Knife Down

Lily Johnston, MD MPH
  • 0.0(0개의 평가)
  • 의학

 "Knife Down" is what a surgeon says in the OR when she puts her scalpel down so no one gets hurt — and it’s the mission here: put the knife down, long before anyone needs to use it. Knife Down is a podcast about how to actually invest in your health so you can live longer, stronger, and with less time in doctors’ offices. The core focus is the world’s leading cause of death—cardiovascular disease—and what to do about it before it shows up as a catastrophe. Hosted by a vascular surgeon on a mission to put herself out of business, the show translates cutting-edge science on prevention, metabolic health, and longevity into real-world strategies you can use in clinic or at your kitchen table. Expect evidence, nuance, and zero wellness hype—plus the occasional dark joke about the state of modern medicine.

  1. 23시간 전

    Do Viagra and Cialis Help You Live Longer? What This Study Actually Found

    Chapters: 00:00 - Introduction & AMA Catch-up  00:28 - Does Fibromyalgia Affect Heart Health?  01:43 - Advanced Markers for Inflammation (hsCRP, oxLDL)  03:04 - Upcoming LIVE AMA Details  03:48 - Is it Safe to Stop Lipitor for High Cholesterol?  05:23 - The "700 Point Drop" in CAC Score: What is Plaque-X?  07:51 - Testosterone & The FDA Black Box Warning Update  08:33 - Deep Dive: Do Viagra and Cialis Impact Mortality?  09:54 - Study Funding and Conflicts of Interest  10:51 - How PDE5 Inhibitors Actually Work  12:53 - Observational Studies vs. Clinical Trials  14:41 - Understanding the Dataset (TriNetX)  16:41 - How Patient Cohorts are Defined  19:54 - Comparing Cialis vs. Viagra for Heart Benefits  21:26 - Why Prostate Health Matters in This Research  24:21 - Breaking Down the Five Key Outcomes  26:30 - Statistical Matching: Making the Groups Fair  30:03 - The Results: Mortality, Stroke, and Dementia Risk 33:57 - Absolute vs. Relative Risk Reduction  37:29 - Tadalafil’s Half-Life Advantage  39:18 - Crossing the Blood-Brain Barrier  41:04 - Study Limitations: What We Might Have Missed  42:24 - The "Partnership" Factor in Longevity Data 43:32 - Final Thoughts: Is it Time for a Label Change? In this session, I'm diving into your questions from our last AMA and taking a deep look at a fascinating new study on PDE5 inhibitors like Cialis (tadalafil) and Viagra (sildenafil). We explore whether these medications could have a role in longevity, heart health, and even dementia prevention. I also address questions on fibromyalgia, stopping statins, and the latest on testosterone and cardiovascular risk. Sign up for more information on my own practice here: https://corsighthealth.com/ High Quality 3rd-party tested supplements at Fullscript (10% discount): https://us.fullscript.com/welcome/ljohnstonmd/store-start Other tools for optimal health (note these are affiliate links): Home BP Cuff: https://amzn.to/49Cq7rh Sonicare Toothbrush: https://amzn.to/3KllfMS WaterPik: https://amzn.to/4894Xi8 Apple Watch with sleep & HR monitoring: https://amzn.to/3XaUn5d Oura Ring with sleep, cycle, and recovery monitoring: https://amzn.to/4riyhLS Intake Breathing Nasal Support: https://amzn.to/48dfQQ1 Personal Blender: https://amzn.to/4pyNGGl True Nutrition Protein: https://oken.do/q2xzqeqw Glass Meal Prep Containers: https://amzn.to/4ocEPJ2 Sleep Mask: https://amzn.to/48fSJV5 Air Purifier: https://amzn.to/4puzTQZ ___________________________ 🧬 About Dr. Lily Johnston    Dr. Johnston is a double board-certified vascular and general surgeon in San Diego, specializing in metabolic and cardiovascular prevention. She’s the founder of CorSight Health and a passionate advocate for reimagining how medicine approaches chronic disease.    #MetabolicHealth #CardiovascularPrevention #HeartHealth #Longevity #InsulinResistance #DrLilyJohnston #DrLily #WomenInMedicine #Surgeon #VascularSurgeon #PreventiveMedicine #PADPrevention #HeartAttackRisks #HealthPortfolio #California #SanDiego #Arizona #Virginia #Minnesota

