medicine Ohio State University | Columbus, OH USA Ambalavanan Arunachalam, MD Assistant Professor, Medicine (Pulmonary and Critical Care) Northwestern Medicine | Chicago, IL USA The content of this podcast was developed entirely by ISHLT's industry partner, Natera. It is not an official educational program of the ISHLT, and therefore is not eligible for CME under the ISHLT.

    31 min
  3. Trio of Insights: Commentary on the TRIFECTA Studies Analyzing Three Rejection Diagnostic Tools in Heart, Lung, and Kidney Transplantation, From Natera

    15/12/2023

    Trio of Insights: Commentary on the TRIFECTA Studies Analyzing Three Rejection Diagnostic Tools in Heart, Lung, and Kidney Transplantation, From Natera

    Presented by Natera Natera returns with another ISHLT Voices podcast. Post-transplant monitoring with noninvasive donor derived cell free DNA (dd-cfDNA) has been growing in popularity and usage with several transplant centers significantly reducing surveillance biopsies in favor of a single blood test. But, as with all new technology, there are outstanding questions to understand how and why the technology works as well as it does. In this episode, leading investigators from the Alberta Transplant Applied Genomics Centre (ATAGC), Drs. Phil Halloran, Kieran Halloran, and Patrick Gauthier will walk you through their efforts in the TRIFECTA series of studies to triangulate insights from dd-cfDNA, molecular diagnostics, and donor specific antibody versus standard histological assessments in heart, lung, and kidney transplantation. Philip F. Halloran, MD, PhD, FRCP(C), OC, FRSC Professor of Medicine & Medical Microbiology and Immunology Director, Alberta Transplant Applied Genomics Centre University of Alberta Edmonton, AB Canada Kieran Halloran, MD, MSc Transplant Pulmonologist Associate Professor University of Alberta Edmonton, AB Canada Patrick Gauthier, PhD Senior Data Scientist Alberta Transplant Applied Genomics Centre Edmonton, AB Canada   This episode was created for ISHLT Voices and sponsored by Natera. The content of this podcast was developed entirely by our industry partner, Natera. It is not an official educational program of the ISHLT, and therefore is not eligible for CME under the ISHLT.

    27 min
  4. Exploratory Evidence Supports Use of Donor-Derived Cell-Free DNA to Monitor Pediatric Heart Transplant Recipients, From Natera

    18/10/2023

    Exploratory Evidence Supports Use of Donor-Derived Cell-Free DNA to Monitor Pediatric Heart Transplant Recipients, From Natera

    Presented by Natera In this episode of the ISHLT Voices podcast, Dr. Shri Deshpande, a cardiologist at the National Children's Hospital in Washington, DC USA, discusses his work on improving the care of pediatric heart transplant patients.  Dr. Deshpande's research focuses on the use of cell-free DNA in monitoring transplant recipients for rejection. He explains that cell-free DNA, released when cells break down, can be detected in the bloodstream and used as a non-invasive screening tool to assess the health of transplanted organs.  The discussion covers the external validation of the Prospera™ assay by Natera, which has shown high negative predictive value and specificity, making it a promising tool for reducing the need for invasive biopsies and improving long-term transplant outcomes. Dr. Deshpande also highlights the potential for wider implementation of this technology in standard transplant care and ongoing research to optimize its use. Shriprasad Deshpande, MD Cardiologist Director, Advanced Cardiac Therapies Director, Heart Transplant Program National Children's Hospital Washington, DC USA   This episode was created for ISHLT Voices and sponsored by Natera. The content of this podcast was developed entirely by our industry partner, Natera. It is not an official educational program of the ISHLT, and therefore is not eligible for CME under the ISHLT.

    23 min

About

ISHLT Voices features conversations, studies, and member profiles. Explore advanced heart and lung failure, transplantation, mechanical circulatory support, and pulmonary vascular disease through the eyes of your community. The content of industry-supported ISHLT Voices podcasts are developed entirely by our industry partners. They are not official ISHLT educational programs, and therefore are not eligible for CME under the ISHLT.