Healio Rheuminations

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Rheumatology is an incredibly fast-moving and exciting field of medicine that can be difficult to keep up with. This Healio podcast provides busy clinicians with quick updates in the field of autoimmunity, with emphasis on new medications, treatment guidelines and explorations into the pathophysiology of diseases. The show will also feature historical perspectives in the field of rheumatology, as well as fascinating case presentations of medical mysteries complete with discussions from experts in the field.

  1. Healio Community Book Club: A conversation between Leonard Calabrese, DO and Kevin Tracey, MD, author of The Great Nerve

    1일 전

    Healio Community Book Club: A conversation between Leonard Calabrese, DO and Kevin Tracey, MD, author of The Great Nerve

    This special edition episode features the latest installment of Healio Community's book club. Physician author Kevin J. Tracey, MD, discussed his book, The Great Nerve: The New Science of the Vagus Nerve and How to Harness Its Healing Reflexes in which he explores the potential of stimulating the vagus nerve to treat rheumatoid arthritis and other diseases. ·        Intro by Adam J. Brown, MD 0:14 ·        A warm welcome from Leonard H. Calabrese, DO 0:25 ·        Introducing Kevin J. Tracey, MD 0:58 ·        The connection between the brain and the immune system 3:25 ·        Where was the switch that combined neural networks and immune response? 5:55 ·        A brief summary of the main parts of The Great Nerve: The New Science of the Vagus Nerve and How to Harness Its Healing Reflexes 9:18 ·        The science of vagal nerve stimulation 11:03 ·        What are the pros and cons of different strategies of stimulating the vagus nerve? 16:28 ·        Different inflammatory responses to implant devices 17:35 ·        Data on vagus nerve stimulation 21:38 ·        Adopting new technology 25:40 ·        Enhancing immune health through brain health 28:35 ·        Wellness behaviors 32:55 ·        A motivated patient 36:16 ·        Thank you, Dr. Tracey 38:03 ·        Thanks for listening 39:26 Don't miss out! To engage in future conversations like this with physician authors on Healio Community, register here. We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.

    40분
  2. Celebrating 101 episodes of Healio Rheuminations with Dr. Leonard Calabrese

    1월 29일

    Celebrating 101 episodes of Healio Rheuminations with Dr. Leonard Calabrese

    To celebrate 101 episodes, I sit with Leonard H. Calabrese, DO, to discuss his unique career in Rheumatology, spanning immunology, HIV, MECFS, IRES, CNS vasculitis and more. We also discuss how medical history shaped our careers.  ·        Intro 0:12 ·        Welcome Leonard H. Calabrese, DO 3:11 ·        A quick friendship begins over medical history 4:14 ·        How Healio Rheuminations began and where the show is now 5:38 ·        How Dr. Calabrese got interested in medical history 7:11 ·        Serotherapy 10:52 ·        Why patients get certain diseases 12:33 ·        Dr. Calabrese's career trajectory 14:43 ·        One day in 1981… 17:52 ·        A few things happened in the 90's 20:20 ·        Tell us about CNS vasculitis 21:53 ·        Don't be afraid to reinvent yourself 24:30 ·        Checkpoint inhibitors 25:09 ·        How do you keep up? 26:43 ·        Placebo science 28:25 ·        Do you think we'll ever be able to answer where diseases come from? 29:33 ·        Thank you, Dr. Calabrese 31:01 ·        Thanks for listening 31:26 We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.

    32분
  3. The history of giant cell arteritis: Infections, injections and the man who couldn't wear a hat

    2025. 11. 25.

    The history of giant cell arteritis: Infections, injections and the man who couldn't wear a hat