  2. 1일 전

    AMA #3: When Can You Actually Stop a Statin? Plus Plaque, Lp(a), Sleep Apnea & Heart Scans

    Two hours, your questions, and no script. You brought the good stuff: when it's actually safe to come off a statin, whether the enzyme supplements are worth it, what sleep apnea does to your arteries, how I build and read a full lab panel, and which heart-imaging test to get if you can only get one. I answer fast, and I answer honestly — including the parts where the real answer is "we don't know yet." If you want the short version of how I think about metabolic and vascular risk, this is a good place to start. Grab a coffee, skip around with the chapters, and take what's useful for you. ⏱️ CHAPTERS 0:00 Welcome, and how these AMAs work 0:33 Shockwave therapy for ED, and how it grows new blood vessels 3:05 Can an ultrasound tech get CIMT-qualified? Why CardioRisk controls quality 6:52 Aspirin after a stent: how long, and who actually needs it 11:04 Small vessel disease and brain bleeds: the stroke signs to watch 13:01 Nattokinase, lumbrokinase, serrapeptase: do the enzymes work? 16:20 The genetic lottery: 45 years of partying and still standing 18:15 How long does a statin take to work? (and the clotting angle) 21:02 How often should you really see your preventive cardiologist? 25:23 Soft plaque, leg cramps, and the statin-intolerance playbook 29:52 Age 73: when can I stop my statin, aspirin, and lisinopril? 33:47 Supplements worth the money: magnesium, creatine, D3/K2, fish oil 40:05 Why all the statin hate? Relative vs. absolute risk, and trust 45:15 Lp(a): who should test, and why it matters for your family 49:48 Will Lp(a)-lowering drugs be covered for prevention? 53:36 Thyroid and heart health: why I check free T3 and free T4 55:26 Sleep, sleep apnea, and metabolic health 57:32 Walking after meals: GLUT4, meal timing, and insulin resistance 1:06:50 Testosterone and heart disease, for men and for women 1:10:51 What sleep apnea physically does to your arteries 1:13:31 The real problem with long-term PPIs 1:16:52 Is a carotid ultrasound worth it? It depends who reads it 1:19:35 Is plaque stabilization real science, or a gamble? 1:23:12 Nitric oxide lozenges, ADMA, and the oral microbiome 1:30:44 Building a lab panel: the tests I want, and how I read them 1:35:31 Microalbumin (UACR): the underused early-warning test 1:41:50 Why there's no one perfect diet (and why nutrition science is so hard) 1:53:25 Retatrutide, peptides, and the "just buy it online" problem 1:59:35 CAC vs. CIMT vs. CCTA: which imaging should you get? 2:14:18 CAC of 8 at 47, LDL 110: do you need a statin? 2:15:32 Wrap-up, and where to find me 📚 STUDIES & TERMS REFERENCED JUPITER (rosuvastatin lowers events via hsCRP): Ridker PM, Danielson E, Fonseca FAH, et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med. 2008;359(21):2195-2207. PMID: 18997196. https://pubmed.ncbi.nlm.nih.gov/18997196/ Multivitamin and cognition (COSMOS-Mind): Baker LD, Manson JE, Rapp SR, et al. Effects of cocoa extract and a multivitamin on cognitive function: a randomized clinical trial. Alzheimers Dement. 2023;19(4):1308-1319. PMID: 36102337. https://pubmed.ncbi.nlm.nih.gov/36102337/ ▶️ WATCH NEXT AMA #2 — Why a "Perfect" LDL Won't Save You: https://youtu.be/v2Pa7UUTLO8 AMA #1 — Lp(a), Microplastics, Testosterone & CAC: https://youtu.be/r1p-LpCruHc Try THIS Instead of Nattokinase (the enzyme deep dive): https://youtu.be/yA26H0_7-_U My video on statins and the brain: https://youtu.be/pgfNT7o08_g ⚕️ DISCLAIMER This channel is for education, not medical advice. I'm a board-certified vascular surgeon, but I'm not your surgeon, and nothing here replaces a conversation with your own physician. Supplements and medications carry real risks, including bleeding. Talk to your doctor before starting, stopping, or changing anything — especially statins, aspirin, or any supplement if you take blood thinners or antiplatelet medication. 💬 If you got something out of this, subscribe and share it with a friend.  Every new viewer helps our small channel grow one curious mind at a time. ___________________________ 🧬 About Dr. Lily Johnston    Dr. Johnston is a double board-certified vascular and general surgeon in San Diego, specializing in metabolic and cardiovascular prevention. She’s the founder of CorSight Health and a passionate advocate for reimagining how medicine approaches chronic disease.

