Y Combinator

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3月27日

How François Chollet Is Building A New Path To AGI

François Chollet has spent years asking a different question than most of the AI world. Instead of scaling what already works, he’s trying to understand what intelligence actually is—and how to build it from first principles. In this episode of Lightcone, he traces that path from his early work on deep learning to the creation of the ARC prize, and the launch of ARC V3, a new benchmark designed to measure something deeper than performance: the ability to learn, adapt, and reason efficiently in entirely new environments. He explains why today’s systems may be hitting limits, what recent breakthroughs really mean, and why reaching true general intelligence may require a fundamentally different approach.00:00 - AGI by 2030?00:31 - Introducing Ndea: A New Path Beyond Deep Learning01:08 - A New ML Paradigm 01:30 - Replacing neural nets with compact symbolic programs03:04 - Why Ndea Isn’t Competing With Coding Agents05:20 - Why Everyone Might Be Wrong About Scaling LLMs07:22 - Why Coding Agents Suddenly Work So Well08:50 - The Limits of LLMs in Non-Verifiable Domains10:48 - What AGI Actually Means (And Why Most Definitions Are Wrong)13:30 - Why Deep Learning Hits a Wall 14:00 - ARC’s Origin Story18:20 - ARC Benchmarks Explained: From V1 to V322:49 - The RL Loop Powering Coding Agents Today27:03 - ARC-AGI V3: Measuring “Agentic Intelligence”31:14 - Inside the ARC Game Studio35:31 - Could AGI Fit in 10,000 Lines of Code?44:01 - Building Ndea: From Idea to Compounding Research Stack46:46 - The Future of ARC: Benchmarks That Evolve With AI47:21 - Why There’s Still Huge Opportunity for New AI Paradigms53:37 - How to Build a Breakout Open Source Project - Lessons From Kera56:39 - Advice For How To Think About AIApply to Y Combinator: https://www.ycombinator.com/applyWork at a startup: https://www.ycombinator.com/jobs

3月27日

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57 分鐘
30/05/2025

State-Of-The-Art Prompting For AI Agents

At first, prompting seemed to be a temporary workaround for getting the most out of large language models. But over time, it's become critical to the way we interact with AI. On the Lightcone, Garry, Harj, Diana, and Jared break down what they've learned from working with hundreds of founders building with LLMs: why prompting still matters, where it breaks down, and how teams are making it more reliable in production. They share real examples of prompts that failed, how companies are testing for quality, and what the best teams are doing to make LLM outputs useful and predictable. The prompt from Parahelp (S24) discussed in the episode: https://parahelp.com/blog/prompt-design

30/05/2025

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31 分鐘
18/06/2025

Alexandr Wang: Building Scale AI, Transforming Work with Agents & Competing With China

Alexandr Wang started Scale AI to help machine learning teams label data faster.It started as a simple API for human labor, but behind the scenes, he was tackling a much bigger problem: how to turn messy, real-world data into something AI could learn from. Today, that early idea powers a multi-hundred-million-dollar engine behind America's AI infrastructure—fueling everything from Fortune 500 workflows to real-time military planning. Just last week, Meta agreed to invest over $14 billion in Scale AI, valuing the company at $29 billion.Alexandr joined us on the Lightcone to share how Scale AI evolved from a scrappy YC startup into the backbone of some of the world's most advanced AI systems, how he thinks about competition with Chinese AI labs, and what it takes to build infrastructure that shapes the frontier.

