This Week in Startups

Jason Calacanis

Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world's greatest founders, operators, investors, and innovators.

  1. 1d ago

    Why a Do-Nothing Congress could be great for markets | E2359

    This Week In Startups is made possible by: Every: https://every.io/ Vanta: https://www.vanta.com/twist G2i: https://g2i.co/twist Plaud: https://plaud.ai/twist Fintrx: https://www.fintrx.com/ Today’s show: Democrats took the House and Senate, and overnight trading suggested a huge market drop. But in the morning, the markets went another way, and D.A. Wallach thinks he knows why. A Congress that can’t get anything done can’t do anything BAD, like start a war or a tariff fight. The only thing markets hate than gridlock is uncertainty. On the first post-midterm This Week in VC roundtable, Jason is joined by Wallach (Time BioVentures), Elana Gold (Two Roads Capital), and Tomasz Tunguz (Theory Ventures). Together, they work out what a split government could mean for tech and venture. Data centers are now a political target for both parties. 2027 might be the last major window for big M&A. Plus, D.A. worries that an intergenerational war could be brewing, between the people who own AI’s upside, and the young workers who fear getting replaced. Plus thoughts on Cava’s 22% layoffs, Sequoia shutting down its Scouts and Arc program, the SPV “boiler room,” and more. Guests D.A. Wallach on X: https://x.com/dawallach Time BioVentures: https://www.timebioventures.com/ Elana Gold on X: https://x.com/ItsElanaGold Two Roads Capital: https://tworoads.vc/ Tomasz Tunguz on X: https://x.com/ttunguz Theory Ventures: https://theoryvc.com/ Relevant Links: NBC exit poll: 56% say AI and data centers were a crucial or major factor (DCD): https://www.datacenterdynamics.com/en/news/nbc-exit-poll-56-say-ai-data-centers-were-a-crucial-or-major-factor-in-congressional-vote-decision/ How AI backlash shaped the 2026 midterms (TIME): https://time.com/article/2026/11/04/midterm-elections-results-ai-industry-data-centers/ Musk on chips outrunning electricity in 2026, with Elon's reply: https://x.com/elonmusk/status/2117649850644705591 Panthalassa raises $140M for wave-powered AI compute at sea (Tom's Hardware): https://tomshardware.com/tech-industry/artificial-intelligence/palantir-co-founder-peter-thiel-backs-usd140m-wave-powered-ai-data-center-startup-panthalassa-aims-to-run-offshore-compute-nodes-using-ocean-energy Marvell to buy Lumentum in a $115B deal (The Next Web): https://thenextweb.com/news/marvell-lumentum-acquisition-115bn-all-stock San Francisco mourns bodega cat killed by a Waymo (CBS SF): https://www.cbsnews.com/sanfrancisco/news/sf-mission-district-mourns-store-cat-killed-by-waymo Meta launches $115M program to train workers for data center jobs (Axios): https://www.axios.com/2026/06/08/meta-data-center-workforce-academy-job-guarantee Keep track of the value you're getting from AI (TWiST): https://twistartups.substack.com/p/keep-track-of-the-value-youre-getting-da4 Meta's Muse hits 10.9M downloads (Yahoo Finance): https://finance.yahoo.com/markets/article/metas-muse-ai-agent-hits-109-million-downloads-as-chatgpt-slides-25-153532560.html Curbie (Revere Robotics): https://www.revererobotics.com/ Canva lays off over 1,200 people amid slowing growth (TechCrunch): https://techcrunch.com/2026/11/04/canva-lays-off-over-1200-people-amid-slowing-growth/ Ollama raises $65M as it nears 9M developers (Startup Fortune): https://startupfortune.com/ollama-raises-65-million-as-it-grows-to-nearly-9-million-developers/ Sequoia hits rewind, undoing 20 years of expansion (TechCrunch): https://techcrunch.com/2026/11/04/sequoia-hits-rewind-undoing-20-years-of-expansion/ "The Sequoia of Tomorrow" (Sequoia): https://x.com/sequoia/status/2117961312143855764 Travis Kalanick's Atoms raises $1.7B (TechCrunch): https://techcrunch.com/2026/07/22/travis-kalanicks-robotics-company-raises-1-7b-led-by-a16z/ Vast: https://www.vastspace.com SEC accredited investor exam could expand private-market access (CNBC): https://www.cnbc.com/2026/10/01/sec-accredited-investor-exam-private-markets.html General Compute raises a $100M Series A (DCD): https://datacenterdynamics.com/en/news/neocloud-general-compute-raises-100m-in-series-a-funding-round Hyperliquid CEO Jeff Yan on democratizing pre-IPO access (Motley Fool): https://www.fool.com/investing/2026/10/19/hyperliquid-ceo-jeff-yan-says-perpetual-futures-ma/ Kalshi Perps: https://kalshi.com/perps Aalo Atomics: https://www.aalo.com Exowatt: https://www.exowatt.com Timestamps: 0:00 The Blue Wave: Dems take Congress 0:10 Plaud: If your work depends on conversations - interviews, meetings, calls - you need a Plaud NotePin S. You can check it out at https://plaud.ai/twist and use code TWIST for 10% off! 6:42 What a split gov’t means for defense tech 9:21 Is 2027 the last big window for tech M&A? 11:04 Every.io: For all of your incorporation, banking, payroll, benefits, accounting, taxes or other back-office administration needs, visit https://every.io. 13:44 Are anti-robotaxi laws coming? 18:51 The need for positive AI stories 24:12 Vanta - Get $1000 off your SOC 2 at https://www.vanta.com/twist 25:59 How AI can make voters smarter 31:22 Self-driving and the future of car insurance 40:17 G2i has been recruiting software engineers for over a decade. Go to https://g2i.co/twist to find out how G2i vets engineers, and can help you hire them in days, not weeks. 45:00 Jason’s $12K Mac Studio 50:12 Sequoia retires its Scouts and Arc programs 58:21 Jason’s barbell: Zipline, Atoms, and Vast 1:01:19 When VC firms go public 1:08:42 Scrap the accredited investor rule 1:14:26 Hyperliquid and permissionless synthetic markets 1:17:17 Kalshi perps and Anthropic price discovery Subscribe to our newsletters on Substack: TWiST: https://twistartups.substack.com/ TWiAI: https://www.thisweekinai.ai/ TWiVC: https://thisweekinvc.substack.com/ Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Check out all our partner offers: https://partners.launch.co/ Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

