The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

  1. Pandemic Fever Is BACK, Testosterone and Brain Tumors, Rabies, and Dog Flu

    17 HR AGO

    Pandemic Fever Is BACK, Testosterone and Brain Tumors, Rabies, and Dog Flu

    *Testosterone Directly Suppresses Brain Tumor Growth in Males by 38%  Cleveland Clinic research funded by NIH shows testosterone binds androgen receptors in glioblastoma stem cells — the root of tumor recurrence — and cuts growth by 38% when levels are restored. Dave breaks down why the mainstream framing of testosterone and cancer risk has it backwards, what androgen deprivation therapy may be doing to every other cancer pathway simultaneously, and why your hormone panel is now a cancer conversation, not just a performance one.  Sources:   -https://www.nih.gov/news-events/news-releases/nih-funded-study-suggests-testosterone-suppresses-brain-tumor-growth-males   -https://bioengineer.org/nih-funded-research-indicates-testosterone-may-inhibit-brain-tumor-growth-in-males/    *CDC Halts Rabies Testing Nationwide   A CDC staffing crisis has pushed rabies, mpox, and Epstein-Barr testing to overwhelmed state labs, creating one-to-two week diagnostic delays in a disease where post-exposure prophylaxis must begin within ten days of a bite — and where fatality is virtually 100% once symptoms appear. Dave explains exactly what to do if you or a pet is exposed, why outdoor biohackers are the most exposed population, and what pre-travel prevention looks like for anyone heading to endemic regions.  Sources:   -https://www.nbcnews.com/health/health-news/cdc-pauses-testing-rabies-monkeypox-epstein-barr-viruses-rcna266377   -https://www.cidrap.umn.edu/rabies/state-public-health-labs-step-cdc-pauses-testing-various-pathogens-including-rabies-mpox    *Mifepristone Mail Ban   The Supreme Court issued a one-week stay blocking a 5th Circuit ruling that would have ended telehealth and mail access to mifepristone, used in over 63% of U.S. abortions. Dave sets aside the moral debate to focus on what this legal precedent means for FDA-approved compounded peptides, bioidentical hormones, and telehealth access to any treatment without full pharmaceutical backing — and why this case is one every biohacker should be tracking closely.  Sources:   -https://www.usnews.com/news/health-news/articles/2026-05-05/supreme-court-issues-stay-keeping-abortion-pill-mifepristone-available-by-mail-for-now   -https://www.npr.org/2026/05/04/nx-s1-5810510/supreme-court-mifepristone-appeals-telehealth  *Cow Flu and Dog Coronavirus   University of Florida scientists are watching Influenza D — endemic in U.S. cattle herds — and canine coronavirus HuPn-2018, which already jumped to humans in China, as the two zoonotic threats most likely to achieve widespread human transmission. Dave covers why the conditions producing these jumps aren't going away, what the Influenza D finding means for the raw milk conversation right now, and the mucosal immunity stack that puts you in the strongest position regardless of which virus makes the leap next.  Sources:   -https://ufhealth.org/news/2026/scientists-say-these-two-viruses-may-become-the-next-public-health-threats  -https://www.gavi.org/vaccineswork/six-major-health-threats-could-shape-2026-heres-what-experts-are-watching  *Hantavirus Kills 3 on Cruise Ship   Eight confirmed or suspected cases of Andes hantavirus aboard the MV Hondius off the Canary Islands have killed three and left two critical, with passengers from 23 countries already dispersed through global airports. Dave cuts through the pandemic panic to explain why American and South American hantavirus strains are categorically more lethal than European ones, why Andes is the only strain on earth that spreads human to human via respiratory droplets, and what early symptom recognition could mean for your survival window if exposure reaches your community.  Sources:  -https://www.cnn.com/2026/05/07/world/hantavirus-ship-tenerife-outbreak-intl  -https://www.nbcnews.com/health/health-news/hantavirus-andes-virus-what-is-cruise-ship-outbreak-deadly-strain-rcna343901    This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on hormonal optimization, infectious disease risk, immune resilience, and the legal infrastructure shaping medical autonomy. Host Dave Asprey connects emerging NIH research, Supreme Court developments, and live outbreak data into actionable frameworks for protecting your biology when institutions can't do it for you.    New episodes every Tuesday, Thursday, Friday, and Sunday.    Keywords: testosterone brain cancer, testosterone glioblastoma, low testosterone tumor risk, androgen deprivation therapy cancer, CDC rabies testing paused, rabies post-exposure prophylaxis, rabies exposure protocol, mifepristone telehealth ban, SCOTUS mifepristone stay, telehealth medical autonomy, compounded hormones legal risk, influenza D cattle virus, canine coronavirus HuPn-2018, zoonotic virus 2026, raw milk bird flu risk, mucosal immunity biohacking, hantavirus cruise ship, Andes hantavirus outbreak, MV Hondius hantavirus, hantavirus human to human transmission, hantavirus vs coronavirus, biohacking news 2026, Dave Asprey weekly roundup, longevity research 2026    Thank you to our sponsors!   - Dave Asprey's 2026 Clean Nicotine Roadmap | Enroll for free at: daveasprey.com/2026-clean-nicotine-roadmap  - Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade.  - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE    Resources:    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.   • Danger Coffee: https://dangercoffee.com/discount/dave15    • My Daily Supplements: SuppGrade Labs (15% Off)    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    • Dave Asprey’s BEYOND Conference: https://beyondconference.com    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated   • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/  • Upgrade Labs: https://upgradelabs.com      Timestamps:  00:00 – Intro  00:35 – 1. Testosterone & Brain Cancer  02:30 – 2. CDC Pauses Rabies Testing  04:09 – 3. Mifepristone & Telehealth Access  05:42 – 4. Influenza D & Canine Coronavirus  07:15 – 5. Hantavirus Cruise Ship Outbreak  09:36 – Takeaways  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    11 min
  2. iPhone Poisoning Is REAL: Here's How To Reverse the Hidden Damage | Quantum Upgrade