18/06/2025

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1 小時 1 分鐘
22/08/2018

#91 - David Zeevi

David Zeevi is a James S. McDonnell independent fellow at the Rockefeller University Center for Studies in Physics and Biology. He focuses on developing computational methods for studying microbial ecology in the human gut and in the marine environment, and its contribution to human and environmental health.He was one of the authors on the paper Personalized Nutrition by Prediction of Glycemic Responses.The YC podcast is hosted by Craig Cannon.Apply for $120K in funding from YC. ***Topics01:15 - Why did David start working on personalized nutrition?4:45 - How did the measure the effects of food in their study?11:55 - How was the study standardized across people?15:55 - How they measured an individual’s gut microbiome.17:30 - What is the gut microbiome?22:05 - Is there an ideal gut microbiome?23:20 - How do you manipulate your gut microbiome?24:50 - Fecal transplants.26:55 - Elizabeth Iorns asks - Does post prandial glucose response regulation track with weight regulation? I.e. can they use their test to determine what individual people should eat or not eat to lose weight?28:35 - Has this research been turned into a product?29:35 - Who else worked on this research?30:35 - How was their predictive algorithm made?35:15 - Did they end up with any dietary suggestions?36:15 - David’s bread study.38:55 - Has David changed his own diet?39:25 - Why fat was vilified.43:15 - David’s ocean microbiome and other research.51:05 - Traveling and your microbiome.56:35 - Trying this out yourself.

22/08/2018

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57 分鐘
25/06/2025

Satya Nadella: Microsoft's AI Bets, Hyperscaling, Quantum Computing Breakthroughs

A fireside with Satya Nadella on June 17, 2025 at AI Startup School in San Francisco.Satya Nadella started at Microsoft in 1992 as an engineer. Three decades later, he’s now Chairman & CEO, navigating the company through one of the most profound technological shifts yet: the rise of AI.In this conversation, he shares how Microsoft is thinking about this moment— from the infrastructure needed to train frontier models, to the social permission required to use that compute. He draws parallels to the early PC and internet eras, breaks down what makes a great team, and reflects on what he’d build if he were starting his career today.

25/06/2025

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40 分鐘
09/06/2017

#9 - Sam Altman and Reid Hoffman - From Startup to Scaleup

Sam Altman and Reid Hoffman discuss the key changes founders should think about as they scale their company. The conversation was recorded at The Scaleup Offsite, a private event hosted by Y Combinator Continuity and Greylock Partners in April 2017.

09/06/2017

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41 分鐘
30/04/2024

Consumer is back, What’s getting funded now, Immaculate vibes

What's happening in startups right now and how can you get ahead of the curve? In this episode of the Lightcone podcast, we dive deep into the major trends we're seeing from the most recent batch of YC using data we've never shared publicly before. This is a glimpse into what might be the most exciting moment to be a startup founder ever. It's time to build.

30/04/2024

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42 分鐘
27/03/2019

#119 - Amy Buechler and Michael Seibel

Amy Buechler is an executive coach for startup founders.Michael Seibel is a partner and the CEO of YC.In this episode we talk about coaching and use examples from Michael’s time working on Justin.tv and Socialcam.You can find Amy at her site foundercoach.io and on Twitter at @amybue.Michael is on Twitter at @mwseibel.The YC podcast is hosted by Craig Cannon.***Topics00:00 - Intro00:41 - What is coaching?01:11 - How is coaching different from therapy?2:31 - What are the most common challenges founders in coaching have?3:26 - Challenges with roles and responsibilities at Twitch7:46 - How would Amy have coached Michael around roles and responsibilities?9:41 - Not being disruptive as a leader11:31 - Switching roles at Twitch12:46 - Uneven equity splits15:01 - Distributing and negotiating equity21:16 - Communicating your own value22:51 - Can there be too much communication?24:11 - Productive arguments28:11 - Talking about performance issues30:16 - Setting clear goals and managing motivation33:16 - Enjoying the work34:01 - Conversations about runway36:51 - Digging your company out of the grave and continuing40:21 - Michael being against coaching initially42:31 - How to have hard conversations44:16 - Removing a responsibility from someone49:51 - Returning to roles and responsibilities 50:41 - Jeanie McCallister asks - What’s the single most important piece of advice you can give a founder?

27/03/2019

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54 分鐘
01/09/2017

#31 - Spotting Ecommerce Trends in Shipping Data – Laura Behrens Wu

Laura Behrens Wu is the CEO and cofounder of Shippo. Read the transcript here.

01/09/2017

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44 分鐘
01/12/2017

#50 - Growth Office Hours with Anu Hariharan and Gustaf Alstromer

Anu Hariharan and Gustaf Alstromer are Partners at YC.This episode is a follow-up to Anu's Growth Guide.The YC podcast is hosted by Craig Cannon.

01/12/2017

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33 分鐘

Make something people want.