Core IM | Internal Medicine Podcast

Core IM Team

Core Internal Medicine via following series: 5 Pearls || Clinically relevant pearls Mind the Gap || Why do we do what we do? Gray Matters || Management Reasoning Hoofbeats || Dissecting clinical reasoning At the Bedside || Explore everyday challenges

  1. #211  Breaking Down MASLD vs. MASH and the MAESTRO-NASH & ESSENCE Trials: Beyond Journal Club Segment

    17 uur geleden

    #211 Breaking Down MASLD vs. MASH and the MAESTRO-NASH & ESSENCE Trials: Beyond Journal Club Segment

    MASLD affects nearly one in three adults worldwide, yet many patients remain undiagnosed until advanced fibrosis or cirrhosis develops. So, which patients should clinicians actually be screening? When is a FIB-4 enough, and when should we move to elastography or hepatology referral? And are we finally entering an era where we can meaningfully treat MASH? In this Beyond Journal Club episode, we unpack the evolving language of steatotic liver disease and take a close look at two major trials: MAESTRO-NASH studying resmetirom, the first FDA-approved liver-directed therapy for MASH, and ESSENCE, evaluating semaglutide in biopsy-confirmed disease. Along the way, we explore what these biopsy-based histologic endpoints really mean, why placebo responses were surprisingly high, and whether improvements in steatohepatitis and fibrosis will ultimately translate into better clinical outcomes for patients. This episode is for clinicians trying to understand where the field is headed, which patients deserve closer attention, and how metabolic liver disease is increasingly becoming part of everyday primary care and hospital medicine. 🔹Sponsor: Oakstone CME Use the code "CORE325" for 25% off: https://www.coreimpodcast.com/MKSAP  🔹Transcript and Shownotes:   01:57 | Understanding MASLD as a Systemic Disease  05:45 | MASLD vs MASH vs Met-ALD: Spectrum Steatotic Liver Disease  08:55 | How to Screen for Fibrosis (FIB-4 & FibroScan)  16:15 | Lifestyle Treatment & Weight Loss Targets  19:00 | ESSENCE Trial: Semaglutide for MASH  21:58 | MAESTRO-NASH Trial: Resmetirom  27:27 | Future Treatments for MASH  30:51 | Key Takeaways for Clinicians  Tags: CoreIM, Internal Medicine, Medical Education, Hepatology, Fatty Liver Disease, Metabolic Dysfunction Associated Steatohepatitis, Nonalcoholic Fatty Liver Disease, Liver Fibrosis Find the best disability insurance for you: https://www.patternlife.com/disability-insurance?campid=497840 Our Sponsors: * Check out Branch Basics and use my code branchbasics.com/COREIM for a great deal: https://branchbasics.com * Check out ElevenReader and use my code PODCAST for a great deal: https://elevenreader.io * Check out FIGS and use my code FIGSRX for a great deal: https://wearfigs.com * Check out Quince for high-quality clothes with affordable pricing and use code quince.com/coreim Advertising Inquiries: https://redcircle.com/brands Privacy & Opt-Out: https://redcircle.com/privacy

    34 min.
  2. #210 HTN in Dialysis: 5 Pearls Segment

    17 jun

    #210 HTN in Dialysis: 5 Pearls Segment

    What blood pressure should we target in patients on hemodialysis? Why volume control remains the foundation of treatment? How blood pressure targets differ from the general population. Learn practical pearls on medication timing around dialysis, drug dialyzability, antihypertensive selection, and strategies to prevent intradialytic complications while optimizing long-term outcomes.  🔹Sponsor: Search “Amazon Pharmacy Nationwide Home Delivery" in your EHR to get home delivery (often same-day). Learn more here.  🔹Transcript and Shownotes:   02: 19 | Pearl 1: Blood Pressure Targets  09: 40 | Pearl 2: Timing Medications and Dialyzability  15: 31 | Pearl 3 - Pharmacologic Management Nuances in Dialysis Patients  22: 57 | Putting It All Together: The Medication Hierarchy  Tags: CoreIM, Internal Medicine, Medical Education, Nephrology, ESRD, End-Stage Kidney Disease, Hypertension, Kidney Health, Dry Weight, Volume Overload Find the best disability insurance for you: https://www.patternlife.com/disability-insurance?campid=497840 Our Sponsors: * Check out Branch Basics and use my code branchbasics.com/COREIM for a great deal: https://branchbasics.com * Check out ElevenReader and use my code PODCAST for a great deal: https://elevenreader.io * Check out FIGS and use my code FIGSRX for a great deal: https://wearfigs.com * Check out Quince for high-quality clothes with affordable pricing and use code quince.com/coreim Advertising Inquiries: https://redcircle.com/brands Privacy & Opt-Out: https://redcircle.com/privacy

