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قبل ٤ أيام

From Copilots to Agents: Rebuilding the Company Around AI

a16z's Angela Strange and Gabriel Vasquez speak with Carlos García Ottati, founder and CEO of Kavak, about building Latin America's largest online used car marketplace across Mexico, Brazil, Chile, Argentina, and the Middle East. They discuss why building in emerging markets means constructing four businesses underneath your business, how Kavak replaced copilot tools with AI agents handling 90 to 95% of customer interactions, and what it took to go flat for a year during the transition before growing four times on the other side. Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

قبل ٤ أيام

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قبل يومين

Patrick Collison on Stripe’s Early Choices, Smalltalk, and What Comes After Coding

Michael Truell, CEO of Cursor, sits down with Patrick Collison, CEO of Stripe and an investor in Anysphere, to talk about Collison's history with Smalltalk and Lisp, the MongoDB and Ruby decisions Stripe still lives with 15 years later, why he'd spend even more time on API design if he could do it over, and whether AI is actually showing up in economic productivity data. This episode originally aired on Cursor's podcast. Resources: Follow Patrick Collison on X: https://twitter.com/patrickc Follow Michael Truell on X: https://twitter.com/mntruell Follow Cursor: https://www.youtube.com/@cursor_ai Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

قبل يومين

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٥٣ من الدقائق
١١ فبراير

From Eater to Blackbird: Ben Leventhal on Restaurants, Loyalty, and Rebuilding Payments

Restaurants generated more than a trillion dollars in sales last year — but they don’t control the payment rails those dollars flow through. In this episode, Ben Leventhal (founder of Eater, Resy, and now Blackbird) joins Robert Hackett to explain why that’s a problem, how loyalty and payments have failed independent restaurants, and where crypto fits into fixing it. Ben breaks down: Why most restaurant tech misses the pointHow Blackbird uses crypto without making restaurants think about cryptoWhat “restaurant-first” really means in payments and loyaltyWhy decentralization only makes sense at scaleLessons from building multiple companies in hospitalityWhy we’re living in the golden age of restaurantsPlus: favorite NYC spots, founder productivity hacks, and the smallest hill he’ll die on.This is a grounded conversation about technology, ownership, and the future of restaurants — from someone who’s been building in the space for over a decade. Follow a16z crypto for more... X: https://x.com/a16zcryptoLinkedIn: https://www.linkedin.com/showcase/a16zcrypto/posts/Spotify: https://open.spotify.com/show/7pMZvsNXEnb0CYcPiDQywEApple Podcasts: https://podcasts.apple.com/us/podcast/web3-with-a16z-crypto/id1622312549Youtube: https://www.youtube.com/@a16zcrypto📩 Subscribe for more industry reports, trend updates, news analysis, builder guides, and other resources: https://a16zcrypto.substack.com/subscribe/ 🎙️ Like, subscribe, comment, share the show: https://a16zcrypto.com/posts/podcast/ *** As always, none of the following should be taken as investment, business, legal, or tax advice. Please see a16z.com/disclosures for more important information, including a link to a list of our investments. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

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How to Build a Successful Company in an Era of Disruption

What happens when a startup becomes a giant—and then has to reinvent itself all over again? In this episode, Martin Casado sits down with Raghu Raghuram (former CEO of VMware) and Jeetu Patel (President and CPO at Cisco) for a deep, tactical conversation on scaling, disruption, and navigating transformation from the inside. They share hard-won lessons from leading two of the most iconic infrastructure companies in tech—through waves like virtualization, cloud, containers, and now AI. They cover: How to keep innovation alive inside large companiesWhy the best companies operate with a founder’s mindset, even without foundersThe difference between selling to buyers vs. practitionersWhy the story is the strategy, and how to tell it at scaleHow Cisco is rebuilding its startup DNA in the age of AIIf you're building or leading through a major tech wave, this episode is a playbook. Timecodes: 0:00 Introduction 2:02 Weapons of Mass Disruption: Abstractions, Business Models, and Cloud 5:57 Cisco’s Missed Cloud Wave & Resetting for Innovation 6:39 Operating Like a Startup: Speed, Scale, and Leadership 10:00 Go-to-Market Challenges: Fencing Off Innovation 11:04 Organic vs. Inorganic Growth: Lessons from VMware 12:04 The 10x Rule and Competing with Incumbents 14:39 Structuring for Disruption: Two-Pizza Teams and Ideal Customer Profiles 18:43 Storytelling as Strategy: Galvanizing Large Organizations 19:42 The AI Wave: Consumerization and Infrastructure Demands 25:34 Founders vs. Operators: Leading Transformations 31:47 Product-Led Organizations: From Sales to Product Focus 34:35 The Future of Infrastructure: AI, Market Size, and Vertical Integration 39:34 Timing, Market, Team, Product, Brand, and Scale 41:19 Authenticity, Opportunity, and Final Thoughts Resources: Find Martin on X: https://x.com/martin_casado Find Raghu on X: https://x.com/raghuraghuram Find Jeetu on X: https://x.com/jpatel41 Stay Updated: Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://x.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