    1 DAY AGO

    iPhone Poisoning Is REAL: Here's How To Reverse the Hidden Damage | Quantum Upgrade

    What if an invisible field could protect your brain from EMF damage, improve your HRV, accelerate recovery, and optimize your biology without pills, devices, or a single lifestyle change? Host Dave Asprey sits down with Philippe Samor von Holtzendorff-Fehling, founder of Leela Quantum Tech and Quantum Upgrade, to explore one of the most controversial and compelling frontiers in biohacking today: quantum energy fields delivered remotely, in real time, to your body, your pets, your home, and even your business.    -Try Quantum Upgrade Free for 15 days, no credit card required: quantumupgrade.io/dave  -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR   Philippe Samor von Holtzendorff-Fehling is a coach, conscious entrepreneur, and energy healer who built a parallel path alongside a high-level international business career, working through his own blockages to fully connect with his true self. He served as Vice President at both T-Mobile International and T-Mobile US, and is now the founder and CEO of Leela Quantum Tech and Quantum Upgrade. He is also a kundalini yoga teacher, a passionate bio and bio-energy hacker, a father of two, a dog lover, and the number one ranked tennis player in the US in the Men 50+ category. His work sits at the intersection of functional medicine, quantum biology, and human performance, and the science behind his technology is harder to dismiss than most people expect.  Dave and Philippe go deep on how chronic EMF exposure from 5G towers, Starlink satellites, electric vehicles, and everyday Wi-Fi actively disrupts your brain waves, blood cells, heart rate variability, and mitochondria function. They also break down how Quantum Upgrade works as a remote, customizable field that can harmonize these frequencies in real time, and why it may be one of the most underrated tools for sleep optimization, brain optimization, recovery, anti-aging, and longevity.  This episode also covers the groundbreaking work Philippe is doing with autistic children, including a clinical study showing measurable reductions in autism spectrum scores, and a remarkable collaboration with Susie Miller of the Telepathy Tapes.  This is essential listening for anyone serious about biohacking, human performance, anti-aging, longevity, brain optimization, sleep optimization, functional medicine, mitochondria health, and hacking every system in your body with smarter not harder solutions.  You'll Learn:  Why EMF from 5G, Starlink, and electric vehicles is more biologically dangerous than most people realize How a 256-channel EEG captured real-time brain changes triggered by Quantum Upgrade What "quantum coherence" actually means for your biology and why it matters for human performance and longevity How remote quantum fields affect HRV, blood clarity, ATP production, and mitochondria function Why autistic children showed measurable spectrum score reductions in a clinical trial using this technology How to customize your own quantum field for sleep optimization, recovery, energy, and brain optimization What Dave uses Quantum Upgrade for at his 40 Years of Zen facility in Austin   Thank you to our sponsors!       - Superstratum Labs | Get Dave's exact home mold detox kit and save 10% at superstratumlabs.com/products/dave  - Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today  - Timeline | Go to timeline.com/dave and you’ll get an additional 20% off your first month  - Amp | If you're ready to make fitness fit into your life, go to amp.ai to check it out  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: Philippe Samor von Holtzendorff-Fehling, Quantum Upgrade, Leela Quantum Tech, quantum energy, EMF protection, electromagnetic fields, 5G health effects, Starlink radiation, biohacking, human performance, longevity, anti-aging, brain optimization, sleep optimization, mitochondria, functional medicine, HRV, heart rate variability, dark field microscopy, EEG, ATP production, quantum coherence, biofield, energy healing, autism spectrum, telepathy tapes, Susie Miller, kundalini yoga, electric vehicle EMF, Wi-Fi health effects, smarter not harder, Dave Asprey, 40 Years of Zen, wound healing, placebo controlled trials, quantum biology, coherent field, EMF harmonization, remote quantum field, energy frequency, conscious entrepreneurship  Resources:    • Try Quantum Upgrade Free for 15 days, no credit card required: quantumupgrade.io/dave  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.   • Danger Coffee: https://dangercoffee.com/discount/dave15    • My Daily Supplements: SuppGrade Labs (15% Off)    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    • Dave Asprey’s BEYOND Conference: https://beyondconference.com    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated   • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/  • Upgrade Labs: https://upgradelabs.com    Timestamps:   00:00 – Trailer  01:15 – What Science Can't Explain  04:05 – What Is Quantum Upgrade?  06:04 – The Research  07:47 – Origin Story  12:20 – EEG Testing & Brain Effects  12:53 – EMFs, Electric Cars & 5G  17:57 – Measuring Results  21:25 – Autism Study & Telepathy Tapes  26:16 – Frequencies & Settings  29:09 – Starlink & Global EMF  30:54 – Skeptics & Proof  33:08 – Kids & Pets  37:10 – Wrap-Up & Free Trial  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    37 min
  3. Eat These Foods + Spices for 8 Weeks To Get 3 Years Younger | Kara Fitzgerald

