The College of Glycation with Dr. Paul Reynolds

Paul Reynolds

The College of Glycation with Dr. Paul Reynolds explores how sugar impacts aging, health, and disease. Join Dr. Reynolds as he unpacks the science of glycation and AGEs through expert interviews, myth-busting insights, and practical takeaways. Whether you're a health professional or simply curious, this podcast brings clarity to the sticky world of sugar metabolism. New episodes weekly.

  1. Glycated LDL and Cardiovascular Health

    5 dgn geleden

    Glycated LDL and Cardiovascular Health

    In this episode of the College of Glycation, Professor Paul Reynolds challenges the decades-old story that heart disease risk is simply a matter of lowering your LDL cholesterol number. He explains how glycation — driven by glucose, fructose, and especially methylglyoxal — chemically modifies LDL particles, turning ordinary LDL into small, dense, sticky versions with defaced apoB that the liver can no longer clear efficiently. These modified particles are instead taken up by scavenger receptors on macrophages, creating foam cells that build atherosclerotic plaque. At the same time, high blood sugar and glycated LDL strip away the protective endothelial glycocalyx, the slippery non-stick coating that normally keeps LDL particles from sticking to artery walls, creating a self-reinforcing vicious cycle of damage and inflammation mediated by RAGE.Drawing on key studies showing that methylglyoxal alone can convert LDL into its most atherogenic form, that blocking RAGE dramatically reduces plaque even without lowering glucose or lipids, and that modified LDL in circulation predicts real cardiovascular events, Reynolds reframes heart disease as a metabolic and glycation problem rather than purely a cholesterol quantity problem. The practical takeaway is clear: instead of obsessing only over the LDL number, focus on tightening glucose control, reducing sugar and fructose load, and using the triglyceride-to-HDL ratio as a readily available proxy for the small, dense, glycation-prone LDL particles that actually drive disease. The most powerful protection for your heart comes from controlling the chemistry that turns normal LDL into a weapon. Paul’s favorite yerba mate: https://unicity.link/121f260bfe   Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds   For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds   Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.   Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb   Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)   Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)

    21 min.
  2. Leaky Gut Meets RAGE

    24 jun

    Leaky Gut Meets RAGE

    In this episode of the College of Glycation, Professor Paul Reynolds reveals how glycation and leaky gut don’t just coexist — they actively multiply each other’s damage. A diet high in heat-generated advanced glycation end-products (AGEs) reshapes the gut microbiome, weakens the intestinal barrier, and allows bacterial lipopolysaccharide (LPS) to leak into the bloodstream in a state called metabolic endotoxemia. At the same time, elevated glucose and dietary AGEs keep the RAGE receptor constantly engaged. Because RAGE and TLR4 (the LPS receptor) physically interact and upregulate one another in a feed-forward loop, the leaked LPS lands on an immune system that glycation has already primed — dramatically amplifying inflammation and insulin resistance through shared NF-κB signaling.Drawing on landmark studies from Cani, Qu, Snelson & Coughlan, Yan, Uribarri, and others, Reynolds shows that this synergy is not additive but multiplicative. The same modern dietary pattern that generates AGEs also opens the door for LPS and then lowers the threshold for its inflammatory effects. Practical takeaways include shifting to gentler, moisture-based cooking methods to slash dietary AGEs, feeding butyrate-producing bacteria with fiber and dairy fats to strengthen tight junctions, and controlling blood glucose and insulin to disengage RAGE and raise the inflammatory threshold. Ultimately, glycation is reframed not merely as tissue damage, but as a recalibration of immune judgment — turning an ordinary bacterial leak into the spark that meets the gasoline. Paul’s favorite yerba mate: https://unicity.link/121f260bfe   Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds   For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds   Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.   Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb   Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)   Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)

