Today on Talk Python: What really happens when your data work outgrows your laptop. Matthew Rocklin, creator of Dask and cofounder of Coiled, and Nat Tabris a staff software engineer at Coiled join me to unpack the messy truth of cloud-scale Python. During the episode we actually spin up a 1,000 core cluster from a notebook, twice! We also discuss picking between pandas and Polars, when GPUs help, and how to avoid surprise bills. Real lessons, real tradeoffs, shared by people who have built this stuff. Stick around.
Episode sponsors
Seer: AI Debugging, Code TALKPYTHON
Talk Python Courses
Links from the show
Matthew Rocklin: @mrocklin
Nat Tabris: tabris.us
Dask: dask.org
Coiled: coiled.io
Watch this episode on YouTube: youtube.com
Episode #519 deep-dive: talkpython.fm/519
Episode transcripts: talkpython.fm
Developer Rap Theme Song: Served in a Flask: talkpython.fm/flasksong
--- Stay in touch with us ---
Subscribe to Talk Python on YouTube: youtube.com
Talk Python on Bluesky: @talkpython.fm at bsky.app
Talk Python on Mastodon: talkpython
Michael on Bluesky: @mkennedy.codes at bsky.app
Michael on Mastodon: mkennedy
Information
- Show
- FrequencyUpdated weekly
- Published18 September 2025 at 08:00 UTC
- Length1h 3m
- Episode519
- RatingClean