The Generalist

Mario Gabriele

“The future is already here. It’s just not evenly distributed.” The Generalist Podcast brings you weekly conversations with the people who live in these pockets of the future – visionary founders, prescient investors, and original thinkers. Each episode is designed to introduce you to new ideas, technologies, and markets and help you prepare for the world of tomorrow.

  1. 8月18日

    38x in Ten Months: Inside One of Fintech’s Fastest-Growing Infrastructure Companies (Farooq Malik, CEO of Rain)

    Farooq Malik is the co-founder and CEO of Rain, a financial infrastructure company powered by stablecoins. Growing up in an immigrant family, Farooq saw firsthand the friction involved in moving money across borders. Alongside co-founder Charles Yoo-Naut, Farooq spent years building infrastructure before stablecoins became mainstream, betting that tokenized money would eventually become a foundational layer of the global financial system. Today, Rain powers card issuance, payments, and other financial products built on stablecoin rails, helping companies move money faster and operate across markets. In our conversation, we explore: How stablecoins combine the advantages of cash and electronic moneyThe barriers that still make moving money across borders expensive and inefficientThe parallels between being an immigrant and being an entrepreneurHow Farooq and Charles met through On Deck and decided to build togetherWhat Rain gained by building before the market was readyHow Rain earned the trust of early partners who later became customersWhat The Art of War taught Farooq about patienceThe misconception that stablecoins are only for emerging marketsWhy the payments market is big enough for multiple winnersWhy he believes Rain’s infrastructure is well positioned for a future shaped by AI agents— Thank you to the partners who make this possible Brex: The intelligent finance platform. — Timestamps (00:00) Intro (02:46) An overview of Rain and global-first financial infrastructure (06:57) The barriers to moving money and how technology can reduce them (15:34) How stablecoins behave like cash (18:46) The economic opportunity of a more efficient monetary system (22:06) How Farooq’s childhood as an immigrant shaped him (26:00) Farooq’s first entrepreneurial venture (29:11) Lessons from Farooq’s career before founding Rain (36:09) Connecting with Charles through On Deck (39:51) From Sign and Wire to Rain (42:18) Why Rain bet on stablecoins (47:25) How a Rain card works (49:15) How Rain thinks about its business (51:12) Lessons from The Art of War (54:30) Rain’s approach to hiring and management (55:47) Why the US is a stablecoin hub (59:10) Why there’s room for more than Stripe (1:03:39)How Farooq and Charles stay aligned with limited meetings (1:05:54) Rain’s most critical mantras (1:08:56) Why Rain is ready for AI agents (1:12:30) Final meditations — Follow Farooq Malik LinkedIn: https://www.linkedin.com/in/fhmalik X: https://x.com/rooqster Website: https://fhmalik.com — Resources and episode mentions: https://www.generalist.com/p/38x-in-ten-months-inside-one-of-fintechs — Production and marketing by penname.co. For inquiries about sponsoring the podcast, email jordan@penname.co.

    38x in Ten Months: Inside One of Fintech’s Fastest-Growing Infrastructure Companies (Farooq Malik, CEO of Rain)

  2. 8月4日

    AI Got Good at Language. Now It’s Learning the Language of Life. (Eric Nguyen, Co-Founder and CEO of Radical Numerics)

