Peptides and Longevity: Redefining Aging and Transforming Health with Dr. Kent Holtorf

Kent Holtorf, MD

Join Dr. Kent Holtorf as he explore groundbreaking science, innovative therapies, and the future of health and aging. In each episode, he dives deep into the world of peptides—potent molecules that regulate immune function, boost cellular regeneration and optimize metabolism. Through conversations with leading experts, Dr. Holtorf explains how peptides differ from traditional hormones, their role in reversing chronic illness, and their potential to enhance sleep, brain function, and overall vitality. https://holtorfmed.com/ https://integrativepeptides.com/

  1. 1 DAY AGO

    Making the Connection - Looking at Unconventional Patterns to Solve Autoimmune Disorders

    Reversing autoimmunity isn’t about chasing perfect lab numbers. It’s about teaching your immune system how to find balance again. In this episode of Peptides and Longevity, Elizabeth Tringali joins us to reveal how small, strategic steps like the right peptides, detox support, and food choices can quiet flares, rebuild energy, and help you feel like yourself again. ---- Elizabeth Tringali is a Board-Certified Physician Assistant and a Diplomate of the American Academy of Anti-Aging Medicine. A graduate of the University of Florida, she began her career in nutrition science and research with the Women’s Health Initiative, an experience that shaped her lifelong passion for holistic, patient-centered care. Blending her roots in nutrition with advanced training in anti-aging and regenerative medicine, she has spent more than two decades helping patients uncover the root causes of fatigue, hormone imbalance, and autoimmune conditions. Known for combining natural therapies with cutting-edge medical innovations, she creates personalized healing plans that restore energy, balance, and long-term wellness. ---- Elizabeth Tringali, PA-C Website: tringali-health.com Instagram: instagram.com/etringali Facebook: facebook.com/elizabeth.tringali.2025/ LinkedIn: linkedin.com/in/elizabeth-tringali-pa-c-0010a523 ---- Holtorf Medical Group Website: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://holtorfmed.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/holtorfmed/⁠⁠⁠⁠⁠⁠⁠⁠⁠ Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/holtorfmedicalgroup/⁠⁠⁠⁠⁠⁠⁠⁠⁠ ---- Kent Holtorf, MD YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠⁠⁠⁠⁠⁠⁠⁠ ---- Produced by DrTalks ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠

    1h 34m

  2. 5 NOV

    An Intro to Biohacking and Psychedelics

    In this episode of Peptides & Longevity, Dr. Kent Holtorf speaks with Dr. Sanjeev Goel, a Toronto-based biohacker and longevity expert. They explore how psychedelics, peptides, and data-driven therapies are transforming health, performance, and aging—revealing what’s next in the science of self-optimization. Born in Montreal and now based in Toronto, Dr. Goel’s journey has been far from conventional. With over five decades of lived experience and a résumé that spans remote medical service in Himalayan villages to teaching mindfulness to healthcare professionals, his voice carries both wisdom and credibility. His biological age is a full ten years younger than his chronological one, a living testament to the anti-aging practices he preaches. But his path hasn’t been without hardship. In 2019, a severe Lyme-like illness brought him face-to-face with his own mortality. The experience sparked a deeper commitment to healing, self-exploration, and science-backed rejuvenation. Sanjeev Goel, MD Website: https://www.sanjeevgoel.com/  YouTube: https://www.youtube.com/channel/UCVLk0UmBqWSiUU3SFKrFtig  Instagram: https://www.instagram.com/drsanjeevgoel  Facebook: https://www.facebook.com/drsanjeevgoel/ ---- Holtorf Medical Group Website: ⁠⁠⁠⁠⁠⁠⁠⁠https://holtorfmed.com/⁠⁠⁠⁠⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/holtorfmed/⁠⁠⁠⁠⁠⁠⁠⁠ Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/holtorfmedicalgroup/⁠⁠⁠⁠⁠⁠⁠⁠ ---- Kent Holtorf, MD YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠⁠⁠⁠⁠⁠⁠ ---- Produced by DrTalks ⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠

