Pharmacy Focus

Pharmacy Times
  • ٠٫٠ (٠)
  • طب
  • يتم التحديث أسبوعيًا

The Pharmacy Times® Pharmacy Focus podcast provides the latest industry news and information, thought-leader insights, clinical updates, patient counseling tools, and innovative solutions for the everyday practice and business of pharmacy. Winner of the 2021 Digital Health Media/Publications Audio Merit Award. 

  1. قبل يوم واحد

    Centanafadine May Offer Second-Line Option for Patients With ADHD If Stimulants Fail

    In this episode of Psychiatric Pharmacy Pulse, host Megan Maroney, PharmD, BCPP, FAAPP, speaks with Danielle Stutzman, PharmD, BCPP, clinical assistant professor at the University of Colorado Skaggs School of Pharmacy and assistant adjunct professor at the Child and Adolescent Mental Health Division of the Department of Psychiatry at the University of Colorado School of Medicine, and member of the American Association of Psychiatric Pharmacists Board of Directors, about where centanafadine (Simtriyo; Otsuka Pharmaceutical) fits into attention-deficit/hyperactivity disorder (ADHD) pharmacotherapy. Centanafadine received FDA approval in July 2026 as a norepinephrine-dopamine-serotonin reuptake inhibitor (NDSRI) for ADHD in both pediatric and adult patients, with DEA scheduling still pending. Maroney and Stutzman note its mechanism is not entirely novel, drawing comparisons to tricyclic antidepressants, atomoxetine (Eli Lilly), and viloxazine (Qelbree; Supernus Pharmaceuticals, Inc).  A pooled meta-analysis of 4 phase 3 trials plus a phase 2b crossover study found a Hedges’ g effect size of about 0.37 for overall symptom severity versus placebo, a modest result that falls short of typical stimulant effect sizes of 0.8 to 1.0, though executive functioning outcomes on caregiver-rated scales appeared more promising. Safety data showed a nonsignificant increase in adverse effects (AEs) overall (pooled risk ratio, 1.29), with appetite suppression, nausea, and rash among the most common issues. Rash was the leading cause of study discontinuation in the youngest age group. Indirect comparisons suggested centanafadine may carry a lower risk of insomnia than methylphenidate and fewer AEs than atomoxetine and viloxazine, though lisdexamfetamine (Vyvanse; Takeda Pharmaceuticals) remained more effective. A boxed warning for suicidal ideation applies, which is consistent with other ADHD medications. Practical advantages discussed include a lack of reliance on cytochrome P450 metabolism, lower drug interaction risk than atomoxetine or viloxazine, and capsules that can be opened and sprinkled on applesauce, yogurt, or orange juice. Centanafadine did increase caffeine exposure roughly 2-fold, warranting patient counseling. Both Maroney and Stutzman positioned the drug as a potential second-line option for patients who are not candidates for stimulants or who have not tolerated or responded to first-line therapies.To provide feedback or suggest topics of discussion for Psychiatric Pharmacy Pulse, please reach out to Gillian McGovern, Editor (gmcgovern@pharmacytimes.com).REFERENCES1. Mattingly GW, Turkoglu O, Chang D, Ward C, Skubiak T, Zhang Z, Cutler AJ. 52-week open-label safety and tolerability study of centanafadine sustained release in adults with attention-deficit/hyperactivity disorder. J Clin Psychopharmacol. 2025;45(5):454-462. doi:10.1097/JCP.00000000000020202. Otsuka Pharmaceutical Development & Commercialization, Inc; Otsuka Pharmaceutical Co, Ltd. Otsuka receives FDA approval for first-in-class SIMTRIYO (centanafadine) for the treatment of attention-deficit/hyperactivity disorder. Otsuka US. July 24, 2026. Accessed September 16, 2026. https://www.otsuka-us.com/otsuka-shares-fda-review-update-for-centanafadine3. Adler LA, Adams J, Madera-McDonough J, et al. Efficacy, safety, and tolerability of centanafadine sustained-release tablets in adults with attention-deficit/hyperactivity disorder: results of 2 phase 3, randomized, double-blind, multicenter, placebo-controlled trials. J Clin Psychopharmacol. 2022;42(5):429-439. doi:10.1097/JCP.00000000000015754. Muneer MA, Naveed M, Amjad M, et al. Efficacy and safety of centanafadine in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of randomized controlled trials. Psychopharmacol Bull. 2026;56(3):47-65. https://pubmed.ncbi.nlm.nih.gov/42267239/5. Schein J, Cloutier M, Gauthier-Loiselle M, et al. Assessment of centanafadine in adults with attention-deficit/hyperactivity disorder: a matching-adjusted indirect comparison vs lisdexamfetamine dimesylate, atomoxetine hydrochloride, and viloxazine extended-release. J Manag Care Spec Pharm. 2024;30(6):528-540. doi:10.18553/jmcp.2024.30.6.5286. Stein MA. Editorial: centanafadine for adolescents with attention-deficit/hyperactivity disorder: is a broader mechanism of action better? J Am Acad Child Adolesc Psychiatry. 2026;65(6):764-765. doi:10.1016/j.jaac.2025.10.0207. Ward CL, Childress AC, Jin N, et al. Centanafadine for attention-deficit/hyperactivity disorder in adolescents: a randomized clinical trial. J Am Acad Child Adolesc Psychiatry. 2026;65(6):805-817. doi:10.1016/j.jaac.2025.06.023

