Staying Healthy Today Show with Kirk Hamilton

Information to keep the indivdiual, your community and the world society living healthfully and in peace
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Practicing physician assistant in nutrition, prevention, integrative and lifestyle medicine since 1983 who will discuss practical guidelines and share links and research dealing with individual, community and societal health through personal commentary and interviews. stayinghealthytoday.substack.com

  1. What is the Evidence for the Use of Low Dose Naltrexone (LDN) in Long Covid (Covid Long Haul) - An Interview with Oyungerel Byambasuren, MD, PhD, Bond University, Australia

    1D AGO

    What is the Evidence for the Use of Low Dose Naltrexone (LDN) in Long Covid (Covid Long Haul) - An Interview with Oyungerel Byambasuren, MD, PhD, Bond University, Australia

    Long Covid - The Evidence For and Use of Low Dose NaltrexoneOyungerel Byambasuren, MD, PhDInstitute for Evidence-Based HealthcareBond University14 University Dr, Robina QLD 4226 AustraliaTel: 61 7 5595 4182obyambas@bond.edu.au“Effect of Low-Dose Naltrexone for Long COVID:Systematic Review”, medRxiv 2025 (3/2026) Kirk Hamilton: Can you please share with me your educational background and current position? Oyuka Byambasuren: I am an Assistant Professor at the Institute for Evidence-Based Healthcare, Bond University, Australia. I am a medical doctor and general practitioner by background. My current work focuses on Long COVID (LC), clinical trial methodology, and improving the evidence base for primary care interventions. I recently led a systematic review examining the effectiveness of low-dose naltrexone for Long COVID. KH: What do you mean by Long Haul COVID?OB: Long Haul COVID (also known as Long COVID or post-COVID-19 condition) refers to persistent or new symptoms that continue beyond 12 weeks after acute SARS-CoV-2 infection and cannot be explained by another diagnosis. It is a highly heterogeneous condition. The most disabling symptoms typically include fatigue, post-exertional malaise or symptom exacerbation, cognitive dysfunction (brain fog”), pain, sleep disturbance, and dyspnea. KH: What systems or pathophysiology are hypothesized in LC? OB: The pathophysiology remains uncertain. Multiple non-exclusive mechanisms are under investigation: * Immune dysregulation and persistent inflammation * Neuroinflammation and microglial activation * Endothelial dysfunction * Autonomic dysfunction * Microvascular abnormalities and hypercoagulability * Mitochondrial dysfunction and altered cellular energy metabolism * TRPM3 ion channel impairment * Possible viral persistence or antigen reservoirs Clinically speaking, there is a big overlap between ME/CSF and LC and both conditions have been associated with impairment of TRPM3 ion channel shown by another Australian team. It’s highly likely that multiple mechanisms play at the same time and therefore these conditions would require combination treatments to be treated successfully. KH: What is Low Dose Naltrexone (LDN)? Why does it act differently than normal doses of Naltrexone? OB: Naltrexone at standard doses (50–100 mg/day) is approved for opioid and alcohol use disorders. Low Dose Naltrexone (LDN) refers to doses typically between 1–10 mg/day and at these lower doses, proposed mechanisms of action include: * Transient opioid receptor antagonism with possible rebound endogenous opioid upregulation * Modulation of microglial activation * Antagonism of Toll-like receptor 4 * Potential restoration of TRPM3 ion channel function (based on mechanistic studies) KH: What illnesses have LDN been used for? What are common doses used and timing? OB: LDN has been studied in small trials or observational studies in fibromyalgia, multiple sclerosis, Crohn’s disease, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). In the Long COVID studies included in our review, doses ranged from 0.5 mg/day to 6 mg/day, with various titration schedules. There is no standardized regimen. KH: What are common side effects of LDN if any? Same as full-dose naltrexone? OB: In the four observational studies included in our review (n=155 total participants), no serious adverse events were reported. Reported side effects were mild and included vivid dreams, insomnia, gastrointestinal upset, mild mood changes, and skin irritation (in the study that combined LDN with NAD+ patches). KH: Why did you want to do this study? OB: LDN was increasingly being prescribed off label for Long COVID despite the absence of high-quality evidence. Given the scale of disability and patient desperation for treatment, it was important to systematically assess all available evidence regarding its effectiveness for Long COVID. The goal was to move the conversation from anecdote to evidence. KH: Can you summarize your study and the basic results? OB: We conducted a systematic review of published and registered studies up to May 2025. Key findings: * No randomized controlled trials were identified. * Four pre–post observational studies (n=155 participants) met inclusion criteria. * Doses ranged from 1–6 mg/day. * Pooled analyses showed: * Moderate improvement in fatigue (Hedges’ g −0.74) * Moderate improvement in brain fog (−0.53) * Moderate improvement in sleep (−0.60) * Large improvement in pain (−0.93) * Large improvement in daily functioning (−0.93) However, all studies were uncontrolled, and all outcomes were self-reported. Therefore, regression to the mean, placebo effects, natural recovery, and other bias cannot be excluded. Certainty of evidence remains low. Three registered trials are ongoing and will be critical for determining true efficacy. KH: Is the mechanism for brain fog and fatigue the same as for pain and sleep? OB: Unfortunately, the current evidence does not allow us to distinguish these mechanisms yet. KH: Do you have any comments on the SarsCov2 spike protein being a triggering agent in the etiology of Long Covid? OB: The spike protein is one of several hypotheses under investigation, but there is currently no definitive evidence establishing it as the cause of Long COVID. A monoclonal antibody trial targeting the spike protein is underway at Nova Southeastern University in Florida. That study, together with ongoing basic science research, may contribute useful data, although it is unlikely to resolve the broader question of causation on its own (See Spike Protein Guide by The Wellness Company below). KH: I realize RCT are needed to make a definitive statement about LDN’s efficacy but people currently living with Long Covid don’t have years to wait. If you or a family member had severe Long Covid disrupting your quality of life significantly, would you consider a therapeutic trial as being reasonable and safe? If so, for how long? 1 month, 2 months, etc. before saying this therapy was having no benefit? OB: I completely understand why people don’t want to wait years for definitive trials. Living with severe Long COVID can be devastating. If it were me or a close family member, I would consider a therapeutic trial of LDN. I would probably give it around 2–3 months to see if there was any meaningful improvement, and if not, I would stop. It’s important to be hopeful, but also realistic about the uncertainty. KH: Any final comments? OB: LDN is a biologically plausible, inexpensive, and accessible candidate for repurposing. The preliminary signal is encouraging. However, the history of medicine is full of promising uncontrolled findings that did not survive randomized testing. So, the most important next step is rigorous, adequately powered randomized trials. Until then, LDN should be framed as investigational therapy. Kirk Hamilton PA’s Clinical Pearls: Dr. Oyuka Byambasuren and colleagues’ paper and this interview came at a perfect time. I was discussing with a compounding pharmacist just yesterday what compounded agent she liked the most. Hands down she stated Low Dose Naltrexone (LDN)! She says it is excellent for many pain patients, those with autoimmune illness like Hashimoto’s Thyroiditis and she sees it used for Long Covid quite frequently and successfully. She reemphasized LDNs distinct, sometimes dramatic benefit in chronic pain patients like fibromyalgia and just the improvement in quality of life in those who take LDN. I have been practicing integrative medicine for 43 years. In this type of medicine there maybe 5-10 agents that show some benefit in a condition and have some reasonable biological rationale. Sometimes I lose track of a therapy that I may have used in the past because I started using other treatment (s). It is easy in this medicine to think of 10-20 things you can give someone for a condition that make biological sense (aside from lifestyle change which is the most important) but really 5 or less things to take for a problem is ideal. So LDN is going to be “bumped” up on my list to try again in LC patients which I have used in the past. Quick Treatment Thoughts on Long Covid… 1) Low glycemic diet (no processed carbs, added sugars or alcohol), Prolon – Fasting Mimicking Diet once per month for 6 months. 2) Minimize caffeine intake initially. 3) Vitamins C, D, B1, B12, methyl folate, Zinc, magnesium, free form amino acids, CoQ10, probiotic/bifidobacter, colostrum product, N-acetylcystiene 500-600 mg twice daily, Ultimate Spike Detox 4/d or an empty stomach (or at least 400 mg / 8000 FU nattokinase, bromelain 1000 mg, Curcumin 1000-2000 mg and N-Acetylcysteine 500-600 mg/d) Read/Watch “SPIKE PROTEIN EFFECT” - Guide to Understanding the Spike Protein Effect. Dr McCullough reviews public educational brochure with Dr Michael Gaeta. Peter A. McCullough, MD, MPH, Focal Points, Feb 27, 2026. ”Spike Protein Guide” by The Wellness Company . 4) Adrenal Glandular Support or low dose cortisone acetate (Safe Uses of Cortisol by William McK. Jefferies, MD) especially between 12-2 p.m. 5) LDN 1.5-4.5 mg at bedtime 2-3 month. 6) Ivermectin ½ mg/kg 1 month trial. 7) IV vitamin C (vits/mins), NAD SQ injections and/or B1B12folic acid home injections. 8) Exercise daily 30-60 minutes of gentle aerobics and then strength training 20 minutes 3 x week (circuit training) ***Note if your are tired after exercising but recover by the next day keep at the same intensity or gently increase it. If you feel “wiped out” the next day you have to cut back on the duration and intensity of the exercise. But always keep trying. Any movement is better than no movement. People who move get well faster. Try to get to an intensity where you sweat. 9) Meditation daily (www.drjoedispenza.com Dr. Hemal Patel Interviews 1. 2. / Falun Dafa Practice ) 10) Far-infared saunas. ( I have one. Reasonable price and mobile. Definitely makes you sweat)