    3 DAYS AGO

    Eat These Foods + Spices for 8 Weeks To Get 3 Years Younger | Kara Fitzgerald

    Your biological age can drop by over three years in just eight weeks, and the tools to do it are already in your kitchen. This episode breaks down the cutting-edge science of methylation, polyphenols, Yamanaka mimetics, and epigenetic reprogramming that is rewriting what we know about anti-aging, longevity, and human performance.    -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR  Host Dave Asprey sits down with Dr. Kara Fitzgerald, ND, IFMCP, a leading voice in functional medicine and epigenetic aging research. Her award-winning clinical studies published in Aging (2021, 2023, and 2025) proved that targeted diet and lifestyle interventions can measurably reverse biological age on validated epigenetic clocks. She is the author of Younger You, an IFM faculty member and Certified Practitioner, and one of the most rigorously credentialed researchers working at the intersection of functional medicine, nutrition, and longevity science today.  Together, they go deep on Yamanaka factors, the Nobel Prize-winning discovery that can wind back a 90-year-old cell to its 20s, and the emerging class of compounds called Yamanaka mimetics, polyphenol-based supplements that may replicate some of those same cellular rejuvenation effects without the risks. They cover why polyphenols do the heavy lifting in biological age reversal, how AI is accelerating longevity research, and why the dark matter of nutrition may matter more than macros, carnivore protocols, or ketosis for long-term health. They also get into oxalates, mitochondria, fibroids, ovarian rejuvenation, and why the original Horvath clock may be more relevant than scientists thought.  This is essential listening for anyone serious about biohacking, longevity, supplements, functional medicine, anti-aging, brain optimization, human performance, and using smarter not harder strategies to take control of your biology.  You'll Learn:  How diet, supplements, and meditation reversed biological age by over three years in eight weeks in a randomized controlled trial What Yamanaka factors are and why scientists are calling partial cellular reprogramming the future of anti-aging Which polyphenols do the heaviest lifting for epigenetic rejuvenation, including EGCG, urolithin A, rosemary, marjoram, and yarrow Why the Horvath epigenetic clock may actually be touching on programmatic aging rather than just exposomic wear and tear How AI is unlocking patterns in longevity data that no human researcher could find alone The problem with high-oxalate superfoods and how to get polyphenol benefits without the inflammatory downside Why ovarian rejuvenation may be the highest-leverage Yamanaka application for women's longevity and brain health How compounds like AKG, sodium butyrate, and forskolin may act as Yamanaka mimetics already available today What the PRC2 polycomb clock reveals about programmatic aging and why it matters more than second-generation clocks Why perimenopause does not have to be painful, and how functional medicine addresses it at the root   Thank you to our sponsors!       - Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave.  - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.  - STEMREGEN | Go to stemregen.co/dave30 Use code DAVE30 for 30% OFF your next order.  - Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order.  