Cardiology Today

Deconstructed Cardiology

Stay current with cardiovascular medicine without the time commitment. Every morning, we deliver concise audio summaries of the latest original research from top cardiology journals. Top 5 breakthrough studies briefed in under 5 minutes (perfect for your commute or between patients). PubMed links included for full articles. Perfect for cardiologists, cardiothoracic surgeons, cardiac nurses, researchers, and healthcare workers who need to stay informed but lack time to scan multiple journals daily. For educational and reference purposes only. Not intended as medical advice.

  1. 11 HR AGO

    Sirolimus Balloon Challenges Paclitaxel Mortality 02/19/26

    Welcome to Cardiology Today – Recorded February 19, 2026. This episode summarizes 5 key cardiology studies on topics like mind-body exercise and older adults. Key takeaway: Sirolimus Balloon Challenges Paclitaxel Mortality. Article Links: Article 1: Comparison of Sirolimus- vs Paclitaxel-Coated Balloon Angioplasty for Femoropopliteal Artery Disease: The SIRONA Randomized Noninferiority Trial. (Journal of the American College of Cardiology) Article 2: Effect of Baduanjin on Blood Pressure Among Individuals With High-Normal Blood Pressure: A Multicenter, Open-Label, Blinded-Outcome Randomized Controlled Trial. (Journal of the American College of Cardiology) Article 3: Impact of Long-Term Cumulative Exposure to Wildfire Smoke PM2.5 on Cardiovascular Hospital Admissions Among Older Adults in the United States: A Population-Based Cohort Study. (Journal of the American College of Cardiology) Article 4: Mitral Valve Repair for Degenerative MR With Moderate or Less Tricuspid Regurgitation: 2-Year Outcomes From a Multicenter Echocardiographic Core Laboratory-Adjudicated Cohort. (Journal of the American College of Cardiology) Article 5: Menopausal Status Associated With Docetaxel-Induced Vascular Dysfunction in Breast Cancer Patients. (Journal of the American College of Cardiology) Full episode page: https://podcast.explainheart.com/podcast/sirolimus-balloon-challenges-paclitaxel-mortality-02-19-26/ Featured Articles Article 1: Comparison of Sirolimus- vs Paclitaxel-Coated Balloon Angioplasty for Femoropopliteal Artery Disease: The SIRONA Randomized Noninferiority Trial. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41706076 Summary: Paclitaxel-coated balloon angioplasty effectively treats femoropopliteal artery disease; however, an increased mortality risk associated with it remains unresolved. Sirolimus-coated balloon angioplasty offers an alternative antiproliferative drug approach for these interventions. The SIRONA randomized noninferiority trial evaluated sirolimus-coated balloon angioplasty against paclitaxel-coated balloon angioplasty. This comparison determines if sirolimus-coated balloons achieve noninferior primary vessel patency and clinical efficacy with an improved safety profile. Article 2: Effect of Baduanjin on Blood Pressure Among Individuals With High-Normal Blood Pressure: A Multicenter, Open-Label, Blinded-Outcome Randomized Controlled Trial. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41706075 Summary: Achieving sustained blood pressure lowering with traditional lifestyle guidance and exercise presents a challenge for individuals with high-normal blood pressure. Baduanjin, a traditional Chinese mind-body exercise, serves as a non-pharmacological therapeutic approach under investigation for this population. A multicenter, open-label, blinded-outcome randomized controlled trial assessed Baduanjin’s short-term impact on ambulatory blood pressure and its long-term effects. This study evaluated participants aged 40 years or older who presented with systolic blood pressure of 130 to 139 mmHg or diastolic blood pressure of 85 mmHg or higher. Article 3: Impact of Long-Term Cumulative Exposure to Wildfire Smoke PM2.5 on Cardiovascular Hospital Admissions Among Older Adults in the United States: A Population-Based Cohort Study. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41706074 Summary: M. 2.5 on Cardiovascular Hospital Admissions Among Older Adults in the United States: A Population-Based Cohort Study. Intensifying wildfires in a warming climate result in prolonged exposure to smoke-derived fine particulate matter (P. M. 2.5), which poses significant health risks. The cardiovascular impacts of long-term cumulative exposure to wildfire smoke P. M. 2.5, particularly in older adults, represent an area of critical clinical investigation. This population-based cohort study analyzed associations between long-term cumulative exposure to wildfire smoke P. M. 2.5 and first cardiovascular disease hospitalizations. The research focused on U.S. Medicare beneficiaries, examining the effects on cardiovascular health in this vulnerable population. Article 4: Mitral Valve Repair for Degenerative MR With Moderate or Less Tricuspid Regurgitation: 2-Year Outcomes From a Multicenter Echocardiographic Core Laboratory-Adjudicated Cohort. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41706073 Summary: R. With Moderate or Less Tricuspid Regurgitation: 2-Year Outcomes From a Multicenter Echocardiographic Core Laboratory-Adjudicated Cohort. Recurrent mitral regurgitation degree serves as a key indicator for the quality of mitral valve repair for degenerative mitral regurgitation. This multicenter study evaluated 2-year survival and mitral regurgitation recurrence following mitral valve repair in patients with degenerative mitral regurgitation and moderate or less concomitant tricuspid regurgitation. The research utilized echocardiographic core laboratory-adjudicated data from a cohort of patients who underwent repair between 2016 and 2018. This analysis established long-term outcomes of mitral valve repair in this specific patient group. Article 5: Menopausal Status Associated With Docetaxel-Induced Vascular Dysfunction in Breast Cancer Patients. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41532932 Summary: Breast cancer chemotherapy elevates cardiovascular risk, with a notable impact on postmenopausal women. While vascular damage, endothelial dysfunction, and oxidative stress are implicated, the precise role of menopausal status in these vascular mechanisms remains unknown. This study investigated the potential protective role of estrogens in premenopausal women against neoadjuvant chemotherapy-induced endothelial dysfunction, specifically focusing on the vascular effects of docetaxel. The research provides insights into how menopausal status influences vascular changes from cancer therapy. Transcript Today’s date is February 19, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Comparison of Sirolimus- vs Paclitaxel-Coated Balloon Angioplasty for Femoropopliteal Artery Disease: The SIRONA Randomized Noninferiority Trial. Paclitaxel-coated balloon angioplasty effectively treats femoropopliteal artery disease; however, an increased mortality risk associated with it remains unresolved. Sirolimus-coated balloon angioplasty offers an alternative antiproliferative drug approach for these interventions. The SIRONA randomized noninferiority trial evaluated sirolimus-coated balloon angioplasty against paclitaxel-coated balloon angioplasty. This comparison determines if sirolimus-coated balloons achieve noninferior primary vessel patency and clinical efficacy with an improved safety profile. Article number two. Effect of Baduanjin on Blood Pressure Among Individuals With High-Normal Blood Pressure: A Multicenter, Open-Label, Blinded-Outcome Randomized Controlled Trial. Achieving sustained blood pressure lowering with traditional lifestyle guidance and exercise presents a challenge for individuals with high-normal blood pressure. Baduanjin, a traditional Chinese mind-body exercise, serves as a non-pharmacological therapeutic approach under investigation for this population. A multicenter, open-label, blinded-outcome randomized controlled trial assessed Baduanjin’s short-term impact on ambulatory blood pressure and its long-term effects. This study evaluated participants aged 40 years or older who presented with systolic blood pressure of 130 to 139 mmHg or diastolic blood pressure of 85 mmHg or higher. Article number three. Impact of Long-Term Cumulative Exposure to Wildfire Smoke P. M. 2.5 on Cardiovascular Hospital Admissions Among Older Adults in the United States: A Population-Based Cohort Study. Intensifying wildfires in a warming climate result in prolonged exposure to smoke-derived fine particulate matter (P. M. 2.5), which poses significant health risks. The cardiovascular impacts of long-term cumulative exposure to wildfire smoke P. M. 2.5, particularly in older adults, represent an area of critical clinical investigation. This population-based cohort study analyzed associations between long-term cumulative exposure to wildfire smoke P. M. 2.5 and first cardiovascular disease hospitalizations. The research focused on U.S. Medicare beneficiaries, examining the effects on cardiovascular health in this vulnerable population. Article number four. Mitral Valve Repair for Degenerative M. R. With Moderate or Less Tricuspid Regurgitation: 2-Year Outcomes From a Multicenter Echocardiographic Core Laboratory-Adjudicated Cohort. Recurrent mitral regurgitation degree serves as a key indicator for the quality of mitral valve repair for degenerative mitral regurgitation. This multicenter study evaluated 2-year survival and mitral regurgitation recurrence following mitral valve repair in patients with degenerative mitral regurgitation and moderate or less concomitant tricuspid regurgitation. The research utilized echocardiographic core laboratory-adjudicated data from a cohort of patients who underwent repair between 2016 and 2018. This analysis established long-term outcomes of mitral valve repair in this specific patient group. Article number five. Menopausal Status Associated With Docetaxel-Induced Vascular Dysfunction in Breast Cancer Patients. Breast cancer chemotherapy elevates cardiovascular risk, with a notable impact on postmenopausal women. While vascular damage, endothelial dysfunction, and oxidative stress are implicated, the precise role of menopausal status in these vascular mechanisms remains unknown. This study investigated the potential protective role of estrogens in pre