  2. 3d ago

    Odyssey CEO Oliver Cameron is 90% sure we live in a simulation | E2358

    This Week In Startups is made possible by: Paper: https://getpaper.ai/twist G2i: https://G2i.co/twist Northwest Registered Agent: https://www.northwestregisteredagent.com/twistdomain Plaud: https://Plaud.ai/twist Today’s show: Odyssey co-founder and CEO Oliver Cameron builds simulated worlds for a living, so we asked him the obvious question: are we all living in one, right now? He says he’s 90% certain that, yes, we are. To help make the case (and show off their world model technology), Oliver’s team dropped a simulated fruit fly brain into an AI world, that’s being rendered and created in real time. So far, on X, 6.2 million people have watched the virtual fly navigate an imaginary world. On TWiST, we’re digging into how world models learn about physics, gravity, and causality just by watching videos, what make Odyssey-3 an ideal trainig ground for AI agents, and why a world model only renders the parts of the world that are currently being experienced. It’s a peek inside the technology that may, one day, allow us to enslave people in The Matrix and turn them into batteries. Or train self-driving cars more effectively! One of those. Plus: SpaceX throttles Grok Bot over unsustainably high costs, but Jason says it’s worth every penny. And will OpenAI’s suggested name change from data centers to “compute campuses,” and Meta’s efforts to improve El Paso, help turn around American attitudes? Or is blasting them into space the only remaining viable option? Guest Oliver Cameron on X: https://x.com/olivercameron Odyssey: https://odyssey.systems/ Relevant Links The fruit fly brain flying inside Odyssey-3 (6.2M views): https://x.com/odysseyml/status/2111589148146749616 Meet Odyssey-3, Odyssey's foundation world model: https://odyssey.systems/meet-odyssey-3 FlyWire: https://flywire.ai/ Nick Bostrom, "Are You Living in a Computer Simulation?”: https://simulation-argument.com/simulation.pdf Do we live in a simulation? Chances are about 50-50 (Scientific American): https://www.scientificamerican.com/article/do-we-live-in-a-simulation-chances-are-about-50-50/ "Beyond Perception: Proposing Our Reality as an ASI Alignment Simulation" (Ali Eslami, IPI Letters): https://ipipublishing.org/index.php/ipil/article/view/350 The double-slit experiment explained (Royal Institution, Jim Al-Khalili): https://www.youtube.com/watch?v=A9tKncAdlHQ “A Glitch in the Matrix” trailer: https://www.youtube.com/watch?v=au8eT79WUJ0 Elon Musk throttles Grok Bot limits over "unsustainably high" costs (TechCrunch): https://techcrunch.com/2026/11/02/elon-musk-throttles-grok-bot-limits-due-to-unsustainably-high-costs/ Elon's post: "The cost of serving Grok Bot was unsustainably high relative to revenue”: https://x.com/elonmusk/status/2116992258520064397 Jason's post: " $40k a year on tokens… getting $2m+ in value": https://x.com/Jason/status/2117126320962351277 Grok Bot: https://x.ai/bot Plaud Web: https://web.plaud.ai Founder University Japan: https://japan.founder.university/ Most Americans say AI is bad for society and oppose more data centers (ABC/WaPo/Ipsos): https://abc7ny.com/story/most-americans-say-ai-is-bad-society-oppose-more-data-centers-abcpostipsos-poll/19964027/ Chris Lehane's memo: AI will be the issue in 2028 (TNW): https://thenextweb.com/news/chris-lehane-memo-openai-2028-ai-election Meta touts El Paso water and grid pledges as council weighs incentives (KFOX): https://kfoxtv.com/news/local/meta-touts-10b-el-paso-data-center-water-and-grid-pledges-as-council-weighs-incentives UT Austin's Texas Advance Commitment (free tuition under $100K): https://admissions.utexas.edu/cost-aid/financial-aid/texas-advance-commitment/ Andrej Karpathy's HackerTube post: https://x.com/karpathy/status/2116957135661945283 Jason's "Unsponsored" Chrome extension for Amazon: https://x.com/Jason/status/2116380861167714594 Google's first data center satellite is online and writing poetry (TechCrunch): https://techcrunch.com/2026/10/30/googles-first-data-center-satellite-is-online-and-writing-poetry/ What is low Earth orbit? (Universe Today): https://www.universetoday.com/articles/what-is-low-earth-orbit Timestamps: 0:00 Grok Bot users are at their limit 3:36 How Jason and LAUNCH get $2M+ in value out of AI 5:46 Jason’s Grok-made jacket lookbook 10:35 Paper is the legal backbone for thousands of startup founders and fund managers - including Jason. Use https://getpaper.ai/twist to get your cap table free for a year - or two years if you're leaving Carta. 14:12 Everything changed in AI over the last 90 days 20:41 G2i has been recruiting software engineers for over a decade. Go to https://g2i.co/twist to find out how G2i vets engineers, and can help you hire them in days, not weeks. 22:06 Plaud: If your work depends on conversations - interviews, meetings, calls - you need a Plaud NotePin S. You can check it out at https://plaud.ai/twist and use code TWIST for 10% off! 22:37 Wiring our Plaud into our Grok Bot 23:24 Odyssey’s fruit fly video zooms to 6.2M views 27:32 All About Simulation Theory 34:34 Got a new business idea? Northwest Registered Agent helps you bring it to life. Get a free domain, email, phone number, and more - with no purchase required! Learn more at https://www.northwestregisteredagent.com/twistdomain 38:33 What is the double slit experiment? 40:47 How to teach a robot about physics 50:01 OpenAI’s plan to make Americans love data centers 56:53 Meta’s El Paso data center pitch 1:02:26 AI companies should overfund local schools 1:06:27 Karpathy’s HackerTube project 1:13:02 Google’s first space data center goes online 1:17:51 How much room is there in low Earth orbit? Subscribe to our newsletters on Substack: TWiST: https://twistartups.substack.com/ TWiAI: https://www.thisweekinai.ai/ TWiVC: https://thisweekinvc.substack.com/ Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Thank you to our partners: Paper is the legal backbone for thousands of startup founders and fund managers - including Jason. Use https://getpaper.ai/twist to get your cap table free for a year - or two years if you're leaving Carta. G2i has been recruiting software engineers for over a decade. Go to G2i.co/twist to find out how G2i vets engineers, and can help you hire them in days, not weeks. Got a new business idea? Northwest Registered Agent helps you bring it to life. Get a free domain, email, phone number, and more - with no purchase required! Learn more at https://www.northwestregisteredagent.com/twistdomain Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin S. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off! Check out all our partner offers: https://partners.launch.co/ Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

