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06/10/2025
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04/09/2025

12 GEN

A Conversation About the FDA's Regulation of Mifepristone

Mifepristone used with misoprostol is the most common abortion regimen in the US. It is also a focal point of reproductive health policy and politics, with controversy over its legal status and regulation by the US Food and Drug Administration (FDA). Author G. Caleb Alexander, MD, MS, from Johns Hopkins discusses this and more with JAMA Deputy Editor Joseph S. Ross, MD, MHS. Related Content: The US Food and Drug Administration's Regulation of Mifepristone Politics, Science, and the Future of FDA Drug Regulation

12 gen

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21 min
12/01/2016

Advances in Diagnosis and Treatment of Constipation

Constipation is one of the most frequent problems clinicians are asked to deal with. Despite how common it is, constipation is frequently not treated adequately. In this podcast, Arnold Wald, MD, explains a stepwise approach to the management of constipation ranging from very simple measures to the most novel and complicated new medical therapies. Articles discussed in this episode: JAMA Clinical Review: Constipation: Advances in Diagnosis and Treatment JAMA Clinical Guidelines Synopsis: Evaluation and Treatment of Patients With Constipation From The Medical Letter on Drugs and Therapeutics: Naloxegol (Movantik) for Opioid-Induced Constipation JAMA Patient Page: Constipation

12/01/2016

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28 min
17/07/2025

Early-Onset Gastrointestinal Cancers

Early-onset gastrointestinal cancers, typically defined as occurring in patients younger than age 50, are increasing worldwide. A recent JAMA Review summarizes current data on early-onset colorectal, pancreatic, and esophagogastric cancers. Coauthor Kimmie Ng, MD, MPH, of Dana-Farber Cancer Institute joins JAMA Deputy Editor Kristin Walter, MD, MS to discuss. Related Content: Early-Onset Gastrointestinal Cancers Screening for Helicobacter pylori to Prevent Gastric Cancer First-Line Sugemalimab Plus Chemotherapy for Advanced Gastric Cancer ----------------------------------- JAMA Editors' Summary

17/07/2025

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25 min
21/07/2025

Ovarian Cancer: Clinical Risk Factors and Treatment

A recent Review discusses the epidemiology, risk factors, diagnosis, and treatment of ovarian cancer. William Cliby, MD, and John Weroha, MD, PhD, both from the Mayo Clinic in Rochester, Minnesota, discuss this and more with JAMA Associate Editor Margaret Wheeler, MD. Related Content: Ovarian Cancer Endometriosis Typology and Ovarian Cancer Risk Screening for Ovarian Cancer ----------------------------------- JAMA Editors' Summary

21/07/2025

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19 min
24/07/2025

Diverticulitis: Diagnosis and Management

Approximately 200 000 people are hospitalized for diverticulitis each year in the US, and the incidence of diverticulitis is increasing, particularly among younger people. Author Anthony Charles, MD, MPH, of the University of Vermont and JAMA Deputy Editor Mary M. McDermott, MD, discuss current evidence regarding the epidemiology, diagnosis, and treatment of diverticulitis. Related Content: Diverticulitis Quality-of-Life and Recurrence Outcomes Following Laparoscopic Elective Sigmoid Resection vs Conservative Treatment Following Diverticulitis Racial and Ethnic Disparities in Locoregional Recurrence Among Patients With Hormone Receptor–Positive, Node-Negative Breast Cancer ----------------------------------- JAMA Editors' Summary

24/07/2025

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15 min
28/04/2025

Non–Cystic Fibrosis (CF) Bronchiectasis in Adults

Non-cystic fibrosis (CF) bronchiectasis, which affects approximately a half million people in the US, is a chronic lung condition that involves permanent bronchial dilation and inflammation; it is characterized by a productive cough and recurrent exacerbations. Author Alan F. Barker, MD, of Oregon Health and Science University joins JAMA Deputy Editor Kristin Walter, MD, MS, to discuss non-CF bronchiectasis. Related Content: Non–Cystic Fibrosis Bronchiectasis in Adults

28/04/2025

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23 min
24/11/2025

US Burden of Disorders Affecting the Nervous System

Interview with John P. Ney, MD, MPH, author of US Burden of Disorders Affecting the Nervous System: From the Global Burden of Disease 2021 Study. Hosted by Cynthia E. Armand, MD. Related Content: US Burden of Disorders Affecting the Nervous System

24/11/2025

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24 min
15/10/2025

Microplastic Pollution and Human Health

Microplastics, defined as plastics smaller than 5 mm, have been detected in human tissues at increasing rates and are associated with potential adverse health effects. Author David Christiani, MD, MPH, from the Department of Environmental Health at Harvard T.H. Chan School of Public Health, discusses this topic and more with JAMA Deputy Editor Kristin Walter, MD, MS. Related Content: Microplastics and Human Health ----------------------------------- JAMA Editors' Summary

15/10/2025

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15 min
30/12/2025

JAMA Editors' Choice 2025: Clinical Reviews Podcasts

JAMA Deputy Editor Mary McDermott, MD, and JAMA Deputy Editor Kristin Walter, MD, MS, highlight their selections of top JAMA Clinical Reviews podcasts in 2025. Related Content: Managing Adverse Effects of Obesity Medications Diagnosis and Management of Hypothyroidism Type 2 Diabetes: Diagnosis and Current Guidelines for Treatment Managing Adverse Effects of Incretin-Based Medications for Obesity Hypothyroidism Diagnosis and Treatment of Type 2 Diabetes in Adults JAMA Editors' Choice 2024: Clinical Reviews Podcasts

30/12/2025

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17 min
28/07/2025

Patent Foramen Ovale-Associated Stroke

A patent foramen ovale (PFO) is present in approximately 25% of all adults. Author David M. Kent, MD, MS, of Tufts Medical Center and JAMA Associate Editor David Simel, MD, MHS, discuss how to evaluate the likelihood that a PFO was causal in a patient with a cryptogenic ischemic stroke, and closure of a PFO to lower the incidence of recurrent strokes for affected patients. Related Content: Patent Foramen Ovale and Stroke Patent Foramen Ovale and Dysarthria in a Man in His 60s Management of Patients With a Patent Foramen Ovale With History of Stroke or TIA Heterogeneity of Treatment Effects in an Analysis of Pooled Individual Patient Data From Randomized Trials of Device Closure of Patent Foramen Ovale After Stroke Transesophageal Echocardiogram Detecting a High-Risk Patent Foramen Ovale ----------------------------------- JAMA Editors' Summary

28/07/2025

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20 min

JAMA Network™ is a collection of 13 medical journals spanning specialties and general medicine. JN podcasts include Editor summaries, author interviews, conversations, clinical updates and more.

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