  2. 1 DAY AGO

    Xenotransplant: Genetic Editing for Success 02/18/26

    Welcome to Cardiology Today – Recorded February 18, 2026. This episode summarizes 5 key cardiology studies on topics like congenitally corrected transposition of the great arteries and complex congenital heart disease. Key takeaway: Xenotransplant: Genetic Editing for Success. Article Links: Article 1: Arrhythmias in congenitally corrected transposition of the great arteries: an international study. (European heart journal) Article 2: Catheter ablation in congenital heart diseases: a French nationwide study. (European heart journal) Article 3: Residual lipid risk in atherosclerotic cardiovascular disease. (European heart journal) Article 4: Advancing Hope Through Science: The Inaugural Richard Slayman International Workshop on Xenotransplantation. (Transplantation) Article 5: Echocardiographic morpho-functional parameters predictors of maximal oxygen uptake and oxygen pulse in a large cohort of elite athletes practicing different sporting disciplines. (International journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/xenotransplant-genetic-editing-for-success-02-18-26/ Featured Articles Article 1: Arrhythmias in congenitally corrected transposition of the great arteries: an international study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40679844 Summary: An international multicenter retrospective cohort study quantified the incidence of atrial arrhythmia, ventricular arrhythmia, and complete atrioventricular block in patients with congenitally corrected transposition of the great arteries. This extensive study, conducted across 29 tertiary hospitals in six countries, identified factors associated with these significant cardiac rhythm disturbances. The research found specific prevalence rates for atrial arrhythmia, ventricular arrhythmia, and complete atrioventricular block within this complex patient population. These findings provide definitive data on the arrhythmia burden and associated risk factors for improved clinical management. Article 2: Catheter ablation in congenital heart diseases: a French nationwide study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40396276 Summary: A French nationwide prospective study documented the outcomes of catheter ablation in patients with congenital heart disease across 28 centers from 2020 to 2024. The study found the per-procedural acute success rate for catheter ablation in this complex patient population. It also meticulously recorded associated complications and evaluated long-term freedom from arrhythmia recurrence. These comprehensive findings provide definitive national data on the effectiveness and safety of catheter ablation in congenital heart disease. Article 3: Residual lipid risk in atherosclerotic cardiovascular disease. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41701506 Summary: Residual lipid risk persists in patients with or at risk of atherosclerotic cardiovascular disease, even after optimizing low-density lipoprotein cholesterol. Evidence highlights that non-low-density lipoprotein cholesterol fractions, including remnant cholesterol, lipoprotein(a), and apolipoprotein B, are key contributors to this residual risk. These non-low-density lipoprotein components definitively demonstrate their independent role in driving the progression of atherosclerotic cardiovascular disease. The identification of these persistent risk factors provides critical insights for developing therapeutic strategies beyond traditional low-density lipoprotein lowering. Article 4: Advancing Hope Through Science: The Inaugural Richard Slayman International Workshop on Xenotransplantation. Journal: Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41700849 Summary: The inaugural Richard Slayman Clinical Xenotransplantation Workshop, attended by over 140 international participants, identified significant advances and challenges in xenotransplantation. Discussions highlighted the increasing clinical readiness of kidney, heart, and liver xenotransplantation. Key findings from the workshop emphasized the crucial importance of meticulous patient selection and the pivotal role of genetic editing in reducing immune incompatibility. These consensuses establish current best practices and future directions for successfully translating xenotransplantation into wider clinical application. Article 5: Echocardiographic morpho-functional parameters predictors of maximal oxygen uptake and oxygen pulse in a large cohort of elite athletes practicing different sporting disciplines. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41702446 Summary: A study of 1033 Olympic-level athletes identified specific echocardiographic morpho-functional parameters that predict maximal oxygen uptake and oxygen pulse. The research established direct correlations between structural cardiac adaptations, commonly known as the athlete’s heart, and functional indices of cardiovascular performance. Results demonstrated how particular morphological changes observed via echocardiography are associated with enhanced cardiac efficiency during exertion. These findings provide measurable echocardiographic markers for assessing and monitoring cardiovascular performance and adaptive remodeling in elite athletes. Transcript Today’s date is February 18, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Arrhythmias in congenitally corrected transposition of the great arteries: an international study. An international multicenter retrospective cohort study quantified the incidence of atrial arrhythmia, ventricular arrhythmia, and complete atrioventricular block in patients with congenitally corrected transposition of the great arteries. This extensive study, conducted across 29 tertiary hospitals in six countries, identified factors associated with these significant cardiac rhythm disturbances. The research found specific prevalence rates for atrial arrhythmia, ventricular arrhythmia, and complete atrioventricular block within this complex patient population. These findings provide definitive data on the arrhythmia burden and associated risk factors for improved clinical management. Article number two. Catheter ablation in congenital heart diseases: a French nationwide study. A French nationwide prospective study documented the outcomes of catheter ablation in patients with congenital heart disease across 28 centers from 2020 to 2024. The study found the per-procedural acute success rate for catheter ablation in this complex patient population. It also meticulously recorded associated complications and evaluated long-term freedom from arrhythmia recurrence. These comprehensive findings provide definitive national data on the effectiveness and safety of catheter ablation in congenital heart disease. Article number three. Residual lipid risk in atherosclerotic cardiovascular disease. Residual lipid risk persists in patients with or at risk of atherosclerotic cardiovascular disease, even after optimizing low-density lipoprotein cholesterol. Evidence highlights that non-low-density lipoprotein cholesterol fractions, including remnant cholesterol, lipoprotein(a), and apolipoprotein B, are key contributors to this residual risk. These non-low-density lipoprotein components definitively demonstrate their independent role in driving the progression of atherosclerotic cardiovascular disease. The identification of these persistent risk factors provides critical insights for developing therapeutic strategies beyond traditional low-density lipoprotein lowering. Article number four. Advancing Hope Through Science: The Inaugural Richard Slayman International Workshop on Xenotransplantation. The inaugural Richard Slayman Clinical Xenotransplantation Workshop, attended by over 140 international participants, identified significant advances and challenges in xenotransplantation. Discussions highlighted the increasing clinical readiness of kidney, heart, and liver xenotransplantation. Key findings from the workshop emphasized the crucial importance of meticulous patient selection and the pivotal role of genetic editing in reducing immune incompatibility. These consensuses establish current best practices and future directions for successfully translating xenotransplantation into wider clinical application. Article number five. Echocardiographic morpho-functional parameters predictors of maximal oxygen uptake and oxygen pulse in a large cohort of elite athletes practicing different sporting disciplines. A study of 1033 Olympic-level athletes identified specific echocardiographic morpho-functional parameters that predict maximal oxygen uptake and oxygen pulse. The research established direct correlations between structural cardiac adaptations, commonly known as the athlete’s heart, and functional indices of cardiovascular performance. Results demonstrated how particular morphological changes observed via echocardiography are associated with enhanced cardiac efficiency during exertion. These findings provide measurable echocardiographic markers for assessing and monitoring cardiovascular performance and adaptive remodeling in elite athletes. Thank you for listening. Don’t forget to subscribe. Keywords congenitally corrected transposition of the great arteries, complex congenital heart disease, electrophysiology, per-procedural success, kidney xenotransplantation, heart xenotransplantation, complete atrioventricular block, arrhythmia recurrence, catheter ablation, atrial arrhythmia, atherosclerotic cardiovascular disease, maximal oxygen uptake, genetic editing, xenotransplantation, echocardiography, congenital heart disease, ventricular arrhythmia, lipoprotein(a), immune incompatibility, low-density lipoprotein cholesterol, athlete’s heart, remnant cholesterol, oxygen pulse