    Eric Nguyen is the co-founder and CEO of Radical Numerics, an AI research lab that has raised $50 million to train models directly on biological data. Before starting the company, Eric helped develop Evo and Evo 2, large-scale genome language models trained on unlabeled DNA sequences. Radical Numerics is now building models that can connect information across DNA, RNA, proteins, epigenetics, and other parts of biology, rather than treating each as a separate problem. Researchers have already used Evo to generate viable bacteriophage genomes, and Eric says Radical Numerics’ newer model, Omnii, matched key findings from two years of Alzheimer’s wet-lab research in a matter of days. He also believes these tools could make it easier to create dangerous pathogens, which is why the company is working on both biological design and biodefense. In our conversation, we explore: What AI models can learn by treating DNA as a languageWhy reading scientific papers is not the same as learning directly from biological dataHow Eric’s unusually free-range childhood shaped the way he follows his curiosityWhy biology may have more useful data than researchers know how to useHow Radical Numerics plans to connect information across DNA, RNA, proteins, and other biological systemsWhere the company sees early opportunities in drug discovery, diagnostics, synthetic biology, and biodefenseWhy testing AI-generated biology in the lab is still slow and difficultHow models that design biological systems could also help detect dangerous or manipulated pathogensHow to make powerful biology models safer without eliminating the capabilities that make them valuable— Thank you to the partners who make this possible Ahrefs Brand Radar: Find your brand in AI results. Brex: The intelligent finance platform. Guru: The AI source of truth for work. — Timestamps (00:00) Intro (03:35) An overview of Radical Numerics (06:35) From protein models to modeling all of biology (11:08) Why they started with DNA (15:04) The process of mapping DNA as a language (19:47) What’s unknown, and how we learn from novelty (26:24) The limits of language models in biology (31:15) Eric’s free-range upbringing and path to his PhD program (41:20) Applying long-context models to DNA and meeting his co-founders (46:36) Biology’s untapped data opportunity (49:02) Why biology needs multimodal AI (55:30) How better general LLMs benefit Radical Numerics (57:19) The challenges of biological verification (1:02:05) Making biology more concrete (1:04:51) Radical Numerics’ strategy and early use cases (1:07:26) Balancing safety with capable AI models (1:15:47) What success in biodefense looks like (1:18:09) Final meditations — Follow Eric Nguyen LinkedIn: https://www.linkedin.com/in/nguyenstanford X: https://x.com/exnx Website: https://erictnguyen.com — Resources and episode mentions: https://www.generalist.com/p/ai-got-good-at-language-now-its-learning — Production and marketing by penname.co. For inquiries about sponsoring the podcast, email jordan@penname.co.

    AI Got Good at Language. Now It’s Learning the Language of Life. (Eric Nguyen, Co-Founder and CEO of Radical Numerics)

  3. 6月30日

    The Token Budget Problem Nobody Is Talking About (Matan Grinberg, Co-Founder & CEO of Factory)

    Matan Grinberg is the co-founder and CEO of Factory, an AI company valued at $1.5 billion that helps enterprises like Nvidia, Morgan Stanley, and Adobe automate software development through “Droids,” intelligent agents designed to streamline software engineering. Before Factory, Matan spent more than a decade in theoretical physics, studying string theory at Princeton and UC Berkeley. His work now centers on a different kind of complex system: how software gets built in an era of increasingly capable AI agents, open models, and shifting compute economics. In our conversation, we explore: How Emmy Noether’s theorem continues to shape Matan’s approach to technology, business, and AIWhy Matan believes there will always be more problems to solve, even as AI becomes more capableThe resource allocation problem facing CEOs as they balance headcount, compute, and token budgetsWhy Factory is betting on model independence and Matan’s take on the SpaceX-Cursor dealWhy Matan pushes back on conflating open models with “Chinese models” and wants a stronger open-model ecosystemThe identity crisis that followed Matan’s decision to leave physicsLessons from Factory’s first few years, including learning to push back and identify gaps in his own knowledgeFactory’s culture, values, and Matan’s partnership with co-founder Eno Reyes— Thank you to the partners who make this possible .tech domains: An identity for builders at their core. Brex: The intelligent finance platform. Persona: Trusted identity verification for any use case. — Transcript: https://www.generalist.com/p/the-token-budget-problem — Timestamps (00:00) Intro (03:50) Noether’s theorem explained (06:45) How the search for what’s conserved informs Matan’s work (10:53) Why there will always be more problems to solve (11:58) The resource allocation problem of the AI era (15:54) Factory’s mission: bringing autonomy to software engineering (18:28) How Factory decides what to build next (20:10) Why Factory abstracts away model choice (22:07) How Factory wins enterprise customers (23:15) Matan’s take on the SpaceX-Cursor deal (27:48) Why open-weight models matter (29:19) Anthropic’s Fable 5 release and the debate over AI guardrails (35:33) How Matan got into string theory (38:21) Working with Juan Maldacena (41:53) Startup founders vs. theoretical physicists (46:15) Rethinking physics and redefining his identity (51:29) Discovering AI and code generation (52:53) The origins of Factory (55:52) Lessons from Factory’s first few years (59:58) Learning to push back and finding the holes in his knowledge (1:03:17) Factory’s culture and values (1:08:11) Matan’s predictions for the future of AI and Factory (1:10:49) Final meditations — Follow Matan Grinberg LinkedIn: https://www.linkedin.com/in/matan-grinberg X: https://x.com/matanSF Website: https://factory.ai — Resources and episode mentions: https://www.generalist.com/p/the-token-budget-problem⁠ — Production and marketing by penname.co. For inquiries about sponsoring the podcast, email jordan@penname.co.