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Dylan Patel: GPT-5, NVIDIA, Intel, Meta, Apple

The AI hardware race is heating up, and NVIDIA is still far ahead. What will it take to close the gap? In this episode, Dylan Patel (Founder & CEO, SemiAnalysis) joins Erin Price-Wright (General Partner, a16z), Guido Appenzeller (Partner, a16z), and host Erik Torenberg to break down the state of AI chips, data centers, and infrastructure strategy. We discuss: Why simply copying NVIDIA won’t work, and what it takes to beat themHow custom silicon from Google, Amazon, and Meta could reshape the marketThe economics of AI model launches and the shift toward cost efficiencyInfrastructure bottlenecks: power, cooling, and the global supply chainThe rise of AI silicon startups and the challenges they faceExport controls, China’s AI ambitions, and geopolitics in the chip raceBig tech’s next moves: advice for leaders like Jensen Huang, Sundar Pichai, Mark Zuckerberg, and Elon MuskResources: Find Dylan on X: https://x.com/dylan522p Find Erin on X: https://x.com/espricewright Find Guido on X: https://x.com/appenz Learn more about SemiAnalysis: https://semianalysis.com/dylan-patel/ Stay Updated: Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://x.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

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Faster Science, Better Drugs

Can we make science as fast as software? In this episode, Erik Torenberg talks with Patrick Hsu (cofounder of Arc Institute) and a16z general partner Jorge Conde about Arc’s “virtual cells” moonshot, which uses foundation models to simulate biology and guide experiments. They discuss why research is slow, what an AlphaFold-style moment for cell biology could look like, and how AI might improve drug discovery. The conversation also covers hype versus substance in AI for biology, clinical bottlenecks, capital intensity, and how breakthroughs like GLP-1s show the path from science to major business and health impact. Resources: Find Patrick on X: https://x.com/pdhsu Find Jorge on X: https://x.com/JorgeCondeBio Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

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Chris Best of Substack on the Future of Media

What if the future of media isn’t controlled by algorithms or legacy institutions—but by independent voices building directly with their audiences? In this episode, Erik Torenberg is joined by Chris Best, cofounder and CEO of Substack, along with a16z general partners Katherine Boyle and Andrew Chen. We trace the origin story of Substack and its cultural impact, including how it reinvented the business model for independent media. We also explore the evolution of blogging, the rebundling of media, and what the future holds as attention becomes the scarcest resource. Timecodes: 00:00 Introduction 03:50 Origins of Substack 06:29 The Evolution of Blogging & Media Models 09:15 Direct Audience Connection & Platform Independence 10:57 Vision for Substack & The Role of Algorithms 21:06 Business Models: Ads, Subscriptions, and AI 26:10 The Scarcity of Attention & Value of Good Content 27:45 Unbundling, Rebundling, and the Future of Media Companies 37:12 Academia, Books, and Changing Content Formats 44:31 Substack’s Next Phase & Closing Thoughts Resources: Find Chris on Substack: https://cb.substack.com/ Find Chris on X: https://x.com/cjgbest Find Andrew Chen on Substack: https://andrewchen.substack.com/ Find Andrew on X: https://x.com/andrewchen Find Katherine on X: https://x.com/KTmBoyle Find Katherine on Substack: https://boyle.substack.com/ Stay Updated: Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://x.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

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Mark Zuckerberg & Priscilla Chan: How AI Will Cure All Disease

Priscilla Chan and Mark Zuckerberg join a16z’s Ben Horowitz, Erik Torenberg, and Vineeta Agarwala to share how the Chan Zuckerberg Initiative is building the computational tools that will accelerate the cure, prevention, and management of all disease by century's end. They explain why basic science needs $100 million-scale projects that traditional NIH grants can't fund, how their Cell Atlas became biology's missing periodic table with millions of cells catalogued in open-source format, and why their new virtual cell models will let scientists test high-risk hypotheses in silico before investing in expensive wet lab work. Plus: the organizational shift unifying the Biohub under AI leadership, what happens when biologists and engineers sit side-by-side, and why modern biology labs are expanding compute instead of square footage. Timestamps: 4:17 - Building tools to accelerate scientific discovery 5:47 - The credible path to funding basic science 7:21 - Biohub = Frontier Biology + Frontier AI 9:05 - Challenges building on a 10-15 year timeline 9:43 - How CZI chooses what to work on 11:15 - Making sense of science with LLMs 11:31 - Measuring success in the therapeutic realm 13:32 - “Most diseases should be thought of as rare diseases” 15:39 - Inspiration: building a periodic table for biology 19:27 - Why virtual cells? 21:17 - The Biohub Master Plan 21:51 - How virtual cell models allow more risk taking 28:15 - Bringing CZI & Biohub together 30:32 - Why Biohub matters 33:36 - The importance of interface design in democratizing scientific discovery 35:34 - How Biohub encourages cross-functional collaboration 40:38 - Looking ahead: the broader impact of AI on biotech Stay Updated: If you enjoyed this episode, be sure to like, subscribe, and share with your friends! Find a16z on X: https://x.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Listen to the a16z Podcast on Spotify: https://open.spotify.com/show/5bC65RDvs3oxnLyqqvkUYX Listen to the a16z Podcast on Apple Podcasts: https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711 Follow our host: https://x.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