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: Kara Fitzgerald, biological age reversal, epigenetics, DNA methylation, Yamanaka factors, polyphenols, EGCG, urolithin A, anti-aging, longevity, biohacking, functional medicine, supplements, mitochondria, epigenetic clock, cellular reprogramming, AKG, sodium butyrate, methylation, Steve Horvath, Vittoria Sebastiano, coleus, perimenopause, ovarian rejuvenation, pluripotent stem cells, PRC2, dark matter of nutrition, TRIM study, dihydroxyflavone, BDNF, Prenuvo, chemical cellular rejuvenation  Resources:    • Learn more about all of Dr. Fitzgerald’s work at: https://www.drkarafitzgerald.com/  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.   • Danger Coffee: https://dangercoffee.com/discount/dave15    • My Daily Supplements: SuppGrade Labs (15% Off)    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    • Dave Asprey’s BEYOND Conference: https://beyondconference.com    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated   • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/  • Upgrade Labs: https://upgradelabs.com    Timestamps:   0:00 – Trailer  1:28 – Explaining Study  3:45 – What Is The Diet  6:49 – Age Reversal  8:17 – Polyphenols vs. Supplements  9:27 – Food vs. Supplement Dosing  12:41 – Oxalate & Polyphenol Trade-offs  18:41 – Yamanaka Factors Explained  28:59 – Chemical Cocktails  32:15 – PRC2 Clocks & Programmatic Aging  40:28 – Seasonal Eating  43:40 – Carnivore Diet: Short vs. Long Term  45:31 – Inuit Diet  46:39 – Flavones & Brain-Crossing Compounds  48:50 – Why Only Men in the Study?  51:05 – Women, Perimenopause & the Protocol  53:20 – Fibroids & Gaps in Women's Research  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    54 min
  4. This 9,000-Year-Old Ritual Cleared 15 Years Of Brain Fog

    5 DAYS AGO

    This 9,000-Year-Old Ritual Cleared 15 Years Of Brain Fog

    I spent fifteen years living with brain fog until I realized the problem wasn’t in my brain, but in a nervous system stuck in a survival mode that pulls energy away from focus and memory. In this video, I explain why "trying harder" or popping supplements rarely works, and instead, I show you the 9,000-year-old ritual of heat and cold that pulls your body out of stress mode so clarity can actually return. I break down the specific science of how I use infrared wavelengths and contrast therapy to retrain the brain to stay calm under pressure, moving beyond temporary fixes to target the root cause of mental fatigue. Follow this protocol to finally complete your body's stress cycles, reset your biological default settings, and reclaim the lasting mental performance you’ve been missing. 00:00 – Introduction 01:02 – What Brain Fog Really Is 03:00 – Why Trying Harder Doesn't Work 04:51 – Supplements: Useful But Not Enough 06:14 – Why Sauna Works 07:32 – Infrared vs Traditional Sauna 08:02 – Sunlighten Sauna Overview 09:28 – Sauna Routine & Protocol 10:34 – Why Home Access Matters 11:41 – Post-Session Recovery 12:11 – Contrast Therapy 13:11 – How to Do Contrast Therapy 13:54 – Closing & Takeaways Thank you to our sponsors! -TRU KAVA | Head to trukava.com and use code DAVE10 for 10% off. -Neuronic | Go to www.neuronic.online Code DAVE for $100 off -iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Danger Coffee: https://dangercoffee.com/DAVE15 Dave Asprey’s BEYOND Conference: https://beyondconference.com/ Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15 Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    15 min
  5. Selfies Predict Cancer, Dirty Feed, Bone Vibration, and more...