    14 min
  2. Immune and Hematological Responses to the Third Dose of an mRNA COVID-19 Vaccine: a Six-Month Longitudinal Study. An Interview with Dr. Yasar Yousafzai, MD, PhD, Peshawar, Pakistan...

    FEB 23

    Immune and Hematological Responses to the Third Dose of an mRNA COVID-19 Vaccine: a Six-Month Longitudinal Study. An Interview with Dr. Yasar Yousafzai, MD, PhD, Peshawar, Pakistan...

    Yasar Mehmood Yousafzai, MD, PhDHematologist/PathologistInstitute of Pathology and Diagnostic MedicineKhyber Medical University, Peshawar, Pakistanyasar.yousafzai@kmu.edu.pk “Immune and hematologicak responses to the third dose of an mRNA COVID-19 vaccine: a six-month longitudinal study. Front Cell Infect Microbiol. 2025 Jul 10;15:1615227. “ Kirk’s Comment… I decided to put my commentary at the top of this summary and outline of my interview with Dr. Yasar Yousafzai, MD, PhD, from Pakistan regarding the study he and his colleagues did on a third dose of a Covid-19 vaccine in young adults, this one being the Pfizer mRNA vaccine, because I had some biases when I first looked at this paper. I have a very negative view of the mRNA Covid-19 vaccine so I was looking for anything that could be possibly negative about the vaccine in this study. Truthfully this study did not show any real “negative” sequelae from the single mRNA vaccine given (Pfizer) in this healthy young population. Only some transient and expected elevations in some inflammatory markers were observed. The real importance of doing this interview for me wasn’t any unique finding of the study. It was realizing that we all have different world views and experiences when looking at Covid 19 vaccine information. The benefit for me was opening my mind up of how an extremely well trained health professional (M.D., PhD) halfway around the world (13 hours ahead of my PST time zone) viewed Covid vaccine use during the pandemic from a different perspective than where I was coming from. And by doing this interview in an open-minded fashion I may have exposed an open and honest physician researcher to look at the Covid 19 mRNA vaccine differently. Dr. Yousafzai told me he still sees cases of polio. He feels that vaccines are critical for his patient population which comes from his country of Pakistan and neighboring Afghanistan. Vaccines are seen has agents that can save needless death and suffering. Yet he was open to my comment of “What if these populations who are poor had excellent sanitation, pure water and basic whole food nutrition. Would there be a need for such vaccinations? Would there be these polio cases?” (Encourage reading Vaccines: Mythology, Ideology, and Reality, by Peter McCullough, MD and John Leake) He was open to the fact that the spike protein is something he needed to look at in a more in-depth fashion as a potential pathogenic agent that might cause thrombotic/vascular events, accelerated cancer and other side effects even though in this study there wasn’t any findings that were truly remarkable. In closing I think I made a positive connection with a professional colleague half-way around the world that is open to seeing some of the evidence and sources on vaccine harm not only from the Covid vaccination viewpoint but other vaccines as well without confrontation, but with cooperation and openness. That is why I am so thankful for this interview to have taken place! Enjoy. I hope you get something from this interview and summary to help your decision making on your own and/or your patient’s health. P.S. ?? Since China (Chinese Communist Party-CCP) appears not to have used an mRNA Covid 19 vaccine on their people (they used either inactivated Covid 19 virus (Sinovac) or innocuous vector borne delivery of DNA (CanSino) you have to ask the question why? Did they (CCP) know something about the Covid-19 mRNA vaccine technology (Moderna, Pfizer) that they didn’t want their people to be exposed to in mass?? (See Below) Databases Chronicling Covid Vaccine Adverse Events… Open VAERS (Vaccine Adverse Events Reporting System) Red Boxes1) Click on US for U.S. Statistics versus world-wide.2) All Deaths Reported to VAERS by Year (scroll down page)3) VAERS Covid Vaccine Reports of Deaths by Days to Onset All-Ages (scrol0 down page) World Council for Health Covid-19 Vaccine Pharmacovigilance Report 1. Data from Pharmacovigilance Databases about Covid-19 Vaccines and Other Commonly Administered Vaccines and Interventions This report collates adverse event data on COVID-19 vaccines from the following pharmacovigilance databases: The World Health Organization (WHO) – VigiAccess The U.S. Center for Disease Control (CDC) – Vaccine Adverse Events Reporting System (VAERS) EudraVigilance – European Database of Suspected Adverse Drug Reaction Reports Medicines & Healthcare products Regulatory Agency – UK Yellow Card Reporting Site The Covid-19 vaccine adverse event data gathered on each pharmacovigilance database is compared with the adverse event data of similar pharmacological products (other common vaccines) on the same databases when possible. Detailed Summary of Interview… In this Staying Healthy Today interview, Kirk Hamilton, PA speaks with Yasar Mehmood Yousafzai, MD, PhD—Professor of Hematology and Director at Khyber Medical University—about his 2025 study published in Frontiers in Cellular and Infection Microbiology titled “Immune and hematologic responses to the third dose of an mRNA COVID-19 vaccine: a six-month longitudinal study.” Dr. Yousafzai explains that his team conducted a prospective study of 68 healthy young adults (ages 20–30) who received a third (Pfizer mRNA) COVID-19 vaccine dose (the first two vaccines prior to this study were were Sinovac and CanSino vaccines), intentionally selecting a uniform, low-comorbidity population to isolate biologic effects without confounding disease variables. The researchers evaluated short-term inflammatory and coagulation markers within 48 hours post-vaccination—including C-reactive protein (CRP), interferon levels, prothrombin time (PT), activated partial thromboplastin time (aPTT), and D-dimer—and found a subtle but consistent transient increase in inflammatory markers along with mild, temporary alterations in coagulation parameters across participants. These changes normalized over time and were not associated with clinical thrombotic events, suggesting a short-lived inflammatory and hematologic response expected after immunization. At six months follow-up there was focused antibody persistence (IgG and IgA against SARS-CoV-2 antigens), demonstrating sustained humoral immune response, though these assays were not spike-protein–specific quantitative tests. Dr. Yousafzai hypothesized that while these physiologic shifts were mild and self-limited in healthy individuals, rare exaggerated responses in susceptible persons (due to genetic predisposition, comorbidities, or immune variability) might help explain infrequent severe adverse events reported in broader populations. The discussion also explored evolving perspectives on COVID-19 severity, natural immunity, vaccine risk-benefit balance over time, and public health ethics, with Dr. Yousafzai noting that as population-level natural immunity increased and disease severity declined, the justification for ongoing broad vaccination campaigns became less compelling outside high-risk groups. NOTE: The first two doses of Covid Vaccines used in subjects prior to this study were a combination of either the Sinovac and CanSino vaccines… This study did not use three consecutive mRNA doses of vaccine. Only the last one was an mRNA vaccine from Pfizer. How The Sinovac Vaccine Works… The Sinovac vaccine uses an inactivated form of the COVID-19 virus, instead of the mRNA technology that Pfizer and Moderna use. Developed by the Chinese biopharmaceutical company Sinovac Biotech, this vaccine has been approved for use and widely used in countries like China, Indonesia and other South American countries. How The CanSino Vaccine Works… * Viral vector platform (adenovirus-based):The vaccine uses a modified (non-replicating) adenovirus type 5 (Ad5) as a vector to carry the DNA — a harmless cold-like virus altered so it cannot reproduce or cause disease. The CanSino vaccine, formally known as Convidicea, is produced by CanSino Biologics Inc. often referred to as CanSinoBIO. Founded in 2009 in Tianjin, China, this biotechnology company specializes in developing and manufacturing vaccines, including mRNA and adenovirus-based platforms. * It delivers DNA instructions:Inside this vector is DNA that encodes the spike (S) protein of SARS-CoV-2, the part of the virus your immune system learns to recognize. * Inside your cells:Once injected, the adenovirus enters your cells and delivers the spike gene to the cell’s nucleus. There the DNA is transcribed into mRNA, which is then used by the cell’s machinery to make the spike protein (translation). This is similar in concept to how mRNA vaccines lead to spike protein production, but the delivery method is different. * Immune response:The cell displays the spike protein on its surface, and your immune system sees it as foreign and builds protective responses (antibodies and T-cells) against it. Key difference vs. mRNA vaccines * mRNA vaccines (like Pfizer-BioNTech [the 3rd dose in this study] and Moderna) contain synthetic mRNA that directly instructs cells to make the spike protein. * CanSino’s vaccine uses a viral vector delivering DNA that must first be converted to mRNA within the cell — it does not contain or deliver mRNA itself in the same way. Summary In Short… - The CanSino vaccine delivers instructions for a piece of the coronavirus (the spike protein) using a harmless virus carrier.- Your cells make that spike protein.- Your immune system learns to fight it without you ever being infected with actual COVID-19. This is similar in concept to the adenovirus-based vaccines from other manufacturers (like Johnson & Johnson’s), but uses a specific Ad5 vector. Study Vaccine mRNA Third Dose… The vaccine used for the third dose was the Pfizer/BioTech mRNA vaccine (Batch/Lot No#36310BA, ex. date 08/2022) mRNA vaccines work by delivering synthetic mRNA into cells, instructing them to produce the spike protein The immune system recognizes this protein as fore

    46 min
  3. Galectin-3 Good for Assessing Neuroinflammation, Heart Disease, Cancer and Other Chronic Diseases and the Lifestyle Factors (Diet, Supplements, Exercise, Sleep, Stress) That Can Lower It.

    FEB 19

    Galectin-3 Good for Assessing Neuroinflammation, Heart Disease, Cancer and Other Chronic Diseases and the Lifestyle Factors (Diet, Supplements, Exercise, Sleep, Stress) That Can Lower It.