  3. 2 DAYS AGO

    Cell-free DNA Reveals Heart Transplant Recipient Injury 02/17/26

    Welcome to Cardiology Today – Recorded February 17, 2026. This episode summarizes 5 key cardiology studies on topics like Endothelial function and Venous thromboembolism. Key takeaway: Cell-free DNA Reveals Heart Transplant Recipient Injury. Article Links: Article 1: Six-Year Outcomes After Transcatheter vs Surgical Aortic Valve Replacement in Low-Risk Patients With Aortic Stenosis. (Journal of the American College of Cardiology) Article 2: Hypertensive Disorders of Pregnancy and Premature Cardiovascular Disease in a Diverse Cohort of Young US Women. (Circulation) Article 3: Novel Plasma Proteomic Markers and Risk of Venous Thromboembolism. (Circulation) Article 4: Allograft and Recipient Tissue Injury during Cardiac Allograft Rejection: Evidence from Cell-free DNA. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons) Article 5: Effects of Increasing Total Fruit Intake With Avocado and Mango on Endothelial Function and Cardiometabolic Risk Factors in Adults With Prediabetes. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/cell-free-dna-reveals-heart-transplant-recipient-injury-02-17-26/ Featured Articles Article 1: Six-Year Outcomes After Transcatheter vs Surgical Aortic Valve Replacement in Low-Risk Patients With Aortic Stenosis. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41697183 Summary: The Evolut Low Risk trial provided 6-year clinical outcomes comparing transcatheter aortic valve replacement and surgical aortic valve replacement in patients with severe aortic stenosis at low surgical risk. Researchers observed an increase in reintervention rates at 6 years, prompting additional analyses using available 7-year data to further characterize these trends. This long-term follow-up is crucial for understanding the durability and reintervention needs of both treatment modalities in this patient population, especially concerning long-term structural valve deterioration. Article 2: Hypertensive Disorders of Pregnancy and Premature Cardiovascular Disease in a Diverse Cohort of Young US Women. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41697979 Summary: Hypertensive disorders of pregnancy were identified as early indicators of cardiovascular risk in a diverse cohort of young United States women. The study specifically found a quantifiable association between these disorders and incident cardiovascular disease in a real-world population. These findings, replicated across multiple health systems, underscore that hypertensive disorders of pregnancy independently increase the risk for premature cardiovascular disease, rather than solely reflecting pre-pregnancy health. Article 3: Novel Plasma Proteomic Markers and Risk of Venous Thromboembolism. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41693575 Summary: This study identified new circulating protein biomarkers and biological pathways for incident venous thromboembolism. Researchers employed large-scale, high-throughput aptamer-based proteomics across four longitudinal cohorts, including the Atherosclerosis Risk in Communities study, the Cardiovascular Health Study, the Multi-Ethnic Study of Atherosclerosis, and the Trøndelag Health study. These findings advance the understanding of venous thromboembolism etiology and hold implications for improved risk prediction and potential therapeutic strategies. Article 4: Allograft and Recipient Tissue Injury during Cardiac Allograft Rejection: Evidence from Cell-free DNA. Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41698554 Summary: This study provided evidence that cardiac allograft rejection is linked to recipient tissue injury, challenging the conventional view of rejection solely as an allograft disease. Researchers measured recipient tissue injury through plasma cell-free DNA, a recognized biomarker of tissue damage, confirming its occurrence during allograft rejection. The analysis identified genetic and epigenetic signatures associated with this process, clarifying a previously poorly defined risk factor for poor survival in cardiac transplant recipients. Article 5: Effects of Increasing Total Fruit Intake With Avocado and Mango on Endothelial Function and Cardiometabolic Risk Factors in Adults With Prediabetes. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41698896 Summary: This randomized, two-arm parallel feeding study investigated the effects of increased total fruit intake, specifically incorporating avocado and mango, on endothelial function and cardiometabolic risk factors. Eighty-two adults with prediabetes followed an eight-week diet daily including one avocado and one cup of mango, compared to an energy-matched low-fat control diet. The study provided a structured intervention to assess how these specific fruits impact vascular and metabolic health in a population at risk for cardiometabolic diseases, addressing a global risk factor of low fruit intake. Transcript Today’s date is February 17, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Six-Year Outcomes After Transcatheter vs Surgical Aortic Valve Replacement in Low-Risk Patients With Aortic Stenosis. The Evolut Low Risk trial provided 6-year clinical outcomes comparing transcatheter aortic valve replacement and surgical aortic valve replacement in patients with severe aortic stenosis at low surgical risk. Researchers observed an increase in reintervention rates at 6 years, prompting additional analyses using available 7-year data to further characterize these trends. This long-term follow-up is crucial for understanding the durability and reintervention needs of both treatment modalities in this patient population, especially concerning long-term structural valve deterioration. Article number two. Hypertensive Disorders of Pregnancy and Premature Cardiovascular Disease in a Diverse Cohort of Young US Women. Hypertensive disorders of pregnancy were identified as early indicators of cardiovascular risk in a diverse cohort of young United States women. The study specifically found a quantifiable association between these disorders and incident cardiovascular disease in a real-world population. These findings, replicated across multiple health systems, underscore that hypertensive disorders of pregnancy independently increase the risk for premature cardiovascular disease, rather than solely reflecting pre-pregnancy health. Article number three. Novel Plasma Proteomic Markers and Risk of Venous Thromboembolism. This study identified new circulating protein biomarkers and biological pathways for incident venous thromboembolism. Researchers employed large-scale, high-throughput aptamer-based proteomics across four longitudinal cohorts, including the Atherosclerosis Risk in Communities study, the Cardiovascular Health Study, the Multi-Ethnic Study of Atherosclerosis, and the Trøndelag Health study. These findings advance the understanding of venous thromboembolism etiology and hold implications for improved risk prediction and potential therapeutic strategies. Article number four. Allograft and Recipient Tissue Injury during Cardiac Allograft Rejection: Evidence from Cell-free DNA. This study provided evidence that cardiac allograft rejection is linked to recipient tissue injury, challenging the conventional view of rejection solely as an allograft disease. Researchers measured recipient tissue injury through plasma cell-free DNA, a recognized biomarker of tissue damage, confirming its occurrence during allograft rejection. The analysis identified genetic and epigenetic signatures associated with this process, clarifying a previously poorly defined risk factor for poor survival in cardiac transplant recipients. Article number five. Effects of Increasing Total Fruit Intake With Avocado and Mango on Endothelial Function and Cardiometabolic Risk Factors in Adults With Prediabetes. This randomized, two-arm parallel feeding study investigated the effects of increased total fruit intake, specifically incorporating avocado and mango, on endothelial function and cardiometabolic risk factors. Eighty-two adults with prediabetes followed an eight-week diet daily including one avocado and one cup of mango, compared to an energy-matched low-fat control diet. The study provided a structured intervention to assess how these specific fruits impact vascular and metabolic health in a population at risk for cardiometabolic diseases, addressing a global risk factor of low fruit intake. Thank you for listening. Don’t forget to subscribe. Keywords Endothelial function, Venous thromboembolism, Cardiac allograft rejection, Prediabetes, Transplant immunology, Women’s health, Plasma biomarkers, Avocado, Hypertensive disorders of pregnancy, Transcatheter aortic valve replacement, Mango, Cell-free DNA, Surgical aortic valve replacement, Cardiovascular disease, Proteomics, Premature cardiovascular disease, Recipient tissue injury, Cardiovascular risk, Aortic stenosis, Biological pathways, Cardiometabolic risk factors, Low surgical risk, Cardiac transplantation, Etiology, Reintervention rates, Fruit intake. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • Follow The post Cell-free DNA Reveals Heart Transplant Recipient Injury 02/17/26 first appeared on Cardiology Today.