    1 MAY

    Selfies Predict Cancer, Dirty Feed, Bone Vibration, and more...

    This week's stories:  *Mud Playgrounds Double Kids' Bacterial Diversity and Spike Immune Genes 30%  Finland swapped rubber playground surfaces for natural soil and mud across eight kindergartens — and after just one month, kids in dirt had twice the bacterial species diversity on their skin and a 30% increase in expression of ten immune-related genes. Dave breaks down why your immune system requires microbial exposure to calibrate properly, what the hygiene hypothesis actually means for adults, and the dead-simple weekly habit that primes your innate immunity the same way. Sources:  https://creators.yahoo.com/lifestyle/story/finland-replaced-artificial-playground-surfaces-with-natural-elements-like-mud-and-soil--and-the-results-surprised-even-researchers-184318556.html https://www.sciencedaily.com/releases/2026/04/mud-playground-immunity.htm  *Mixing Exercise Types Cuts All-Cause Mortality Up to 40% in 170,000-Person Study  A 30-year BMJ Medicine cohort study found that people who rotate at least three different types of exercise weekly see 19 to 40% lower all-cause mortality — and that benefit held independent of total training volume. Dave explains why variety is a distinct biological signal, not a motivation trick, and why grinding more of the same thing is leaving longevity gains on the table. Sources:  https://bmjmedicine.bmj.com/content/early/2026/04/26/bmjmed-2025-001513 https://www.sciencedaily.com/releases/2026/04/260426012305.htm https://www.theguardian.com/society/2026/apr/26/exercise-diversity-mortality  *Facial Aging Rate from Photos Predicts Cancer Survival Better Than Blood Biomarkers  AI analysis of serial facial photos in 1,000+ cancer patients found that computed facial aging rate independently predicted five-year survival with a hazard ratio of 2.1 — outperforming CRP and other standard blood markers. Dave covers what the AI is actually reading in those photos, why your face is a more accurate biological ledger than most labs your doctor orders, and the free monthly habit that turns this into an early warning system. Sources:  https://medicalxpress.com/news/2026-04-photos-reveal-faster-biological-aging.html https://www.nature.com/articles/s43587-026-00123-4  *Vibration Vest OsteoBoost Mimics Weight-Bearing Exercise to Rebuild Bone Density  OsteoBoost raised $8M for a wearable vest delivering 30–50Hz vibrations to the spine and hips, triggering the same Wnt/β-catenin osteoblast pathway activated by mechanical loading — with early trials showing 2–5% bone mineral density gains in six months. Dave makes the case forwhy bone loss is one of the most underrated aging crises in the biohacking community, and who should be watching this category closely. Sources:  https://longevity.technology/news/osteoboost-raises-8m-to-scale-bone-wearable/ https://www.crunchbase.com/organization/osteoboost  *10+ States Advance Raw Milk Bills as H5N1 Hits 100+ Dairy Herds  Legislation expanding raw milk access is moving in Arizona, Iowa, New Hampshire, and elsewhere — while the CDC flags H5N1 in over a hundred dairy herds with documented aerosol transmission concerns. Dave gives an honest read on where the freedom argument, the microbiome argument, and the current risk calculus actually stand in April 2026, and what more rigorous sourcing looks like right now. Sources:  https://www.yahoo.com/news/articles/us-med--raw-milk-legislation-120124275.html https://www.cdc.gov/flu/avianflu/dairy.htm  This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on immune priming, exercise science, biological age tracking, bone health, and real food risk assessment. Host Dave Asprey connects emerging clinical research, large-scale cohort data, and real-world protocols into actionable frameworks for extending healthspan and sharpening performance.  New episodes every Tuesday, Thursday, Friday, and Sunday.  Keywords: mud playground immune system microbiome, soil bacteria skin diversity, hygiene hypothesis biohacking, exercise variety longevity, BMJ exercise mortality study, mixed training lifespan, facial aging rate cancer survival, biological age face AI, facial photo biomarker longevity, OsteoBoost vibration vest bone density, whole body vibration osteoporosis, bone mineral density wearable, raw milk H5N1 bird flu, raw milk legislation 2026, raw dairy safety biohacking, biohacking news, longevity research 2026, Dave Asprey weekly roundup   Thank you to our sponsors!   - KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off  - Puori | Go to Puori.com/DAVE or use code DAVE at checkout to get 32% off your Puori Fish Oil subscription. You save more than $18.  - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE  Resources:    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.   • Danger Coffee: https://dangercoffee.com/discount/dave15    • My Daily Supplements: SuppGrade Labs (15% Off)    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    • Dave Asprey’s BEYOND Conference: https://beyondconference.com    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated   • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/  • Upgrade Labs: https://upgradelabs.com      Timestamps:  00:00 – Intro  00:20 – Dirt & Immune Training  02:22 – Exercise Variety & Longevity  04:16 – Facial Aging as a Health Biomarker  05:47 – Bone Loss & Vibration Tech  07:31 – Raw Milk & H5N1 Risk  09:20 – The Wrapup  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    11 min
  6. The Strangest Thing I Do Every Morning for 15 Minutes | Brad Pitzele