    Galectin-3 Not Just for Heart Failure and Heart Damage. A “High End” Marker to Follow Multiple Chronic Diseases…Especially Neurodegenerative Disease I first became aware of Galectin-3 listening to internist-cardiologist-epidemiologist Dr. Peter McCullough talk about it’s use in following heart damage post-Covid 19 vaccine. At the recent A4M Longevity Fest December 12-14, 2025 in Las Vegas I heard a very informative lecture on the use of Galectin-3 as an assessment tool focused on neurologic disease and the use of anit-galectin-3 antibodies as a very promising treatment for Alzheimer’s disease and neurodegeneration. Here is a summary of the talk below. I personally am using Galectin-3 as a “high-end” C-reactive protein following not just heart disease and neurologic diseases but cancers and most other chronic diseases. Whatever chronic disease I am trying to help the patient with I have been monitoring levels of Galectin-3 and trying to get them below Talk Summary… Anti-Galectin-3 Antibody and How to Assess Individual OutcomesJames LaValle, RPh, CCN, MT & Sheldon Jordon, MD(Longevity Fest 2025 12-12-25) Galectin-3 is a central driver of chronic inflammation, neurodegeneration, and metabolic dysfunction, linking conditions such as Parkinson’s disease, Alzheimer’s disease, diabetes, heart failure, and fibrosis through shared inflammatory and immune pathways. James LaValle, RPh, CCN, MT explained how insulin resistance, gut-derived lipopolysaccharides (LPS), environmental toxins, and aging elevate Galectin-3, triggering microglial activation, oxidative stress, abnormal protein aggregation, and loss of neuronal function. Neurologist Sheldon Jordan, MD, then introduced TB-006, an investigational monoclonal antibody that blocks Galectin-3 and has shown early promise in improving cognition and motor symptoms in neurodegenerative patients. He emphasized that individual outcomes must be measured with sensitive tools—such as advanced MRI, proteomic biomarkers, and validated cognitive scales—to detect changes beyond placebo effects and natural variability. Galectin-3 inhibition was presented as a potentially transformative strategy in precision brain health and aging-related disease management. Galectin-3 (Gal-3) is presented as a critical mediator linking: * Neuroinflammation * Metaflammation / Inflammaging * Insulin resistance & metabolic syndrome * Neurodegeneration (Parkinson’s, Alzheimer’s, post-TBI, etc.) * Fibrosis & organ dysfunction (heart, kidney, liver, lung) Galectin-3’s Role in Neuroinflammation * Gal-3 is released by microglia in neuroinflammation * Binds LPS and amplifies inflammatory signaling * Promotes: * α-synuclein aggregation (Parkinson’s) * Tau phosphorylation (Alzheimer’s) * ROS generation * Fibrosis & tissue stiffening * Persistently elevated Gal-3 creates self-propagating neuronal damage: 1. Neuron injury → release of α-synuclein & laminin fragments 2. Fragments → activate microglia 3. Microglia → produce more Gal-3 4. Gal-3 → amplifies inflammation + protein aggregation Monitoring Galectin-3… Galectin-3 serum levels for chronic disease monitoring and risk reduction * * 17.8–22 ng/mL = moderate risk * 22.2 ng/mL = high risk * 25.9 ng/mL = rapid progression toward heart failure Other markers frequently correlated with Gal-3: * hs-CRP * HbA1c / fasting glucose * MMP-9 * Neutrophil/Lymphocyte ratio (NLR) Possible Neurogenerative Treatment TB-006: Anti-Galectin-3 Antibody Intervention TB-006 is an investigational humanized monoclonal antibody developed by TrueBinding, Inc. that targets Galectin-3 (Gal-3), a protein involved in neuroinflammation and protein aggregation. It acts by inhibiting Gal-3, potentially reversing amyloid plaques and tau tangles to improve cognitive function in Alzheimer’s patients. TB-006 is available via FDA Expanded Access. Proposed actions: * Blocks Gal-3 binding * Reduces α-synuclein aggregation * Suppresses NLRP3 inflammasome * Improves: * Synaptic function * Glymphatic clearance * Blood Brain Barrier integrity * Cognitive performance Clinical Takeaways… * Galectin-3 is a central amplifier of neuroinflammation * Strongly linked to Parkinson’s, Alzheimer’s, TBI, stroke, metabolic disease * Insulin resistance + LPS = Gal-3 activation * Supports “Type 3 diabetes” dementia model * Environmental toxicants are major contributors * Most Parkinson’s cases are non-genetic * TB-006 shows early promise * Objective improvements in cognition and motor function * Case videos showed dramatic Parkinson’s functional recovery “General” Galectin-3 Facts… The Galectin-3 test measures a protein in the blood associated with inflammation and fibrosis (scarring) and is used “classically” to assess the risk, prognosis, and progression of heart failure. It helps clinicians identify patients with chronic heart failure at high risk for hospitalization or death, assisting in personalized treatment, disease management, and monitoring. Traditional Reasons