  3. 5일 전

    Cholesterol Balance & Keto Bias

    Chapters:  00:00 The Replication Crisis & Messy Science  02:11 Why the KETO-CTA Study Was Retracted  03:25 Mediterranean Keto vs. Standard Keto  06:14 Cholesterol Balance: Absorption vs. Production  10:50 The Million-Dollar Question: What Causes Plaque?  13:07 Small Studies & Statistical Manipulation  15:03 Addressing Bias, Personalities, and Grifters  16:56 My Position on ApoB and Personalized Care In this video, I dive into the "spicy" comments from my recent keto reaction video to address the complexities of heart health, the reality of the scientific replication crisis, and the nuances of personalized medicine. We discuss why a major keto study was retracted, how to think about cholesterol absorption vs. production, and why "testing, not guessing" is the only way to truly understand your own cardiovascular risk. Sign up for more information on my own practice here: https://corsighthealth.com/ High Quality 3rd-party tested supplements at Fullscript (10% discount): https://us.fullscript.com/welcome/ljohnstonmd/store-start Other tools for optimal health (note these are affiliate links): Home BP Cuff: https://amzn.to/49Cq7rh Sonicare Toothbrush: https://amzn.to/3KllfMS WaterPik: https://amzn.to/4894Xi8 Apple Watch with sleep & HR monitoring: https://amzn.to/3XaUn5d Oura Ring with sleep, cycle, and recovery monitoring: https://amzn.to/4riyhLS Intake Breathing Nasal Support: https://amzn.to/48dfQQ1 Personal Blender: https://amzn.to/4pyNGGl True Nutrition Protein: https://oken.do/q2xzqeqw Glass Meal Prep Containers: https://amzn.to/4ocEPJ2 Sleep Mask: https://amzn.to/48fSJV5 Air Purifier: https://amzn.to/4puzTQZ ___________________________ 🧬 About Dr. Lily Johnston    Dr. Johnston is a double board-certified vascular and general surgeon in San Diego, specializing in metabolic and cardiovascular prevention. She’s the founder of CorSight Health and a passionate advocate for reimagining how medicine approaches chronic disease.    #MetabolicHealth #CardiovascularPrevention #HeartHealth #Longevity #InsulinResistance #DrLilyJohnston #DrLily #WomenInMedicine #Surgeon #VascularSurgeon #PreventiveMedicine #PADPrevention #HeartAttackRisks #HealthPortfolio #California #SanDiego #Arizona #Virginia #Minnesota

  4. 6월 30일

    Try THIS instead of Nattokinase (Surgeon Explains)