    23 min.
  3. Glycocalyx and the Role of Glycation

    17 jun

    Glycocalyx and the Role of Glycation

    In this episode of the College of Glycation, Paul Reynolds flips the script on sugar. While glycation is usually portrayed as the villain that damages proteins, lipids, and DNA through advanced glycation end products, today he reveals a place where sugar is actually the hero: the glycocalyx. This dense, gel-like sugar coat covers nearly every cell in your body, with its most important version lining the inside of all your blood vessels like an invisible protective forest.Paul explains the structure of the glycocalyx, its surprising thickness, and its four critical roles as a selective filter, a shear-stress sensor that triggers nitric oxide release, a physical and electrical barrier against clotting and inflammation, and a non-stick coating for smooth blood flow. He then shows how high blood sugar rapidly destroys this layer—halving its volume in just six hours through oxidative stress and the AGE-RAGE pathway that activates heparanase. The breakdown of the glycocalyx appears to be one of the earliest events in vascular dysfunction, atherosclerosis, and kidney disease, while also contributing to leaky gut. The solution, Paul argues, is the same approach that protects the rest of the body: keeping blood glucose stable and low so the cell can build and maintain this life-saving sugar coat instead of tearing it down.Paul’s favorite yerba mate: https://unicity.link/121f260bfe Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)

    23 min.
  4. Adipose Glycation and Fat Cell Hypertrophy

    10 jun

    Adipose Glycation and Fat Cell Hypertrophy

    Podcast Episode Description:In this eye-opening episode of the College of Glycation, Professor Paul Reynolds explores adipose glycation — the hidden process where fat cells themselves become chemically modified by sugar, turning them into drivers of metabolic dysfunction. Far from being passive storage tanks, hypertrophic adipocytes generate their own glycating agents like methylglyoxal (MGO), activating the AGE-RAGE axis, inflammation, hypoxia, and fibrosis. This creates a self-reinforcing loop that promotes insulin resistance, cytokine release, and impaired fat expandability — explaining why fat cell size and behavior matter far more than total body fat.Drawing on key studies, Reynolds connects the dots between chronic hyperinsulinemia, fructose intake, RAGE-driven hypertrophy, and the breakdown of healthy adipose remodeling. The episode reveals why some people develop metabolic disease at lower BMIs and offers practical, empowering strategies: lower insulin through carb restriction and time-restricted eating, minimize fructose, support the glyoxalase system, and stay active to keep fat cells healthy and quiet. A must-listen for anyone interested in body composition, inflammation, and breaking the cycle of metabolic illness.Paul’s favorite yerba mate: https://unicity.link/121f260bfe Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)

    24 min.
  5. GLP-1 Beyond Glucose

    3 jun

    GLP-1 Beyond Glucose

    In this eye-opening episode of the College of Glycation, biomedical scientist and Professor of Cell Biology Paul Reynolds goes beyond the headlines on the blockbuster GLP-1 receptor agonists—semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound). While everyone talks about dramatic weight loss, Reynolds reveals what these drugs are actually doing at the cellular level: directly downregulating the RAGE receptor, suppressing AGE-induced inflammation, and powerfully activating autophagy. Drawing on landmark trials like SELECT (which showed a 20% drop in major cardiovascular events even in people without diabetes), he demonstrates how these benefits stem from four overlapping anti-glycation mechanisms that go far deeper than glucose control or appetite suppression. Reynolds walks listeners through the full family of incretin therapies, the science of the dangerous AGE-RAGE-NF-κB axis, and how GLP-1 agonists restore cellular recycling by shifting the AMPK-mTOR balance—clearing damaged, glycated proteins in ways that explain their impressive tissue-protective effects. He closes with a balanced, practical perspective: these are powerful pharmacologic tools that mimic healthy metabolic states, but they work best as temporary bridges to real food, movement, sleep, and fasting rather than lifelong crutches. If you want to truly understand why metabolic dysfunction drives chronic disease—and what the GLP-1 story teaches us about fixing it at the root—this episode is essential listening. Paul’s favorite yerba mate: https://unicity.link/121f260bfe   Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds   For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds   Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount.   Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb   Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20)   Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)

    26 min.
  6. Autophagy and Glycation

    27 mei

    Autophagy and Glycation

    In this episode of the College of Glycation, Dr. Paul Reynolds explores autophagy—one of the body’s most powerful yet underappreciated defenses against aging. Autophagy, the Nobel Prize-winning cellular “self-eating” process, allows cells to identify, package, and recycle damaged proteins, dysfunctional mitochondria, misfolded molecules, and glycated junk before they mature into advanced glycation end-products (AGEs). These sugar-modified compounds stiffen tissues, impair insulin signaling, promote inflammation, and accelerate chronic disease. Dr. Reynolds explains how constant eating and elevated insulin keep autophagy suppressed, trapping cells in perpetual “build and store” mode and allowing glycation damage to accumulate.Intermittent fasting changes everything by lowering insulin, suppressing mTOR, and activating AMPK—triggering the metabolic switch that rapidly ramps up autophagy and delivers a true glycation reset. Drawing on landmark research, Dr. Reynolds shows how even short fasting windows (like 16:8) can clear glycated proteins, improve metabolic health, and support cellular renewal. He offers practical, step-by-step guidance for beginners through advanced fasters, while clearly outlining who should avoid fasting and how to combine it with smart eating and exercise for maximum benefit. This episode delivers the science and the actionable strategy to harness your body’s built-in cellular housekeeping system.Paul’s favorite yerba mate: https://unicity.link/121f260bfe Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)