for the Galectin-3 Test: * Heart Failure Prognosis: It is used alongside clinical evaluations to predict the severity and progression of chronic heart failure. * Risk Assessment: Elevated levels (typically ng/mL) are associated with a higher hazard for mortality and re-hospitalization. * Monitoring Disease Progression: Because Galectin-3 levels have low biological variability, regular testing (e.g., twice yearly) helps detect worsening heart failure, such as when levels increase by. * Fibrosis Detection: Galectin-3 is a biomarker for cardiac, liver, and kidney fibrosis (tissue scarring). * Preventive Strategy: Early detection of rising levels can lead to timely adjustments in treatment to prevent further cardiac damage. Things That Lower Galectin-3… Reducing Galectin-3 is an emerging area of immunology, metabolic health, and longevity research. There is evidence that certain dietary fibers, polyphenols, metabolic interventions, and gut/oral health strategies can help reduce Galectin-3 signaling or its downstream effects. Natural Compounds with Evidence of Lowering Galectin-3 Activity 1. Natural Compounds A. Modified Citrus Pectin (MCP) * Most studied natural inhibitor of Galectin-3 * Binds Galectin-3 lectin domains and blocks its pro-inflammatory/fibrotic effects * Used in cardiovascular fibrosis, kidney support, and cancer support research * Doses vary in studies (often 5–15g/day, divided) B. Green Tea Catechins (EGCG) * EGCG inhibits Galectin-3 binding interactions in lab models * Also reduces oxidative stress and inflammation * Supports metabolic health C. Curcumin (Turmeric Extract) * Inhibits NF-κB, TLR-4, and inflammatory cascades linked to Galectin-3 * Shows anti-fibrotic actions in liver, kidney, and cardiovascular tissues D. Resveratrol / Pterostilbene (dimethylated analog of resveratrol - more potent) * Anti-fibrotic and anti-inflammatory signaling via AMPK activation * Supports endothelial function and insulin sensitivity E. Quercetin * Inhibits mast cell activation and pro-fibrotic cytokines * May blunt LPS-induced inflammatory pathways that upregulate Galectin-3 F. Berberine * Improves insulin sensitivity and gut barrier function * Reduces LPS translocation * Helps reduce metabolic drivers of Galectin-3 G. Omega-3 Fatty Acids (EPA/DHA) * Lower systemic inflammation * Support neuronal and cardiovascular anti-fibrotic responses 2. Nutritional & Dietary Patterns Certain patterns reduce the biological triggers that elevate Galectin-3: A. Low-Glycemic, Insulin-Sensitizing Diet Because insulin resistance is a major driver of Galectin-3: * Emphasize vegetables, legumes, lean proteins, healthy fats * Minimize refined sugars and ultra-processed carbs B. Anti-Inflammatory Diet Focus on: * Olive oil, nuts/seeds, fish, berries, dark greens * Spices (turmeric, ginger, garlic) * Polyphenol-rich plants (tea, cacao, citrus) C. High Fiber & Prebiotic Foods Fiber reduces: * Gut permeability * Lipopolysaccharide (LPS) absorption * Metainflammation Sources: * Beans/lentils, oats, chia, flax, root vegetables, leafy greens D. Fermented Foods Support microbial diversity: * Kefir, yogurt, sauerkraut, kimchi, tempeh 3. Lifestyle Interventions That Lower Galectin-3 Drivers A. Insulin Sensitivity & Metabolic Fitness Exercise lowers insulin resistance, which strongly correlates with Galectin-3. Most evidence supports: * Zone 2 aerobic training (30–60 min, 4–5x/week) (Zone 2 training is a low-intensity, long-duration aerobic exercise performed at 60-70% of your maximum heart rate, often referred to as a "conversation pace"). * Strength training (2–3x/week) * Intermittent fasting or time-restricted eating (if medically appropriate) These improve: * Mitochondrial function * AMPK activation (AMPK (AMP-activated protein kinase) activation acts as a master cellular energy sensor that restores energy balance by switching on catabolic pathways (fatty acid oxidation, glucose uptake, autophagy) and switching off anabolic pathways (cholesterol/protein synthesis). It is activated by low energy (high AMP/ADP-to-ATP ratio), exercise, calorie restriction, and compounds like metformin) * Glucose utilization * Neuroinflammation B. Gut Health & Barrier Integrity Because LPS upregulates Galectin-3, protecting the gut is key: * Avoid frequent alcohol excess * Minimize NSAID overuse (if applicable) * Treat chronic GI issues (IBS, SIBO, IBD) * Increase fiber + probiotics C. Oral Health Dental plaque contains LPS that drives Galectin-3.Important steps: * Brush & floss daily * Dental cleanings 2x/year * Treat gum disease promptly D. Sleep & Stress Poor sleep and chronic cortisol elevation amplify Galectin-3 pathways.Helpful habits: * 7–8 hours consistent sleep * Morning light exposure * Stress reduction (breathing, meditation, yoga, HRV training) 4. Environmental Factors to Reduce Environmental toxins drive neuroinflammation and fibrosis. Key contributors: * Diesel/pollution * Heavy metals (lead, mer

