The Metabolic Link

Dr. Dominic D'Agostino PhD, Dr. Angela Poff PhD, and Victoria Field
  • 0.0（0）
  • 医学
  • アップデート：隔週

Welcome to The Metabolic Link, a medical and science podcast that explores the common thread of metabolism in health and disease. Join Dr. Dominic D'Agostino PhD, Dr. Angela Poff PhD, and Victoria Field as they dive into the latest research on metabolic health and therapy alongside some of the world’s leading experts. They'll also discuss how this science is being applied in the real world. This is where science meets society.

  1. 4月7日

    Vagal Nerve Stimulation, TBI, and Brain Health: Rethinking Neurological Care | Dr. Michael Hoffman, MD | The Metabolic Link Ep. 92

    A veteran walks into the clinic with a persistent migraine. Four minutes of vagal nerve stimulation later, the migraine is gone. This is not a one-off result. It is what Dr. Michael Hoffman has been observing for over seven years in the VA hospital system, using non-invasive devices he considers severely underutilized. Dr. Hoffman is a stroke and cognitive-behavioral neurologist who trained at Columbia University, spent 14 years in the VA system, and has evaluated an estimated 10,000 stroke patients across his career. He now practices at the University of Central Florida, where he integrates ketogenic nutrition, advanced imaging, vagal nerve stimulation, and hyperbaric oxygen into his neurological care. In this episode, Dr. Hoffman walks through what he calls the "five brain fitness rules," the specific, measurable lifestyle prescriptions he gives every patient, and explains why standard cognitive screening tools like the MoCA and Mini Mental miss the most dramatic behavioral syndromes caused by brain injury. He also discusses why PET scans and diffusion tensor imaging should be used far more often, and why post-TBI hormonal evaluation is critical but routinely overlooked. Questions Answered in This Episode: What are the five brain fitness rules every neurological patient should follow?Why do standard cognitive tests fail to detect some of the most severe brain injury syndromes?How is vagal nerve stimulation treating migraines, and why is it so underutilized outside the VA?What clinical changes would most improve neurological care today?Does the evidence support hyperbaric oxygen therapy for traumatic brain injury?Could fungal infections contribute to some long-standing Alzheimer's diagnoses?What is the surprising decade when your brain's cognitive function peaks?Dr. Hoffman makes a case that the gap between what we know about the brain and what we do in clinical practice has never been wider, and that closing it starts with giving clinicians the time and tools to actually examine their patients. Learn more about Dr. Hoffman on his website here. Special thanks to the sponsors of this episode: ✅ Fatty15 – Get 15% off a 90-day Starter Kit with code METABOLICLINK here ✅ Troscriptions – Get 10% off your first order with code METABOLICLINK here ✅ ZocDoc - Find and instantly book a top-rated doctor here ✅ MudWtr – Get up to 43% off + free shipping and a free rechargeable frother with code METABOLICLINK here In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in! You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel! Find us on social:  InstagramFacebookYouTubeLinkedInPlease keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

    1時間27分

  2. 3月24日

    What's in Your Tap Water? Contaminants, Filtration, and How to Test It | Johnny Pujol | The Metabolic Link Ep. 91

    You could have elevated levels of contaminants like uranium or arsenic in your drinking water—and not know it. Many of these compounds are colorless, odorless, and undetectable without testing. Johnny Pujol is a water chemist and the founder of Tap Score, a drinking water testing platform supported by a network of roughly 270 specialized laboratories. His path from electrochemistry research to consumer water testing was driven by a simple realization: the chemistry inside what looks like a clear glass of water is far more complex than most people realize. In this episode, Dr. Dominic D’Agostino and Johnny break down what’s actually in drinking water, how regulatory standards are set, and where they may lag behind emerging research. They also discuss how chronic exposure to certain contaminants may intersect with metabolic health and long-term disease risk. Johnny also shares insights from Tap Score’s forthcoming research comparing contaminant profiles in unfiltered tap water, bottled water, and filtered tap water. Questions Answered in This Episode: Why does the EPA action level for lead differ from the ideal target of zero?Can certain filtration systems introduce unintended issues, like microbial growth, if not properly maintained?How can environmental factors like rainfall impact private well water quality?What's the difference between a "first draw" sample and a "representative" sample, and why does it matter?Is the health risk from showering in contaminated water meaningful compared to drinking it?Why do some water tests cost $600 to $800 while others cost a fraction of that?Understanding your drinking water starts with recognizing the difference between what’s legally permitted and what may be considered optimal from a health perspective. This conversation explores that gap, and what individuals can do to better assess their own water quality. Learn more here: https://mytapscore.com/ Special thanks to the sponsors of this episode: ✅ Troscriptions – Get 10% off your first order with code METABOLICLINK here. ✅ Toups and Co – Get 15% off your first order with code METABOLIC here. ✅ iRestore – Get a huge discount on the Elite and the Illumina bundle with the code LINK here. ✅ MudWtr – Get up to 43% off + free shipping and a free rechargeable frother with code METABOLICLINK here. In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in! You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel! Find us on social:  InstagramFacebookYouTubeLinkedInPlease keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