    The Token Budget Problem Nobody Is Talking About (Matan Grinberg, Co-Founder & CEO of Factory)

  4. 6月23日

    Own or Be Owned: Why Every Company Needs Its Own AI Model (Yash Patil, Co-Founder & CEO of Applied Compute)

    Yash Patil is the 23-year-old founder and CEO of Applied Compute, a $1.3 billion company helping businesses train custom AI models on their own data: smaller, cheaper, and purpose-built for the work they actually do. Before founding the company, Yash dropped out of Stanford and spent two years at OpenAI working on post-training infrastructure and Codex. He left with one core conviction: every company that runs its critical workflows on someone else’s model is building on shifting sand. Applied Compute is his answer to that problem, already serving customers including DoorDash, Cognition, and Mercor. In our conversation, we explore: Why “own or be owned” is becoming existential for any company that relies on frontier AI modelsWhat it was like inside OpenAI the weekend the board fired, and then reinstated, its CEOWhy post-training is where competitive advantage is now being built, and what reinforcement learning with verifiable rewards actually isWhy evals have become the new production environment, and why companies will never share them with frontier providersHow a specialized model built for DoorDash outperformed frontier models on a narrow, high-value taskWhy cost, not capability, is now the primary driver pushing companies toward custom modelsWhy Yash believes AI’s transformation of the economy will unfold over decades, and why near-term fears about mass job displacement are misplaced— Thank you to the partners who make this possible Brex: The intelligent finance platform. Guru: The AI source of truth for work. Persona: Trusted identity verification for any use case. — Transcript: https://www.generalist.com/p/own-or-be-owned-why-every-company — Timestamps (00:00) Introduction (03:50) Fable 5 and the case for owning your own models (09:22) Why Applied Compute is betting on custom AI models (12:30) Yash's early influences and first projects (17:42) His brief time building at Stanford (19:29) Leaving Stanford for OpenAI (25:58) Inside OpenAI during Sam Altman's firing (28:18) What Yash admires about Sam Altman (29:43) Teaching models to reason (35:39) The core insight behind Applied Compute (39:40) How Applied Compute works with its customers (45:55) Why model training never ends (48:56) Why not every task needs a frontier model (51:25) The culture and people of Applied Compute (54:50) Applied Compute's training infrastructure (58:43) The coming compute crunch and other predictions (1:03:48) Final meditations — Follow Yash Patil X: https://x.com/ypatil125 Website: https://yashpatil.me LinkedIn: https://www.linkedin.com/in/yash-s-patil — Resources and episode mentions: https://www.generalist.com/p/own-or-be-owned-why-every-company⁠ — Production and marketing by penname.co. For inquiries about sponsoring the podcast, email jordan@penname.co.