    16 min
  4. Meditation "Cures" Pancreatic Cancer? It's Hard to Heal the Body You Hate, Some Thoughts on the Carnivore Diet, Combining Ivermectin, Febendazole and Mebendazole, Herbs Help Pain and Opioid Addiction

    FEB 3

    Meditation "Cures" Pancreatic Cancer? It's Hard to Heal the Body You Hate, Some Thoughts on the Carnivore Diet, Combining Ivermectin, Febendazole and Mebendazole, Herbs Help Pain and Opioid Addiction

    Highlights… PANCREATIC CANCER - MEDITATION - Healed From Pancreatic Cancer - His Doctor Called Him A Miracle. Dr. Joe Dispenza, Stories of Transformation. January 25, 2026. 12:53 min:sec “…One week after planning retirement with his wife, Mark was told he was inoperable, incurable, and terminal. Stage four pancreatic cancer had spread to his lymph nodes and liver, and doctors were clear- stabilization was the best outcome he could hope for. With limited time and undergoing chemotherapy, Mark fully committed to change. Having never meditated before, he and his wife meditated twice a day, every day, focusing on Blessing of the Energy Centers. Two weeks after a powerful meditation experience, a scheduled PET scan showed something no one expected - no tumor in his pancreas. Two years later, Mark continues to receive clear scans. As he says, “I didn’t cure cancer. I became somebody who no longer has it.”…”1) Watch documentary. “Source: It’s Within You”2) My favorite Story of Transformation I found before I knew I had my cancer. Then sent to me again months later after I knew I had my cancer. Patience, Practice and Persistence. Family physician cures herself of rare sarcoma after chemo, radiation and natural therapies fail. 3) See my interviews with head UCSD researcher Hemal Patel, PhD documenting whole body physiologic change from this form of meditation. Interview 1 ; Interview 2.4) Recommended home course I am enjoying currently. I have continued “work” to do to. ”Count Your Blessings” HEALING - SHAME - SELF-ESTEEM - CHILDHOOD EXPERIENCES - ADULT DISEASE - You Can’t Heal a Body You Hate. Before you can heal, shame needs to go. Makai Allbert, EPOCH Times, January 24, 2026. 1) Self-Kindness Over Self-Judgment2) Common Humanity Over Isolation3) Mindfulness Over Over-Identificationa) The harming power of shame. “…Shame is a pervasive, multidimensional emotion influencing brain, body and social life. While shame can foster accountability, its toxic forms drive stigma, withdrawal and mental illness….”b) Acute Stressors and Cortisol Responses: A Theoretical Integration and Synthesis of Laboratory Research. “…Tasks containing both uncontrollable and social-evaluative elements were associated with the largest cortisol and adrenocorticotropin hormone changes and the longest times to recovery….”c) Acute Threat to the Social Self: Shame, Social Self-esteem, and Cortisol Activity. “…Cortisol changes may be specifically tied to the experience of emotions and cognitions reflecting low self-worth…”d) Immunological Effects of Induced Shame and Guilt. “…those individuals in the self-blame condition reporting the greatest increases in shame in response to the task showed the greatest elevations in pro-inflammatory cytokine activity…”e) Adverse childhood experiences and the risk of premature mortality. “…ACEs (Adverse Childhood Experiences) are associated with an increased risk of premature death…”f) The Relation Between Adverse Childhood Experiences and Adult Health: Turning Gold into Lead. “…Clearly, we have shown that adverse childhood experiences are both common and destructive. This combination makes them one of the most important, if not the most important, determinants of the health and well-being of the nation…”g) Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. “…We found a strong graded relationship between the breadth of exposure to abuse or household dysfunction during childhood and multiple risk factors for several of the leading causes of death in adults…” Kirk’s Comment: Change your thoughts and emotions (energy and frequency) and change who you are. Leave the old “energetic self” behind. If we don’t manage those 60,000-70,000 thoughts per day of which 90-95% are the same as yesterday we never change our energetics, therefore we never change our physiology and we remain the same and susceptible to the same old disease (s). I work everyday at this. For some it may come quickly like the above cancer example, for others, like myself, the work continues :-))!PAIN - OPIODS - HERBALS - Struggling with Chronic Pain? New Research Unveils Innovative Approaches to Pain and Opioid Use Disorder, IMA, October 11, 2025. Can Herbal Medicine Help End the Opioid Crisis? IMA Researchers Propose a Clinical Trial. A new study published in the Journal of Independent Medicine proposes testing a combination of herbal therapies as adjunctive treatment for opioid use disorder. Independent Medical Alliance, Jan 30, 2026. * Saffron 100 mg twice daily - components like crocin have demonstrated effects on reducing opioid craving and withdrawal scores in patients on methadone maintenance therapy. Gemini AI “…evidence suggests that saffron ( Crocus sativuscap C r o c u s space s a t i v u s 𝐶𝑟𝑜𝑐𝑢𝑠 𝑠𝑎𝑡𝑖𝑣𝑢𝑠 ) can help manage pain due to its anti-inflammatory, analgesic, and antioxidant properties. Clinical studies indicate it is effective for chronic pain conditions like fibromyalgia, rheumatoid arthritis, and menstrual cramps. It acts by reducing pain-causing inflammation and modulating neurotransmitters…” * Berberine 100 mg twice daily - can inhibit morphine-induced sensitization and has potential to induce extinction of drug-related behavior. Gemini AI “…Berberine shows promise for pain relief by targeting inflammation and nerve pathways, demonstrating analgesic effects in studies for conditions like diabetic neuropathy, nerve injury pain, and chronic pelvic pain, working through mechanisms like reducing inflammatory markers (NF-κB) and modulating opioid/neurotransmitter systems, though it can cause GI side effects and interacts with medications, requiring medical consultation…” * Nigella sativa 100 mg twice daily - supplementation has been linked with alleviation of withdrawal symptoms and improved psychological health. Gemini AI “…Nigella sativa (black seed) helps manage pain, particularly for arthritis, knee osteoarthritis, and neuropathic pain, due to its anti-inflammatory, antioxidant, and analgesic properties. Studies suggest it can be as effective as topical diclofenac or superior to acetaminophen for reducing joint pain. The primary active compound, thymoquinone (TQ), is responsible for these effects…” * Corydalis 100 mg twice daily - alkaloids are modulatory neurotransmitters of analgesia and dopamine, directly relevant to the neurobiology of OUD. Gemini AI “… Corydalis yanhusuo is widely recognized in Traditional Chinese Medicine (TCM) and supported by recent studies as an effective herbal, non-addictive pain reliever, particularly for chronic, inflammatory, and neuropathic pain. It contains alkaloids like dehydrocorybulbine (DHCB) and L-tetrahydropalmatine (L-THP) that help reduce pain, including headaches, menstrual cramps, back pain, and muscle aches. COMMENT: Elimination diets as simple as eating no dairy products, wheat products, eggs, sugar, alcohol and eliminating caffeine while the rest of the diet is eating only whole food for 2-4 weeks can bring about rapid and dramatic pain reduction frequently. In fact, in all my shockwave patients which is a treatment for many “itises”, I encourage them to go on the diet I just mentioned above, or modified-fast like Prolon (www.prolonlife.com) to see how much of their pain condition is related to food? 10%, 60%, 90%? It sometimes can be a dramatic reduction in pain in a very short time. Pain and Depression Relief with the Carnivore Diet…I just got finished reading “The Carnivore Diet” by orthopedic surgeon Shawn Baker, MD and he mentions pain reduction frequently and improvement in mood as a result of being on the “Carnivore” diet. I am sure the Carnivore Diet if done as mentioned will help a lot of people with pain reduction, metabolic normalization and weight loss. The question has always been for me “Is it a lifelong diet or just a therapeutic diet?” Dr. Baker reviews many arguments in his book including “Where are the longevity or Blue Zone cultures that eat a purely carnivore diet?” There isn’t in the traditional Blue Zone areas of Ikaria (Greece), Sardinia (Italy), Nicoya (Costa Rica), Okinawa (Japan) and Loma Linda (CA). BUT there ISN’T a purely plant-based one either. Loma Linda may be the closest but they are not all pure vegans. He does mention Hong Kong (where I was born) being one of the longest lived areas in the world and they eat a very high per capita consumption of meat. Gemini AI “…Hong Kong has one of the highest per capita meat consumption rates in the world, with residents consuming approximately 664g of meat per day, equivalent to about two 10-oz steaks. Total annual meat consumption is estimated at 189.48 kg per person, driven by high intakes of pork, beef, and seafood…” Gemini AI “…Hong Kong consistently ranks as having one of the longest life expectancies in the world, frequently topping global lists alongside Japan. While sometimes ranking #1, recent 2022-2024 data indicates it now ranks in the top 3, with life expectancy for women reaching approximately 86.8 years and men around 80.7 years…” I enjoyed hearing his many logical arguments from his perspective even though I have listened to counter arguments in favor of whole food plant-based eating for 25 years being a vegan. I am eating more animal food now starting before I “got” my colon cancer (9/26/23) and the tumor was removed (1/16/25). It was after I got my first Covid infection in August of 2021 and I had to stay away from the office for about 10 days that I remember going out and having a hamburger at “In and Out” after about 25 years of not eating meat. That two year period from then until I was diagnosed with colon CA was not my best period of eating let’s