    1時間11分

  3. 3月10日

    Rethinking Cognitive Decline: Stimulus, Exercise, and the Aging Brain | Dr. Tommy Wood, MD, PhD | The Metabolic Link Ep. 90

    Register for a live Q&A with Dr. Tommy Wood on Wednesday, March 25th. Decreased glucose uptake in the brain is often considered a hallmark of Alzheimer's disease. But Dr. Tommy Wood asks whether part of that metabolic signature may reflect how little cognitive demand we place on the brain. He sits down with Dr. Dominic D'Agostino for a nuanced conversation on metabolic health and cognitive function.. Dr. Wood is a neuroscientist, neonatal brain injury researcher, and author of The Stimulated Mind. This episode follows the metabolic thread through every stage of brain health. Pre-diabetes and type 2 diabetes as predictors of cognitive decline. Neurovascular coupling as the reason heart disease risk factors double as brain disease risk factors. Lactate crossing the blood-brain barrier to drive BDNF production where it actually matters. Creatine as a brain energy distributor that most people still only associate with muscle. Dr. Wood lays out his Three S Model — Stimulus, Supply, Support — and makes the case that cognitive demand drives glucose uptake into the brain the same way muscular contraction drives it into skeletal muscle. Questions Answered in This Episode: Does the brain respond to energy demand the same way skeletal muscle does?What role does creatine play in brain energy distribution, and what do the clinical trials show?Can heavy resistance training produce the same brain-relevant lactate response as HIIT?How should exercise be dosed after a concussion or traumatic brain injury?Is cognitive decline in your 50s, 60s, and 70s actually inevitable, or is that a statistical artifact?Why are pre-diabetes and metabolic syndrome among the strongest predictors of dementia?The mechanistic throughline here is demand-driven metabolism. Dr. Wood makes the case that the same principles governing glucose uptake in skeletal muscle apply to the brain — and the conversation gets into what that means for how we interpret FDG-PET data, design lifestyle interventions, and think about neurodegeneration itself. Find more at DrTommyWood.com Special thanks to the sponsors of this episode: ✅ Fatty15 – Get 15% off a 90-day Starter Kit with code METABOLICLINK here ✅ Troscriptions – Get 10% off your first order with code METABOLICLINK here ✅ Toups and Co – Get 15% off your first order with code METABOLIC here ✅ ZocDoc - Find and instantly book a top-rated doctor here In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in! You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel! Find us on social:  InstagramFacebookYouTubeLinkedInPlease keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

    1時間43分

  4. 3月3日

    Journal Club: Five Papers Pushing the Boundaries of Metabolic Therapy | The Metabolic Link Ep. 89

    Get free access to our new Ketogenic Metabolic Therapy ebook here. Could changing your metabolism reduce alcohol cravings, ease psychiatric symptoms, and even make cancer immunotherapy more effective? The science is pointing to yes, and the mechanisms are fascinating. In this Journal Club episode, co-hosts Victoria Field, Dr. Dominic D'Agostino, and Dr. Angela Poff break down five peer-reviewed papers from their newly released Ketogenic Metabolic Therapy ebook (Volume 4). From a French preclinical study showing ketogenic diet enhances PD-L1 immunotherapy response in kidney cancer, to an NIH/UPenn trial using machine-learning-derived fMRI signatures to measure reduced alcohol cravings during ketosis, to Stanford's pilot trial demonstrating notable metabolic and psychiatric improvements in schizophrenia and bipolar disorder, this episode covers the cutting edge of metabolic therapy research. Questions Answered in This Episode: Why does the brain crave alcohol in people with alcohol use disorder, and how might ketones help? How might a ketogenic diet affect a tumor’s response to immunotherapy?Can insulin resistance in the brain contribute to psychiatric symptom severity?How does the ketogenic diet compare to the Mediterranean diet for autoimmune inflammation?Does timing of ketogenic diet initiation matter for chronic pain relief?Is it realistic for people with serious mental illness to adhere to a ketogenic diet?Whether you're a clinician, researcher, or someone looking to understand the latest science, this episode reveals just how far-reaching ketogenic metabolic therapy has become, spanning oncology, psychiatry, addiction, autoimmune disease, chronic pain, and much more! In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in! You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel! Find us on social:  InstagramFacebookYouTubeLinkedInPlease keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

    1時間9分

  5. 2月24日

    Mitochondria, Muscle, & Aging: What Longevity Drugs Miss | Dr. Mark Tarnopolsky | The Metabolic Link Ep. 88