    Centanafadine May Offer Second-Line Option for Patients With ADHD If Stimulants Fail

  2. قبل ٣ أيام

    Blood Cancer Awareness Month: Advances, Access, and Hope in Blood Cancer Care

    Pharmacy Focus

    Blood Cancer Awareness Month: Advances, Access, and Hope in Blood Cancer Care

  3. ٣ سبتمبر

    Vaccine Timing and Safety in Patients With Neurological Diseases

    This episode of Mind the Meds features guest Patti Yager-Stone, PharmD, BCPS, a clinical pharmacist in neurology at the Veterans Affairs Medical Center in Portland, Oregon, who oversees infusion management and vaccine coordination for about 120 neurology patients. Yager-Stone explains that immunomodulating and immunosuppressant therapies both increase infection risk and can blunt vaccine response, making pretreatment vaccination and timing central to her practice. When vaccination history is incomplete, she recommends avoiding live vaccines in patients on many of these therapies and stresses using serologies and thorough documentation review, instead of patient recall alone. For pneumococcal vaccination, she highlights the CDC's PneumoRecs VaxAdvisor tool for navigating vaccine selection based on patient age and risk conditions. For Yager-Stone’s institution, the 20-valent pneumococcal conjugate vaccine is favored over the 21-valent option for those who are immunocompromised because the latter excludes serotype 4, which is responsible for more than 30% of invasive pneumococcal disease cases in Oregon and several other western states.Marini and Yager-Stone discuss a recent cohort study that eased longstanding concerns about live vaccines, particularly the measles, mumps, and rubella vaccine, triggering relapses in those with multiple sclerosis, a finding both say has reinforced their practice of offering the measles, mumps, and rubella vaccine to patients without documented immunity amid current measles activity. They also note that immunosuppressed patients with measles may present atypically, without the characteristic rash. The conversation also touches on the newly approved mRNA influenza vaccine for patients aged 50 years and older, which showed superior relative efficacy against influenza-like illness compared with standard-dose vaccine in trials; however, higher rates of reactogenic side effects such as fatigue were observed with the vaccine.The episode closes on emerging observational evidence linking several vaccines, most notably the recombinant zoster vaccine, along with respiratory syncytial virus, influenza, and tetanus-diphtheria-acellular pertussis vaccines, to reduced dementia risk, including a large study of skilled nursing facility residents showing a 24% relative risk reduction among those who received the zoster vaccine. Yager-Stone also flags an underrecognized risk with complement inhibitors, which increase meningitis risk substantially, and points to updated guidance suggesting concurrent antimicrobial prophylaxis alongside vaccination for these patients.

    Vaccine Timing and Safety in Patients With Neurological Diseases

  4. ٢٨ أغسطس

    Beyond CRS and ICANS: Managing the Delayed Toxicities of Cilta-cel

    Sara Scott, PharmD, BCOP, Emma Uchida, PharmD, MBA, BCOP, and Rebecca Gonzalez, PharmD, BCOP, gather for a roundtable on the rare, delayed toxicities associated with ciltacabtagene autoleucel in relapsed/refractory multiple myeloma.

    Beyond CRS and ICANS: Managing the Delayed Toxicities of Cilta-cel

  5. ٢٦ أغسطس

    Food, Fungals, and Flexibility: Real-World Dosing of Revumenib

    Pharmacy Focus

    Food, Fungals, and Flexibility: Real-World Dosing of Revumenib

  6. ٢١ أغسطس

    Introducing the Psychiatric Pharmacist Pulse Podcast

    Megan Maroney, PharmD, BCPP, FAAPP: Hello, I'm Megan Maroney, and this is Psychiatric Pharmacy Pulse, a monthly podcast where we talk about hot topics in psychiatric pharmacy. I'm a clinical associate professor at the Ernest Mario School of Pharmacy at Rutgers University, and a clinical psychiatric pharmacist at Monmouth Medical Center. I am also a board-certified psychiatric pharmacist and a fellow of the American Association of Psychiatric Pharmacists. So, this podcast is really just a chance to talk about hot topics in psychiatry, new literature coming out, new drugs coming out, things that are coming down the pipeline. We also are going to have guests on the show to discuss these topics. Some of the upcoming episodes we have are on the new [attention-deficit hyperactivity disorder] drug centanafadine (Simtriyo; Otsuka Pharmaceutical) and the rescheduling of cannabis and what that means in terms of pharmacy practice. So, I hope you'll join me for these podcasts and feel free to write in with your ideas for topics and things that you want to hear about and give us feedback. We'd love to hear it. If there’s a topic you want to come on the podcast and talk about, let us know. [I would be] happy to cover things that everyone wants to hear about. To provide feedback or suggest topics of discussion for Psychiatric Pharmacy Pulse, please reach out to Gillian McGovern, Editor (gmcgovern@pharmacytimes.com).