  3. 6d ago

    Binance Hacked $6.3B Stolen, DoorDash Buys Instacart For $17B, Jake Newfield from Hermetiq, + More!

    This Week In Startups is made possible by: Stripe: https://stripe.com/startups Rippling: https://rippling.ai/twist Northwest Registered Agent: https://www.northwestregisteredagent.com/twistdomain Plaud: https://plaud.ai/twist Today’s show: Binance lost an estimated $6.3 billion in the biggest crypto hack ever, and Jason proposes a radical solution. The entire tech industry should stop shipping new features for one month a year, and do nothing but patch. (Call it No App November?) On a busy Friday show, Jason and Lon dig into the. Binance breach and look back at Jason’s prescient 2021 warning about leaving your money in crypto exchanges. (He recommends spreading your wealth around various different banks!) Plus, why he’s giving CZ credit for backstopping customer losses out of his own fortune. Plus, DoorDash’s $17B acquisition of Instacart… Did DoorDash overpay? And is this happening now to avoid the harsher regulatory climate should Democrats regain power in the midterms? Then we’ve got Hermetiq co-founder and CEO Jake Newfield, who has twice won the LAUNCH Accelerator’s pitch competition. Hear the celebrated two-minute pitch for an AI build engineer, and find out why Jason thinks having a “lighthouse customer” makes such a huge difference. Finally, we’re awarding the Grand Prize in our $5K bounty competition to create Jason’s Annotated app, and remembering the legendary film and TV actor Sir Patrick Stewart. Guest Jake Newfield on LinkedIn: https://www.linkedin.com/in/jakenewfield/ Hermetiq: https://www.hermetiq.com/ Bazel: https://bazel.build Apply to the LAUNCH Accelerator: https://www.launch.co/apply Relevant Links Binance links the $6.3B theft to a compromised DevOps laptop (BleepingComputer): https://www.bleepingcomputer.com/news/security/binance-links-63-billion-crypto-theft-to-compromised-devops-laptop/ The 1978 Lufthansa heist (History.com): https://www.history.com/articles/1978-lufthansa-heist-jfk-henry-hill-goodfellas Trump pardons Binance founder Changpeng Zhao (KWTX/AP): https://www.kwtx.com/2025/10/23/trump-pardons-binance-founder-changpeng-zhao CrowdStrike: https://www.crowdstrike.com/en-us/ Palo Alto Networks: https://www.paloaltonetworks.com/ Grant Cardone challenges Jason to $1M Bitcoin bet: https://www.thestreet.com/crypto/markets/grant-cardone-challenges-bitcoin-bear-to-1-million-bet DoorDash to acquire Instacart for $17B (TechCrunch): https://techcrunch.com/2026/10/29/doordash-to-acquire-instacart-for-17b/ Economic Liberties calls on the FTC to block the deal: https://www.economicliberties.us/press-release/economic-liberties-calls-on-ftc-to-block-doordash-instacart-merger/ Central Market, H-E-B's upscale banner, expands home delivery (Supermarket News): https://www.supermarketnews.com/foodservice-retail/central-market-expands-curbside-and-home-delivery People are using AI to make their smart TVs dumb again (TechCrunch): https://techcrunch.com/2026/10/19/people-are-using-ai-to-make-their-smart-tvs-dumb-again/ TWiST $5K Bounties: https://bounty.thisweekinstartups.com/ Founder University: https://founder.university/ Founder University x Japan: https://japan.founder.university/ Inside.com domain auction: https://inside.com/ Yank Sing: https://yanksing.com/ Cafe du Monde coffee and chicory: https://shop.cafedumonde.com/product/coffee-beignets/cafe-du-monde-coffee-and-chicory Patrick Stewart, "Star Trek" and "X-Men" actor, dead at 86 (CNN): https://www.cnn.com/2026/10/29/entertainment/patrick-stewart-death “Time Squared” (Star Trek: TNG S2E13): https://memory-alpha.fandom.com/wiki/Time_Squared_(episode) “Green Room” trailer: https://www.youtube.com/watch?v=Q8XSARX3DQg “X-Men: Days of Future Past” trailer: https://www.youtube.com/watch?v=pK2zYHWDZKo Timestamps: 0:00 The largest crypto hack or theft in history 5:45 Jason gives CZ credit for backstopping losses 7:34 Jason’s cybersecurity proposals 11:48 Stripe Startups - Stripe Startups offers early-stage, venture-backed startups access to Stripe fee credits and more. Apply today on https://stripe.com/startups. 14:49 DoorDash buys Instacart for $17B 18:48 Is DoorDash overpaying? 24:28 Thanks to our partners at Rippling! Head to https://rippling.ai/twist and get the only AI built to give you full visibility across your startup and take complex actions across your entire business. 26:26 Vibecoding your smart TV 27:20 Plaud: If your work depends on conversations - interviews, meetings, calls - you need a Plaud NotePin S. You can check it out at https://plaud.ai/twist and use code TWIST for 10% off! 30:04 Jake Newfield (Hermetiq) gives a perfect pitch 34:13 Got a new business idea? Northwest Registered Agent helps you bring it to life. Get a free domain, email, phone number, and more - with no purchase required! - Learn more at https://www.northwestregisteredagent.com/twistdomain 37:12 Lead with your lighthouse customer 43:14 The Cafe Du Monde branding lesson 51:10 The Annotated Bounty finals begin 1:04:00 Jason announces the grand prize winner 1:07:34 RIP Sir Patrick Stewart Subscribe to our newsletters on Substack: TWiST: https://twistartups.substack.com/ TWiAI: https://www.thisweekinai.ai/ TWiVC: https://thisweekinvc.substack.com/ Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

