Manifold

Steve Hsu

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Steve Hsu is Professor of Theoretical Physics and Computational Mathematics, Science, and Engineering at Michigan State University. Join him for wide-ranging conversations with leading writers, scientists, technologists, academics, entrepreneurs, investors, and more.

6 ദിവസം മുമ്പ്

Beff Jezos and Effective Accelerationism: Machine God of Loving Grace

Beff Jezos (Guillaume Verdon) is a Canadian physicist, quantum computing researcher, and tech entrepreneur. He is best known as the founder of the Effective Accelerationism (e/acc) movement. This interview was recorded in collaboration with John Greer and Lei Huang for the documentary film Machine God. John Greer: https://www.johncgreer.com/ Chapter Markers: (00:00) - Meet Beff Jezos (01:56) - Hyperstition vs AI Doom (21:29) - Accelerate or Die (37:51) - Scaling Intelligence Upside (40:26) - Doomers Power Centralization (47:17) - EAC Physics Framework (01:10:10) - Debating Doom Narratives (01:16:13) - Beff Jezos Origin Story (01:28:06) - Pause Debate and Rapid Fire – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models. Mechanize is hiring! https://mechanize.work/b/hsu Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists. For example: Research Engineer, Alignment: Build evals that test for misaligned model behaviors $500K salary Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve $300K salary Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above.

1മ 41മി.
ജൂൺ 18

Razib Khan at Manifest 2026: Genetic Discoveries, AI, and Academia – #114

This episode was recorded live at Manifest 2026. Razib Khan is a prominent writer, population geneticist, and podcaster. He is best known for his extensive deep-dives into human evolutionary history, consumer genomics, culture, and ancient DNA. https://x.com/razibkhan https://x.com/razibkhan?lang=en Chapter Markers: (00:00) - Razib Khan at Manifest 2026: Genetic Discoveries, AI, and Academia (01:18) - Manifest Q&A Kickoff (02:43) - Yamnaya: Ancient DNA Mysteries (15:01) - Yamnaya: Y Chromosome Conquests (22:10) - Embryo Screening and AI (42:15) - Conformity and Tenure (46:34) - Academia: Reforms (53:55) - Academia: Ideological Capture and Funding (58:19) - Controversies and Closing Q&A – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models. Mechanize is hiring! https://mechanize.work/b/hsu Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists. For example: Research Engineer, Alignment: Build evals that test for misaligned model behaviors $500K salary Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve $300K salary Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above.

1മ 21മി.
ജൂൺ 4

Letter from Beijing 2: Tsinghua University – #113

This special episode was recorded at Tsinghua University in Beijing, generally regarded as the top university in China. Our guests are 3 Americans studying and working at Tsinghua: Gabriel (undergrad), Justin (PhD student in AI), and Alex (Professor in AI research). Topics discussed include: Tsinghua University and elite human capital, AI in China, US-China competition, and the flow of human capital between the US and China Han Feizi, columnist at Asia Times and the guest from the previous "Letter from Beijing" episode, is also in the room. Letter from Beijing with Han Feizi: https://www.manifold1.com/episodes/letter-from-beijing-with-han-feizi-72 Chapter Markers: (00:00) - Welcome to Tsinghua University (02:47) - Gabriel’s Undergrad Journey (12:35) - Justin’s PhD (25:10) - Professor Alex on AI and Rankings (42:51) - Second Chances and Status Signals (46:48) - China’s Exam Ladder Explained (50:20) - Infrastructure and Tech Competition (01:17:18) - Semiconductors, EUV, and Wrap Up – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models. Mechanize is hiring! https://mechanize.work/b/hsu Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists. For example: Research Engineer, Alignment: Build evals that test for misaligned model behaviors $500K salary Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve $300K salary Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above.

1മ 21മി.
മേയ് 21

AI Billionaire on Existential Risk: Jaan Tallinn

Jaan Tallinn is a tech billionaire and founding engineer of Skype who leverages his wealth to mitigate existential risks from artificial general intelligence (AGI). He co-founded the Future of Life Institute and the Centre for the Study of Existential Risk, while making early foundational investments in frontier AI labs like DeepMind andAnthropic. Chapter Markers: 00:00 Assessing Current AI Risk Levels03:28 Inside Self-Sustaining AI Scenarios09:10 The Global AI Race Dynamics42:25 Explaining the Techno-Capital Flywheel45:34 Insider Origins of AI Safety56:06 Race Politics and Public Fear01:23:12 Pop Culture, Movies, and Fame01:30:15 Big Questions for Humanity's Future – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models. Mechanize is hiring! https://mechanize.work/b/hsu Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists. For example: Research Engineer, Alignment: Build evals that test for misaligned model behaviors $500K salary Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve $300K salary Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above.