  4. 3 DAYS AGO

    Percutaneous Coronary Intervention Mortality Breakdown. 02/16/26

    Welcome to Cardiology Today – Recorded February 16, 2026. This episode summarizes 5 key cardiology studies on topics like heart transplant rejection and Percutaneous coronary intervention. Key takeaway: Percutaneous Coronary Intervention Mortality Breakdown.. Article Links: Article 1: ADAR1 and RIPK1 orchestrate the ZBP1-mediated PANoptosis and mouse heart transplant rejection. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons) Article 2: Global Longitudinal Strain Reference Values in the Hispanic/Latino Population: Echocardiographic Study of Latinos (ECHO-SOL). (The American journal of cardiology) Article 3: Optical Coherence Tomography versus Intravascular Ultrasound-Guided Primary Percutaneous Coronary Intervention in ST-Elevation Myocardial Infarction: A Multicenter Propensity-Matched Analysis. (The American journal of cardiology) Article 4: Revascularization in Patients Over 75 With Acute Coronary Syndrome. (The American journal of cardiology) Article 5: Death Following Percutaneous Coronary Intervention: Data from the PROGRESS-COMPLICATIONS registry. (The American journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/percutaneous-coronary-intervention-mortality-breakdown-02-16-26/ Featured Articles Article 1: ADAR1 and RIPK1 orchestrate the ZBP1-mediated PANoptosis and mouse heart transplant rejection. Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41692363 Summary: This study found that Z-DNA induced PANoptosis in human microvascular endothelial cells through ZBP1. Researchers observed that ADAR1 and R. I. P. K. one collaboratively regulated the activation of the ZBP1-R. I. P. K. three complex, controlling PANoptosis in a time-dependent manner. The interaction of ADAR1 with ZBP1 specifically protected against Z-DNA-induced cell death. These findings reveal crucial molecular mechanisms driving PANoptosis and its potential relevance in heart transplant rejection. Article 2: Global Longitudinal Strain Reference Values in the Hispanic/Latino Population: Echocardiographic Study of Latinos (ECHO-SOL). Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41478442 Summary: This study established global longitudinal strain reference values for the Hispanic/Latino population using data from the Echocardiographic Study of Latinos. Researchers defined the 95th-percentile lower limit of normal global longitudinal strain values from a healthy reference sample. These established values provide essential clinical benchmarks for detecting early cardiac dysfunction in this specific demographic. The findings offer crucial guidance for assessing heart failure risk factors and interpreting echocardiographic results in Hispanic/Latino patients. Article 3: Optical Coherence Tomography versus Intravascular Ultrasound-Guided Primary Percutaneous Coronary Intervention in ST-Elevation Myocardial Infarction: A Multicenter Propensity-Matched Analysis. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41421515 Summary: This multicenter analysis compared clinical outcomes of optical coherence tomography versus intravascular ultrasound guidance for primary percutaneous coronary intervention in patients with S. T.-elevation myocardial infarction. The study utilized data from 2777 S. T.-elevation myocardial infarction patients who underwent primary percutaneous coronary intervention at 12 Japanese hospitals. Researchers found comparative data on the use of both imaging modalities, which are recommended by current guidelines for percutaneous coronary intervention guidance. These findings contribute to understanding the relative performance and clinical utility of optical coherence tomography and intravascular ultrasound in this critical patient population. Article 4: Revascularization in Patients Over 75 With Acute Coronary Syndrome. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41391816 Summary: This retrospective analysis investigated revascularization strategies in patients over 75 years old presenting with acute coronary syndromes. Observational data previously showed that coronary artery bypass graft was associated with improved one-year outcomes, including lower rates of death and rehospitalization, compared to percutaneous coronary intervention and medical management in general acute coronary syndrome patients with multivessel coronary artery disease. This study provided specific data addressing these outcomes in the elderly population. The findings contribute to clinical decision-making for optimal revascularization strategies in acute coronary syndrome patients aged over 75. Article 5: Death Following Percutaneous Coronary Intervention: Data from the PROGRESS-COMPLICATIONS registry. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41692131 Summary: This study analyzed mortality following percutaneous coronary intervention using data from the P. R. O. G. R. E. S. S. minus C. O. M. P. L. I. C. A. T. I. O. N. S. registry. Among 22503 patients undergoing percutaneous coronary intervention, 115 patients, representing 0.5 percent, died before hospital discharge. Researchers found that 15 patients, 13.0 percent of the mortalities, died during the procedure, while 10 patients, 8.7 percent, died within the first 24 hours post-procedure, and 90 patients, 78.3 percent, died more than 24 hours after the intervention. The study also revealed that patients who died exhibited a high burden of comorbidities. Transcript Today’s date is February 16, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. ADAR1 and RIPK1 orchestrate the ZBP1-mediated PANoptosis and mouse heart transplant rejection. This study found that Z-DNA induced PANoptosis in human microvascular endothelial cells through ZBP1. Researchers observed that ADAR1 and R. I. P. K. one collaboratively regulated the activation of the ZBP1-R. I. P. K. three complex, controlling PANoptosis in a time-dependent manner. The interaction of ADAR1 with ZBP1 specifically protected against Z-DNA-induced cell death. These findings reveal crucial molecular mechanisms driving PANoptosis and its potential relevance in heart transplant rejection. Article number two. Global Longitudinal Strain Reference Values in the Hispanic/Latino Population: Echocardiographic Study of Latinos (ECHO-SOL). This study established global longitudinal strain reference values for the Hispanic/Latino population using data from the Echocardiographic Study of Latinos. Researchers defined the 95th-percentile lower limit of normal global longitudinal strain values from a healthy reference sample. These established values provide essential clinical benchmarks for detecting early cardiac dysfunction in this specific demographic. The findings offer crucial guidance for assessing heart failure risk factors and interpreting echocardiographic results in Hispanic/Latino patients. Article number three. Optical Coherence Tomography versus Intravascular Ultrasound-Guided Primary Percutaneous Coronary Intervention in ST-Elevation Myocardial Infarction: A Multicenter Propensity-Matched Analysis. This multicenter analysis compared clinical outcomes of optical coherence tomography versus intravascular ultrasound guidance for primary percutaneous coronary intervention in patients with S. T.-elevation myocardial infarction. The study utilized data from 2777 S. T.-elevation myocardial infarction patients who underwent primary percutaneous coronary intervention at 12 Japanese hospitals. Researchers found comparative data on the use of both imaging modalities, which are recommended by current guidelines for percutaneous coronary intervention guidance. These findings contribute to understanding the relative performance and clinical utility of optical coherence tomography and intravascular ultrasound in this critical patient population. Article number four. Revascularization in Patients Over 75 With Acute Coronary Syndrome. This retrospective analysis investigated revascularization strategies in patients over 75 years old presenting with acute coronary syndromes. Observational data previously showed that coronary artery bypass graft was associated with improved one-year outcomes, including lower rates of death and rehospitalization, compared to percutaneous coronary intervention and medical management in general acute coronary syndrome patients with multivessel coronary artery disease. This study provided specific data addressing these outcomes in the elderly population. The findings contribute to clinical decision-making for optimal revascularization strategies in acute coronary syndrome patients aged over 75. Article number five. Death Following Percutaneous Coronary Intervention: Data from the PROGRESS-COMPLICATIONS registry. This study analyzed mortality following percutaneous coronary intervention using data from the P. R. O. G. R. E. S. S. minus C. O. M. P. L. I. C. A. T. I. O. N. S. registry. Among 22503 patients undergoing percutaneous coronary intervention, 115 patients, representing 0.5 percent, died before hospital discharge. Researchers found that 15 patients, 13.0 percent of the mortalities, died during the procedure, while 10 patients, 8.7 percent, died within the first 24 hours post-procedure, and 90 patients, 78.3 percent, died more than 24 hours after the intervention. The study also revealed that patients who died exhibited a high burden of comorbidities. Thank you for listening. Don’t forget to subscribe. Keywords heart transplant rejection, Percutaneous coronary intervention, P. C. I. mortality, comorbidities, O

