I had heard about "This American Life" before from a friend who's into podcasts as I was.
And although I listen to podcasts almost everyday on my commutes, I tend to stick to the ones I've always listened to, and haven't had a chance to check them out.
Just recently, I'm starting a company, and as I googled away through tips and ideas, etc... I came accross this podcast, I wasn't sure what to expect, but it has blown me away.
It's such an honest podcast, with real struggles. It has helped me stay cheered up through tough times, and has given me some interesting ideas as well!
Regardless of your current entrepeneur status, it's a very good listen!