  4. Oct 29

    Is AI the new cigarettes? Our VC panel digs into Anthropic’s S-1 | E2356

    This Week In Startups is made possible by: PayPal: https://paypal.com/business The Conservation Fund: https://www.conservationfund.org/ Hostinger: https://hostinger.com/twist Plaud: https://plaud.ai/twist Today’s show: Anthropic’s S-1 is here, and finally, we can start to develop a real understanding for the AI economy and whether the numbers add up. Anthropic shows an operating profit, a mostly non-cash $80.7 billion loss, and customers spending a shocking 9x what they were spending on intelligence just one year ago. Is this the greatest business in history? Is AI now as addictive to enterprises as cigarettes once were to impressionable teens? On this week’s VC Roundtable, Jason Calacanis is joined by D.A. Wallach (Time BioVentures), Dave McClure (Practical Venture Capital), and Ben Black (Akkadian Ventures / Powerlaw Corp.) to seek some answers. They dig into the numbers, including that wild 900% net revenue retention, and consider how retail investors will consider the convertible-note charge behind their $80B loss. Plus they’ll debate whether Anthropic’s founders are really true believers driven by religious fervor, and if so, whether they’re destined to be out-competed by “rabid capitalists.” Guests D.A. Wallach on X: https://x.com/dawallach Time BioVentures: https://www.timebioventures.com/ Dave McClure on X: https://x.com/davemcclure Practical Venture Capital: https://practicalvc.com/ Trading Places podcast: https://www.youtube.com/@PracticalVentureCapital Ben Black on LinkedIn: https://linkedin.com/in/benblack Akkadian Ventures: https://akkadian.vc/ Powerlaw Corp: https://pwrl.com Relevant Links Anthropic’s S-1, by the numbers (Fortune): https://fortune.com/2026/10/27/anthropic-s1-ipo-filing-financials-profits/ 900% NRR and an $80.7B loss that mostly ins’t (HackerNoon): https://hackernoon.com/anthropics-s-1-shows-163b-in-half-year-revenue-a-900percent-nrr-and-an-807b-loss-that-mostly-isnt Tickertrends: https://tickertrends.io/ Replit makes OpenAI its default (TechCrunch): https://techcrunch.com/2026/10/17/replit-is-no-longer-working-with-anthropic-ceo-says/ Dario Amodei warns that rivals’ spending could risk bankruptcy (Fortune): https://fortune.com/2026/02/14/anthropic-ceo-dario-amodei-spending-capex-risk-ai-revenue-forecasts-bankruptcy Machines of Loving Grace (Dario Amodei): https://www.darioamodei.com/essay/machines-of-loving-grace Palantir CTO Shyam Sankar says AI researchers are taking up smoking (Fortune): https://fortune.com/2026/10/13/palantir-cto-shyam-sankar-ai-researchers-smoking-cigarettes-cure-cancer-artificial-general-intelligence-silicon-valley-mass-psychosis-effective-altruism/ Microsoft offers its first-ever voluntary buyouts (TechSpot): https://www.techspot.com/news/112174-microsoft-offers-voluntary-buyouts-thousands-us-workers-ai.html Canva ranks among the top consumer AI apps (SmartCompany): https://www.smartcompany.com.au/artificial-intelligence/canva-new-ai-consumer-web-app-ranking-andreesen-horowitz/ SpaceX Q3: Musk says it could rent out its AI compute several times over (Constellation Research): https://www.constellationr.com/insights/news/spacexs-q3-musk-says-it-could-rent-out-its-ai-compute-several-times-over Jason’s 2026 “Bitcoin is Dead” post: https://x.com/Jason/status/2114956980674605075 Jason to Michael Saylor: "there are better places to invest your money”: https://x.com/Jason/status/2115274438979756346 Timestamps: 0:00 Anthropic files its public S-1 4:58 Anthropic vs. OpenAI revenue run rates 9:20 PayPal is built for all businesses. Get started at https://paypal.com/business 10:02 “The greatest business in the history of capitalism” 11:58 Is intelligence the new tobacco? 18:08 The “meat sack constraint” 20:36 Thanks to our partner, The Conservation Fund! Learn more at https://www.conservationfund.org/ 22:13 Plaud: If your work depends on conversations - interviews, meetings, calls - you need a Plaud NotePin S. You can check it out at https://plaud.ai/twist and use code TWIST for 10% off! 24:32 The Who Has the Most Subscribers Challenge 28:08 Is Apple waiting out the AI race on purpose 30:22 Hostinger: The all-in-one platform for domains, websites, email, and marketing. Go to https://hostinger.com/twist and use the code TWIST for an additional 10% off Black Friday and Cyber Monday 34:19 Is Canva an AI company? 39:08 True Believers who still want to make money 48:21 The $72.4B convertible-note charge, explained 51:03 How long does AI compute stay useful? 58:19 Jason’s monthly “Bitcoin is Dead” post 1:04:41 Alicorns are unicorns with pegasus wings 1:09:58 Subscribe to the TWiST Newsletter! Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Thank you to our partners: PayPal is built for all businesses. Get started at https://paypal.com/business The Conservation Fund: Thanks to our partner, The Conservation Fund! Learn more at https://www.conservationfund.org/ Hostinger: The all-in-one platform for domains, websites, email, and marketing. Go to https://hostinger.com/twist and use the code TWIST for an additional 10% off Black Friday and Cyber Monday Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin S. You can check it out at https://plaud.ai/twist and use code TWIST for 10% off! Check out all our partner offers: https://partners.launch.co/ Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Subscribe to our Substack Newsletters! TWiST: https://twistartups.substack.com/ TWiAI: https://www.thisweekinai.ai/ TWiVC: https://thisweekinvc.substack.com/ Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