    20 min.
  7. The Sugar Diet and Glycation

    20 mei

    The Sugar Diet and Glycation

    In this episode of the College of Glycation, Dr. Paul Reynolds takes a clear-eyed look at the viral “sugar diet” trend sweeping social media — where people are eating bowls of sugar, drinking large amounts of fruit juice and honey, and eliminating fat while claiming major improvements in energy, mood, and metabolism. He asks the question almost no one else is asking: what does this dietary pattern actually do to glycation? Drawing on peer-reviewed research, Dr. Reynolds explains why fructose is dramatically more glycating than glucose, how it drives rapid methylglyoxal formation and advanced glycation end product (AGE) accumulation, and why even short-term high-fructose intake can increase liver fat, visceral adiposity, and insulin resistance within days to weeks.While acknowledging the real short-term effects some people experience (such as feeling warmer or more energetic), Dr. Reynolds shows why these acute benefits do not reflect long-term safety. He highlights the critical gap between normal fasting glucose and hidden glycation damage, the complete lack of long-term clinical trials on sugar-dominant diets, and why this approach ultimately maximizes the very biochemical pathways that accelerate tissue aging, vascular stiffening, and chronic disease. The episode offers a science-based alternative perspective for anyone prioritizing metabolic health and longevity over trending dietary extremes.Paul’s favorite yerba mate: https://unicity.link/121f260bfe Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)

    18 min.
  8. Fermentation and Glycation

    13 mei

    Fermentation and Glycation

    In this episode of the College of Glycation, Dr. Paul Reynolds reveals why traditional fermented foods—staples of every human culture for thousands of years—may be one of the most powerful, yet underused tools for lowering your glycation burden and resetting metabolic health. He explains how fermentation pre-digests sugars, delivers living microbes and bioactive compounds (lactic acid, acetic acid, short-chain fatty acids, and peptides), and counteracts the modern Western diet’s relentless drive toward advanced glycation end products (AGEs), chronic inflammation, and insulin resistance.Drawing on landmark research including the 2021 Stanford study, Dr. Reynolds walks through the five key mechanisms by which real fermented foods boost gut microbial diversity, blunt post-meal glucose spikes, inhibit AGE formation and RAGE signaling, improve insulin sensitivity, and strengthen the intestinal barrier. He also shares a clear, practical protocol: which foods matter most, how much to eat, smart timing strategies, and important cautions for getting the maximum benefit. If you’re serious about reducing glycation and reclaiming the metabolic protection our ancestors took for granted, this episode shows you exactly how to make fermented foods a daily, non-negotiable habit.Paul’s favorite yerba mate: https://unicity.link/121f260bfe Yerbe mate with a special formulated Balance fiber: https://ufeelgreat.com/c/PaulReynolds For the full Metabolic System storefront: https://shop.unicity.com/paulreynolds Paul’s favorite source for clean, earth-sourced essentials such as salt, electrolytes, hydration, pre-workout and more. Go to https://redmond.life and use PAULSALT for 15% discount. Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/products/go-bhb Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other products)

    23 min.
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The College of Glycation with Dr. Paul Reynolds explores how sugar impacts aging, health, and disease. Join Dr. Reynolds as he unpacks the science of glycation and AGEs through expert interviews, myth-busting insights, and practical takeaways. Whether you're a health professional or simply curious, this podcast brings clarity to the sticky world of sugar metabolism. New episodes weekly.

Informatie

  • Maker
    Paul Reynolds
  • Jaren actief
    2025 - 2026
  • Afleveringen
    62
  • Beoordeling
    Veilig
  • Copyright
    © Paul Reynolds
  • Website van aflevering
    The College of Glycation with Dr. Paul Reynolds
  • Provider

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