    Own or Be Owned: Why Every Company Needs Its Own AI Model (Yash Patil, Co-Founder & CEO of Applied Compute)

  5. 6月2日

    What America Is Missing Between Sanctions and Nuclear War (Bryon Hargis, Co-Founder & CEO of Castelion)

    Bryon Hargis is the co-founder and CEO of Castelion, a defense startup building low-cost hypersonic missiles designed to be manufactured at scale. Before founding Castelion, Bryon spent more than a decade at Johns Hopkins Applied Physics Laboratory and nearly six years at SpaceX, where he worked on national security space programs and saw firsthand how iterative engineering and manufacturing speed could reshape aerospace. Castelion’s first missile, Blackbeard, is slated for integration on the Navy’s F/A-18 Super Hornet in roughly a year. — In our conversation, we explore: Why Bryon believes building missiles is paradoxically essential to maintaining peaceThe game theory behind warfare and why tit-for-tat strategies require credible middle-ground responsesHow China’s 2021 hypersonic test revealed not just a capability gap but a manufacturing and cost advantageWhy traditional aerospace processes—optimized for low risk and high cost—can’t compete with rapid iterationWhat Bryon learned in his first week at SpaceX (after 12 years in traditional aerospace)Why building a carrier-based, air-launched hypersonic missile as a first product was the hard but right choiceHow focusing on manufacturability and cost over maximum capability can produce more effective deterrenceWhy the person who adapts faster in warfare always wins, and how that shapes Castelion’s philosophy— Thank you to the partners who make this possible .tech domains: An identity for builders at their core. Ahrefs Brand Radar: Find your brand in AI results. Persona: Trusted identity verification for any use case. — Timestamps (00:00) Intro (04:01) Why America needs hypersonic missiles (07:13) China’s edge in hypersonics (12:05) The missing middle ground in deterrence (18:05) Preventing warhead ambiguity (19:40) How hypersonics differ from ballistic missiles (25:05) The economics of defensive vs. offensive systems (28:21) How SpaceX differs from traditional aerospace (37:40) Why Bryon chose to build in defense over space (42:42) Key factors that drove Castelion’s success (48:28) Designing Blackbeard, Castelion’s first hypersonic missile (1:01:06) The importance of lower costs and quicker manufacturing (1:10:04) Book recommendations — Follow Bryon Hargis LinkedIn: https://www.linkedin.com/in/hargsb X: https://x.com/hargsb — Resources and episode mentions: https://www.generalist.com/p/what-america-is-missing-between-sanctions — Production and marketing by penname.co. For inquiries about sponsoring the podcast, email jordan@penname.co.

    What America Is Missing Between Sanctions and Nuclear War (Bryon Hargis, Co-Founder & CEO of Castelion)

  6. 5月19日

    “Our Goal Is to Build an Electrical Engineer.” (Davide Asnaghi, Co-Founder & CEO of Diode)