  5. Oct 26

    Pregame Your Launch Before Your App Exists (w/ Amanda Bradford) | E2355

    This Week In Startups is made possible by: Odoo: https://odoo.com/twist G2i: https://g2i.co/twist Rippling: https://rippling.ai/twist Plaud: https://plaud.ai/twist Today’s show: Amanda Bradford’s “launch party” for her dating app The League actually extended for months. She “pre-gamed” the app’s formal launch with months of mixers, boat parties, and free events, where the only ticket required for admission was having the app on your phone. By launch day, she had a massive wait list, and still just let in 500 people, who ensure maximum buzz (and FOMO). At LAUNCH’s first-ever Tactical & Practical live event from San Francisco, Amanda walks the crowd through how she built a vetted, two-sided dating marketplace as a solo founder, eventually getting prominent enough to attract the attention of Match Group. (She sold The League for ~$30 million in 2020.) Hear exclusive tips you won’t get anywhere else, like how Amanda used a “fake paywall” to gauge willingness to pay for subscriptions, and how to time your rate of expansion into new markets. Plus, an all-new Flashback segment, featuring Alex and Lon looking back at a classic 2017 interview between Jason and Stripe’s Patrick Collison. Guests Amanda Bradford on X: https://x.com/amandabradford Book a Call with Amanda: https://intro.co/amandabradford The League: https://www.theleague.com/ Patrick Collison on X: https://x.com/patrickc?lang=en Stripe: https://stripe.com/ Relevant Links: The League was called "elitist." Its founder says that was never the case (CNBC): https://www.cnbc.com/2023/10/20/founder-of-the-league-on-dating-ambition-and-that-viral-ad-campaign.html Alex Wilhelm’s Cautious Optimism: https://www.cautiousoptimism.news/ TWiST E723: Patrick Collison (2017): https://www.youtube.com/watch?v=P-NepiMQGvY Timestamps: 0:00 Amanda Bradford on building The League 4:30 Hand-reviewing early applications 6:40 Building an MVP with a rented co-founder 8:56 The VIP approach 13:10 Why Amanda only let in 500 people 15:44 The “Heavy Hitter” fake paywall test 16:44 Odoo: The all-in-one business platform. Your first app is free! Get started today at https://odoo.com/twist 17:46 Why live events are the real unlock 21:35 Controversy as a hook 24:22 Flashback to Patrick Collison in 2017 25:13 Plaud: If your work depends on conversations - interviews, meetings, calls - you need a Plaud NotePin S. You can check it out at https://plaud.ai/twist and use code TWIST for 10% off! 28:13 Stripe: Then vs. Now 30:53 G2i has been recruiting software engineers for over a decade. Go to https://g2i.co/twist to find out how G2i vets engineers, and can help you hire them in days, not weeks. 32:17 Why did PayPal stay PayPal? 37:50 Problem, not a product 44:33 Thanks to our partners at Rippling! Head to https://rippling.ai/twist and get the only AI built to give you full visibility across your startup and take complex actions across your entire business. 45:46 The outage nobody noticed 51:00 Why persistence beats pivoting 52:13 What’s left before a Stripe IPO? Subscribe to our newsletters on Substack: TWiST: https://twistartups.substack.com/ TWiAI: https://www.thisweekinai.ai/ TWiVC: https://thisweekinvc.substack.com/ Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Thank you to our partners: Odoo: The all-in-one business platform. Your first app is free! Get started today at https://Odoo.com/twist G2i has been recruiting software engineers for over a decade. Go to G2i.co/twist to find out how G2i vets engineers, and can help you hire them in days, not weeks. Thanks to our partners at Rippling! Head to https://Rippling.ai/twist and get the only AI built to give you full visibility across your startup and take complex actions across your entire business. Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin S. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off! Check out all our partner offers: https://partners.launch.co/