    The nattokinase video clearly hit a nerve. Your comments were sharp, occasionally feisty, and worth a real answer. So this is the follow-up Q&A: natto the food versus nattokinase the isolated capsule, whether CIMT is a test I actually trust, the dosing argument a lot of you raised, and the supplement many of you asked about instead — lumbrokinase. The back half is a proper walk through the one randomized trial testing lumbrokinase for secondary stroke prevention. I go through the design, the parts that gave me pause, and the plaque and IMT findings that genuinely caught my attention. My take, for what it's worth with the evidence we have: if you're going to hang your hat on an enzyme, lumbrokinase looks like the safer bet. Watch and decide for yourself. ⏱️ CHAPTERS 0:00 Why I'm answering your nattokinase comments 0:25 Natto the food vs. nattokinase the supplement 1:54 Is nattokinase the same as vitamin K2? 2:46 Do I trust CIMT? Plaque vs. IMT, explained 3:59 The "n=1" critique, Susan, and Dr. Brewer 6:01 The dosing fight: 2,000 vs. 10,800 FU 7:58 Lumbrokinase and serrapeptase: what they actually are 10:22 The 2013 lumbrokinase stroke trial: setup 13:09 Where the trial design gives me pause 15:46 Results: the patients and the open-label problem 17:26 Baseline data and the missing standard meds 20:20 Lab results: fibrinogen, CRP, D-dimer, tPA 22:29 The interesting part: plaque and IMT changes 24:57 Stroke scores, outcomes, and the low event count 27:52 How lumbrokinase differs from nattokinase (and why it's likely safer) 30:15 Bottom line: should you take it? 📚 STUDY DISCUSSED Cao YJ, Zhang X, Wang WH, et al. Oral fibrinogen-depleting agent lumbrokinase for secondary ischemic stroke prevention: results from a multicenter, randomized, parallel-group and controlled clinical trial. Chin Med J (Engl). 2013;126(21):4060-4065. PMID: 24229674. https://pubmed.ncbi.nlm.nih.gov/24229674/ ▶️ WATCH NEXT "I Stopped Using Nattokinase. Here's Why.":  https://youtu.be/vpenJQ3UJh0 The VitaK-CAC study: https://youtu.be/ArxAXtzsue4 Vit K Comments & Questions: https://youtu.be/uORGxMsedic ⚕️ DISCLAIMER This channel is for education, not medical advice. I'm a board-certified vascular surgeon, but I'm not your surgeon, and nothing here replaces a conversation with your own physician. Supplements carry real risks, including bleeding. Talk to your doctor before starting, stopping, or changing anything — especially if you take blood thinners or antiplatelet medication. 💬 Found this useful? Subscribe, and drop your lumbrokinase questions in the comments. We'll get to as many as we can next time.  Sign up for more information on my own practice here: https://corsighthealth.com/ High Quality 3rd-party tested supplements at Fullscript (10% discount): https://us.fullscript.com/welcome/ljohnstonmd/store-start Other tools for optimal health (note these are affiliate links): Home BP Cuff: https://amzn.to/49Cq7rh Sonicare Toothbrush: https://amzn.to/3KllfMS WaterPik: https://amzn.to/4894Xi8 Apple Watch with sleep & HR monitoring: https://amzn.to/3XaUn5d Oura Ring with sleep, cycle, and recovery monitoring: https://amzn.to/4riyhLS Intake Breathing Nasal Support: https://amzn.to/48dfQQ1 Personal Blender: https://amzn.to/4pyNGGl True Nutrition Protein: https://oken.do/q2xzqeqw Glass Meal Prep Containers: https://amzn.to/4ocEPJ2 Sleep Mask: https://amzn.to/48fSJV5 Air Purifier: https://amzn.to/4puzTQZ ___________________________ 🧬 About Dr. Lily Johnston    Dr. Johnston is a double board-certified vascular and general surgeon in San Diego, specializing in metabolic and cardiovascular prevention. She’s the founder of CorSight Health and a passionate advocate for reimagining how medicine approaches chronic disease.    #MetabolicHealth #CardiovascularPrevention #HeartHealth #Longevity #InsulinResistance #DrLilyJohnston #DrLily #WomenInMedicine #Surgeon #VascularSurgeon #PreventiveMedicine #PADPrevention #HeartAttackRisks #HealthPortfolio #California #SanDiego #Arizona #Virginia #Minnesota

  5. 6월 24일

    I Stopped Using Nattokinase. Here’s Why.