    What does a goiter and syphilis have in common with the first descriptions of giant cell arteritis? Join us as we dive into the history of the most common type of vasculitis! Intro 0:13 GCA at ACR 2025 00:30 How Brown has approached framing this episode 1:01 A primer leading us to GCA 3:15 Let's get to the story 4:02 The man who couldn't wear a hat 4:57 Dr. Bayard Horton's 7:40 A tangent on cluster headaches 8:27 Let's get back to GCA 13:16 The first temporal artery biopsy 14:28 Vision loss and other puzzle pieces of GCA 16:27 What about jaw claudication? 21:15 Could GCA be transmissible? Injecting ground temporal arteries into healthy volunteers 24:13 Oxygen? Histamines? Adrenal cortical extract? Looking for GCA treatments 26:55 Steroids and GCA 28:40 A quote from the 1959 Mayo Clinic Board of Governors 32:24 Extracranial involvement in GCA 33:24 When did we recognize aorta involvement? Syphilis enters the picture 35:08 A recap of the history of GCA 41:25 Thanks for listening 42:19 We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. References: Boes CJ, Cephalalgia. 2007;doi:10.1111/j.1468-2982.2007.01238.x Cummer CL, et al. JAMA. 1912;doi:10.1001/jama.1912.04270080101004 Horton BT, Proc Cent SOC Clin Res. 1946 Sproul EE, et al. Am J Pathol. 1937;PMID: 19970328 Disclosures: Brown reports no relevant financial disclosures.

    43분
  4. The Unnecessarily Complex Story of Rheumatoid Factor

    2025. 10. 13.

    The Unnecessarily Complex Story of Rheumatoid Factor

    The story of rheumatoid factor could be a 10 minute episode, but in this episode, we dig deep into the history of the lab techniques leading up to this discovery…that happened twice.  Intro 0:15 Rheumatoid factor quick background and history 00:36 Rheumatology blood tests 3:02 What is Rheumatoid factor? 3:49 Spiderman and latex agglutination: Testing for rheumatoid factor 4:50 The double discovery of rheumatoid factor 8:03 Putting agglutination on the medical map in 1896 10:08 Pop Quiz! 11:21 Serotherapy 13:10 When did we start using agglutination for testing? 14:17 First discovery of blood groups 14:50 The complement fixation test 17:22 Testing for syphilis with complement fixation and agglutination 21:01 The first discovery of rheumatoid factor 24:11 We forget about rheumatoid factor 27:44 Rediscovering rheumatoid factor 28:20 Analytical ultracentrifugation 32:50 What rheumatoid factor is used for 36:01 Thanks for listening 38:22 We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. References: Assadian O et al. Wien Klin Wochenschr. 2010;doi:10.1007/s00508-009-1297-1 Edelman GM, et al. J Exp Med. 1958;doi:10.1084/jem.108.1.105 Franklin EC, et al. J Exp Med. 1957;doi:10.1084/jem.105.5.425 Fraser KJ. Semin Arthritis Rheum. 1988;doi:10.1016/0049-0172(88)90035-2 Jonsson R. Ann Rheum Dis. 2020;doi:10.1136/annrheumdis-2019-216822 Mohd Noor NH, et al. Cureus. 2024;doi:10.7759/cureus.68903 Tan EM, et al. J Exp Med. 2016;doi:10.1084/jem.20160792 Disclosures: Brown reports no relevant financial disclosures.

    39분
  5. Don't forget the toes: Managing patients with ANCA vasculitis

    2025. 09. 29.

    Don't forget the toes: Managing patients with ANCA vasculitis

    Active or not active, that is the question. In this week's episode we interview Alexandra Villa-Forte, MD, MPH, a staff physician in the Center for Vasculitis Care and Research at Cleveland Clinic and a leading vasculitis expert, on a pragmatic approach to recognizing disease activity in patients with ANCA vasculitis. ·       Intro 0:01 ·       Welcome Alexandra Villa-Forte, MD, MPH 0:10 ·       Dr. Brown sketches a potential patient that may be seen in practice 0:40 ·       How are you monitoring patients' kidneys? 1:28 ·       How reliable are 'no casts' results in urinalysis tests? 4:15 ·       What is happening in the glomeruli? 5:23 ·       The importance of monitoring the urinalysis of patients with ANCA vasculitis 7:06 ·       Symptoms to watch for when tapering off medications 7:43 ·       Different scenarios with lung symptoms 9:35 ·       Evaluating patients with GPA; looking at the nose, ear and sinuses 12:20 ·       Neurologic symptoms in ANCA vasculitis 14:24 ·       Laboratory monitoring 15:52 ·       Should ANCA titers be a part of routine vasculitis monitoring? 17:05 ·       What is your approach using PJP prophylaxis in ANCA-associated vasculitis? 18:05 Thank you, Dr. Villa-Forte! 20:25 We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.   Disclosures: Brown reports no relevant financial disclosures. Healio was unable to confirm relevant financial disclosures for Villa-Forte at the time of publication.