    30 APR

    The Strangest Thing I Do Every Morning for 15 Minutes | Brad Pitzele

    Your cells are starving for oxygen, and it's silently driving inflammation, fatigue, brain fog, and accelerated aging. This episode reveals how pairing Exercise with Oxygen Therapy (EWOT) and red light therapy supercharges your mitochondria, reverses pseudo-hypoxia, and unlocks a level of human performance most people never experience.    -Save up to $500 (through 5/17) at One Thousand Roads: https://www.onethousandroads.com/Dave  -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR  Host Dave Asprey sits down with Brad Pitzele, founder of One Thousand Roads and one of the most credible voices in oxygen therapy and red light therapy. Brad didn't come to this work through a lab. He came to it through desperation. After battling autoimmune arthritis, melanoma, and Lyme disease, he rebuilt his health from the ground up starting in 2016 by targeting mitochondrial function when he could barely walk. Eighteen months later, he founded One Thousand Roads to bring these tools to everyone still searching for a way out.  Together, Dave and Brad break down the unified theory behind oxygen therapy and red light therapy, two of the most powerful and underrated tools in biohacking. They go deep on pseudo-hypoxia, the condition where your blood oxygen looks fine but your tissues are starving, and explain why this hidden dysfunction sits at the root of chronic fatigue, inflammaging, fibromyalgia, long COVID, and poor sleep optimization. They also cover the endothelium, nitric oxide, arterial stiffness, pulse wave velocity, and why your morning biology might be the most honest readout of your metabolic health.  This is essential listening for anyone serious about longevity, anti-aging, brain optimization, functional medicine, mitochondria, metabolism, and smarter not harder approaches to human performance.  You'll Learn:  What EWOT is and why elite athletes and biohackers use it to flood tissues with oxygen in 15 minutes How pseudo-hypoxia silently blocks energy production and drives chronic illness Why stacking red light therapy immediately after EWOT multiplies results for both How mitochondrial dysfunction connects to endothelial aging, microcirculation failure, and systemic inflammation The role of nitric oxide in arterial flexibility, vasodilation, and real anti-aging markers like pulse wave velocity Why your lungs are your biggest detox organ and how oxygen therapy supports that process How ketosis, fasting, and cellular energy interact with EWOT and red light for maximum benefit What LED lighting is doing to your mitochondria every single day and how to fix it How to build an affordable at-home EWOT setup for around $2,500  Thank you to our sponsors!       - Danger Coffee | Grab yours at DangerCoffee.comand use code DAVEPOD at checkout for 15% off.  - ENERGYbits | If you want a simpler, smarter way to support your body… this is it. Head to ENERGYbits.com and use code ASPREY for 20% off your order.  - Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today  - Cowboy Colostrum | Get your gut right by going to cowboycolostrum.com/asprey for 25% off of your entire order.  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: Brad Pitzele, One Thousand Roads, EWOT, exercise with oxygen therapy, oxygen therapy, red light therapy, infrared light therapy, pseudo-hypoxia, mitochondria, mitochondrial dysfunction, biohacking, longevity, anti-aging, human performance, inflammation, inflammaging, microcirculation, endothelium, glycocalyx, nitric oxide, arterial stiffness, pulse wave velocity, capillary health, cellular energy, ATP production, aerobic respiration, anaerobic respiration, VO2 max, chronic fatigue, fibromyalgia, brain fog, autoimmune disease, Lyme disease, Bartonella, long COVID, mast cell activation, detoxification, lung health, sleep optimization, metabolism, functional medicine, ketosis, fasting, red light bulbs, LED lighting, light therapy, wavelengths, near infrared, oxygen concentrator  Resources:    • Save up to $500 (through 5/17) at One Thousand Roads: https://www.onethousandroads.com/Dave  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.   • Danger Coffee: https://dangercoffee.com/discount/dave15    • My Daily Supplements: SuppGrade Labs (15% Off)    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    • Dave Asprey’s BEYOND Conference: https://beyondconference.com    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated   • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/  • Upgrade Labs: https://upgradelabs.com      Timestamps:  00:00 – Trailer  01:41 – Welcome Brad  03:01 – What Is EWOT?  05:27 – EWOT vs. Hospital Oxygen  06:51 – Longevity & Inflammaging  11:42 – Pseudo-Hypoxia  12:57 – Red Light Therapy  15:47 – EWOT + Red Light Unified Theory  18:00 – Nutrition, Ketosis & VO2 Max  19:56 – Stacking EWOT & Red Light  22:01 – Equipment & Cost  26:00 – Junk Light & LED Problems  30:51 – Sunlight & Nitric Oxide  32:36 – Endothelium & Microcirculation  38:49 – Arterial Stiffness & Pulse Wave Velocity  43:29 – Lungs as a Detox Organ  45:04 – EWOT for Long COVID  47:58 – Wrap-Up  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    49 min
  7. How Beef Is Destroying Your Hormones – Cynthia Thurlow