  5. 3 DAYS AGO

    E. C. G. Boosts Microvascular Disease Detection 02/15/26

    Welcome to Cardiology Today – Recorded February 15, 2026. This episode summarizes 5 key cardiology studies on topics like sex differences and heart failure with preserved ejection fraction. Key takeaway: E. C. G. Boosts Microvascular Disease Detection. Article Links: Article 1: Prognostic importance of exercise electrocardiography in patients with suspected microvascular disease. (Heart (British Cardiac Society)) Article 2: Prosthetic annulus size mismatch and recurrent mitral regurgitation after repair in advanced degenerative disease. (Heart (British Cardiac Society)) Article 3: Sex differences in the prevalence and prognosis of tricuspid regurgitation among patients with heart failure. (Heart (British Cardiac Society)) Article 4: Timing of anticoagulation restart after serious bleeding in atrial fibrillation. (Heart (British Cardiac Society)) Article 5: Plasma myeloperoxidase and echocardiographic markers of impaired diastolic function in healthy individuals. (Heart (British Cardiac Society)) Full episode page: https://podcast.explainheart.com/podcast/e-c-g-boosts-microvascular-disease-detection-02-15-26/ Featured Articles Article 1: Prognostic importance of exercise electrocardiography in patients with suspected microvascular disease. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41690708 Summary: Exercise electrocardiography showing ST-segment depression demonstrates a very high positive predictive value for coronary microvascular dysfunction in specific patient groups. The present study focused on chest pain patients, using myocardial perfusion single photon emission computed tomography to rule out ischemia from epicardial coronary stenosis. This approach precisely identifies patients with suspected coronary microvascular dysfunction. Such precise identification is crucial for managing this condition, which is associated with a poor prognosis. Article 2: Prosthetic annulus size mismatch and recurrent mitral regurgitation after repair in advanced degenerative disease. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41320292 Summary: Recurrent mitral regurgitation remains a major limitation of mitral valve repair in patients with advanced degenerative mitral regurgitation and left ventricular enlargement. This retrospective study included 445 patients with advanced degenerative mitral regurgitation, classified as stages C two to D, who underwent mitral valve repair with restrictive annuloplasty. The investigation focused on whether a disproportion between left ventricular size and prosthetic annulus dimension predicts long-term mitral regurgitation recurrence. This research addresses a critical aspect of durable mitral valve repair outcomes and adverse left ventricular remodeling. Article 3: Sex differences in the prevalence and prognosis of tricuspid regurgitation among patients with heart failure. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40707240 Summary: Tricuspid regurgitation is a common finding in heart failure and associates with adverse patient outcomes. This study precisely assessed sex differences in tricuspid regurgitation prevalence, etiology, and prognosis among patients with heart failure and its subgroups. Patients were enrolled with recent transthoracic echocardiography and categorized by left ventricular ejection fraction into groups with reduced and preserved ejection fraction, using a 50 percent cutoff. This research contributes to understanding sex-specific manifestations and prognostic implications of tricuspid regurgitation in heart failure patients. Article 4: Timing of anticoagulation restart after serious bleeding in atrial fibrillation. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40670148 Summary: Restarting direct oral anticoagulants after a serious bleeding event in patients with atrial fibrillation presents a significant clinical dilemma, balancing stroke prevention and recurrent bleeding risk. This study leveraged nationwide Danish registries from 2012 to 2021 to identify atrial fibrillation patients who experienced serious bleeding events. The cohort included individuals with a Congestive heart failure, Hypertension, Age seventy-five (doubled), Diabetes, Stroke (doubled), Vascular disease, Age sixty-five to seventy-four, Sex category (female) (C. H. A. two D. S. two V. A. S. c) score of two or higher. This research provides crucial data to inform the optimal timing of anticoagulation restart in these high-risk patients. Article 5: Plasma myeloperoxidase and echocardiographic markers of impaired diastolic function in healthy individuals. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40645760 Summary: Myeloperoxidase, a neutrophil-derived enzyme, associates with oxidative stress and inflammation, contributing to the pathophysiology of heart failure with preserved ejection fraction. Bioactive myeloperoxidase also causes vascular dysfunction and accumulation of serum uric acid. This cross-sectional analysis of 1677 participants from the STANISLAS cohort investigated the association of plasma myeloperoxidase and serum uric acid with echocardiographic variables of impaired diastolic function in a populational setting. This research helps elucidate mechanisms and identify early biomarkers for heart failure with preserved ejection fraction development. Transcript Today’s date is February 15, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Prognostic importance of exercise electrocardiography in patients with suspected microvascular disease. Exercise electrocardiography showing ST-segment depression demonstrates a very high positive predictive value for coronary microvascular dysfunction in specific patient groups. The present study focused on chest pain patients, using myocardial perfusion single photon emission computed tomography to rule out ischemia from epicardial coronary stenosis. This approach precisely identifies patients with suspected coronary microvascular dysfunction. Such precise identification is crucial for managing this condition, which is associated with a poor prognosis. Article number two. Prosthetic annulus size mismatch and recurrent mitral regurgitation after repair in advanced degenerative disease. Recurrent mitral regurgitation remains a major limitation of mitral valve repair in patients with advanced degenerative mitral regurgitation and left ventricular enlargement. This retrospective study included 445 patients with advanced degenerative mitral regurgitation, classified as stages C two to D, who underwent mitral valve repair with restrictive annuloplasty. The investigation focused on whether a disproportion between left ventricular size and prosthetic annulus dimension predicts long-term mitral regurgitation recurrence. This research addresses a critical aspect of durable mitral valve repair outcomes and adverse left ventricular remodeling. Article number three. Sex differences in the prevalence and prognosis of tricuspid regurgitation among patients with heart failure. Tricuspid regurgitation is a common finding in heart failure and associates with adverse patient outcomes. This study precisely assessed sex differences in tricuspid regurgitation prevalence, etiology, and prognosis among patients with heart failure and its subgroups. Patients were enrolled with recent transthoracic echocardiography and categorized by left ventricular ejection fraction into groups with reduced and preserved ejection fraction, using a 50 percent cutoff. This research contributes to understanding sex-specific manifestations and prognostic implications of tricuspid regurgitation in heart failure patients. Article number four. Timing of anticoagulation restart after serious bleeding in atrial fibrillation. Restarting direct oral anticoagulants after a serious bleeding event in patients with atrial fibrillation presents a significant clinical dilemma, balancing stroke prevention and recurrent bleeding risk. This study leveraged nationwide Danish registries from 2012 to 2021 to identify atrial fibrillation patients who experienced serious bleeding events. The cohort included individuals with a Congestive heart failure, Hypertension, Age seventy-five (doubled), Diabetes, Stroke (doubled), Vascular disease, Age sixty-five to seventy-four, Sex category (female) (C. H. A. two D. S. two V. A. S. c) score of two or higher. This research provides crucial data to inform the optimal timing of anticoagulation restart in these high-risk patients. Article number five. Plasma myeloperoxidase and echocardiographic markers of impaired diastolic function in healthy individuals. Myeloperoxidase, a neutrophil-derived enzyme, associates with oxidative stress and inflammation, contributing to the pathophysiology of heart failure with preserved ejection fraction. Bioactive myeloperoxidase also causes vascular dysfunction and accumulation of serum uric acid. This cross-sectional analysis of 1677 participants from the STANISLAS cohort investigated the association of plasma myeloperoxidase and serum uric acid with echocardiographic variables of impaired diastolic function in a populational setting. This research helps elucidate mechanisms and identify early biomarkers for heart failure with preserved ejection fraction development. Thank you for listening. Don’t forget to subscribe. Keywords sex differences, heart failure with preserved ejection fraction, coronary microvascular dysfunction, stroke prevention, direct oral anticoagulants, mitral regurgitation, atrial fibrillation, ST-segment depression, left ventricular ejection fraction, diagnosis, anticoagulation restart, myeloperoxidase, myocardial perfusion imaging, annuloplasty, bleeding events, prosthetic annulus, diastolic dysfunction, echocardiography, m