    22분
  6. Healio Community Book Club: A conversation between Leonard Calabrese, DO and Eric Topol, MD, author of Super Agers

    2025. 09. 19.

    Healio Community Book Club: A conversation between Leonard Calabrese, DO and Eric Topol, MD, author of Super Agers

    This special edition episode features the latest installment of Healio Community's book club. Physician author Eric Topol, MD, discusses his book, Super Agers: An Evidence-Based Approach to Longevity, a guide to the science of living a long life free of debilitating diseases with Leonard H. Calabrese, DO, chief medical editor of Healio Rheumatology. ·        Intro by Adam J. Brown, MD 0:01 ·        A warm welcome by Leonard H. Calabrese, DO 0:47 ·        Introducing Eric Topol, MD 1:12 ·        "Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again" but did you think it would happen this fast? 1:54 ·        Let's get into "Super Agers" 3:46 ·        What's killing most people? 6:33 ·        An evidence-based treatise on healthy aging 9:42 ·        The role of immune health in longevity 12:55 ·        What's next on the horizon? 16:14 ·        A candle in the dark 19:40 ·        Minimizing the risk of getting old while you age 22:14 ·        The influence of health behaviors on immunologic wellness 25:15 ·        The hot issues: GLP-1's 26:28 ·        A new world for immunology 31:50 ·        Thank you, Dr. Topol 33:09 ·        Thanks for listening 33:57 Don't miss out! To engage in future conversations like this with physician authors on Healio Community, register here. We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. Disclosures: No products or companies that would require financial disclosure are mentioned in this episode.

    34분
  7. The Astounding Account of the IL-17 and Spondylarthritis

    2025. 07. 28.

    The Astounding Account of the IL-17 and Spondylarthritis

    In this episode, we focus on the history of researchers discovering the clinical applicability of the IL 23/17 axis, with a particular emphasis on psoriasis, psoriatic arthritis and axial SpA Intro 0:15 In this episode 0:27 Leonard Calabrese, DO, is listening! 1:07 Recap of last episode 3:23 Putting the pieces together 5:32 Quick overview of this science heavy episode 6:27 What is psoriasis? 7:42 Immunosuppressants for psoriasis/ Throwing meds at people and seeing what happens 10:20 In the modern world of 1986 – olive oil placebo trial 11:45 A quick aside into fungi 12:44 What kind of T-cells are involved here? 16:50 The TH-1 hypothesis 18:31 IL-23 and IL-17 are doing something 19:38 Going back to the drawing board in 2004 20:12 p40 + p19 = IL-23 21:08 IL-23 via minicircle DNA in mice 23:09 Brand new and shiny TH-17 25:30 The family of IL-17 26:40 What do we know about IL-17 and psoriasis? 27:17 IL-17A vs IL-17F in mouse studies 27:42 Finding the difference between IL-17A and IL-17F in humans 28:30 What exactly is IL-17 doing? 29:51 The articular manifestations of psoriatic arthritis 31:13 Spondylarthritis and the IL 23/17 axis 34:10 T-cells we haven't talked about 35:49 Summary of this episode 39:17 Thanks for listening 41:38 We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. References: Bashyam H. J Exp Med. 2007;doi:10.1084/jem.2042fta Bjerke R J. Acta Derm Venereol. 1982;PMID:6179355 Cargill M, et al. Am J Hum Genet. 2007;doi:10.1086/511051 Chan J R, et al. J Exp Med. 2006;doi:10.1084/jem.20060244 Cuthbert R J, et al. Ann Rheum Dis. 2019;doi:10.1136/annrheumdis-2019-215210 Ellis C N, et al. JAMA. 1986;doi:10.1001/jama.1986​ Ettehadi P, et al. Clin Exp Immunol. 1994;doi:10.1111/j.1365-2249.1994.tb06244.x Furue M, et al. Int J Mol Sci. 2020;doi:10.3390/ijms21041275 Gooderham M J, et al. J Eur Acad Dermatol Venereol. 2018;doi:10.1111/jdv.14868 Lee E, et al. J Exp Med. 2004;doi:10.1084/jem.20030451 Leonardi C L, et al. Lancet. 2008;doi:10.1016/S0140-6736(08)60725-4 Mease P J, et al. Lancet. 2000;doi:10.1016/S0140-6736(00)02530-7 Menon B, et al. Arthritis Rheumatol. 2014;doi:10.1002/art.38376 Moos S, et al. J Invest Dermatol. 2019;doi:10.1016/j.jid.2019.01.006 Muelle W, et al. N Engl J Med. 1979;doi:10.1056/NEJM197909063011016 Papp K A, et al. Lancet. 2008;doi:10.1016/S0140-6736(08)60726-6 Reinhardt A, et al. Arthritis Rheumatol. 2016;doi:10.1002/art.39732 Sherlock J P, et al. Nat Med. 2012;doi:10.1038/nm.2817 Tribe H T. Mycologist. 1998;doi:10.1016/S0269-915X(98)80100-6 Yawalkar N, et al. J Invest Dermatol. 1998;doi:10.1046/j.1523-1747.1998.00446.x Zaba L C, et al. J Allergy Clin Immunol. 2009;doi:10.1016/j.jaci.2009.08.046   Disclosures: Brown reports no relevant financial disclosures.

