MedInsights Unleashed

MedInsights Unleashed
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The MedInsights Unleashed Podcast aims to break down complex clinical data to provide insights from cutting-edge developments into tangible benefits for physicians, patients, and caregivers around the globe. Zee Ramji and John Collins will engage with leading global healthcare specialists to bring the latest groundbreaking therapies to you. To learn more about Zee and John, go deeper into each episode and access additional resources, go to https://medinsightsunleashed.com

  1. 10 MAR

    Rethinking Intermediate-Stage HCC: Evolution Beyond TACE as a One-Size-Fits-All Strategy

    In this episode of MedInsights Unleashed, Professor Markus Peck-Radosavljević, MD, MBA—Professor of Medicine and Chairman of the Department of Internal Medicine & Gastroenterology at Klinikum Klagenfurt, Austria— discusses evolving treatment strategies in hepatocellular carcinoma (HCC). The conversation explores the changing role of transarterial chemoembolization (TACE) in intermediate-stage disease, emerging clinical evidence from studies such as REPLACEMENT Emerald-1 and LEAP-012, and how new systemic and immunotherapy approaches are reshaping treatment decisions. The discussion also highlights the importance of curative opportunities, multidisciplinary care, and maintaining overall survival as the most meaningful endpoint in liver cancer treatment.

    44 min

  2. 2 FEB

    When Chronic Spine Pain Becomes Surgical: Advances in Modern Spine Care

    In this episode of MedInsights Unleashed, the discussion focuses on advanced chronic spine pain and when surgery becomes part of the care pathway. Dr. Rohan R. Lall, neurosurgeon at M Health Fairview University of Minnesota Medical Center, shares clinical perspective on evolving surgical approaches for patients with severe degeneration, instability, and chronic nerve-related pain. The conversation explores electrically enhanced transforaminal lumbar interbody fusion (e-TLIF), which combines spinal stabilization with targeted nerve stimulation, as well as broader trends in non-opioid pain management, minimally invasive surgery, robotics, and AI shaping modern spine care.

    43 min

  3. 15/12/2025

    Challenging the “Good Cancer” Myth: What Patients and Clinicians Need to Know

    Dr. Lori Wirth, MD—Elizabeth and Michael Ruane Chair of Endocrine Oncology; Medical Director of the Massachusetts General Hospital Center for Head and Neck Cancers; and Professor of Medicine at Harvard Medical School—joins MedInsights Unleashed to discuss modern thyroid cancer care. She explores differentiated, medullary, and anaplastic disease; advances in diagnosis and treatment; the role of genomic testing, including BRAF V600E and RET; and the use of active surveillance for selected patients. Dr. Wirth underscores the importance of individualized care and shared decision-making, offering clear, practical insights for patients, caregivers, and clinicians navigating an evolving thyroid cancer landscape.

    57 min

  4. 04/12/2025

    A New Approach to Degenerative Disc Disease – Introducing Hydrafil

    In this MedInsights Unleashed episode, we explore an emerging treatment for chronic degenerative disc disease called Hydrafil. Our guests are Bill Niland, CEO of ReGelTec Inc., and Dr. Anthony Lowman, PhD, Professor of Biomedical Engineering and Co-Founder/Chief Medical Officer at ReGelTec. They walk us through the science, creation, and development of this injectable hydrogel technology. Hydrafil is designed to help patients with lumbar back pain by restoring hydration and pressure inside the spinal disc, supporting its structure, and potentially reducing inflammation and pain. ReGelTec has launched its pivotal HYDRAFIL-D Study, a multicenter, randomized U.S. trial enrolling ~225 patients. For details, visit ClinicalTrials.gov and search: Degenerative Disc Disease + Hydrafil (NCT06011551 and NCT04984629).

    32 min

  5. 10/11/2025

    Beyond Obesity and Oncology: How GLP1s Are Reshaping Modern Medicine

    In this episode of MedInsights Unleashed, Professor Pierre Gholam, MD., FAASLD, AGAF, returns to explore the transformative potential of GLP1-based therapies beyond diabetes and obesity. The discussion highlights how these drugs may play a groundbreaking role in **cancer prevention—particularly liver cancer—**by addressing the root causes of metabolic dysfunction, a growing public health crisis affecting millions of Americans. Prof. Gholam emphasizes the need for multidisciplinary collaboration among hepatologists, endocrinologists, and primary care providers to improve early detection and treatment of fatty liver disease through noninvasive diagnostics and proactive referral pathways. The episode also looks ahead to emerging oral and multi-agonist GLP1 therapies, marking a new frontier in personalized metabolic and oncologic care.

    50 min

  6. 12/09/2025

    From Hepatitis to Fatty Liver: Unmasking the New Faces of Liver Cancer

    We’re honored to share a powerful new episode featuring Dr. Pierre Gholam, MD, FAASLD, AGAF—Professor of Medicine at Case Western Reserve University and Director of the Hepatobiliary Multidisciplinary Team at University Hospitals Seidman Cancer Center. With clarity and compassion, Dr. Gholam explores the complex and evolving nature of liver cancer, tracing its historical roots in viral hepatitis to today’s sharp rise in cases driven by fatty liver disease and alcohol use. He highlights both the breakthroughs and ongoing challenges in hepatocellular carcinoma (HCC) care—from early tyrosine kinase inhibitors to the promise of immune checkpoint inhibitors—while underscoring the critical need for improved screening strategies. Throughout the discussion, Dr. Gholam emphasizes the central role hepatologists play in managing HCC, from diagnosis to therapy.

    54 min

  7. 28/08/2025

    Liquid Biopsies in Neo-Adjuvant Head & Neck Cancer: Personalizing Therapy, Reducing Toxicity

    We are privileged to have Dr. Ari Rosenberg, MD, and Dr. Maha Elsebaie, MD, MSc, from the University of Chicago, join us to discuss groundbreaking research in neoadjuvant head and neck cancer treatment. This episode explores how circulating HPV DNA, measured through a simple blood test, is emerging as a powerful tool to guide therapy decisions, personalize treatment, and potentially reduce the need for aggressive surgery or radiation. The discussion highlights early results from trials combining immunotherapy and chemotherapy before standard treatment, showing promising improvements in tumor response while reducing long-term side effects. This research is shaping the future of HPV-related head and neck cancer care and could change how clinicians plan treatments—bringing us closer to a more precise and less invasive approach.

    47 min

  8. 19/08/2025

    Melanoma Breakthroughs: Immunotherapy, ROR2, and Ozuriftamab Vedotin

    Groundbreaking research presented at ASCO with Dr. Elinor Barsh, MD, and Dr. Jacob Keeling, MD, focuses on advances in immunotherapy for CTLA-4 resistant melanoma. This episode highlights the importance of recent progress, including the Phase I study of the antibody–drug conjugate ozuriftamab vedotin. Dr. Barsh and Dr. Keeling discuss new clinical trial data, evolving treatment pathways, and the significant reduction in mortality rates achieved with novel therapies. Their collaboration with the Sarah Cannon Research Institute underscores how innovative research can transform patient outcomes making melanoma more manageable despite its aggressive nature.

    54 min
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The MedInsights Unleashed Podcast aims to break down complex clinical data to provide insights from cutting-edge developments into tangible benefits for physicians, patients, and caregivers around the globe. Zee Ramji and John Collins will engage with leading global healthcare specialists to bring the latest groundbreaking therapies to you. To learn more about Zee and John, go deeper into each episode and access additional resources, go to https://medinsightsunleashed.com

Información

  • Creador
    MedInsights Unleashed
  • Años de actividad
    2024 - 2026
  • Episodios
    35
  • Clasificación
    Apto