    16 min
  5. A Summary of Approaches to Vaccine Injury From Experienced Practicing Clinicians (Drs. Bowden, McCullough, Kory, Tankersley, James). Are We Looking at the Whole Person or Vaccine Injury as a "Disease"

    JAN 20

    A Summary of Approaches to Vaccine Injury From Experienced Practicing Clinicians (Drs. Bowden, McCullough, Kory, Tankersley, James). Are We Looking at the Whole Person or Vaccine Injury as a "Disease"

    SAR-COV2-VIRUS-ORIGINS-MANMADE - SARS-CoV-2 Architect Ralph Baric Collaborated with CIA. UNC Chapel Hill coronavirus expert comes under scrutiny going back over a decade. Peter A. McCullough, MD, MPH., Focal Points (Courageous Disourse), Nov 28, 2025.1) A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence.2) SARS-like WIV1-CoV poised for human emergence. VACCINE SCHEDULE - DENMARK - UNITED STATES - Comparing US CDC ACIP and Denmark Childhood Vaccine Schedules. Policy shift may lessen burden of vaccines on American children. Peter A. McCullough, MD, MPH, Focal Points (Courageous Discourse), Dec 26, 2025.1) CDC Acts on Presidential Memorandum to Update Childhood Immunization Schedule. VACCINE SCHEDULE - CDC SHRINKS ROUTINE CHILDHOOD VACCINE SCHEDULE BY ~55 DOSES - CDC Acts on Presidential Memorandum to Update Childhood Immunization Schedule. The largest rollback of routine childhood vaccination in U.S. history. Nicolas Hulscher, MPH, Focal Points (Courageous Discourse), Jan 05, 2026. 1) CDC Acts on Presidential Memorandum to Update Childhood Immunization Schedule. PDF COLON CANCER - Colorectal cancer is a leading cause of cancer death for adults under 50. Morgan Chamberlain, MindBodyGreen, December 23, 2025. COVID SHOT INJURIES: 4 DOCTORS SHARE PROTOCOLS – McCullough, James, Kory, and Tankersley, Mary Talley Bowden, MD (Host; ENT & Sleep Medicine) Interviews. America Out Loud Pulse, Aug 5, 2025 58:00 min (Summary of interview was edited by Kirk Hamilton PAC after transcript was run through otter.AI and ChatGPT with Kirk Hamilton PA’s own commentary following) Mary Talley Bowden, MD * Houston-based ENT and sleep specialist. * Hosts the program and interviews four physicians about how they treat patients who attribute ongoing symptoms to COVID vaccination. Recommendations * Usually starts vaccine-injured patients on Ivermectin. * Ivermectin has been the single most effective therapy in her practice, but: * Not sufficient by itself, especially for severe neurological injuries. * Most patients improve gradually over many months rather than rapidly. * Vaccine injured patients, especially ones with neurologic issues are complex and results are often slow. * There is a need for more research and collaboration on vaccine injured patients. Peter McCullough, MD (Cardiologist) * Attributes most “long COVID” and many chronic post-vaccine problems to persistence of the spike protein and, in some cases, persistent virus. * Uses spike protein IGG quantitative antibody levels (Lab Corp) as a rough marker of estimated spike protein load: * Vaccine recipients typically have much higher levels than infection-only patients. * In his practice, levels > ~5000 (on the Labcorp/BioRad assay) often correlate with detectable circulating spike in research collaborations. * Considers levels 1. “Spike detox” supplement protocol (his core approach) He describes a three-component supplement combination he calls his spike protein detox protocol: * Nattokinase * Enzyme derived from fermented soy (natto). * Preclinical work suggests it can degrade spike protein and that oral forms reach the bloodstream. * Uses relatively high doses (e.g., 4000 FU twice daily, potentially titrating higher). * Uses it cautiously in some patients on anticoagulants, while watching for bleeding risk. * Bromelain * Enzyme from pineapple. * Added for additional proteolytic effects on spike and clotting/inflammation pathways. * Curcumin * Anti-inflammatory compound from turmeric. * Randomized trials suggest it can improve “long COVID” symptoms by reducing spike-related inflammation. Dr. McCullough’s personal experience with treating patients with elevated IGG spike protein antibodies with Covid Long Haul or post Covid vaccine syndrome. * Notes patients show gradual symptom improvement over ~9–12 months and a decline in spike antibody levels. * The goal is spike antibody levels to be * A subset does not respond or show much change. 2. Additional or experimental spike-related strategies * Augmented / modified N-acetylcysteine (NAC) * Described as a specialized NAC formulation under development in Europe. * Hypothesized to denature or “unfold” spike protein for clearance. * Notes that evidence is still preliminary and not fully peer-reviewed. * Broad enzymatic “cocktails” * References a Japanese case report using combinations of: * Nattokinase * Bromelain * Lumbrokinase * Serrapeptase * Papain * Curcumin * Used aggressively in a single patient with vaccine-related carotid clotting with benefit. 