1മ 41മി.
മേയ് 7

Embryo Selection and Frontier Genomics with Dr. Alex Young – #111

Dr. Alex Young, a statistical geneticist and assistant professor in the Human Genetics department at UCLA, joins Steve Hsu to discuss the cutting edge of genomic prediction. They cover his research on polygenic embryo screening in IVF (including the ImputePGTA method), family-based DNA analysis, missing heritability, and the implications of polygenic scores for traits like education and disease. Alex also discusses his recent battles with cancer. https://x.com/AlexTISYoung Chapter Markers: (00:00) - Alex Young Bio (06:36) - Biobank Era Genetics (10:49) - Missing Heritability Debate (27:18) - Embryo Selection Controversy (50:32) - Embryo Selection Backlash (53:42) - Mexico City Admixture Study (01:00:13) - Censorship Via Data Access Control (01:05:02) - Battle With Cancer and Circulating Tumor DNA (ctDNA) – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models. Mechanize is hiring! https://mechanize.work/b/hsu Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists. For example: Research Engineer, Alignment: Build evals that test for misaligned model behaviors $500K salary Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve $300K salary Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above.

1മ 31മി.
ഏപ്രി 23

Iran War is the First Missile War (crossover with Seeking Truth From Facts podcast) – #110

Steve and Alf discuss the Iran War, emphasizing what it reveals about modern missile and anti-missile technology, drones, and the implications for a US-China conflict in the Western Pacific. Links:https://seekingtruthfromfacts.substack.com/ Chapter Markers: (00:00) - Missile War Reality Check (01:49) - How the War Started (04:46) - Iran Outperforms Expectations (06:22) - Why Missile Defense Fails (14:25) - Ceasefire and Hormuz Brinkmanship (19:52) - Nukes and the JCPOA Fallout (33:44) - US Politics and Israel Lobby Aftershocks – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models. Mechanize is hiring! https://mechanize.work/b/hsu Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists. For example: Research Engineer, Alignment: Build evals that test for misaligned model behaviors $500K salary Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve $300K salary Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above.

49 മി.
ഏപ്രി 9

Dreamers and Doomers: Our AI future, with Richard Ngo – #109

Richard Ngo is an independent AI researcher and philosopher known for his work on AGI safety and alignment. He recently resigned from OpenAI, where he was a member of the Governance team focused on forecasting the capabilities and risks of advanced AI systems. His debut fiction collection is titled "The Gentle Romance: Stories of AI and Humanity", published in December 2025. The book features 22 science fiction stories that explore the psychological and sociological impacts of advanced artificial intelligence. On X: @RichardMCNgo (00:00) - Richard Ngo Origins (03:48) - DeepMind vs LLMs (09:24) - OpenAI Futurist and AGI Risk (39:17) - Machine God Tail Risk (45:20) - Weird Futures and Normies (51:28) - Alignment Research and Academia (01:16:25) - Doomers vs Skeptics (01:23:57) - Labs Governance Futures (01:39:37) - Doom Scenarios Society – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models. Mechanize is hiring! https://mechanize.work/b/hsu Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists. For example: Research Engineer, Alignment: Build evals that test for misaligned model behaviors $500K salary Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve $300K salary Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above.

1മ 52മി.
മാർ 26

China, Acceleration, and Nick Land - with Matt Southey – #108

Matt Southey is an editor for an AI safety organization. He wrote his PhD dissertation on the philosophy of Nick Land. Matt's "A Brief History of Accelerationism" can be found here, and he recommends the second chapter of Crypto-Current as a good introduction to Land's usage of Kant. He and Steve discuss Accelerationism, AI, and Steve's recent meeting with Land in Shanghai. Chapter Markers: (00:00) - Introduction (02:07) - China Trip: Shenzhen, Beijing, Shanghai (03:16) - Tsinghua University: Talent (09:02) - Robotics and AI research (24:01) - Shanghai and Nick Land (35:46) - Land’s Esotericism (37:19) - Accelerationism and Orthogonality (43:01) - Simulation Metaphysics and Physics (54:36) - Dark Enlightenment and Inevitable Complexity – Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. Previously, he was Senior Vice President for Research and Innovation at MSU and Director of the Institute of Theoretical Science at the University of Oregon. Hsu is a startup founder (SuperFocus.ai, SafeWeb, Genomic Prediction, Othram) and advisor to venture capital and other investment firms. He was educated at Caltech and Berkeley, was a Harvard Junior Fellow, and has held faculty positions at Yale, the University of Oregon, and MSU. Please send any questions or suggestions to manifold1podcast@gmail.com or Steve on X @hsu_steve. Announcing this for some friends at Mechanize - a startup that builds environments for training and evaluating frontier LLMs. Its customers include the top AI labs, and it has contributed to the breakthrough in coding capabilities of frontier models. Mechanize is hiring! https://mechanize.work/b/hsu Compensation is extremely competitive. For technical roles, $300-500k. They are also seeking smart generalists. For example: Research Engineer, Alignment: Build evals that test for misaligned model behaviors $500K salary Puzzle Maker: Design interesting and original puzzles that LLMs can’t yet solve $300K salary Mechanize understands that my readership is highly selected. There is a VERY GOOD CHANCE you will be interviewed if you apply via the link above.

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Steve Hsu is Professor of Theoretical Physics and Computational Mathematics, Science, and Engineering at Michigan State University. Join him for wide-ranging conversations with leading writers, scientists, technologists, academics, entrepreneurs, investors, and more.

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Steve Hsu
സജീവമായ വർഷങ്ങൾ

2019 - 2026
എപ്പിസോഡുകൾ

166
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