    Nattokinase is one of the most hyped supplements in cardiovascular health — claimed to lower blood pressure, shrink arterial plaque by 36%, and drop LDL cholesterol without a statin. I put a patient on it. Then I looked closer at the data. Now I've stopped. In this video, I break down what the evidence actually shows: ✅ Blood pressure: Real, but modest. A 2023 meta-analysis of 6 RCTs found just 3.45 mmHg systolic reduction — roughly half the effect of a low-dose ACE inhibitor. ❌ Plaque reduction: The headline 36% plaque reduction comes from a single retrospective chart review (Chen 2022) with no control group, no randomization, co-administered confounders, and 5 of 10 authors employed by the supplement manufacturer. Meanwhile, the rigorous double-blind NAPS trial (Hodis 2021, n=265) found zero effect on carotid plaque. ❌ Lipid lowering: In randomized trials (Yang 2009, Hsia 2009), nattokinase alone doesn't move lipids. The signal only appears in non-randomized studies — often confounded by red yeast rice, which contains monacolin K (chemically identical to lovastatin). 📉 The case study: I put "Susan" on high-dose nattokinase for a year. Her arterial age went from 64 to 73. We stopped. The lesson: Test. Don't guess. Never start a supplement without a plan to stop it if the numbers don't move. ⏱️ Chapters 0:00 Why I stopped using nattokinase 0:21 Meet Susan 1:46 What nattokinase actually is 2:14 How nattokinase works 5:00 Does it survive digestion? 6:14 The real signal: blood pressure 8:34 The plaque-regression claim 9:59 Problems with the 2022 study 13:09 The 2017 plaque study 14:50 The 36% plaque reduction problem 16:30 Does it lower ApoB or LDL? 19:31 Why plaque ultrasound is tricky 22:56 Safety and bleeding concerns 25:57 What’s actually in the bottle? 27:24 The NAPS trial 28:48 Was the dose too low? 30:29 Susan’s one-year follow-up 32:51 What if you take it anyway? 33:42 Final take: test, don’t guess ⚠️ This video is for education only and is not personal medical advice. Please talk with your own physician before starting or stopping any supplement or medication — especially if you take aspirin, clopidogrel, warfarin, Eliquis, Xarelto, Pradaxa, or any other blood thinner. — PRODUCT POTENCY TESTING — Natural Informant (Danny Curtin). "Nattokinase: We Tested Them All… Which Products Can You Trust?" https://youtu.be/K1l_g6-vdC4?si=h4oOnGEw_Vvh51cx Sign up for more information on my own practice here: https://corsighthealth.com/ High Quality 3rd-party tested supplements at Fullscript (10% discount): https://us.fullscript.com/welcome/ljohnstonmd/store-start Other tools for optimal health (note these are affiliate links): Home BP Cuff: https://amzn.to/49Cq7rh Sonicare Toothbrush: https://amzn.to/3KllfMS WaterPik: https://amzn.to/4894Xi8 Apple Watch with sleep & HR monitoring: https://amzn.to/3XaUn5d Oura Ring with sleep, cycle, and recovery monitoring: https://amzn.to/4riyhLS Intake Breathing Nasal Support: https://amzn.to/48dfQQ1 Personal Blender: https://amzn.to/4pyNGGl True Nutrition Protein: https://oken.do/q2xzqeqw Glass Meal Prep Containers: https://amzn.to/4ocEPJ2 Sleep Mask: https://amzn.to/48fSJV5 Air Purifier: https://amzn.to/4puzTQZ ___________________________ 🧬 About Dr. Lily Johnston    Dr. Johnston is a double board-certified vascular and general surgeon in San Diego, specializing in metabolic and cardiovascular prevention. She’s the founder of CorSight Health and a passionate advocate for reimagining how medicine approaches chronic disease.    #MetabolicHealth #CardiovascularPrevention #HeartHealth #Longevity #InsulinResistance #DrLilyJohnston #DrLily #WomenInMedicine #Surgeon #VascularSurgeon #PreventiveMedicine #PADPrevention #HeartAttackRisks #HealthPortfolio #California #SanDiego #Arizona #Virginia #Minnesota