    56 min

  3. 29 OCT

    Living Libido Loca! Supercharge Your Libido at Any Age

    Reignite your libido from the inside out—no shame, no guesswork. In this episode of Peptides and Longevity, Dr. Valerie Phillips joins us to uncover what really drives desire. She shares how rebalancing your hormones, optimizing sleep, calming stress, and even healing your gut and pelvic floor can reignite libido, naming certain peptides may be the missing piece to bringing your passion back. Loss of desire isn’t a life sentence—it’s your body’s way of asking for balance. In this episode of Peptides and Longevity, Dr. Valerie Phillips reveals how she helps women reignite passion by looking beyond hormones to the deeper story unfolding inside the body. She explores what happens when communication between mind, metabolism, and mood breaks down—and how restoring that dialogue can transform not only energy and confidence, but connection itself. Tune in to hear what most people overlook when libido fades: subtle shifts in stress chemistry, sleep cycles, gut health, and emotional health that quietly drain vitality. Dr. Phillips shares how small, strategic adjustments can unlock a natural return of desire, showing that when your body feels safe, nourished, and rested, passion often follows. The takeaway: it’s not about chasing youth—it’s about rediscovering the spark that balance brings naturally. Valerie Phillips, ND (Dr. Val) is a native Angelino who started studying the medical arts as a teenager in Magnet School. She studied Biochemistry at U.C. Davis, and subsequently pursued research in Neuro-Pathology at U.C. San Francisco. She also volunteered at the Berkeley Free Clinic and at the Native American Health Center in San Francisco, and became a “lay healthcare worker,” delivering limited primary care services to the underserved populations of the San Francisco Bay area. Based on this experience, Dr. Val decided to pursue her long term interest in eastern and alternative forms of Medicine by pursuing a Naturopathic Medical degree at Bastyr University in Kenmore, WA. The education was the perfect blend of western scientific medical thought combined with herbal traditions from across the globe, nutrition, physical medicine and many more disciplines designed to train physicians to see all the aspects of the human body as a holistic unit. Valerie Phillips, ND Facebook: https://www.facebook.com/ValeriePhillipsND ---- Holtorf Medical Group Website: ⁠⁠⁠⁠⁠⁠⁠https://holtorfmed.com/⁠⁠⁠⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠⁠⁠⁠https://www.facebook.com/holtorfmed/⁠⁠⁠⁠⁠⁠⁠ Instagram: ⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/holtorfmedicalgroup/⁠⁠⁠⁠⁠⁠⁠ ---- Kent Holtorf, MD YouTube: ⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠⁠⁠⁠⁠⁠ ---- Produced by DrTalks ⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠

    1h 14m

  4. 22 OCT

    The Underpinnings of Aging and What to Do About It

    The secret to living better for longer starts with removing the cells that make you old. In this episode of Peptides and Longevity, Dr. Joe Cleaver pulls back the curtain on senolytics, showing how to clear senescent cells and build you back up with mitochondria, hormones, and targeted peptides. Want to age in reverse? Start by clearing out the cells making you old. In this episode of Peptides and Longevity, Dr. Joe Cleaver reframes longevity around one simple idea, which is that you remove what ages you and then rebuild what keeps you young. He explains how senescent cells accumulate, why they become inflammatory factories, and how fasting and senolytics can clear the backlog. He then shows how to protect and upgrade mitochondria, why telomeres work as a useful marker rather than a destiny, and where peptides belong. The result is a stepwise, precision plan that starts with clearance, moves into cellular energy, and finishes with targeted repair for brain, skin, hair, and whole-body performance. Watch the full episode now and learn how to start clearing the cells that make you old. Dr. Joseph Cleaver is a board-certified internist and fellow in anti-aging and metabolic medicine who blends preventive lifestyle medicine, regenerative therapeutics, and peptide science. He teaches clinicians nationwide and sees patients through the Paradigm Wellness Medical Group. He also hosts small-group masterminds on longevity and regenerative medicine at his winery in Sonoma. Dr. Joseph Cleaver Website: www.pwmgmed.com Integrative Peptides Website: ⁠⁠⁠⁠⁠⁠https://integrativepeptides.com/⁠⁠⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠⁠⁠https://www.facebook.com/integrativepeptidesofficial/⁠⁠⁠⁠⁠⁠ Instagram: ⁠⁠⁠⁠⁠⁠https://www.instagram.com/integrativepeptides/⁠⁠⁠⁠⁠⁠ ---- Holtorf Medical Group Website: ⁠⁠⁠⁠⁠⁠https://holtorfmed.com/⁠⁠⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠⁠⁠https://www.facebook.com/holtorfmed/⁠⁠⁠⁠⁠⁠ Instagram: ⁠⁠⁠⁠⁠⁠https://www.instagram.com/holtorfmedicalgroup/⁠⁠⁠⁠⁠⁠ ---- Kent Holtorf, MD YouTube: ⁠⁠⁠⁠⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠⁠⁠⁠⁠ ---- Produced by DrTalks ⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠

    1h 3m

  5. 15 OCT

    Healing the Sick of the Sick: Inside Dr. Crozier’s Approach

    Tried everything and still sick? This protocol could finally move the needle. In this episode of Peptides and Longevity, Dr. Gordon Crozier reveals how he helped patients with complex chronic conditions recover using specific peptides paired with ozone, amino acid therapy, and detoxification strategies that reset the body from the inside out. What happens when even the top hospitals can’t help? In this episode of Peptides and Longevity, Dr. Gordon Crozier discusses how he takes on the ‘sick of the sick’ using a cellular approach that rebuilds health from the inside out. He delves into how he combines peptides with ozone, amino acid therapy, and phosphatidylcholine to help calm neuroinflammation and restore balance where medicine left off. Dr. Crozier also reveals why advanced tests often tell the story traditional tests miss—and how timing, pulsing, and persistence turn short-term improvements into lasting recovery. Dr. Gordon Crozier is the owner and medical director of Crozier Clinic, a leading genetics-based center specializing in peptides, hormone optimization, and advanced diagnostics. A former neurology and neurosurgery clinician, he combines deep neurological insight with personalized, regenerative protocols. As a faculty member and peptide educator for A4M and the International Peptide Society, he has trained hundreds of practitioners nationwide. He’s also the author of Healing One Cell at a Time, Ticked Off, and Heal Your Cells. Save Your Life., and continues to pioneer innovative, compassionate care in chronic illness and longevity medicine. ----- Dr. Gordon Crozier Website: www.crozierclinic.com Instagram: www.instagram.com/drgordoncrozier Facebook: www.facebook.com/DrCrozier Integrative Peptides Website: ⁠⁠⁠⁠⁠https://integrativepeptides.com/⁠⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠⁠https://www.facebook.com/integrativepeptidesofficial/⁠⁠⁠⁠⁠ Instagram: ⁠⁠⁠⁠⁠https://www.instagram.com/integrativepeptides/⁠⁠⁠⁠⁠ ---- Holtorf Medical Group Website: ⁠⁠⁠⁠⁠https://holtorfmed.com/⁠⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠⁠https://www.facebook.com/holtorfmed/⁠⁠⁠⁠⁠ Instagram: ⁠⁠⁠⁠⁠https://www.instagram.com/holtorfmedicalgroup/⁠⁠⁠⁠⁠ ---- Kent Holtorf, MD YouTube: ⁠⁠⁠⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠⁠⁠⁠ ---- Produced by DrTalks ⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/⁠