  6. 4 DAYS AGO

    Remote Heart Failure Management Sustains Benefits 02/15/26

    Welcome to Cardiology Today – Recorded February 15, 2026. This episode summarizes 5 key cardiology studies on topics like N. L. R. P. three and lipid management. Key takeaway: Remote Heart Failure Management Sustains Benefits. Article Links: Article 1: Lipoprotein(a)-lowering therapies: a promising future. (European heart journal) Article 2: Macrophage SBK2 suppresses inflammation and atherosclerosis by NLRP3 phosphorylation. (European heart journal) Article 3: Seated Pulmonary Artery Pressure Management in Patients With Heart Failure: 12-Month Outcomes of the PROACTIVE-HF Trial. (JACC. Heart failure) Article 4: Early childhood hospital utilization and diagnoses for children born to mothers with kidney transplants: An Australian cohort study. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons) Article 5: Airway molecular signatures in antibody mediated lung transplant rejection. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons) Full episode page: https://podcast.explainheart.com/podcast/remote-heart-failure-management-sustains-benefits-02-15-26/ Featured Articles Article 1: Lipoprotein(a)-lowering therapies: a promising future. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41684258 Summary: This article identifies lipoprotein(a), or L. P. A., as a significant, genetically determined contributor to atherosclerotic cardiovascular disease. Elevated L. P. A. levels drive increased atherogenicity, contributing substantially to residual cardiovascular risk despite successful low-density lipoprotein cholesterol management. Affecting a large proportion of the population, L. P. A. represents a high-impact therapeutic target. Future L. P. A.-lowering therapies therefore hold considerable promise for reducing cardiovascular morbidity and mortality. Article 2: Macrophage SBK2 suppresses inflammation and atherosclerosis by NLRP3 phosphorylation. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41684124 Summary: B. K. two suppresses inflammation and atherosclerosis by N. L. R. P. three phosphorylation. This study found that macrophage S. H. three domain-binding kinase two, known as S. B. K. two, actively suppresses inflammation and atherosclerosis. S. B. K. two achieves this by phosphorylating nucleotide-binding oligomerization domain-like receptor family pyrin domain containing three, or N. L. R. P. three. This specific molecular mechanism highlights S. B. K. two’s pivotal role in modulating macrophage-mediated inflammatory responses. These findings identify S. B. K. two as a significant therapeutic target for managing the progression of atherosclerosis. Article 3: Seated Pulmonary Artery Pressure Management in Patients With Heart Failure: 12-Month Outcomes of the PROACTIVE-HF Trial. Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41686133 Summary: The PROACTIVE-H. F. trial demonstrated that remote heart failure management, using seated mean pulmonary artery pressure and vital signs via the Cordella system, was safe and effective. This approach resulted in a low rate of heart failure hospitalizations and mortality, which was initially observed through 6 months. The 12-month evaluation confirmed the sustained efficacy and continued benefits of this management approach for patients with New York Heart Association class three heart failure. This method offers a valuable strategy for reducing adverse events in this high-risk patient population. Article 4: Early childhood hospital utilization and diagnoses for children born to mothers with kidney transplants: An Australian cohort study. Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41690842 Summary: This Australian cohort study found that children born to mothers with kidney transplants experienced increased hospital utilization during early childhood. From 2067661 babies, 137 children of transplanted mothers were identified, experiencing 137 birth admissions and 444 subsequent admissions. The data demonstrated that these children had a higher burden of adverse health outcomes, requiring more frequent hospitalizations compared to children of mothers not exposed to kidney replacement therapy. This provides critical definition to previously undefined childhood health outcomes for this specific population. Article 5: Airway molecular signatures in antibody mediated lung transplant rejection. Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41690369 Summary: This study found that specific airway inflammation gene signatures effectively distinguished antibody mediated rejection, or A. M. R., cases from controls in lung transplant recipients. The analysis of small airway brush R. N. A. sequencing from 16 A. M. R. cases and 39 controls revealed distinct gene signatures for complement activation, mechanistic target of rapamycin signaling, and natural killer cell-mediated responses. These identified molecular signatures provide novel and precise biomarkers needed for more accurate diagnosis of severe A. M. R. This advancement offers potential for improved diagnostic precision for a condition associated with chronic lung allograft dysfunction and death. Transcript Today’s date is February 15, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Lipoprotein(a)-lowering therapies: a promising future. This article identifies lipoprotein(a), or L. P. A., as a significant, genetically determined contributor to atherosclerotic cardiovascular disease. Elevated L. P. A. levels drive increased atherogenicity, contributing substantially to residual cardiovascular risk despite successful low-density lipoprotein cholesterol management. Affecting a large proportion of the population, L. P. A. represents a high-impact therapeutic target. Future L. P. A.-lowering therapies therefore hold considerable promise for reducing cardiovascular morbidity and mortality. Article number two. Macrophage S. B. K. two suppresses inflammation and atherosclerosis by N. L. R. P. three phosphorylation. This study found that macrophage S. H. three domain-binding kinase two, known as S. B. K. two, actively suppresses inflammation and atherosclerosis. S. B. K. two achieves this by phosphorylating nucleotide-binding oligomerization domain-like receptor family pyrin domain containing three, or N. L. R. P. three. This specific molecular mechanism highlights S. B. K. two’s pivotal role in modulating macrophage-mediated inflammatory responses. These findings identify S. B. K. two as a significant therapeutic target for managing the progression of atherosclerosis. Article number three. Seated Pulmonary Artery Pressure Management in Patients With Heart Failure: 12-Month Outcomes of the PROACTIVE-HF Trial. The PROACTIVE-H. F. trial demonstrated that remote heart failure management, using seated mean pulmonary artery pressure and vital signs via the Cordella system, was safe and effective. This approach resulted in a low rate of heart failure hospitalizations and mortality, which was initially observed through 6 months. The 12-month evaluation confirmed the sustained efficacy and continued benefits of this management approach for patients with New York Heart Association class three heart failure. This method offers a valuable strategy for reducing adverse events in this high-risk patient population. Article number four. Early childhood hospital utilization and diagnoses for children born to mothers with kidney transplants: An Australian cohort study. This Australian cohort study found that children born to mothers with kidney transplants experienced increased hospital utilization during early childhood. From 2067661 babies, 137 children of transplanted mothers were identified, experiencing 137 birth admissions and 444 subsequent admissions. The data demonstrated that these children had a higher burden of adverse health outcomes, requiring more frequent hospitalizations compared to children of mothers not exposed to kidney replacement therapy. This provides critical definition to previously undefined childhood health outcomes for this specific population. Article number five. Airway molecular signatures in antibody mediated lung transplant rejection. This study found that specific airway inflammation gene signatures effectively distinguished antibody mediated rejection, or A. M. R., cases from controls in lung transplant recipients. The analysis of small airway brush R. N. A. sequencing from 16 A. M. R. cases and 39 controls revealed distinct gene signatures for complement activation, mechanistic target of rapamycin signaling, and natural killer cell-mediated responses. These identified molecular signatures provide novel and precise biomarkers needed for more accurate diagnosis of severe A. M. R. This advancement offers potential for improved diagnostic precision for a condition associated with chronic lung allograft dysfunction and death. Thank you for listening. Don’t forget to subscribe. Keywords N. L. R. P. three, lipid management, lung transplant, pulmonary artery pressure, therapeutic targets, remote monitoring, Macrophage, Heart failure, atherosclerosis, biomarkers, birth outcomes, S. B. K. two, airway inflammation, inflammation, Australian cohort, PROACTIVE-H. F. trial, Kidney transplant, cardiovascular risk, Antibody mediated rejection, SH3 domain-binding kinase two, gene signatures, Lipoprotein(a), hospitalization, hospital utilization, childhood health, athe