    Dr. Mark Tarnopolsky's VO2 max was once 87.6 ml/kg/min — an elite-level mark few humans have reached. He's competed at three world championships in three different sports. He's also had three cardiac ablation surgeries, bled from his bowels after races, and watched his vision tunnel to a speck crossing a finish line. His story is a master class in where the line falls between peak performance and self-destruction. Now 63, Tarnopolsky is a neurologist, neuromuscular disease specialist, and supplement formulator who has channeled decades of elite athletic experience and hundreds of published studies into the idea that keeping metabolic throughput high is what protects us as we age. In this conversation with Dom D'Agostino, he shares practical strategies anyone can apply: why resistance training three times per week is non-negotiable after 50, why post-exercise nutrient timing improved performance in a simulated training camp with identical calories, why he says creatine belongs in nearly everyone's regimen, and why he personally takes his mitochondrial supplement stack situationally after hard efforts rather than daily. Questions Answered in This Episode: What is the only intervention proven to extend human lifespan — and by how much?At what point does endurance exercise become pro-aging — and what are the warning signs?What simple nutrient timing strategy improved performance with zero extra calories?How did a bodybuilder bar conversation lead to a published discovery about growth hormone and collagen?What muscle and bone costs of Ozempic aren't getting enough attention?Why did elite endurance athletes need nearly as much dietary protein as bodybuilders — and why were bodybuilders massively overconsuming?This conversation reframes the longevity debate around what's actually been proven in human clinical trials — not Petri dishes, not animal models, and not social media influencers. Special thanks to the sponsors of this episode: ✅ Troscriptions – Get 10% off your first order with code METABOLICLINK here. ✅ Toups and Co – Get 15% off your first order with code METABOLIC here. ✅ iRestore – Get a huge discount on the Elite and the Illumina bundle here. ✅ MudWtr – Get up to 43% off + free shipping and a free rechargeable frother with code METABOLICLINK here. In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in! You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel! Find us on social:  InstagramFacebookYouTubeLinkedInPlease keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

    1時間32分

  6. 2月10日

    Trauma, Inflammation, and Neurodegeneration: A New Framework for Alzheimer's | Dr. Caesar Hernandez, MS, PhD | The Metabolic Link Ep. 87

    Roughly 90% of Alzheimer's patients develop neuropsychiatric symptoms including anxiety, persistent fear, and an inability to recognize safety — but little research is being done to investigate why. New data connecting PTSD, trauma, and accelerated brain aging may hold the answer. Dr. Caesar Hernandez is a behavioral, molecular, and circuit neuroscientist and assistant professor in the Division of Gerontology, Geriatrics & Palliative Care at the University of Alabama at Birmingham. His research program seeks to identify modifiable mechanisms that drive vulnerability to age-related cognitive decline and Alzheimer's disease. In this conversation with Dr. Dominic D'Agostino, Dr. Hernandez walks through epidemiological evidence linking PTSD to increased Alzheimer's risk, the comorbidity cluster of metabolic syndrome, gut permeability, and neuropsychiatric disorders observed in veteran populations, and why ketogenic interventions may offer a unique therapeutic angle — reducing neuroinflammation and anxiety while making the brain more receptive to rewiring traumatic memories. Questions Answered in This Episode:  Could addressing PTSD in midlife meaningfully reduce the risk of cognitive decline and dementia later in life?Why do veteran populations show such high comorbidity between PTSD, metabolic syndrome, and dementia? Could ketogenic therapy serve a similar function to pharmacologically-assisted psychotherapy for PTSD? How does the amygdala - the brain's "fear center" - play a role in Alzheimer's disease? What is the single biggest unanswered question driving Alzheimer's research right now — and why does it go beyond genetics and biochemistry?Dr. Hernandez's driving question — why are negative life experiences associated with an increased the risk of neurodegeneration? — reframes brain aging as something shaped not just by genes and biology, but by the lives we live and the stress we carry. Find more of Dr. Caesar Hernandez online: University of Alabama BirminghamLinkedInSpecial thanks to the sponsors of this episode: ✅ Genova Connect – Get 15% off any test kit with code METABOLICLINK here. ✅ Fatty15 – Get 15% off a 90-day Starter Kit with code METABOLICLINK here. ✅ Troscriptions – Get 10% off your first order with code METABOLICLINK here. ✅ ZocDoc - Find and instantly book a top-rated doctor here. In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in! You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel! Find us on social:  InstagramFacebookYouTubeLinkedInPlease keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

    1時間19分

  7. 1月27日

    The Metabolic Roots of Cardiovascular Disease: A Vascular Surgeon's Perspective | Dr. Lily Johnston | The Metabolic Link Ep. 86