    28 APR

    How Beef Is Destroying Your Hormones – Cynthia Thurlow

    If you're a woman in your 30s, 40s, or 50s feeling like your body is betraying you, this episode reveals the hormonal, gut, and environmental triggers behind perimenopause that most doctors never address, and exactly what you can do about it.    -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR  Host Dave Asprey sits down with Cynthia Thurlow, a nurse practitioner, CEO and founder of the Everyday Wellness Project, and a globally recognized expert in intermittent fasting and women's hormonal health. Her TEDx talk on intermittent fasting has surpassed 10 million views, and she brings over 20 years of functional medicine clinical experience to one of the most underserved conversations in longevity and human performance.  Together, they tear apart the outdated medical narrative around perimenopause and menopause, exposing how a lack of knowledge, not biology, is destroying relationships, careers, and quality of life for millions of women. Dave and Cynthia dig into the gut microbiome's role in every symptom women experience in midlife, the mold toxin that is 10,000 times more potent than human estrogen and directly linked to hormonal chaos, and why biohacking your hormones as early as 35 could be the most important longevity move a woman makes. They also cover why statins are wrecking women's metabolism, how trauma accelerates ovarian aging and mitochondrial decline, the surprising connection between histamine reactions and hot flashes, and why GLP-1 micro-dosing alongside hormone replacement therapy is a game-changer for body composition and anti-aging.  This episode is essential for listening for anyone serious about biohacking, sleep optimization, functional medicine, longevity, brain optimization, supplements, metabolism, human performance, and smarter not harder approaches to women's health.  You'll Learn:  Why perimenopause actually begins around age 35 and what to do about it before symptoms hit How a mold-derived xenoestrogen found in conventional beef disrupts hormones at 10,000 times the potency of human estrogen The gut microbiome changes that drive hot flashes, brain fog, weight gain, and mood disorders in perimenopause Why oral micronized progesterone beats topical for sleep optimization and hormonal stability How testosterone drives executive function, motivation, and brain optimization in women The lab tests every woman in perimenopause should run, including fasting insulin, ApoB, ferritin, and a full thyroid panel Why adverse childhood events and unresolved trauma age the ovaries and tank mitochondria How mold toxicity and Lyme disease create a hormonal perfect storm that no amount of supplements will fix The real reason 70 percent of divorces are initiated by women, and what hormones have to do with it  Thank you to our sponsors!       - Neuronic | Go to www.neuronic.online Code DAVE for $100 off  - Superstratum Labs | Get Dave's exact home mold detox kit and save 10% at superstratumlabs.com/products/dave  - Joymode | Go to tryjoymode.com/DAVE Or enter DAVE at checkout for 20% off.  - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: Cynthia Thurlow, The Menopause Gut, perimenopause, menopause, hormones, hormone replacement therapy, HRT, bioidentical hormones, progesterone, estrogen, testosterone, thyroid health, gut microbiome, women's health, functional medicine, biohacking, longevity, anti-aging, human performance, mitochondria, sleep optimization, metabolism, supplements, mold toxicity, zearalenone, xenoestrogen, hot flashes, brain fog, body composition, GLP-1, intermittent fasting, trauma, cortisol, adrenal health, leaky gut, histamine intolerance, mast cell activation, insulin resistance, fasting insulin, ApoB, ferritin, statins, ovarian aging, Dave Asprey, smarter not harder  Resources:    • Learn More From Cynthia And Get Her New Book The Menopause Gut at: https://www.cynthiathurlow.com/  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.   • Danger Coffee: https://dangercoffee.com/discount/dave15    • My Daily Supplements: SuppGrade Labs (15% Off)    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    • Dave Asprey’s BEYOND Conference: https://beyondconference.com    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated   • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/  • Upgrade Labs: https://upgradelabs.com    Timestamps:  00:00 – Intro  04:35 – Root Causes of Perimenopause  07:50 – When Perimenopause Starts  09:47 – Progesterone: When & How  12:16 – Testosterone for Women  14:14 – Thyroid & Energy  18:41 – FDA's HRT Policy Change  20:15 – Hormones & Divorce 21:53 – GLP-1s & Body Composition  27:17 – Key Lab Tests  31:13 – AI & Budget Labs  39:44 – Gut Microbiome & Menopause  42:57 – Histamine, Mast Cells & Hot Flashes  47:55 – Toxic Mold & Xenoestrogens  50:31 – Dairy, Raw Milk & Leaky Gut  59:27 – Healing Trauma  1:03:00 – Book Recommendations  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    1hr 5min
  8. Supercharge Your Immunity In 4 Weeks With THIS Ancient Fruit

    26 APR

    Supercharge Your Immunity In 4 Weeks With THIS Ancient Fruit

    When you hit your 40s, you start catching colds more easily, wounds take longer to heal, and you feel rundown even after a full night's sleep. Your doctor will tell you "it's just aging." They're wrong. It's actually your immune cells suffocating on toxic waste because their power plants—your mitochondria—are breaking down. In this video, I explain the exact biological mechanism behind "immune aging" and why your body's natural cleanup system (mitophagy) stalls out in your 40s and 50s. More importantly, I'm sharing the breakthrough compound scientists discovered that actually reverses this. It's a molecule called Urolithin A, originally found in pomegranates. I dive into the massive problem with trying to get this molecule from food (only 30% of people have the right gut bacteria to even make it), and the 15 years of human clinical trials behind Mitopure—the supplement that bypasses your gut completely. I even share why I spent $100,000 on an extreme T-cell procedure before I knew I could just take this to get a younger immune system in 28 days. 00:00 – Immune Decline After 40 00:39 – Why Immune Cells Weaken 01:17 – The Role of Mitochondria 02:25 – Mitophagy & Its Decline 05:45 – The Ancient Fruit: Pomegranates 06:39 – The Problem With Pomegranates 07:19 – Urolithin A as a Supplement 08:33 – Trial Results 09:58 – About MitoPure 10:46 – Call to Action Thank you to our sponsors! -GOT MOLD? | Go to http://gotmold.com/shopand use DAVE10 to save 10% and see what’s in your air. -Superstratum Labs | Get Dave's exact home mold detox kit and save 10% at superstratumlabs.com/products/dave -iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Danger Coffee: https://dangercoffee.com/DAVE15 Dave Asprey’s BEYOND Conference: https://beyondconference.com/ Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15 Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    11 min
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4.5
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About

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization. Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more. This isn’t just self-improvement - it’s human enhancement backed by data. Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life. Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.

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