    26 min.
  3. #209 Dialysis and Fluid Management: 5 Pearls Segment

    10 jun

    #209 Dialysis and Fluid Management: 5 Pearls Segment

    Why is fluid management the most important part of dialysis care? This episode explores the fundamentals of hemodialysis, why ESKD patients have unique physiology, and how volume overload, not just hypertension, drives many complications. Learn practical pearls on dry weight, sodium restriction, diuretics, and the strategies that can reduce hospitalizations and improve patient outcomes.  🔹Sponsor: Oakstone CME Use the code "CORE325" for 25% off: https://www.coreimpodcast.com/MKSAP  🔹Transcript and Shownotes:   02:49 | Pearl 1: Foundations of Dialysis 09:21 | Pearl 2: Distinct Physiology 11:42 | Pearl 3: Why is fluid management so important? 19:43 | Pearl 4: Fluid Management Pro-tips 25:31 | Pearl 5: Diuretics in Patients with Residual Kidney Function Tags: CoreIM, Internal Medicine, Medical Education, Nephrology, Dialysis, End-stage kidney disease, Hypertension, Kidney Health, Dry Weight, Volume Overload Find the best disability insurance for you: https://www.patternlife.com/disability-insurance?campid=497840 Our Sponsors: * Check out Branch Basics and use my code branchbasics.com/COREIM for a great deal: https://branchbasics.com * Check out ElevenReader and use my code PODCAST for a great deal: https://elevenreader.io * Check out FIGS and use my code FIGSRX for a great deal: https://wearfigs.com * Check out Quince for high-quality clothes with affordable pricing and use code quince.com/coreim Advertising Inquiries: https://redcircle.com/brands Privacy & Opt-Out: https://redcircle.com/privacy

    32 min.
  4. #208 AI vs. Human with Post-Op AFib: Bread & Butter Series

    27 mei

    #208 AI vs. Human with Post-Op AFib: Bread & Butter Series

    Can AI manage post-op atrial fibrillation or does medicine still require human judgment? Using post-op AFib as a case study, we explore where algorithms help, where evidence falls short, and why clinical context still matters. When evidence is incomplete, and every patient is different, can AI truly practice medicine or only assist the clinicians who do? This episode explores the space between algorithms, uncertainty, and human judgment in modern medical care.  🔹Sponsor: Search “Amazon Pharmacy Nationwide Home Delivery" in your EHR to get home delivery (often same-day). Learn more here. 🔹Transcript and Shownotes:   02:51 | Broad workup for reversible causes and other etiologies of AFib that may occur post-op 05:10 | Considerations for management of post-op atrial fibrillation 13:00 | Stroke risk in atrial fibrillation 20:49 | Outpatient management of atrial fibrillation  25:54 | The role of AI in medical decision-making Tags: CoreIM, Internal Medicine, Medical Education, Atrial Fibrillation, Cardiology, Open Evidence Find the best disability insurance for you: https://www.patternlife.com/disability-insurance?campid=497840 Our Sponsors: * Check out Branch Basics and use my code branchbasics.com/COREIM for a great deal: https://branchbasics.com * Check out ElevenReader and use my code PODCAST for a great deal: https://elevenreader.io * Check out FIGS and use my code FIGSRX for a great deal: https://wearfigs.com * Check out Quince for high-quality clothes with affordable pricing and use code quince.com/coreim Advertising Inquiries: https://redcircle.com/brands Privacy & Opt-Out: https://redcircle.com/privacy