    What if the sequence we've always assumed—plaque causes arterial stiffness—is actually backwards? Dr. Lily Johnston proposes that impaired nitric oxide signaling may stiffen arteries first, creating the endothelial injury that then promotes plaque formation. Dr. Lily Johnston is a board-certified vascular surgeon and newly certified obesity medicine physician who bridges the operating room and metabolic medicine. After years of scraping plaque from arterial walls, she began questioning why surgical outcomes remain so modest—and discovered that what she was treating might represent the end stage of multiple distinct disease phenotypes, not a single condition. In this episode, Dr. Johnston shares her forest fire analogy for understanding LDL risk, explains why tissue surrounding diseased arteries shows profound inflammation even in first-time surgeries, and reveals why 80–90% of the operations she performs could potentially be prevented with upstream metabolic intervention. Questions Answered in This Episode: Do metabolically healthy people with elevated LDL need the same treatment as those with active disease?Why might someone with "great" biomarkers still have significant plaque burden?What will individualized cardiovascular treatment look like in 20 years?To what extent is vascular disease a metabolic disease—and is this accepted in vascular surgery?Where do you stand on the LDL particle number vs. metabolic context debate?What percentage of vascular surgeries could have been avoided with earlier metabolic intervention?A surgeon's-eye view of what happens when metabolic dysfunction goes unaddressed for decades—and a practical framework for intervening before the fire starts. Find more of Dr. Johnston online: Live Q&AYoutube channelLinkedInCoresight HealthSpecial thanks to the sponsors of this episode: ✅ Genova Connect – Get 15% off any test kit with code METABOLICLINK here. ✅ Toups and Co – Get 15% off your first order with code METABOLIC here. ✅ Troscriptions – Get 10% off your first order with code METABOLICLINK here. ✅ MudWtr – Get up to 43% off + free shipping and a free rechargeable frother with code METABOLICLINK here. In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in! You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel! Find us on social:  InstagramFacebookYouTubeLinkedInPlease keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

    1時間18分

  8. 1月13日

    Ultra-Processed Food and Nutrition Policy: What We're Getting Wrong | Dr. David Ludwig | The Metabolic Link Ep. 85

    The term “ultra-processed food” appeared nearly 100 times in the White House’s Make America Healthy Again report. But questions remain about whether the concept is precise enough to guide effective policy. Dr. David Ludwig—Harvard endocrinologist, obesity researcher, and author of Always Hungry—joins Dr. Dominic D'Agostino to dismantle the ultra-processed food framework from the inside out. Ludwig reveals why the NOVA classification system lumps protein bars with soda, why the FDA admitted they can't define what they're trying to regulate, and why the famous studies showing ultra-processed foods cause overeating may be fundamentally flawed. This conversation cuts through the noise to identify what actually matters: the mechanistic difference between processing carbohydrates, fats, and proteins—and why that distinction should reshape nutrition policy. Questions answered in this episode: Can ultra-processed foods be "fixed" through reformulation?What's the most overrated "healthy" food in supermarkets?Should omega-3 levels be part of standard blood work?Are GLP-1 drugs a metabolic reset or a lifelong crutch?If you could pass one food policy law, what would it be?Why did the low-fat diet era make obesity worse?Dr. Ludwig argues that "ultra-processed food" is a compelling marketing term without mechanistic grounding—and that precise, actionable targets like highly processed carbohydrates and demonstrably harmful additives would do far more to improve public health. Where to find more of Dr. Ludwig's work online: Blog on UPFNEJM paper on UPFProblems with short diet trialsCarbohydrate-insulin modelWebsiteSpecial thanks to the sponsors of this episode: ✅ Fatty15 – Get 15% off a 90-day Starter Kit with code METABOLICLINK here. ✅ Troscriptions – Get 10% off your first order with code METABOLICLINK here. ✅ iRestore - Get a huge discount on the iRestore Illumina Face Mask when you use the code METABOLICLINK here. ✅Genova Connect – Get 15% off any test kit with code METABOLICLINK here. In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in! You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel! Find us on social:  InstagramFacebookYouTubeLinkedInPlease keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

    1時間22分
すべて見る（92）

番組について

Welcome to The Metabolic Link, a medical and science podcast that explores the common thread of metabolism in health and disease. Join Dr. Dominic D'Agostino PhD, Dr. Angela Poff PhD, and Victoria Field as they dive into the latest research on metabolic health and therapy alongside some of the world’s leading experts. They'll also discuss how this science is being applied in the real world. This is where science meets society.

情報

  • クリエイター
    Dr. Dominic D'Agostino PhD, Dr. Angela Poff PhD, and Victoria Field
  • 配信期間
    23年 - 26年
  • エピソード
    92
  • 制限指定
    不適切な内容を含む
  • Copyright
    © 2026 The Metabolic Link
  • 番組のWebサイト
    The Metabolic Link

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