3. Targeted prescription agents (based on clinical pattern) Dr. McCullough describes tailoring drug therapy to the predominant clinical picture: * Suspected persistent SARS-CoV-2 virus * Signs: recurrent fever, night sweats, cranial nerve symptoms, sensory loss, persistent pulmonary findings, certain rashes. * Uses ivermectin at relatively high doses for extended durations (e.g., 90 days). * Rationale: antiviral and anti-spike effects, but he emphasizes it does not clear vaccine-derived spike protein. * Autoimmune / inflammatory joint or neuromuscular disease * Positive ANA, rheumatoid factor, or anti-CCP with arthralgia/neuromuscular complaints. * Uses hydroxychloroquine (e.g., 200 mg twice daily for 90 days) as an immunomodulator. * Neuropathy / small fiber neuropathy / cognitive fog * Uses nicotine patches (e.g., 7 mg daily) for ~90 days, citing Swiss data. 4. Approaches Dr. McCullough does not find effective (in his practice) * Maraviroc (CCR5 antagonist, anti-retroviral medication) + high-dose pravastatin * Low-dose naltrexone (LDN) – has not found it helpful. * Ivermectin alone without spike-targeting measures – feels does not work well for chronic injury if spike is not being cleared. Pierre Kory, MD (Critical Care / Leading Edge Clinic) * Distinguishes: * Acute vaccine injuries (e.g., myocarditis, stroke, GBS, etc.). * Post-COVID vaccine syndrome – a chronic condition overlapping strongly with Myalgic Encephalomyelitis (ME), often called Chronic Fatigue Syndrome (CFS): * Core symptoms: profound fatigue, post-exertional malaise, cognitive dysfunction (“brain fog”). * Believes there is no single standard therapy; treatment is trial-and-error and highly individualized. 1. First-line therapies * Ivermectin * “First line” for essentially all new, untreated patients. * Rationale: broad mechanisms (binds spike, reduces inflammation). * Estimates ~70% response, but often modest; a small subset improves dramatically. * Low-dose naltrexone (LDN) * Initiated early and titrated slowly. * For broad immunomodulatory and neuroinflammatory effects. * Mast cell–directed therapies * Dietary changes to reduce triggers. * H1/H2 antihistamines: e.g., famotidine (Pepcid). * Mast cell stabilizers: e.g., cromolyn, ketotifen. * Notes that, in some patients, these can have dramatic effects. 2. Hypercoagulability / microclotting strategies Early approach: * Triple therapy: * Direct oral anticoagulant (e.g., apixaban/Eliquis), * Antiplatelet (e.g., clopidogrel/Plavix), * Aspirin, * Plus nattokinase as a proteolytic enzyme. * Has seen some “dramatic responses” in certain patients. Current preference: * Sulodexide * Oral anticoagulant used outside the U.S. (Italy/Russia/Japan), obtained via international sources. * Used now often as his first-line agent for microclots, sometimes alone, because: * He considers it very safe (low observed bleeding risk in published trials). * Also reported to reduce endothelial inflammation. * Sometimes helpful for tinnitus. * Nattokinase * Still uses as a supportive enzyme for clotting/spike,but rarely sees a clear, isolated response just from nattokinase. 3. Other modalities and multi-modality centers * Describes patients undergoing multi-week intensive programs including: * Apheresis * Ozone therapies * Hyperbaric oxygen * IV vitamin C * Methylene blue * Near-infrared light * Reports: * Many patients improved substantially during these programs. * However, benefits often were not sustained, with relapses over time. * Cost and access are major barriers. 4. Chlorine dioxide (CDS) * Dr. Kory is intensively researching chlorine dioxide and writing a book about the “war” on it. * Notes: * Many patients self-initiate chlorine dioxide “protocols” found online. * He views it as promising and generally safe at those protocol doses based on his literature review. * At present he frames his role more as researcher and observer rather than prescriber. * This is highly controversial and not an accepted mainstream medical treatment. 5. Ketamine (low-dose, daily, oral/sublingual) * Describes daily, low-dose oral/sublingual ketamine as one of the most “transformative” recent additions in his practice, based on mentorship from psychiatrists. * Reported benefits: * Neurologic symptoms, * Dysautonomia, * Fatigue, * Neuroinflammation-related issues. * Protocol: * Compounded as liquid or troches. * Taken mainly at night, slowly titrated. * Combined with curcumin, NAC, and MSM to support glutathione and anti-inflammatory actions. * Notes that typical “IV ketamine depression” protocols (expensive, intermittent infusions) are different from his daily oral approach. 6. DMSO and NAC * Uses DMSO: * Topical: for focal pains, joint swelling, arthritic symptoms. * Oral: for systemic anti-inflammatory and other purported mechanisms. * Values NAC and augmented NAC: * Widely used in his practice as a “fan favorite,” especially among his colleagues. * Helpful for some patients, but again not universally effective. Stewart Tankersley, MD (Family Practice, Alabama) General approach / philosophy * Believes many vaccinated individuals have or will develop injuries. * Uses a broad symptom checklist and history to screen for potential injury. * Encourages vaccinated patients to undergo some form of “detox,” even if they do not initially recognize symptoms. 1. Monitoring and stratifi

    37 min

  6. JAN 18

    Potatoes as a Healthy Food for Diabetes and Weightloss…What’s the Real Story?