    29 min.
  5. #207 Is There a Doctor on Board? In-Flight Emergencies

    18 mei

    #207 Is There a Doctor on Board? In-Flight Emergencies

    We start with a gripping story of seizures and use it as a jumping-off point to unpack practical pearls for in-flight emergencies. Along the way: what’s actually in the emergency medical kit, when planes divert, how ground medical support works, altitude physiology, legal protections, and how to stay calm when medicine suddenly happens at 35,000 feet. By the end, you may still sweat a little…but hopefully less than before. 🔹Sponsor: Oakstone CME Use the code "CORE325" for 25% off: https://www.coreimpodcast.com/MKSAP  🔹Transcript and Shownotes:   04:40 | Emergency Medical Kit (EMK) Standard Contents 08:50 | Role of Ground-Based Medical Support & Flight Diversion Decision-Making 19:35 | Interpreting Hypoxia at Altitude 22:06 | In-Flight Liability 23:35 | Common Chief Concerns & Useful Additional Medications 24:53 | How to Be Resourceful in an Austere Environment Tags: CoreIM, Internal Medicine, Medical Education, In-flight Care, Medical Emergencies, Clinical Reasoning, Seizure Management, Hypoxia, Airway Management, Cardiac Emergency, Syncope, Respiratory Distress Find the best disability insurance for you: https://www.patternlife.com/disability-insurance?campid=497840 Our Sponsors: * Check out Branch Basics and use my code branchbasics.com/COREIM for a great deal: https://branchbasics.com * Check out ElevenReader and use my code PODCAST for a great deal: https://elevenreader.io * Check out FIGS and use my code FIGSRX for a great deal: https://wearfigs.com * Check out Quince for high-quality clothes with affordable pricing and use code quince.com/coreim Advertising Inquiries: https://redcircle.com/brands Privacy & Opt-Out: https://redcircle.com/privacy

    28 min.
  6. #206 Eosinophilia: 5 Pearls Segment

    28 apr

    #206 Eosinophilia: 5 Pearls Segment

    Can you distinguish benign eosinophilia from a sign of serious disease, and know exactly when to act at the bedside? In this high-yield episode, test your clinical reasoning as we tackle: When eosinophilia becomes dangerous and why it mattersHow to distinguish if its from atopy vs. systemic diseaseWhich medications to stop (and which to watch)How travel, diet, and exposure history shape your workupWhen to suspect malignancy before giving steroids 🔹Transcript and Shownotes:  02:34 | Why Do We Care About Eosinophilia? (Pearl 1) 10:24 | Atopy and Eosinophilia (Pearl 2) 18:57 | Drugs and Eosinophilia (Pearl 3) 27:29 | ID and Eosinophilia (Pearl 4) 33:54 | Pearl 5: Eosinophilia, Steroids, and Neoplasms (Pearl 5) Tags: CoreIM, Internal Medicine, Medical Education, Eosinophilia, Hypereosinophilia, Allergy Immunology, Hematology, Pulmonology, Parasitic Infections, Atopy Find the best disability insurance for you: https://www.patternlife.com/disability-insurance?campid=497840 Our Sponsors: * Check out Branch Basics and use my code branchbasics.com/COREIM for a great deal: https://branchbasics.com * Check out ElevenReader and use my code PODCAST for a great deal: https://elevenreader.io * Check out FIGS and use my code FIGSRX for a great deal: https://wearfigs.com * Check out Quince for high-quality clothes with affordable pricing and use code quince.com/coreim Advertising Inquiries: https://redcircle.com/brands Privacy & Opt-Out: https://redcircle.com/privacy

    43 min.
  7. #205 Nutrition Studies, Coffee and the CRAVE Trial: Beyond Journal Club with the NEJM Group

    15 apr

    #205 Nutrition Studies, Coffee and the CRAVE Trial: Beyond Journal Club with the NEJM Group

    Is coffee helping or harming our patients’ hearts? In this Beyond Journal Club, we unpack the CRAVE trial and use it as a lens to answer a bigger question: How should clinicians interpret nutrition research, especially when it feels inconsistent or hard to trust? Listen for a concise, practical framework you can use the next time a patient asks about coffee, diet, or lifestyle. 🔹Sponsor: Oakstone CME Use the code "CORE325" for 25% off: https://www.coreimpodcast.com/MKSAP  🔹 Transcript and Show notes 00:00 | Challenges of interpreting nutritional research. 02:22 | Best practices for evaluating studies in nutrition.  12:35 | Delve into the CRAVE trial as an example of critically appraising nutritional investigations. 26:41 | Applying this to clinical practice for your patients. Tags: IMCore, Internal Medicine, Medical Education, Epidemiology, Diet and Lifestyle Find the best disability insurance for you: https://www.patternlife.com/disability-insurance?campid=497840 Our Sponsors: * Check out Branch Basics and use my code branchbasics.com/COREIM for a great deal: https://branchbasics.com * Check out ElevenReader and use my code PODCAST for a great deal: https://elevenreader.io * Check out FIGS and use my code FIGSRX for a great deal: https://wearfigs.com * Check out Quince for high-quality clothes with affordable pricing and use code quince.com/coreim Advertising Inquiries: https://redcircle.com/brands Privacy & Opt-Out: https://redcircle.com/privacy

    32 min.

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Core Internal Medicine via following series: 5 Pearls || Clinically relevant pearls Mind the Gap || Why do we do what we do? Gray Matters || Management Reasoning Hoofbeats || Dissecting clinical reasoning At the Bedside || Explore everyday challenges

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