  6. 6월 22일

    Can You Take Too Much Vitamin K2? Vascular Surgeon Explains

    Can you take too much vitamin K2? In this video, I answer the most common follow-up questions about vitamin K2, including dose, safety, testing, interactions, and whether more is actually better. Here's the original video on the K2 clinical trial: https://youtu.be/ArxAXtzsue4 We’ll cover: * Whether vitamin K2 toxicity is possible * Whether using MK7 to slow coronary artery calcification is desirable * What we know — and do not know — about upper dosing limits * Who should be especially cautious with vitamin K supplements * Why warfarin/Coumadin changes the conversation * Whether vitamin K2 levels can be tested * The difference between MK-4 and MK-7 * Whether vitamin K2 can “remove” calcium from arteries * How I think about vitamin K2 in real-world cardiovascular prevention The bottom line: vitamin K2 looks promising, but “promising” is not the same thing as “take as much as possible and hope your arteries applaud.” This video is for education only and is not personal medical advice. Do not start, stop, or change supplements or medications based on YouTube — especially if you take warfarin or another medication affected by vitamin K. Talk with your own clinician. ⏰ Chapters 0:00 - More of your vitamin K2 questions 0:22 - Is softer plaque more dangerous than calcified plaque? 2:35 - Should people with high CAC avoid vitamin D3? 4:13 - Didn’t the AVADEC trial already show K2 works? 6:25 - Would a higher dose of K2 work better? 7:33 - Does K2 actively stop calcium from entering plaque? 8:28 - Can too much vitamin K2 cause blood clots? 8:55 - Vitamin K2 and warfarin/Coumadin 9:48 - Is K2 safe with Eliquis or Xarelto? 10:23 - Is 100 mcg enough—or should you take more? 11:16 - Can vitamin K2 remove calcium from arteries? 11:53 - Can you test for vitamin K deficiency? 12:37 - MK-4 vs MK-7: which form is better? 13:25 - Food sources vs K2 supplements 14:33 - Should K2 be taken with vitamin D3? 14:58 - Final takeaways High Quality 3rd-party tested supplements at Fullscript (10% discount): https://us.fullscript.com/welcome/ljohnstonmd/store-start Sign up for more information on my own practice here: https://corsighthealth.com/ Other tools for optimal health (note these are affiliate links): Home BP Cuff: https://amzn.to/49Cq7rh Sonicare Toothbrush: https://amzn.to/3KllfMS WaterPik: https://amzn.to/4894Xi8 Apple Watch with sleep & HR monitoring: https://amzn.to/3XaUn5d Oura Ring with sleep, cycle, and recovery monitoring: https://amzn.to/4riyhLS Intake Breathing Nasal Support: https://amzn.to/48dfQQ1 Personal Blender: https://amzn.to/4pyNGGl True Nutrition Protein: https://oken.do/q2xzqeqw Glass Meal Prep Containers: https://amzn.to/4ocEPJ2 Sleep Mask: https://amzn.to/48fSJV5 Air Purifier: https://amzn.to/4puzTQZ ___________________________ 🧬 About Dr. Lily Johnston    Dr. Johnston is a double board-certified vascular and general surgeon in San Diego, specializing in metabolic and cardiovascular prevention. She’s the founder of CorSight Health and a passionate advocate for reimagining how medicine approaches chronic disease.    #MetabolicHealth #CardiovascularPrevention #HeartHealth #Longevity #InsulinResistance #DrLilyJohnston #DrLily #WomenInMedicine #Surgeon #VascularSurgeon #PreventiveMedicine #PADPrevention #HeartAttackRisks #HealthPortfolio #California #SanDiego #Arizona #Virginia #Minnesota