  6. Oct 24

    OpenAI’s $1.25T Raise, Starlink Mobile & Zuck’s Tax Deal | EP 2354

    This Week In Startups is made possible by: Plaud - https://plaud.ai/twist Sentry - https://sentry.io/twist Lightfield - https://lightfield.app Rippling - https://rippling.ai/twist Today’s show: Is OpenAI finally priced correctly? Jason argues that the reported $30 billion raise at a $1.25 trillion valuation is finally “right-sized.” He also says that he’d put money in at that price, while walking through the risks that could still sink the investment. It’s a Friday all-news episode with Jason and Lon, covering OpenAI’s latest round, SpaceX’s push to become America’s fourth major carrier, Zuck and Meta’s creative move around the proposed California billionaire tax, and some of Lon and Jason’s favorite documentaries. Plus we’re asking the timely question: who watches the AI watchdogs? Relevant Links OpenAI nears up to $30B round at $1.25T valuation, led by UAE investors (CNBC): https://www.cnbc.com/2026/10/22/openai-funding-round-uae-investors.html Anthropic investors eye a $2T IPO (Nasdaq): https://www.nasdaq.com/articles/move-over-spacex-anthropic-targets-2-trillion-valuation Uber puts all 30,000 employees on ChatGPT Work (TechCrunch): https://techcrunch.com/2026/10/22/uber-puts-all-30000-employees-on-chatgpt-work/ Telecom stocks fall as SpaceX eyes 80,000 cell sites (Yahoo Finance): https://finance.yahoo.com/markets/stocks/articles/telecom-stocks-fall-spacex-eyes-134838815.html Verizon launches simpler plans and drops activation and upgrade fees (Fox Business): https://foxbusiness.com/markets/verizon-launches-simpler-plans-new-loyalty-program-drops-some-fees Amazon Leo's launch slips past early 2026 (ITdaily): https://itdaily.com/news/network/amazon-leo-faces-delays/ METR and Redwood Research's write-up on red-teaming OpenAI's agent monitoring: https://metr.org/blog/2026-10-22-red-teaming-openai-agent-monitoring/ Open Philanthropy is now Coefficient Giving: https://coefficientgiving.org/research/the-story-behind-our-new-name/ Court documents show the alleged FSU shooter's ChatGPT chats (AOL): https://www.aol.com/news/court-documents-show-florida-state-233829466.html Meta's 8-K filing on the Founder Alignment Agreement (SEC): https://www.sec.gov/Archives/edgar/data/0001326801/000162828026066700/meta-20261019.htm Polymarket: will California's billionaire tax pass?: https://polymarket.com/event/billionaire-one-time-wealth-tax-passes-in-california-election-2026 Mark Cuban vs. Ro Khanna on the billionaire tax (Fortune): https://fortune.com/2026/08/17/mark-cuban-california-billionaires-tax-wealth-ro-khanna/ Elizabeth Holmes: The Theranos Deception (60 Minutes archive): https://cbsnews.com/video/elizabeth-holmes-the-theranos-deception-60-minutes-archive “The Act of Killing” trailer: https://www.youtube.com/watch?v=Q3FcB1UZHlg “Grizzly Man” trailer: https://www.youtube.com/watch?v=uWA7GtDmNFU “Hoop Dreams” trailer: https://www.youtube.com/watch?v=uf9Nq2ju0t0 “The King of Kong” trailer: https://www.youtube.com/watch?v=L5XvArGGIzk “A Short Stay in Hell” by Steven L. Peck: https://www.amazon.com/dp/0983748446 “The Library of Babel” by Jorge Luis Borges [PDF]: https://sites.evergreen.edu/politicalshakespeares/wp-content/uploads/sites/226/2015/12/Borges-The-Library-of-Babel.pdf “The Eureka Machine” by Richard Socher: https://www.amazon.com/dp/154170570X Timestamps: 0:00 Jason’s in SF with the LAUNCH Accelerator 37 cohort 2:40 Plaud: If your work depends on conversations - interviews, meetings, calls - you need a Plaud NotePin S. You can check it out at https://plaud.ai/twist and use code TWIST for 10% off! 6:34 Tactical & Practical talks live at Salesforce Tower 10:21 Using Claude for brainstorming, not writing 19:26 Sentry - New users can get $240 in free credits when they go to https://sentry.io/twist and use the code TWIST26 20:42 OpenAI closing $30B at a $1.25T valuation 26:04 Why OpenAI could still lose 30:25 Would you put 30% of your retirement into OpenAI? 32:34 Lightfield - Name one person who's ever enjoyed updating a CRM. Exactly. Lightfield's AI agent does it for you - it even prospects and books your meetings. Used by thousands of startups. Free at https://lightfield.app 34:27 Every Tesla becomes a Starlink hotspot 43:06 What would be the ultimate SpaceX domain name? 45:00 Thanks to our partners at Rippling! Head to https://rippling.ai/twist and get the only AI built to give you full visibility across your startup and take complex actions across your entire business. 46:10 Is METR a fair watchdog for OpenAI? 54:03 Jason’s “Know Your Customer” plan for AI models 1:03:34 Meta’s deal to keep Zuckerberg in Cali 1:14:35 Why Jason would raise the minimum wage 1:18:42 Does Nathan Fielder give Liz Holmes a pass? 1:30:59 “A Short Stay in Hell” and “The Eureka Machine” Subscribe to our newsletters on Substack: TWiST: https://twistartups.substack.com/ TWiAI: https://www.thisweekinai.ai/ TWiVC: https://thisweekinvc.substack.com/ Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Check out all our partner offers: https://partners.launch.co/ Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

