Today on Talk Python: What really happens when your data work outgrows your laptop. Matthew Rocklin, creator of Dask and cofounder of Coiled, and Nat Tabris a staff software engineer at Coiled join me to unpack the messy truth of cloud-scale Python. During the episode we actually spin up a 1,000 core cluster from a notebook, twice! We also discuss picking between pandas and Polars, when GPUs help, and how to avoid surprise bills. Real lessons, real tradeoffs, shared by people who have built this stuff. Stick around.
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Links from the show
 Matthew Rocklin: @mrocklin
 Nat Tabris: tabris.us
 Dask: dask.org
 Coiled: coiled.io
 Watch this episode on YouTube: youtube.com
 Episode #519 deep-dive: talkpython.fm/519
 Episode transcripts: talkpython.fm
 Developer Rap Theme Song: Served in a Flask: talkpython.fm/flasksong
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Information
- Show
 - FrequencyUpdated Weekly
 - PublishedSeptember 18, 2025 at 8:00 AM UTC
 - Length1h 3m
 - Episode519
 - RatingClean
 