  7. 6월 17일

    Vitamin K Slows Coronary Calcium: NEW Netherlands Study

    Can vitamin K2 slow coronary artery calcium? A new JAMA Cardiology randomized trial found that MK-7 may reduce CAC progression over 2 years — but the real story is more complicated. TL;DR: In this randomized trial, people with symptomatic coronary artery disease and CAC scores between 50–400 took either MK-7, a form of vitamin K2, at 360 mcg daily or placebo for 2 years. The MK-7 group had slower progression of coronary artery calcium and calcium mass, with no major safety signal. But this study did not prove fewer heart attacks, fewer stents, or lower mortality — so this is interesting, not a miracle. Especially important: do not start vitamin K supplements without medical guidance if you take warfarin/Coumadin. Article link: https://jamanetwork.com/journals/jamacardiology/fullarticle/2850256 In this video, I break down the VitaK-CAC trial: who was studied, what dose was used, what happened to CAC scores, why plaque calcification is biologically complicated, and what I would — and would not — take away from this as a vascular surgeon. ⏰ Chapters 0:00 - New vitamin K study: why this matters 0:39 - The paper: MK-7 and coronary artery calcium 1:42 - Vitamin K1 vs K2, why MK-7 2:13 - What the VitaK-CAC trial tested 3:08 - Calcified plaque vs total plaque burden 3:28 - Study design: randomized, placebo-controlled, double-blind 4:41 - Who was included and excluded in the trial, plus why it matters 6:32 - What “symptomatic CAD” actually meant here 8:47 - The intervention: 360 mcg MK-7 daily 9:13 - CT scans, CAC scoring, and calcium mass 10:59 - How vitamin K status was measured 12:29 - Primary outcome: CAC progression, not heart attacks 13:03 - Statistical methods and “fast progression” 16:44 - LDL levels, statins, and a possible data discrepancy 18:25 - Baseline characteristics of the study population 22:12 - Adherence, adverse events, and vitamin K blood levels 23:31 - Matrix Gla protein: did MK-7 do what it was supposed to? 24:58 - Primary results: CAC progression slowed with MK-7 26:21 - Why the effect is exciting but modest 29:17 - Fast progressors: no significant difference 30:07 - Calcium mass and intention-to-treat analysis 32:02 - Secondary outcomes: plaque type and stenosis 33:32 - The big question: is less calcification always better? 35:40 - Discussion: promising, but clinical significance unknown 37:13 - Why MK-7 does not “remove” existing calcium 38:23 - Vitamin K biomarkers and possible under-dosing 42:25 - Study limitations 43:41 - Funding, conflicts of interest, and final takeaways 44:48 - My clinical take on vitamin K2/MK-7 This video is for education only and is not personal medical advice. Do not start, stop, or change supplements or medications based on YouTube — especially if you take warfarin or any medication affected by vitamin K. Talk with your own clinician. High Quality 3rd-party tested supplements at Fullscript (10% discount): https://us.fullscript.com/welcome/ljohnstonmd/store-start Other tools for optimal health (note these are affiliate links): Home BP Cuff: https://amzn.to/49Cq7rh Sonicare Toothbrush: https://amzn.to/3KllfMS WaterPik: https://amzn.to/4894Xi8 Apple Watch with sleep & HR monitoring: https://amzn.to/3XaUn5d Oura Ring with sleep, cycle, and recovery monitoring: https://amzn.to/4riyhLS Intake Breathing Nasal Support: https://amzn.to/48dfQQ1 Personal Blender: https://amzn.to/4pyNGGl True Nutrition Protein: https://oken.do/q2xzqeqw Glass Meal Prep Containers: https://amzn.to/4ocEPJ2 Sleep Mask: https://amzn.to/48fSJV5 Air Purifier: https://amzn.to/4puzTQZ Sign up for more information on my own practice here: https://corsighthealth.com/ ___________________________ 🧬 About Dr. Lily Johnston    Dr. Johnston is a double board-certified vascular and general surgeon in San Diego, specializing in metabolic and cardiovascular prevention. She’s the founder of CorSight Health and a passionate advocate for reimagining how medicine approaches chronic disease.