  7. Oct 22

    We asked 3 VCs: would you invest in Elizabeth Holmes’ next startup? | E2353

    This Week In Startups is made possible by: DigitalOcean - Head to https://do.co/twist to start building on DigitalOcean's AI-Native Cloud today — and cut your AI workload costs by up to 50% Odoo: The all-in-one business platform. Your first app is free! Get started today at https://odoo.com/twist Thanks to our partners at Rippling! Head to https://rippling.ai/twist and get the only AI built to give you full visibility across your startup and take complex actions across your entire business. Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin S. You can check it out at https://plaud.ai/twist and use code TWIST for 10% off! Today’s show: Elizabeth Holmes remains in prison for defrauding Theranos investors, even as she stars in the hit Nathan Fielder/Lance Oppenheim documentary “You Can See Everything.” But we’re asking the real question: After all the very public accusations… the hit pieces in the press and the Hulu drama series picking apart the scandal… would tech investors and VCs be willing to back her NEXT startup, if the numbers were right? On today’s TWiST roundtable, Jason Calacanis is joined by Sam Lessin (Slow Ventures), Paige Finn Doherty (Behind Genius Ventures), and Jenny Fielding (Everywhere Ventures). In addition to reviews of the movie tech insiders can’t stop talking about, they cover why every seed portfolio needs a little bit of fraud, how diligence scales with check size, having trademark rights to your own voice, and the pro rata rights debate that’s still raging over Valar Atomics’ lawsuit with seed investors Day One Ventures. Guests Sam Lessin on X: https://x.com/lessin Slow Ventures: https://slow.co/ Paige Finn Doherty on X: https://x.com/paigefinnn Behind Genius Ventures: https://www.behindgeniusventures.com/ Jenny Fielding on X: https://x.com/jefielding Everywhere Ventures: https://www.everywhere.vc/ Relevant Links OpenSnow: https://opensnow.com/ “You Can See Everything” trailer: https://www.youtube.com/watch?v=HvW_N5p1q44 HBO Max “The Rehearsal” trailer: https://www.youtube.com/watch?v=2fjPFt8cpic Elizabeth Holmes moves to halfway house in 2027 (ABC7): https://abc7.com/story/elizabeth-holmes-scheduled-move-halfway-house-august-2027/19862832/ Billy Evans’ blood-testing startup Haemanthus (TechCrunch): https://techcrunch.com/2025/05/10/elizabeth-holmes-partner-reportedly-fundraising-for-new-blood-testing-startup/ Polymarket: Oscars 2027 Best Picture: https://polymarket.com/event/oscars-2027-best-picture-winner-20260727173620857 Kalshi: Oscars 2027 Best Documentary: https://kalshi.com/markets/kxoscardocu/event/kxoscardocu-27 Charlie Javice sentenced to 7 years (NBC News): https://www.nbcnews.com/business/business-news/charlie-javice-sentenced-7-years-prison-fraudulent-175m-sale-financial-rcna234536 Trump pardons Nikola founder Trevor Milton (Axios): https://www.axios.com/2025/03/28/trump-pardons-nikola-founder-trevor-milton Sequoia writes its FTX stake down to zero (Fortune): https://fortune.com/2022/11/10/ftx-sam-bankman-fried-sequoia-writes-down-214-million-investment-to-zero-venture-capital-crypto Who lost money on Theranos? (Fortune): https://fortune.com/2018/05/04/theranos-investment-lost “Barbarians at the Gate” on Amazon: https://www.amazon.com/Barbarians-Gate-Fall-RJR-Nabisco/dp/B08YP9MDHX a16z backs Adam Neumann’s Flow (Commercial Observer): https://commercialobserver.com/2022/08/adam-neumann-350m-backing-andreessen-horowitz/ Martin Shkreli lifetime pharma ban (FTC): https://www.ftc.gov/news-events/news/press-releases/2022/01/statement-chair-lina-m-khan-ruling-judge-denise-l-cote-federal-trade-commission-et-al-v-vyera Isaia Taylor post announcing Valar suit: https://x.com/isaiah_p_taylor/status/2108679133467414855 Day One Ventures response: https://x.com/mashadrokova/status/2108732979191390528 ElevenLabs Iconic Marketplace: https://elevenlabs.io/iconic-marketplace Apple Corps vs. Apple Computer, a history (MacTech): https://www.mactech.com/2004/04/09/a-history-of-the-apple-vs-apple-dispute Cameo for Business: https://www.cameo.com/business Nox Metals: https://noxmetals.co Electric Plant Company: https://www.electricplant.co/ Ablieration: https://abliteration.ai/ Timestamps: 0:00 Our new “This Week in VC” newsletter 2:15 Panel intro: Sam Lessin, Paige Doherty, Jenny Fielding 8:09 Why gambling loses appeal for VCs 11:02 Plaud: If your work depends on conversations - interviews, meetings, calls - you need a Plaud NotePin S. You can check it out at https://plaud.ai/twist and use code TWIST for 10% off! 16:18 DigitalOcean - Head to https://do.co/twist to start building on DigitalOcean's AI-Native Cloud today - and cut your AI workload costs by up to 50% 17:35 Best moments from “You Can See Everything” 21:42 Unreliable narrators and unknowable situations 24:41 Living in a post-truth moment 30:02 Due diligence horror stories 32:45 Odoo: The all-in-one business platform. Your first app is free! Get started today at https://odoo.com/twist 34:50 The VCs remember their fraud investments 38:39 How LAUNCH trains founders to prep for diligence 44:31 How Elizabeth Holmes kept raising money 54:54 Would you invest in an Elizabeth Holmes company? 57:27 Thanks to our partners at Rippling! Head to https://rippling.ai/twist and get the only AI built to give you full visibility across your startup and take complex actions across your entire business. 1:02:28 Why seed funds need pro rata rights 1:09:02 When “founder friendly” means rolling over 1:16:25 The three investor relationships: team, founders, LPs 1:21:02 ElevenLabs “Archer” voice controversy 1:27:16 How NIL deals reshaped college sports 1:33:54 Cameo for Business and long-tail celeb endorsements 1:35:51 Portfolio company shoutouts Subscribe to our newsletters on Substack: TWiST: https://twistartups.substack.com/ TWiAI: https://www.thisweekinai.ai/ TWiVC: https://thisweekinvc.substack.com/ Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Check out all our partner offers: https://partners.launch.co/ Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekin Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

