Theoretical Neuroscience Podcast

Gaute Einevoll
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The podcast focuses on topics in theoretical/computational neuroscience and is primarily aimed at students and researchers in the field.

  1. HACE 11 H

    On extracting spiking network models from experiments - with Richard Gao - #38

    While some models aim to explain qualitative features of brain activity, other aim to reproduce experimental data quantitatively. If so, model parameters must be adjusted to make the model predictions fit the experimental data. A complication is that in most neurobiological applications, there is not a unique best fit: many parameter combinations give equally good model fits. Recently, the guest, together with colleagues, made the tool AutoMIND to fit spiking network models to data.

    1 h y 36 min

  2. 31 ENE

    On reproducibility of modeling and 10 years with the Potjans-Diesmann network model - with Hans Ekkehard Plesser - #37

    Reproducibility is key for scientific progress. If research results cannot be reproduced and trusted, other researchers cannot build on them. Reproducibility is a challenge also in computational neuroscience, and today's guest has worked on how this can be remedied, for example, through standardized model description and model sharing. He also recently organised a workshop celebrating a decade with the (reproducible) Potjans-Diesmann neural network model, which has become an important community tool.

    1 h y 29 min

  3. 3 ENE

    On low-dimensional manifolds in motor cortex - with Sara Solla - #36

    Historically, the analysis of neural recordings focused on responses of single neurons recorded by single-contact electrodes. Modern electrodes with multiple electrode contacts can instead record spikes (action potentials) from hundreds of neurons simultaneously. Manifold analysis of the overall population activity of these neurons has become a critical tool for interpretation of such data. The podcast guest is a pioneer in the development and use of such analysis.

    2 h y 5 min

  4. 06/12/2025

    On modeling metabolic networks in the brain – with Polina Shichkova - #35

    Neurons need particular sodium and potassium concentration gradients across their membranes to function. These gradients are set up by so-called ion pumps which require energy stored in ATP molecules to run. ATP is the common energy currency in the brain and is produced from nutrients delivered by the blood by a complicated set of chemical reactions known as a metabolic network. Today's guest has just published a comprehensive model of such a network and explains how it can shed light on differences between young and brains.

    1 h y 32 min

  5. 08/11/2025

    On balanced neural networks - with Nicolas Brunel - #34

    An important discovery that has come out of computational neuroscience, is that cortical neurons in vivo appear to receive so-called balanced inputs. In the balanced state the excitatory and inhibitory synaptic inputs to a neuron are about equal, and action potentials occur when a fluctuation temporarily makes the excitation dominate. The theory, for example, explains the observed irregular firing of cortical neurons in the background state. Today's guest was one of the key developers of the theory in the late 1990s.

    1 h y 39 min

  6. 11/10/2025

    On computational neurotechnology for the clinic - with Anthony Burkitt, Nada Yousif & Esra Neufeld - #33

    How can computational neuroscience contribute to developing neurotechnology to help people with brain disorders and disabilities? This was the topic of a panel debate I hosted at the 34th Annual Computational Neuroscience Meeting in Florence in July this year. Electric or magnetic recording and/or stimulation are key clinical tools for helping patients, and the three panelists have all used computational methods to aid this endeavor.

    1 h y 1 min

  7. 13/09/2025

    On IIT and adversarial testing of consciousness theories - with Christof Koch - #32

    In an adversarial collaboration researchers with opposing theories jointly investigate a disputed topic by designing and implementing a study in a mutually agreed unbiased way. Results from adversarial testing of two well-known theories for consciousness, Global Neuronal Workspace Theory (GNWT) and Integrated Information Theory (IIT), were presented earlier this year. In this podcast one of the proponents and developers of IIT describes this candidate theory, and also the design of, and results from, the adversarial study.

    2 h y 18 min

  8. 16/08/2025

    On how to cure brain diseases - with Nicole Rust - #31

    A promise of basic neuroscience research is that the new insights will lead to new cures for brain diseases. But has that happened so far? Today's guest, an accomplished professor of neuroscience, decided to investigate. Her book "Elusive cures: why neuroscience hasn't solved brain disorders - and how we can change that" came out this summer. Here she argues that we need to consider the brain as a complex adaptive system, not as a chain of dominos as in the typical linear thinking.

    2 h y 13 min
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The podcast focuses on topics in theoretical/computational neuroscience and is primarily aimed at students and researchers in the field.

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