  8. 6월 15일

    Surgery for Alzheimer's...Is It Real? (and other questions)

    In this Q&A session, Dr. Lily Johnston dives into complex viewer questions regarding cardiovascular health and emerging medical research. She covers the impact of hormone therapies on LP(a), the nuances of managing cholesterol after a heart attack, and how to interpret advanced imaging like CIMT and Calcium Scores. The episode concludes with a fascinating look at a novel, experimental microsurgical approach for Alzheimer’s disease being studied in China, which aims to improve the brain's waste clearance through lymphatic connections. Dr. Lily breaks down the mechanistic rationale, the early clinical data, and the significant physiological and ethical concerns surrounding this "brain plumbing" surgery. Timestamps 00:00 – Intro: Meet Dr. Lily Johnston, Vascular Surgeon & Cardiometabolic Specialist. 00:16 – Q&A 1: Can hormone replacement therapy (HRT) or testosterone reduce LP(a)? 02:53 – Q&A 2: Recovery after a STEMI—Statins vs. PCSK9 inhibitors and the role of Colchicine. 06:49 – Q&A 3: How to distinguish between stable and inflamed plaque using CIMT tests. 09:34 – Q&A 4: High Calcium Score (CAC) vs. CIMT results—Is a heart cath or CT angiogram next? 12:39 – Q&A 5: Does starting Menopausal Hormone Therapy (MHT) late increase cardiac risk? 16:48 – Addressing the "Omega minus-3" nomenclature (A quick biochemistry deep dive). 17:53 – Q&A 6: Does taking Phosphatidylcholine improve fish oil absorption? 19:02 – Q&A 7: Krill oil vs. traditional fish oil. 20:47 – Deep Dive: Deep Cervical Lymphovenous Anastomosis—A surgical treatment for Alzheimer's? 25:40 – Reviewing clinical evidence and controversies of Alzheimer's surgery. Sign up for more information on my own practice here: https://corsighthealth.com/ High Quality 3rd-party tested supplements at Fullscript (10% discount): https://us.fullscript.com/welcome/ljohnstonmd/store-start Other tools for optimal health (note these are affiliate links): Home BP Cuff: https://amzn.to/49Cq7rh Sonicare Toothbrush: https://amzn.to/3KllfMS WaterPik: https://amzn.to/4894Xi8 Apple Watch with sleep & HR monitoring: https://amzn.to/3XaUn5d Oura Ring with sleep, cycle, and recovery monitoring: https://amzn.to/4riyhLS Intake Breathing Nasal Support: https://amzn.to/48dfQQ1 Personal Blender: https://amzn.to/4pyNGGl True Nutrition Protein: https://oken.do/q2xzqeqw Glass Meal Prep Containers: https://amzn.to/4ocEPJ2 Sleep Mask: https://amzn.to/48fSJV5 Air Purifier: https://amzn.to/4puzTQZ ___________________________ 🧬 About Dr. Lily Johnston    Dr. Johnston is a double board-certified vascular and general surgeon in San Diego, specializing in metabolic and cardiovascular prevention. She’s the founder of CorSight Health and a passionate advocate for reimagining how medicine approaches chronic disease.    #MetabolicHealth #CardiovascularPrevention #HeartHealth #Longevity #InsulinResistance #DrLilyJohnston #DrLily #WomenInMedicine #Surgeon #VascularSurgeon #PreventiveMedicine #PADPrevention #HeartAttackRisks #HealthPortfolio #California #SanDiego #Arizona #Virginia #Minnesota

모두 보기(47개)

소개

 "Knife Down" is what a surgeon says in the OR when she puts her scalpel down so no one gets hurt — and it’s the mission here: put the knife down, long before anyone needs to use it. Knife Down is a podcast about how to actually invest in your health so you can live longer, stronger, and with less time in doctors’ offices. The core focus is the world’s leading cause of death—cardiovascular disease—and what to do about it before it shows up as a catastrophe. Hosted by a vascular surgeon on a mission to put herself out of business, the show translates cutting-edge science on prevention, metabolic health, and longevity into real-world strategies you can use in clinic or at your kitchen table. Expect evidence, nuance, and zero wellness hype—plus the occasional dark joke about the state of modern medicine.

정보

  • 제작진
    Lily Johnston, MD MPH
  • 방송 연도
    2026년
  • 에피소드
    47
  • 등급
    무삭제판
  • 저작권
    © 2026 Knife Down
  • 웹사이트 보기
    Knife Down

좋아할 만한 다른 항목