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Where We Are in the AI Cycle

In this episode of ‘This Week in Consumer’, a16z General Partners Anish Acharya and Erik Torenberg are joined by Steven Sinofsky - Board Partner at a16z and former President of Microsoft’s Windows division - for a deep dive on how today’s AI moment mirrors (and diverges from) past computing transitions. They explore whether we’re at the “Windows 3.1” stage of AI or still in the earliest innings, why consumer adoption is outpacing developer readiness, and how frameworks like partial autonomy, jagged intelligence, and “vibe coding” are shaping what gets built next. They also dig into where the real bottlenecks lie, not in the tech, but in how companies, products, and people work. Resources: Find Anish on X: https://x.com/illscience Find Steven on X: https://x.com/stevesi Watch Andrej Karpathy’s talk: https://www.youtube.com/watch?v=LCEmiRjPEtQ Stay Updated: Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://x.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

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How Apple Became So Reliant on China & What it Means For Their Future

What if the rise of Apple also built modern China? a16z’s Erik Torenberg is joined by board partner and former Microsoft Windows chief Steven Sinofsky to unpack how Apple’s pursuit of design excellence and supply chain scale catalyzed China’s manufacturing superpower status - and why that partnership is now under intense scrutiny. Inspired by the book Apple in China (but not a book review), the episode dives deep into: The early days of Apple’s shift to Chinese manufacturing What experts got wrong in 1999 about trade, globalization, and China’s trajectoryHow Tim Cook’s operational playbook reshaped the global tech industryBehind-the-scenes stories from Microsoft’s own hardware battles and Surface launchWhy Apple’s entanglement with China may now be a strategic liabilityWhat COVID revealed about fragile global dependencies — and where innovation goes nextHow national policy, intellectual property, and AI intersect in the new industrial eraThe episode opens with a few reactions to WWDC: Apple’s new UI, the iPad’s evolving role, and why Apple’s AI story still feels unfinished - before zooming out into one of the most consequential tech and geopolitical stories of our time. TImecodes: 00:00 Introduction 00:37 Guest Introduction: Steven Sinofsky 00:49 WWDC Reactions and Apple's AI Story 02:27 WWDC Highlights: Liquid Glass and iPad Updates 05:16 Apple's AI Strategy and Market Dynamics 06:34 Meta's AI Moves and Market Implications 13:30 Apple's Manufacturing Evolution: From Garage to Global 20:50 The Rise of ODMs and Global Manufacturing 26:32 Microsoft's Struggle with Piracy in China 27:19 Apple's Revolutionary MacBook Air 29:30 Challenges in PC Manufacturing 31:05 The Rise of Chinese Manufacturing Skills 32:07 The Point of No Return for Apple and China 32:59 Global Trade and Intellectual Property Issues 37:04 COVID-19's Impact on Global Manufacturing 41:19 Future of Innovation and Manufacturing 47:10 Navigating Intellectual Property in the AI Era 48:55 Conclusion and Final Thoughts Resources: Find Steven on X: https://x.com/stevesi Find Erik on X: https://x.com/eriktorenberg Stay Updated: Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://x.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Stay Updated: Find a16z on YouTube: YouTube Find a16z on X Find a16z on LinkedIn Listen to the a16z Show on Spotify Listen to the a16z Show on Apple Podcasts Follow our host: https://twitter.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

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٤٩ من الدقائق

Get the inside take on technology, startups, and business with a16z. Produced by Silicon Valley venture capital firm Andreessen Horowitz, the a16z Podcast network is the go-to place for in-depth discussions about the innovations shaping our world—straight from the builders, entrepreneurs, and researchers on the front lines of the future. From crypto to AI and biotech to the latest consumer apps, a16z has podcasts to keep you ahead of what’s next in tech.

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From Copilots to Agents: Rebuilding the Company Around AI

Patrick Collison on Stripe’s Early Choices, Smalltalk, and What Comes After Coding

From Eater to Blackbird: Ben Leventhal on Restaurants, Loyalty, and Rebuilding Payments

How to Build a Successful Company in an Era of Disruption

Dylan Patel: GPT-5, NVIDIA, Intel, Meta, Apple

Faster Science, Better Drugs

Chris Best of Substack on the Future of Media

Mark Zuckerberg & Priscilla Chan: How AI Will Cure All Disease

Where We Are in the AI Cycle

How Apple Became So Reliant on China & What it Means For Their Future

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