    1h 22m

  6. 8 OCT

    Secrets to Fatigue, Brain Fog, Mood Disorders, Chronic Pain

    This protocol helps even the most sensitive patients move forward. In this episode of Peptides and Longevity, Dr. Christopher Wakely joins us to lay out a roadmap for complex chronic illness that involves opening detox pathways, restoring immune tolerance, and tackling infections and toxins. Watch now to get practical tips on reading basic tests and knowing when to add peptides, neural therapy, ozone, hypercoagulation support, and even strategies for kids with PANS/PANDAS. ----- Still stuck? This doctor’s roadmap skips the guesswork. In this episode of Peptides and Longevity, Dr. Christopher Wakely joins us to share a clear plan for tackling complex chronic illness. He explains why treatment must start by ‘opening the drains’ or helping the liver, gut, kidneys, and brain move toxins out. He also shows how simple labs and natural killer cell testing can guide what to treat first, saving time and money. Dr. Wakely also dives into restoring immune balance, using binders safely, and choosing the right tools at the right time. You will hear about drainage remedies, herbs, neural therapy, peptides, ozone, and other strategies designed to help patients heal without big flares. If you’ve felt stuck or flared with every new protocol, this episode is for you. ----- Dr. Christopher Wakely is a naturopathic physician and the owner of Aster Integrative Medicine in Edmonds, Washington. Known for helping patients who have seen countless doctors without answers, he specializes in complex chronic illness, including tick-borne diseases, mycotoxin illness, chemical sensitivity, and autoimmune conditions. Dr. Wakely blends the best of conventional and naturopathic care. His approach includes targeted detox and drainage, immune system retraining, herbal and homeopathic therapies, peptides, nutritional support, and, when needed, pharmaceuticals—always to help patients heal safely and sustainably. When he’s not in the clinic, he enjoys life in Seattle with his wife and two daughters, hiking, weightlifting, reading, and cheering on the Boston Red Sox. ----- Christopher Wakely, ND Website: https://www.drwakely.com/ LinkedIn: https://www.linkedin.com/in/christopher-wakely-8a906369/ ----- Integrative Peptides Website: ⁠⁠⁠https://integrativepeptides.com/⁠⁠⁠ Facebook: ⁠⁠⁠https://www.facebook.com/integrativepeptidesofficial/⁠⁠⁠ Instagram: ⁠⁠⁠https://www.instagram.com/integrativepeptides/⁠⁠⁠ ---- Holtorf Medical Group Website: ⁠⁠⁠https://holtorfmed.com/⁠⁠⁠ Facebook: ⁠⁠⁠https://www.facebook.com/holtorfmed/⁠⁠⁠ Instagram: ⁠⁠⁠https://www.instagram.com/holtorfmedicalgroup/⁠⁠⁠ ---- Kent Holtorf, MD YouTube: ⁠⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠⁠ ---- Produced by DrTalks ⁠⁠⁠https://drtalks.com/podcast-service/

    1h 8m

  7. 1 OCT

    The Metabolic Code®: A Roadmap to Real Results

    If your protocol isn’t working, you might be starting in the wrong place. In this episode of Peptides and Longevity, Dr. Kelly Halderman joins us to explain how the Metabolic Code® helps decode your unique biochemistry into simple TRIADS™, revealing where to focus first so protocols don’t stall. She shares her personal recovery story and the often-missed detox step that opens up healing and turns scattered data into an actionable plan. ---- If your detox isn’t working, it might be your bile. Here’s how to fix it. In this episode of Peptides and Longevity, Dr. Kelly Halderman shows how the Metabolic Code® combines symptom questionnaires with key tests to map five interconnected TRIADS™ in the body. This map gives patients and clinicians a clear starting point, helps target the right nutraceuticals and peptides, and provides measurable feedback so progress doesn’t feel like guesswork. Dr. Halderman also shares her own journey from being bedridden and misdiagnosed to reclaiming her health through nutrition, detox, and root-cause thinking. One of her biggest breakthroughs is fixing bile flow to reopen the body’s toxin highways and reduce systemic inflammation. With better detox and precise personalization, patients can stop spinning their wheels, and practitioners can finally deliver the results they’ve been chasing. ---- Dr. Kelly Halderman is a physician and clinical nutritionist with a uniquely broad background in medicine, research, and nutraceutical innovation. She currently serves as Chief Health Officer at Weo. Her career includes academic roles such as adjunct professor at North Central University and instructor for the American Heart Association, as well as advanced training in functional neurology, plant-based nutrition, and neurofeedback. Dr. Halderman earned her MD from SABA University School of Medicine, completed family practice training at the University of Minnesota, and holds a Doctorate in Clinical Nutrition. Passionate about translating complex science into actionable care, she is known for making precision health accessible and helping both patients and practitioners move beyond guesswork toward measurable, personalized results. ---- Kelly Halderman, DCN Website: https://drkellyhalderman.com/ Instagram: https://www.instagram.com/nutraceuticalformulators/ LinkedIn: https://www.linkedin.com/in/dr-kelly-halderman-b8253346/ ----- Integrative Peptides Website: ⁠⁠https://integrativepeptides.com/⁠⁠ Facebook: ⁠⁠https://www.facebook.com/integrativepeptidesofficial/⁠⁠ Instagram: ⁠⁠https://www.instagram.com/integrativepeptides/⁠⁠ ---- Holtorf Medical Group Website: ⁠⁠https://holtorfmed.com/⁠⁠ Facebook: ⁠⁠https://www.facebook.com/holtorfmed/⁠⁠ Instagram: ⁠⁠https://www.instagram.com/holtorfmedicalgroup/⁠⁠ ---- Kent Holtorf, MD YouTube: ⁠⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠⁠ ---- Produced by DrTalks ⁠⁠https://drtalks.com/podcast-service/