    Davide Asnaghi is the co-founder and CEO of Diode, a Brooklyn-based startup using AI to design and manufacture circuit boards in the United States. Before Diode, Davide worked on Apple’s Special Projects Group and spent time in Hong Kong and Shenzhen studying Asia’s electronics manufacturing ecosystem. That experience convinced him that PCB design, despite powering everything from smartphones and satellites to medical devices and autonomous systems, remained one of the most overlooked layers of the tech stack. Since its founding just two years ago, Diode has landed Physical Intelligence and Saronic as customers and partnered with Anthropic to help Claude become a better electrical engineer. The company’s ultimate ambition: to make hardware as nimble as software. In our conversation, we explore: Why the West outsourced PCB manufacturing to Asia in the 2000s and why bringing it back matters for American competitivenessWhat Shenzhen’s manufacturing culture does better than Silicon Valley (and what the U.S. can learn from it)How Diode’s models can one-shot much of schematic design and compress hardware timelines from months to weeksThe three-week YC pivot that transformed Diode from a design validation tool into a full-stack manufacturerWhy circuit boards are the “forgotten middle child” between silicon and softwareHow Diode partners with Anthropic to make LLMs better electrical engineersWhat it takes to build a hardware company in 2025—and why the talent bar must stay incredibly highHow Italian, American, and Chinese cultures shaped Davide’s approach to entrepreneurship and manufacturing— Thank you to the partners who make this possible .tech domains: An identity for builders at their core. Guru: The AI source of truth for work. Brex: The intelligent finance platform. — Transcript: https://www.generalist.com/p/our-goal-is-to-build-an-electrical-engineer — Timestamps (00:00) Intro (04:15) Why Davide calls himself a copper merchant (05:53) Diode’s mission to rebuild PCB manufacturing in the U.S. (07:58) What success looks like (09:00) Growing up in northern Italy and spending a year in Minnesota (13:14) Why Italy produces fewer venture-backed founders (15:30) Why Hong Kong accelerated Davide’s learning (19:09) Silicon Valley vs. Shenzhen (22:05) What Davide learned in Apple’s Special Projects Team (24:11) Why Davide left Apple after two years (26:54) Meeting his co-founder, Lenny (29:32) How Davide uncovered the need for better PCB design and manufacturing (33:23) PCB manufacturing in Asia, and Diode’s approach (41:29) The YC pivot that changed Diode’s business (44:39) Inside Diode’s customer journey (48:10) Where the value is in electronics manufacturing, and Davide’s AGI thesis (51:30) What separates a working board from a great one (55:32) Where Diode fits in the electronics stack (59:55) Diode’s early near-death moment and long-term vision (1:02:30) Diode’s exceptionally high bar for hiring (1:04:48) Where Davide gets his best ideas (1:07:00) Final meditations — Follow Davide Asnaghi LinkedIn: https://www.linkedin.com/in/d-asnaghi X: https://x.com/davideasnaghi GitHub: https://hexdae.github.io — Resources and episode mentions: https://www.generalist.com/p/our-goal-is-to-build-an-electrical-engineer⁠ — Production and marketing by penname.co. For inquiries about sponsoring the podcast, email jordan@penname.co.

    “Our Goal Is to Build an Electrical Engineer.” (Davide Asnaghi, Co-Founder & CEO of Diode)

  7. 5月5日

    Investing Like A Mystic: How Cyan Banister Finds Outliers (Co-Founder of Long Journey Ventures)

    Cyan Banister has built one of the most distinctive early-stage track records of the last fifteen years, with early bets on companies like Uber, SpaceX, DeepMind, Niantic, and Postmates. Today, she is co-founder and general partner at Long Journey Ventures, where she backs what she calls “magical weirdos.” Banister describes herself as a professional daydreamer, running constant thought experiments and paying close attention to signals others ignore. In this episode, she explains how that mindset translates into investing, and why many of her best opportunities have come from observation, curiosity, and a willingness to look in unlikely places. In our conversation, we explore: Cyan’s philosophy of treating life as a series of experimentsThe strange, profound experiences that led her to question and ultimately move beyond her atheismHow scanning Wi-Fi networks in a Four Seasons café led her to Flock Safety, last valued at $8.4 billionLong Journey Ventures’ “Biz, Tizz, and Rizz” framework for identifying exceptional founders and why the trifecta is rareHow AI will enable the age of the polymathWhy she believes brain-computer interfaces are closer than most people thinkWhy she says Pokémon Go was “the closest we ever came to world peace”Why she lives part-time in a retirement community and her vision for a more connected future— Thank you to the partners who make this possible .tech domains: An identity for builders at their core. Brex: The intelligent finance platform. Persona: Trusted identity verification for any use case. — Transcript: https://www.generalist.com/p/investing-like-a-mystic-cyan-banister — Timestamps (00:00) Intro (03:51) Never playing the game you appear to be playing (07:18) Practicing childlike wonder as a daily discipline (10:08) Questioning belief after her stroke (13:30) Cyan’s metaphysical experiments (23:24) Non-local consciousness and creativity (27:22) Investing with extreme openness to signals (29:05) The importance of timing in investing (32:26) Meeting Travis Kalanick (34:19) Finding Flock Safety through a chance encounter (38:23) The summer of Pokémon Go (what worked and what didn’t) (39:55) Human nature and what makes something "stick" (42:15) Brain-computer interfaces and AI’s accelerating effect (52:53) “Biz, Tiz, Riz:” her framework for evaluating founders (59:20) Why Cyan lives in a retirement community part-time (1:03:50) A unique way of finding books that speak to you (1:08:44) Final meditations — Follow Cyan Banister: LinkedIn: https://www.linkedin.com/in/cyanb X: https://x.com/cyantist Newsletter: https://uglyduckling.substack.com Website: https://cyanbanister.com — Resources and episode mentions: https://www.generalist.com/p/investing-like-a-mystic-cyan-banister — Production and marketing by penname.co. For inquiries about sponsoring the podcast, email jordan@penname.co.