  7. 5 DAYS AGO

    Soluble S. T. 2 Drives Fulminant Myocarditis 02/14/26

    Welcome to Cardiology Today – Recorded February 14, 2026. This episode summarizes 5 key cardiology studies on topics like C. C. R. 8 and Left Heart Dysfunction. Key takeaway: Soluble S. T. 2 Drives Fulminant Myocarditis. Article Links: Article 1: Elevated Pulmonary Artery Wedge Pressure in Group 1 Pulmonary Hypertension. (Circulation) Article 2: CCR8 Expression on Regulatory T Cells Reveals Trajectories of Tissue Adaptation and Protects Against Myocardial Infarction-Induced Tissue Damage. (Circulation) Article 3: Spatial transcriptomics reveals a key role of fibroblast-like vascular smooth muscle cells in human atherosclerotic cell crosstalk and stability. (European heart journal) Article 4: Soluble ST2 drives fulminant myocarditis progression via the IGF2R-YY1 mitochondrial axis. (European heart journal) Article 5: Air pollution before and during the COVID-19 pandemic: changes in risk of acute myocardial infarction. (European heart journal) Full episode page: https://podcast.explainheart.com/podcast/soluble-s-t-2-drives-fulminant-myocarditis-02-14-26/ Featured Articles Article 1: Elevated Pulmonary Artery Wedge Pressure in Group 1 Pulmonary Hypertension. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41685452 Summary: The study identified a distinct subgroup of patients within adjudicated Group 1 Pulmonary Hypertension who demonstrated an elevated pulmonary artery wedge pressure, exceeding 15 mmHg. It characterized this patient population by comparing their profiles to those with normal pulmonary artery wedge pressure and to patients with combined pre- and postcapillary pulmonary hypertension. This work establishes that not all Group 1 Pulmonary Hypertension patients present with the expected normal pulmonary artery wedge pressure, highlighting diagnostic complexities. Article 2: CCR8 Expression on Regulatory T Cells Reveals Trajectories of Tissue Adaptation and Protects Against Myocardial Infarction-Induced Tissue Damage. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41685444 Summary: C. R. 8 Expression on Regulatory T Cells Reveals Trajectories of Tissue Adaptation and Protects Against Myocardial Infarction-Induced Tissue Damage. This study revealed that C. C. R. 8 expression on regulatory T cells dictates their tissue adaptation trajectories within the heart following myocardial infarction. It found that these C. C. R. 8-positive regulatory T cells provide protection against myocardial infarction-induced tissue damage. The data delineated specific differentiation pathways of heart regulatory T cells in a murine model, establishing a molecular mechanism for regulatory T cell-mediated cardiac protection. Article 3: Spatial transcriptomics reveals a key role of fibroblast-like vascular smooth muscle cells in human atherosclerotic cell crosstalk and stability. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41685669 Summary: This study, using spatial and single-cell transcriptomics on 13 human carotid plaques, revealed a key role for fibroblast-like vascular smooth muscle cells in atherosclerotic cell crosstalk and plaque stability. It precisely mapped intercellular communication patterns within the human plaque microenvironments. The data demonstrated that these specific fibroblast-like vascular smooth muscle cells are critical mediators, identifying specific cellular interactions as potential novel targets for preventing atherosclerotic events. Article 4: Soluble ST2 drives fulminant myocarditis progression via the IGF2R-YY1 mitochondrial axis. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41684269 Summary: T. 2 drives fulminant myocarditis progression via the I. G. F. 2. R. minus Y. Y. 1 mitochondrial axis. This study demonstrated that soluble S. T. 2 drives the progression of fulminant myocarditis via the I. G. F. 2. R. minus Y. Y. 1 mitochondrial axis. It defined the cellular source and function of soluble S. T. 2 in a Coxsackievirus B3-induced fulminant myocarditis mouse model. The research found that markedly elevated soluble S. T. 2 directly contributes to disease pathogenesis, establishing a critical mechanistic pathway that could be targeted for treating this high-mortality inflammatory cardiomyopathy. Article 5: Air pollution before and during the COVID-19 pandemic: changes in risk of acute myocardial infarction. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41684267 Summary: O. V. I. D. minus 19 pandemic: changes in risk of acute myocardial infarction. This study established ambient P. M. 2.5 exposure as a known risk factor for acute myocardial infarction, distinguishing myocardial infarction with non-obstructive coronary arteries as a distinct subtype from myocardial infarction with obstructive coronary disease. It capitalized on the C. O. V. I. D. minus 19 pandemic public health measures, which altered exposure patterns, as a natural experiment. The research characterized the association between short-term P. M. 2.5 exposure and these acute myocardial infarction subtypes during this unique period, providing crucial insights into how environmental shifts can influence risk profiles. Transcript Today’s date is February 14, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Elevated Pulmonary Artery Wedge Pressure in Group 1 Pulmonary Hypertension. The study identified a distinct subgroup of patients within adjudicated Group 1 Pulmonary Hypertension who demonstrated an elevated pulmonary artery wedge pressure, exceeding 15 mmHg. It characterized this patient population by comparing their profiles to those with normal pulmonary artery wedge pressure and to patients with combined pre- and postcapillary pulmonary hypertension. This work establishes that not all Group 1 Pulmonary Hypertension patients present with the expected normal pulmonary artery wedge pressure, highlighting diagnostic complexities. Article number two. C. C. R. 8 Expression on Regulatory T Cells Reveals Trajectories of Tissue Adaptation and Protects Against Myocardial Infarction-Induced Tissue Damage. This study revealed that C. C. R. 8 expression on regulatory T cells dictates their tissue adaptation trajectories within the heart following myocardial infarction. It found that these C. C. R. 8-positive regulatory T cells provide protection against myocardial infarction-induced tissue damage. The data delineated specific differentiation pathways of heart regulatory T cells in a murine model, establishing a molecular mechanism for regulatory T cell-mediated cardiac protection. Article number three. Spatial transcriptomics reveals a key role of fibroblast-like vascular smooth muscle cells in human atherosclerotic cell crosstalk and stability. This study, using spatial and single-cell transcriptomics on 13 human carotid plaques, revealed a key role for fibroblast-like vascular smooth muscle cells in atherosclerotic cell crosstalk and plaque stability. It precisely mapped intercellular communication patterns within the human plaque microenvironments. The data demonstrated that these specific fibroblast-like vascular smooth muscle cells are critical mediators, identifying specific cellular interactions as potential novel targets for preventing atherosclerotic events. Article number four. Soluble S. T. 2 drives fulminant myocarditis progression via the I. G. F. 2. R. minus Y. Y. 1 mitochondrial axis. This study demonstrated that soluble S. T. 2 drives the progression of fulminant myocarditis via the I. G. F. 2. R. minus Y. Y. 1 mitochondrial axis. It defined the cellular source and function of soluble S. T. 2 in a Coxsackievirus B3-induced fulminant myocarditis mouse model. The research found that markedly elevated soluble S. T. 2 directly contributes to disease pathogenesis, establishing a critical mechanistic pathway that could be targeted for treating this high-mortality inflammatory cardiomyopathy. Article number five. Air pollution before and during the C. O. V. I. D. minus 19 pandemic: changes in risk of acute myocardial infarction. This study established ambient P. M. 2.5 exposure as a known risk factor for acute myocardial infarction, distinguishing myocardial infarction with non-obstructive coronary arteries as a distinct subtype from myocardial infarction with obstructive coronary disease. It capitalized on the C. O. V. I. D. minus 19 pandemic public health measures, which altered exposure patterns, as a natural experiment. The research characterized the association between short-term P. M. 2.5 exposure and these acute myocardial infarction subtypes during this unique period, providing crucial insights into how environmental shifts can influence risk profiles. Thank you for listening. Don’t forget to subscribe. Keywords C. C. R. 8, Left Heart Dysfunction, P. M. 2.5, C. O. V. I. D. minus 19, Coxsackievirus B3, Spatial Transcriptomics, I. G. F. 2. R. minus Y. Y. 1 Axis, Air Pollution, Cell Crosstalk, Atherosclerotic Plaques, Myocardial Infarction, Cardiac Protection, Fibroblast-like Vascular Smooth Muscle Cells, Pulmonary Artery Wedge Pressure, Fulminant Myocarditis, Acute Myocardial Infarction, Tissue Damage, Plaque Stability, Pulmonary Hypertension, Group 1 Pulmonary Hypertension, Regulatory T Cells, Inflammatory Cardiomyopathy, Precapillary Hypertension, Soluble S. T. 2, Myocardial Infarction with Non-obstructive Coronary Arteries. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • Follow The post Soluble S. T. 2 Drives Fulminant Myocarditis 02/14/26 first appeared on Cardiology Today.

