GeneInCell

Vinod Reddy Lekkala
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GeneInCell-The AI-powered Biotech Podcast focuses on crisp, science-based podcasts on stem cells, organoids, and gene editing—tracking breakthroughs from bench to bedside for better human health, including Biotech and business.

  1. Intestinal 3D Organ Models: Organoids for Drug Testing

    28/12/2025

    Intestinal 3D Organ Models: Organoids for Drug Testing

    Discover how 3D intestinal organoids—mini-gut tissues grown from stem cells—are transforming preclinical drug testing. We break down how these models capture human barrier function, absorption, metabolism, and host–microbiome interactions better than animal systems, enabling smarter toxicity profiling and efficacy screening. From patient-derived organoids for precision medicine to organoid-on-chip platforms, we cover practical workflows, readouts (TEER, imaging, omics), and what it takes to translate in-vitro hits into clinical candidates.

    31 min
  2. DNA Is Binary Code and Logic | GeneInCell | 2025

    21/12/2025

    DNA Is Binary Code and Logic | GeneInCell | 2025

    DNA as code, cells as computers. We explore how binary models of genomes reveal mutational logic, why evolution mirrors open-source development, and how this lens powers DNA data storage, biomolecular logic gates, and smarter synthetic biology.

    14 min
  3. DNA Storage: Encoding Digital Data in Nature's Code | GeneInCell

    30/11/2025

    DNA Storage: Encoding Digital Data in Nature's Code | GeneInCell

    Silicon is hitting its limits—and our data keeps exploding. In this episode, we explore DNA as a radical new archive: a medium with hyper-dense capacity and millennia-scale stability that doesn’t need power to preserve information. We unpack the workflow—encoding 1s and 0s into A, T, C, and G; writing short DNA oligos; and reading them back with sequencing plus robust error-correction.

    34 min
  4. CRISPR–Cas9 Variants for High-Fidelity Genome Editing

    16/11/2025

    CRISPR–Cas9 Variants for High-Fidelity Genome Editing

    Explore the shift from standard Cas9 nuclease—which makes double-strand breaks—to precision tools like Cas9 nickases (single-strand “nicks”) and dead Cas9 (binding without cutting). We break down how these variants reduce off-target indels and enable safer editing and gene regulation (CRISPRi/a, base/prime editor scaffolds) for high-fidelity genome engineering.

    41 min
  5. Human Liver Organoids- From Stem Cells to Therapies

    10/11/2025

    Human Liver Organoids- From Stem Cells to Therapies

    From stem cells to therapies, this episode dives into the world of human liver organoids—how iPSCs are guided into functional “mini-livers,” the bioengineering tricks that mature them, and the breakthroughs they enable in disease modeling, drug screening, and precision hepatology. In this short episode, we unpack what’s real, what’s next, and how organoids are accelerating the path to regenerative treatments.

    15 min
  6. PiggyBac Transposons-A Switchable, High-Capacity Gene Delivery System in Living Cells

    01/11/2025

    PiggyBac Transposons-A Switchable, High-Capacity Gene Delivery System in Living Cells

    How PiggyBac moves DNA in—and out—without scars. We cover transposase mechanics (TTAA-site integration and footprint-free excision), large cargo delivery (tens to ~100 kb), and why it’s popular for iPSCs, stable cell lines, and cell therapies.

    44 min
  7. Vascularization, Immune Cells, Organoids and Organ-On-Chip | GeneInCell | 2025

    27/10/2025

    Vascularization, Immune Cells, Organoids and Organ-On-Chip | GeneInCell | 2025

    A quick tour of next-gen models that add functional vascularization and immune cells to boost physiological relevance. And strategies (self-assembly, pre-patterning) to build perfusable microvascular networks for real maturation. Educational only; not medical advice.

    19 min
  8. Eyes In a Dish | Modeling Retinal Development with Pluripotent Stem Cells

    19/10/2025

    Eyes In a Dish | Modeling Retinal Development with Pluripotent Stem Cells

    How lab-grown mini-retinas model human vision. In this episode, we show how iPSC-derived retinal organoids form layered photoreceptors, enable gene-editing tests (CRISPR, ASOs), and accelerate drug screening for inherited retinal diseases. Clear takeaways, visuals, and translational notes for bench and clinic. Educational only; not medical advice.

    18 min
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About

GeneInCell-The AI-powered Biotech Podcast focuses on crisp, science-based podcasts on stem cells, organoids, and gene editing—tracking breakthroughs from bench to bedside for better human health, including Biotech and business.

Information

  • Creator
    Vinod Reddy Lekkala
  • Years Active
    2K
  • Episodes
    21
  • Rating
    Clean
  • Copyright
    © Vinod Reddy Lekkala
  • Show Website
    GeneInCell