    42분
  8. The Tumultuous Tale of Th17-and the IL23/IL17 immune axis

    2025. 06. 30.

    The Tumultuous Tale of Th17-and the IL23/IL17 immune axis

    In this episode, we dive into a two-part story of intrigue starting from a paradigm shift in understanding of T cell biology because of a mouse model of post-measles encephalopathy, to the eventual recognition of the IL-23/17 immune axis. •    Intro 0:01 •    In this episode 0:12  •    Interleukin-17 (IL-17) is a relatively recent discovery 1:34 •    The beginning of TH-17 2:20 •    Looking at autoimmune encephalopathy: A story of measles 03:30 •    1790's woman with post measles inflammatory process in the brain 10:26 •    What is causing post-infection encephalitis? 12:00 •    Acute disseminated encephalomyelitis 12:30 •    How did we find out the immune system was behind this - The rabies vaccine 13:09 •    Similarity between the rabies vaccine and infections like measles 16:04 •    T-cell lymphocytes 17:12 •    The forgotten thymus 18:00 •    What's the function of T-cells? 19:35 •    How do you tell T-cells apart? 21:14 •    The Human Leukocyte Differentiation Antigens Party 24:05 •    The godfather of T-cells 24:45 •    The TH-1 and TH-2 axis 27:30 •    Experimental Autoimmune Encephalomyelitis model screwed everything up 29:16 •    Interferon gamma 32:32 •    What's missing? IL-23 surprise 33:40 •    IL-17 in the 1990's 36:44 •    The world is introduced to TH-17 39:12 •    Let's recap what we learned 40:30 •    That is the end! 42:30 •    Thanks for listening 42:39 We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum. References: Bashyam H. J Exp Med. 2007;doi:10.1084/jem.2042fta Bennetto L, et al. J Neurol Neurosurg Psychiatry. 2004;doi:10.1136/jnnp.2003.034256 Berche P. Presse Med. 2022;doi:10.1016/j.lpm.2022.104149 El-behi M, et al. J Neuroimmune Pharmacol. 2010;doi:10.1007/s11481-009-9188-9 Gooderham MJ, et al. J Eur Acad Dermatol Venereol. 2018;doi:10.1111/jdv.14868 Hawkes JE, et al. J Immunol. 2018;doi:10.4049/jimmunol.1800013 Rogozynski N, et al. Immunol Lett. 2024;doi:10.1016/j.imlet.2024.106870 Sospedra M, et al. Annu Rev Immunol. 2005;doi:10.1146/annurev.immunol.23.021704.115707 Steinman L. Nat Med. 2007;doi:10.1038/nm1551 Disclosures: Brown reports no relevant financial disclosures.

    43분
모두 보기(98개)

소개

Rheumatology is an incredibly fast-moving and exciting field of medicine that can be difficult to keep up with. This Healio podcast provides busy clinicians with quick updates in the field of autoimmunity, with emphasis on new medications, treatment guidelines and explorations into the pathophysiology of diseases. The show will also feature historical perspectives in the field of rheumatology, as well as fascinating case presentations of medical mysteries complete with discussions from experts in the field.

정보

  • 채널
    Healio
  • 제작진
    Adam J. Brown, MD
  • 방송 연도
    2018년 - 2026년
  • 에피소드
    98
  • 등급
    전체 연령 사용가
  • 웹사이트 보기
    Healio Rheuminations

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