    Investing Like A Mystic: How Cyan Banister Finds Outliers (Co-Founder of Long Journey Ventures)

  8. 4月21日

    The Future Of Drug Discovery Is 4 Billion Years Old (Viswa Colluru, Founder & CEO at Enveda)

    For decades, drug discovery has shifted away from nature and toward biology-first approaches. Viswa Colluru believes that shift was a catastrophic mistake. His company, Enveda Biosciences, has raised over $500 million to build a “search engine for nature’s chemistry.” The mission is personal: he grew up around his father’s pharmacy in India and later lost his mother to a treatable cancer whose medicine his family couldn’t afford. Many life-changing medicines, including morphine, aspirin, and metformin, originated in nature, but there has never been a reliable, scalable way to systematically explore its chemistry. Colluru founded Enveda in 2019 with $55,000 of his own savings to change that. The company has since identified 18 drug candidates, with three now in clinical trials. In our conversation, we explore: Why the pharmaceutical industry abandoned nature (and why that was a massive mistake)How Enveda built a system to decode unknown molecules in natureThe deeply personal story of his mother’s battle with leukemia and how it shaped his life’s workWhy old ideas, from immunotherapy to natural products, often hold the most latent potentialHow Enveda developed 18 drug candidates for about $1 million each instead of $10-15 millionEnveda’s three leading drug candidates targeting eczema, obesity, and ulcerative colitisWhy first-in-class medicines capture the vast majority of returns in pharmaWhat competitive table tennis taught him about building companies— Thank you to the partners who make this possible Brex: The intelligent finance platform. Ahrefs Brand Radar: Find your brand in AI results. Persona: Trusted identity verification for any use case. — Timestamps (00:00) Introduction to Viswa Colluru (03:57) His father’s pharmacy and early exposure to Western and Ayurvedic medicine (07:06) Early pull toward technology (09:29) His mother’s leukemia diagnosis (14:24) Studying Biotechnology (16:07) Graduate school (17:55) Studying immunotherapy when it was unfashionable (24:23) Innovation vs. novelty (27:24) Lessons from table tennis (32:05) Joining Recursion (37:10) Learning urgency and courage (40:42) What launched Enveda (45:40) The limits of reductionist drug discovery (49:53) Chemistry-first approach (52:17) Raising $225K and investing $55K personally (56:04) Initial studies and targets (1:04:30) Three categories of leading drugs: Eczema, obesity, ulcerative colitis (1:13:27) Why GLP-1s are not the whole answer (1:18:27) Enveda’s long-term vision (1:21:31) Book recommendation — Follow Viswa Colluru LinkedIn: https://www.linkedin.com/in/viswacolluru X: https://x.com/viswacolluru — Resources and episode mentions: https://www.generalist.com/p/the-future-of-drug-discovery — Production and marketing by penname.co. For inquiries about sponsoring the podcast, email jordan@penname.co.

    The Future Of Drug Discovery Is 4 Billion Years Old (Viswa Colluru, Founder & CEO at Enveda)
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予告編

番組について

“The future is already here. It’s just not evenly distributed.” The Generalist Podcast brings you weekly conversations with the people who live in these pockets of the future – visionary founders, prescient investors, and original thinkers. Each episode is designed to introduce you to new ideas, technologies, and markets and help you prepare for the world of tomorrow.

情報

  • クリエイター
    Mario Gabriele
  • 配信期間
    25年 - 26年
  • エピソード
    48
  • 制限指定
    不適切な内容を含む
  • Copyright
    © Mario Gabriele
  • 番組のWebサイト
    The Generalist

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