  8. Oct 20

    Anthropic Gives Away 5% of Its Shares, Clone’s Muscle Robot, ElevenLabs Steals Podcaster's Voice

    This Week In Startups is made possible by: Plaud: https://plaud.ai/twist Northwest Registered Agent: https://www.northwestregisteredagent.com/twistdomain Vanta: https://www.vanta.com/twist Rippling: https://rippling.ai/twist Today’s show: Jason can’t stop praising Nathan Fielder’s new A24 hybrid documentary about Elizabeth Holmes and Theranos, “You Can See Everything,” and he’s insisting that Lon check it out before the next podcast. Hear his spoiler-free review, how the film upended his expectations based on Fielder’s previous work, and why Lon also recommends Lance Oppenheim’s HBO Max series “Ren Faire.” Plus, we’re talking to Clone Robotics co-founder and CEO Dhanush Radhakrishnan about why he thinks robots should not just be humanoid but should look and move precisely like humans. We’re digging deep into how his hydraulic myofiber artificial muscle technology alters and even improves on the pulley-based systems being deployed by competitors, why he thinks the models that power domestic helper-bots will be commoditized, and how quickly he thinks he can put a robo-butler in every American home. Plus we’re comparing the potential impact of Anthropic’s new Public Benefit Fund vs. Elon Musk’s plan to give every baby a share of SpaceX, and re-considering simulation theory after Odyssey dropped an artificial fruit fly brain into an artificial landscape. Guest Dhanush Radhakrishnan on X: https://x.com/dhanushisrad Clone Robotics: https://clonerobotics.com/ Related Links “You Can See Everything” trailer: https://www.youtube.com/watch?v=HvW_N5p1q44 “You Can See Everything” on Rotten Tomatoes: https://www.rottentomatoes.com/m/you_can_see_everything John Carreyrou’s Theranos investigation (Wall Street Journal): https://www.wsj.com/articles/theranos-has-struggled-with-blood-tests-1444881901 “Ren Faire” HBO Max trailer: https://www.youtube.com/watch?v=CHZUVTrrexE “Nathan for You”: Smokers Allowed clip (Comedy Central): https://www.youtube.com/watch?v=HttB2fYAm-8 Anthropic: Investing in the Public Benefit: https://www.anthropic.com/news/public-benefit-fund Elon Musk SpaceX pledge: https://x.com/elonmusk/status/2112089556615123114 Dell’s $6.25B Invest America commitment: https://www.onedell.com/investamerica/ Odyssey Fly Simulation X post: https://x.com/odysseyml/status/2111589148146749616 Chris Williamson: “The ElevenLabs Situation is Crazy”: https://www.youtube.com/watch?v=lxDNHLgWInU ElevenLabs’ Legendary Voices marketplace: https://elevenlabs.io/iconic-marketplace TWiST newsletter on Substack: https://twistartups.substack.com/ LAUNCH Careers page: https://careers.launch.co/ Timestamps: 00:00 Intro 00:10 Plaud - If your work depends on conversations - interviews, meetings, calls - you need a Plaud NotePin S. You can check it out at https://plaud.ai/twist and use code TWIST for 10% off! 03:18 Jason's "You Can See Everything" reaction 14:37 Northwest Registered Agent - Got a new business idea? Northwest Registered Agent helps you bring it to life. Get a free domain, email, phone number, and more - with no purchase required! Learn more at https://www.northwestregisteredagent.com/twistdomain 15:27 What films max out RT's critic and audience scores 20:08 Anthropic commits 5% equity to Public Benefit Fund 24:28 Would equity change how Americans feel about AI? 27:08 Vanta - Get $1000 off your SOC 2 at https://www.vanta.com/twist 38:38 Rippling - Thanks to our partners at Rippling! Head to https://rippling.ai/twist and get the only AI built to give you full visibility across your startup and take complex actions across your entire business. 39:48 Dhanush from Clone Robotics joins the show 42:43 How hydraulic muscle technology actually works 54:55 When can we have our robot butlers please? 56:55 Where will Clone get its robot brains? 1:12:17 Odyssey trapped a fake fly brain in a simulated environment 1:23:09 Did ElevenLabs steal a podcaster's voice? 1:30:13 Check us out on Substack! Subscribe to our newsletters on Substack: TWiST: https://twistartups.substack.com/ TWiAI: https://www.thisweekinai.ai/ TWiVC: https://thisweekinvc.substack.com/ Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Check out all our partner offers: https://partners.launch.co/ Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland Follow TWiST: Twitter: https://twitter.com/TWiStartups YouTube: https://www.youtube.com/thisweekinstartups Instagram: https://www.instagram.com/thisweekinstartups TikTok: https://www.tiktok.com/@thisweekinstartups Substack: https://twistartups.substack.com

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Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world's greatest founders, operators, investors, and innovators.

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  • Creator
    Jason Calacanis
  • Years Active
    2009 - 2026
  • Episodes
    1.5K
  • Rating
    Explicit
  • Copyright
    © Jason Calacanis
  • Show Website
    This Week in Startups

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