  8. 6 DAYS AGO

    AF: The 25% Diabetes Complication You Miss 02/13/26

    Welcome to Cardiology Today – Recorded February 13, 2026. This episode summarizes 5 key cardiology studies on topics like obesity and body mass index. Key takeaway: AF: The 25% Diabetes Complication You Miss. Article Links: Article 1: Second- and Third-Generation BCR-ABL Tyrosine Kinase Inhibitors and the Risk of Pulmonary Arterial Hypertension: A Prevalent New-User Design. (Circulation) Article 2: Prospective Associations of Obesity and Obesity Severity With 9 Cardiovascular Outcomes: The Cross-Cohort Collaboration. (Circulation) Article 3: Atrial fibrillation: an underappreciated complication of diabetes. (European heart journal) Article 4: Left Atrial Volumetric Enlargement in Heart Failure With Reduced Ejection Fraction: Obligatory Consequence or Independent Predictor of Outcome? (JACC. Heart failure) Article 5: Progression From Exercise-Induced to Resting Left Atrial Hypertension in HFpEF: Impact of Reduced Atriopulmonary Compliance. (JACC. Heart failure) Full episode page: https://podcast.explainheart.com/podcast/af-the-25-diabetes-complication-you-miss-02-13-26/ Featured Articles Article 1: Second- and Third-Generation BCR-ABL Tyrosine Kinase Inhibitors and the Risk of Pulmonary Arterial Hypertension: A Prevalent New-User Design. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41674449 Summary: C. R. A. B. L. Tyrosine Kinase Inhibitors and the Risk of Pulmonary Arterial Hypertension: A Prevalent New-User Design. An increasing link between B. C. R. A. B. L. tyrosine kinase inhibitors and pulmonary arterial hypertension has been recognized since 2009. This study precisely evaluated the risk of pulmonary arterial hypertension associated with second- and third-generation inhibitors compared to imatinib in adults. Utilizing the French national health care database, researchers established a robust prevalent new-user design which identified patient cohorts initiating these treatments between 2008 and 2024. The investigation offered a critical framework to quantify this potential adverse event for clinical practice. Article 2: Prospective Associations of Obesity and Obesity Severity With 9 Cardiovascular Outcomes: The Cross-Cohort Collaboration. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41674444 Summary: Obesity is a confirmed risk factor for cardiovascular disease, with specific relationships across the full spectrum of body mass index, including severe obesity, requiring further characterization. The Cross-Cohort Collaboration definitively described the prospective associations of obesity and its severity with nine specific cardiovascular outcomes. This comprehensive analysis included 289875 participants, comprising 79 point 2 percent women, from 21 distinct cohorts enrolled between 1948 and 2017. The study provides an extensive dataset essential for understanding long-term cardiovascular disease risks across various obesity classes. Article 3: Atrial fibrillation: an underappreciated complication of diabetes. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41668366 Summary: Atrial fibrillation is identified as a significant complication of diabetes, demonstrating a prevalence of up to 25 percent in individuals with the condition. The incidence rates of atrial fibrillation are increasing among patients with diabetes. This development of atrial fibrillation in diabetic individuals occurs independently of other risk factors such as hypertension, atherosclerotic cardiovascular disease, or heart failure. The pathogenesis involves multifactorial atrial structural, electrical, and autonomic remodeling directly linked to diabetes. Article 4: Left Atrial Volumetric Enlargement in Heart Failure With Reduced Ejection Fraction: Obligatory Consequence or Independent Predictor of Outcome? Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41677478 Summary: This study definitively investigated the independent association between left atrial volume index and long-term mortality in patients with heart failure. The research specifically considered its interaction with the severity of functional mitral regurgitation, establishing a crucial assessment framework for this relationship. The investigation provided a comprehensive approach to understanding the prognostic implications of left atrial volume index in this patient population. Article 5: Progression From Exercise-Induced to Resting Left Atrial Hypertension in HFpEF: Impact of Reduced Atriopulmonary Compliance. Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41677477 Summary: F. pEF: Impact of Reduced Atriopulmonary Compliance. Approximately one-third of patients with heart failure with preserved ejection fraction demonstrate normal resting pulmonary capillary wedge pressure, yet experience left atrial hypertension exclusively during exercise. This study thoroughly investigated the clinical course of these patients presenting with exercise-induced left atrial hypertension. The research explored whether this condition represents a distinct heart failure with preserved ejection fraction phenotype or an earlier stage that progresses to resting left atrial hypertension over time. This investigation provided critical insights into the natural history and progression of left atrial hypertension in heart failure with preserved ejection fraction. Transcript Today’s date is February 13, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Second- and Third-Generation B. C. R. A. B. L. Tyrosine Kinase Inhibitors and the Risk of Pulmonary Arterial Hypertension: A Prevalent New-User Design. An increasing link between B. C. R. A. B. L. tyrosine kinase inhibitors and pulmonary arterial hypertension has been recognized since 2009. This study precisely evaluated the risk of pulmonary arterial hypertension associated with second- and third-generation inhibitors compared to imatinib in adults. Utilizing the French national health care database, researchers established a robust prevalent new-user design which identified patient cohorts initiating these treatments between 2008 and 2024. The investigation offered a critical framework to quantify this potential adverse event for clinical practice. Article number two. Prospective Associations of Obesity and Obesity Severity With 9 Cardiovascular Outcomes: The Cross-Cohort Collaboration. Obesity is a confirmed risk factor for cardiovascular disease, with specific relationships across the full spectrum of body mass index, including severe obesity, requiring further characterization. The Cross-Cohort Collaboration definitively described the prospective associations of obesity and its severity with nine specific cardiovascular outcomes. This comprehensive analysis included 289875 participants, comprising 79 point 2 percent women, from 21 distinct cohorts enrolled between 1948 and 2017. The study provides an extensive dataset essential for understanding long-term cardiovascular disease risks across various obesity classes. Article number three. Atrial fibrillation: an underappreciated complication of diabetes. Atrial fibrillation is identified as a significant complication of diabetes, demonstrating a prevalence of up to 25 percent in individuals with the condition. The incidence rates of atrial fibrillation are increasing among patients with diabetes. This development of atrial fibrillation in diabetic individuals occurs independently of other risk factors such as hypertension, atherosclerotic cardiovascular disease, or heart failure. The pathogenesis involves multifactorial atrial structural, electrical, and autonomic remodeling directly linked to diabetes. Article number four. Left Atrial Volumetric Enlargement in Heart Failure With Reduced Ejection Fraction: Obligatory Consequence or Independent Predictor of Outcome? Left atrial remodeling, specifically progressive enlargement, is a common observation in heart failure with reduced ejection fraction and reflects left ventricular dysfunction and functional mitral regurgitation. This study definitively investigated the independent association between left atrial volume index and long-term mortality in patients with heart failure. The research specifically considered its interaction with the severity of functional mitral regurgitation, establishing a crucial assessment framework for this relationship. The investigation provided a comprehensive approach to understanding the prognostic implications of left atrial volume index in this patient population. Article number five. Progression From Exercise-Induced to Resting Left Atrial Hypertension in H. F. pEF: Impact of Reduced Atriopulmonary Compliance. Approximately one-third of patients with heart failure with preserved ejection fraction demonstrate normal resting pulmonary capillary wedge pressure, yet experience left atrial hypertension exclusively during exercise. This study thoroughly investigated the clinical course of these patients presenting with exercise-induced left atrial hypertension. The research explored whether this condition represents a distinct heart failure with preserved ejection fraction phenotype or an earlier stage that progresses to resting left atrial hypertension over time. This investigation provided critical insights into the natural history and progression of left atrial hypertension in heart failure with preserved ejection fraction. Thank you for listening. Don’t forget to subscribe. Keywords obesity, body mass index, cardiovascular disease, imatinib, functional mitral regurgitation, pathogenesis, resting left atrial hypertension, long-term mortality, heart failure with reduced ejection fraction, atriopulmonary compliance, severe obesity, prognostic significance, exercise-induced left atrial hypertension, pulmonary capillary wedge pressure, prevalence, incidence, diabetes, drug adverse events, atrial fibrillation, d

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Stay current with cardiovascular medicine without the time commitment. Every morning, we deliver concise audio summaries of the latest original research from top cardiology journals. Top 5 breakthrough studies briefed in under 5 minutes (perfect for your commute or between patients). PubMed links included for full articles. Perfect for cardiologists, cardiothoracic surgeons, cardiac nurses, researchers, and healthcare workers who need to stay informed but lack time to scan multiple journals daily. For educational and reference purposes only. Not intended as medical advice.

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