    44 min

  8. 24 SEPT

    The Brain and Gut Connection

    Leaky gut isn’t just about digestion—it’s also messing with your brain. In this episode of Peptides and Longevity, Kiran Krishnan, a research microbiologist, breaks down the gut–brain connection and why a leaky gut can fuel inflammation, brain fog, and mood issues. He also reveals groundbreaking research on spore-based probiotics—how they repair the gut lining, calm inflammation, and may even help reprogram metabolism for better energy and body composition. ----- A mass extinction is happening inside your gut—and it’s fueling everything from brain fog to autoimmunity. In this episode of Peptides and Longevity, Kiran Krishnan explains why the microbiome is not just trillions of organisms, but a vast genetic toolkit that powers most of our body’s chemistry. He warns that modern living is driving a ‘mass extinction’ of gut species, weakening immune training, fueling leaky gut, and setting the stage for allergies, autoimmunity, and chronic illness. Krishnan then connects the dots to the brain, showing how toxins from a leaky gut trigger inflammation, brain fog, mood issues, and even neurodegeneration. He shares evidence on how spore-based probiotics restore gut diversity, strengthen keystone species, repair the gut barrier, and lower inflammatory markers—sometimes in as little as a month. Krishnan also highlights a pilot study where spores and prebiotics reduced visceral fat and improved insulin health without diet changes, pointing to true ‘metabolic reprogramming.’ He wraps up with a reality check on overhyped probiotics and testing, urging a smarter, science-based approach to gut health. ----- Kiran Krishnan is a research microbiologist with over two decades of experience in the field of nutrition and supplements. Trained in molecular medicine and microbiology at the University of Iowa, he went on to hold leadership roles in global product development before becoming General Manager of Novozymes One Health America, Microbiome Labs. A sought-after speaker at medical and nutrition conferences, he is known for making complex science on the human microbiome practical and accessible. He is actively involved in more than a dozen human clinical trials, serves on multiple scientific advisory boards, and holds peer-reviewed publications and global patents in probiotic and microbiome research. ----- Kiran Krishnan Website: https://microbiomelabs.com/home/ Instagram: https://www.instagram.com/kiranbiome/ Facebook: https://www.facebook.com/kiran.krishnan.9279 LinkedIn: https://www.linkedin.com/in/kiran-k-b302147/ ----- Integrative Peptides Website: ⁠https://integrativepeptides.com/⁠ Facebook: ⁠https://www.facebook.com/integrativepeptidesofficial/⁠ Instagram: ⁠https://www.instagram.com/integrativepeptides/⁠ ---- Holtorf Medical Group Website: ⁠https://holtorfmed.com/⁠ Facebook: ⁠https://www.facebook.com/holtorfmed/⁠ Instagram: ⁠https://www.instagram.com/holtorfmedicalgroup/⁠ ---- Kent Holtorf, MD YouTube: ⁠https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A⁠ ---- Produced by DrTalks ⁠https://drtalks.com/podcast-service/

    1h 6m
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About

Join Dr. Kent Holtorf as he explore groundbreaking science, innovative therapies, and the future of health and aging. In each episode, he dives deep into the world of peptides—potent molecules that regulate immune function, boost cellular regeneration and optimize metabolism. Through conversations with leading experts, Dr. Holtorf explains how peptides differ from traditional hormones, their role in reversing chronic illness, and their potential to enhance sleep, brain function, and overall vitality. https://holtorfmed.com/ https://integrativepeptides.com/

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