The Hamilton Morris Podcast

Hamilton Morris

Hamilton Morris creates and shares content with his followers on Patreon. These podcasts are released on this platform and on Youtube after first being posted on Patreon for a month or longer. The free versions of these conversations are made, in part, with the help of Hamilton's sponsors. Hope you enjoy!

  1. hace 1 día

    Discovering Ketamine with Dr. Edward Domino

    In this episode I sit down the arylcyclohexylamine legend Dr. Edward F. Domino to discuss his pioneering research on ketamine, his subsequent research on NMDA antagonists, and his first encounter with a patient who reported antidepressant activity from using ketamine. _______________ 100s of unreleased episodes available at patreon.com/hamiltonmorris Merchandise available at hamiltonmorris.com _______________ A big thank you for supporting my content:  Amentara - https://www.amentara.com A source for Amanita muscaria, kanna, kava, akuamma, and all your other ethnobotanical needs. Use discount code "HAMILTON" for 22% off! MUD\WTR - Start your new morning ritual & get 20% off your subscription or one-time purchase at https://mudwtr.com/HAMILTONMORRIS  #sponsored #mudwtrpod Lucy Tobacco-Free Nicotine - https://www.lucy.co Lucy's mission is to reduce tobacco-related harm to zero! Use discount code "HAMILTON" Matcha.com - https://matcha.com Andrew Weil MD's matcha tea, it's delicious! Use discount code "HAMILTON" for up to 20% off + a FREE gift! _______________ 0:00 Introduction & context 2:45 The discovery of ketamine 8:30 Phencyclidine derivatives & Parke-Davis 14:15 First human administration of ketamine 19:30 The testicle compression experiment 23:45 Initial impressions & anesthetic potential 28:15 Collaboration with psychiatrists at Lafayette Clinic 32:00 Ketamine as a model for schizophrenia 36:30 The missed antidepressant discovery 42:15 The patient who knew better 46:45 Regret & listening to patients 51:00 FDA approval & antidepressant recognition 55:30 John C. Lilly & Marsha Moore 59:00 R-ketamine vs S-ketamine 63:45 The right-hand form & less dissociation 68:30 The Cal Stevens patent scandal 74:00 Cal Stevens the medicinal chemist 79:00 A missed opportunity to meet Cal Stevens 83:15 The endogenous ligand question 87:45 Complex mechanisms of ketamine action 92:00 Sigma receptors & research opportunities 96:30 R-ketamine as the future direction 101:00 Career advice & getting funded 105:30 The importance of permission from your boss 109:15 LSD-25 & other opportunities 112:45 Final reflections on legacy & family Support the show

    49 min

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Hamilton Morris creates and shares content with his followers on Patreon. These podcasts are released on this platform and on Youtube after first being posted on Patreon for a month or longer. The free versions of these conversations are made, in part, with the help of Hamilton's sponsors. Hope you enjoy!

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