    Introducing the Psychiatric Pharmacist Pulse Podcast

  7. ٢٠ أغسطس

    Under the Skin: What Subcutaneous Isatuximab Means for Myeloma Care

    Matthew Lei, PharmD, BCOP, a clinical oncology pharmacist at Massachusetts General Hospital, joins Pharmacy Focus: Oncology Edition to break down the FDA approval of subcutaneous isatuximab-irfc via the CirCLIQ on-body injector, covering the IRAKLIA trial's noninferiority data, the device's practical rollout challenges, and how the agent positions against subcutaneous daratumumab in an increasingly crowded anti-CD38 landscape.

    Under the Skin: What Subcutaneous Isatuximab Means for Myeloma Care

  8. ٦ أغسطس

    CMSC 2026 Highlights: Biomarkers, DMT Discontinuation, and Pregnancy Planning in MS

    In this episode of Mind the Meds, host Erica Marini, PharmD, MS, BCPS, welcomes Jenelle Hall Montgomery, PharmD, BCACP, CPP, a clinical pharmacist practitioner with Duke Neurological Disorders Clinic at Duke University Hospital, to discuss highlights from the Consortium of Multiple Sclerosis Centers (CMSC) Annual Meeting in Charlotte, North Carolina, where Montgomery was recognized as a Giant of Multiple Sclerosis. Before the CMSC discussion, Marini runs through a roundup of recent neurology news, including approval of at-home initiation dosing for lecanemab-irmb (Leqembi; Eisai, Biogen), fast track designation for remlifanserin (Acadia Pharmaceuticals) in Alzheimer disease psychosis, approval of the oral PCSK9 inhibitor enlicitide (Lipfendra; Merck), and phase 3 data on tavapadon (AbbVie) for Parkinson disease showing a lower rate of impulse control disorders than traditional dopamine agonists.The pharmacists then turn to CMSC sessions on off-label and evolving areas of MS care. They discuss growing interest in neurofilament light chain as a biomarker for tracking subclinical disease progression over time, along with the ongoing debate over when it is safe to discontinue disease-modifying therapy (DMT) in older, stable patients. Both note their practices generally begin this conversation around 60 to 65 years of age, factoring in radiographic and clinical stability over the preceding decade, and describe strategies such as tapering dosing frequency or switching to lower-efficacy agents rather than abrupt discontinuation.The conversation closes with an update on family planning in MS, where new data presented at CMSC reinforce the safety of anti-CD20 therapies during pregnancy and breastfeeding. Montgomery and Marini review a 10-year dataset of about 5000 pregnancies on ocrelizumab (Ocrevus; Genentech), a large safety analysis of ofatumumab (Kesimpta; Novartis Pharmaceuticals) showing no increase in birth malformations, and early transfer-into-breastmilk data on ublituximab (Briumvi; TG Therapeutics). They also touch on the limited but growing evidence for GLP-1 receptor agonists in patients with MS, noting no known drug interactions with DMTs and possible indirect benefit through weight-related disease modulation, though neither pharmacist currently prescribes GLP-1s for an MS indication. Key Takeaways:1. Neurofilament light chain is emerging as a useful, though not yet mainstream, biomarker in MS. Rather than a single value, tracking neurofilament light chain over time alongside clinical status may help identify subclinical disease progression, particularly in patients without clear relapses.2. DMT discontinuation in older, stable patients remains individualized, with most practices starting the conversation around 60 to 65 years of age. Clinicians weigh 10-year clinical and radiographic stability, and some patients opt for a gradual step-down in dosing frequency or a switch to a lower-efficacy agent rather than outright discontinuation.3. New pregnancy and breastfeeding safety data continue to support anti-CD20 therapies as a preferred family planning strategy in MS. A 10-year, 5000-pregnancy dataset on ocrelizumab, reassuring malformation data on ofatumumab, and early breastmilk transfer data on ublituximab are strengthening patient counseling conversations around conception, pregnancy, and postpartum DMT resumption.

    CMSC 2026 Highlights: Biomarkers, DMT Discontinuation, and Pregnancy Planning in MS
مشاهدة الكل (٣٥٨)

حول

The Pharmacy Times® Pharmacy Focus podcast provides the latest industry news and information, thought-leader insights, clinical updates, patient counseling tools, and innovative solutions for the everyday practice and business of pharmacy. Winner of the 2021 Digital Health Media/Publications Audio Merit Award. 

المعلومات

  • صناع العمل
    Pharmacy Times
  • سنوات النشاط
    ٢٠٢٠ - ٢٠٢٦
  • الحلقات
    ٣٥٨
  • التقييم
    ملائم
  • موقع البرنامج على الويب
    Pharmacy Focus

قد يعجبك أيضًا