    Hana Kahleova, MD, PhDPhysicians Committee for Responsible Medicine5100 Wisconsin Ave NW, Ste 400Washington, DC 20016hkahleova@pcrm.org; hana.kahleova@gmail.com Potatoes Can Be a Healthy Food for Diabetes and Weight Loss (Summary of interview transcript generated by otter.AI and ChatGPT edited by Kirk Hamilton PA / Slide presentation follows Summary, Key Takeaways and Outline of Key Points Below) SUMMARY Physician Assistant Kirk Hamilton interviews Hana Kahleova, MD, PhD—an endocrinologist and research physician at the Physicians Committee for Responsible Medicine (PCRM)—on the role of potatoes in nutrition, diabetes prevention, and weight loss. Although potatoes have developed a reputation as harmful for people with diabetes due to their carbohydrate content, Dr. Kahleova argues that whole potatoes are nutritionally dense, low-fat foods that can be metabolically beneficial when prepared without added fats and consumed within a whole-food, plant-based diet. She reviews how observational studies historically conflated fried potatoes and chips with whole potatoes, leading to misleading associations with diabetes risk. She highlights international research showing neutral or protective effects when potatoes are boiled and eaten with vegetables or legumes rather than oils or meats. She further explains the underlying physiology of insulin resistance, emphasizing that ectopic fat—not dietary carbohydrate—is the key driver of impaired glucose metabolism. Practical guidance is given for incorporating potatoes and other carbohydrate-rich foods into diets to improve glycemic control and achieve weight loss. KEY TAKEAWAYS • Whole potatoes are nutrient-dense, fiber-rich, low-fat foods• The “potato problem” is largely due to oil, frying, dairy, and meat pairings• Earlier research misclassified fries/chips as “potatoes”• Boiled potatoes show neutral or beneficial associations with diabetes risk• Cooling cooked potatoes increases resistant starch, lowering glycemic impact• Diabetes pathophysiology involves ectopic fat, not dietary carbohydrate• Low-fat plant-based diets improve insulin sensitivity in ~3 weeks• Legumes + greens are glycemic stabilizers• Whole fruit and potatoes are not restricted in successful diabetes reversal protocols• Potatoes do not need to be feared if prepared without oil and excessive fats OUTLINE OF KEY POINTS I. Interview ContextA. Interviewer: Kirk Hamilton, PA – Staying Healthy Today ShowB. Guest: Hana Kahleova, MD, PhD – Endocrinologist & researcher, PCRMC. Topic Focus: Potatoes, diabetes, and weight managementD. Motivation: Countering widespread fear of carbohydrate-rich whole foods II. Dr. Kahleova’s BackgroundA. Clinical training: MD + endocrinologyB. Research training: PhD in human physiology/pathophysiologyC. Research focus: 1) Mechanisms of type 2 diabetes 2) Diet-based reversal of metabolic diseaseD. Notable contribution: Demonstrated reversal of core metabolic dysfunctions in T2DM through plant-based diets III. Why Potatoes Became VilifiedA. Historical data from Harvard cohorts reported higher diabetes incidence among high potato consumersB. Methodological issue: “Potato” category included: 1) French fries, 2) potato chips, 3) baked/mashed potatoes (Boiled potatoes not included)C. Dietary context con-founders: high consumers also ate more: 1) Red meat 2) Refined grains 3) Total calories; Example meal pattern: hamburger + fries + sodaD. Conclusion: Results reflected eating patterns and cooking methods, not potatoes alone IV. Updated and International EvidenceA. Later Harvard analysis including boiled potatoes showed no association with diabetes riskB. Finland & Netherlands research: 1) High potato intake correlated with higher vegetable/legume intake 2) Associated with lower diabetes riskC. Iran cohort study: 1) High potato intake → 54% lower diabetes incidence 2) Boiled potatoes particularly protective (≈53% reduction) 3) Fried potatoes → no significant associationD. Key finding: Preparation method + dietary pattern drive outcomes V. Potato Nutrition Basics A. Whole potatoes provide: 1) Fiber 2) Micronutrients 3) Naturally low fatB. Problems arise with: 1) Frying (oil absorption) 2) Butter/cream/cheese toppings 3) Meat-heavy meal combinations VI. Resistant Starch & Glycemic ControlA. Cooling boiled potatoes increases resistant starch contentB. Effect: 1) Glycemic index decreases ≈37% 2) Benefit persists after reheatingC. Application: Improves glucose handling for diabetes and weight loss VII. Insulin Resistance MechanismA. Conventional strategy: restrict carbohydrates to lower glucoseB. Root cause physiology: ectopic fat in muscle and liver drives insulin resistanceC. Source of ectopic fat: 1) Excess dietary fat (especially saturated fat) 2) Adipose spillover into organsD. Metabolic effect: impaired carbohydrate metabolism despite unchanged carb intakeE. Intervention: low-fat, plant-based diet restores insulin sensitivityF. Timeframe: meaningful improvement typically within ~3 weeks VIII. Practical Management StrategiesA. Dietary pattern guidance for glycemic control: * Prioritize leafy greens at meal start * Emphasize legumes (beans, lentils, peas) * Titrate starch portion gradually if needed B. Behavioral tools: * 10–15 minute post-meal walking → significantly reduces glucose spikes * Monitoring with glucometer or CGM for feedback IX. Fat Intake ConsiderationsA. Whole-food fats (nuts, seeds, avocado, olive oil) are healthy foodsB. Excessive fat intake slows insulin sensitivity improvementsC. PCRM clinical protocol: X. Fruits & Whole CarbohydratesA. Whole fruits are not restricted in PCRM diabetes studiesB. Glycemic issues largely resolve once fat overload is reduced XI. Cultural & Culinary NotesA. Czech cuisine example: potato soups prepared without dairy or oil can be nutritionally beneficialB. Reinforces that health outcome depends on preparation rather than carbohydrate content alone XII. Core ConclusionsA. Potatoes are not inherently harmful for diabetesB. Frying methods and meat-based dietary patterns created false associationsC. When prepared appropriately, potatoes can support: 1) Weight loss 2) Improved insulin sensitivity 3) Reduced diabetes riskD. Whole, minimally processed carbohydrate foods need not be feared (Slide presentation with permission from Hana Kahleova, MD, PhD / References, Patient Education Handout and Bottom Line follow slide presentation) REFERENCES Potato and french fry consumption and risk of type 2 diabetes in women. Halton TL et al. Am J Clin Nutr 2006;83:284-90Total and specific potato intake and risk of type 2 diabetes: results from three US cohort studies and a substitution meta-analysis of prospective cohorts. Mousavi SM et al. BMJ 2025;390:e082121Dietary factors determining diabetes and impaired glucose tolerance. A 20-year follow-up of the Finnish and Dutch cohorts of the Seven Countries Study. Feskens EJ et al. Diabetes Care. 1995 Aug;18(8):1104-12The Association of Potato Intake With Risk for Incident Type 2 Diabetes in Adults. Farhadnejad H et al. Can J Diabetes. 2018 Dec;42(6):613-618Glycemic index of potatoes commonly consumed in North America. Fernandez G et al. J Am Diet Assoc. 2005 Apr;105(4):557-62.Effect of preparation method on the glycaemic index of novel potato clones. Kinnear T et al. Food Funct. 2011 Aug;2(8):438-44.Determination of the glycaemic index of various staple carbohydrate-rich foods in the UK diet. Aston LM et al. Eur J Clin Nutr. 2008 Feb;62(2):279-85.Lower nocturnal blood glucose response to a potato-based mixed evening meal compared to rice in individuals with type 2 diabetes. Devlin BL et al. Clin Nutr. 2021 Apr;40(4):2200-2209A satiety index of common foods. Holt SH et al. Eur J Clin Nutr 1995 Sep;49(9):675-90Low-Energy Dense Potato- and Bean-Based Diets Reduce Body Weight and Insulin Resistance: A Randomized, Feeding, Equivalence Trial. Rebello CJ et al. J Med Food. 2022 Dec;25(12):1155-1163. PATIENT EDUCATION HANDOUTPotatoes, Diabetes, and Weight: What You Should Know What is this handout about?This handout explains how potatoes fit into a healthy eating plan for people who are trying to manage blood sugar, prevent diabetes, or lose weight. A. ARE POTATOES “BAD” FOR BLOOD SUGAR? Many people have heard that potatoes are not healthy because they contain carbohydrates. However, research shows that the real problem is not the potato itself, but how it is prepared and what it is eaten with. Examples of unhealthy potato choices:• French fries (deep fried in oil)• Potato chips• Mashed potatoes with butter, cheese, or cream• Baked potatoes loaded with butter, cheese, sour cream, or bacon These versions are high in fat and calories, and they can raise blood sugar more quickly. B. WHAT MAKES POTATOES HEALTHY? A plain potato contains:• Vitamins (especially Vitamin C and B vitamins)• Minerals (like potassium)• Fiber• Almost no fat Potatoes are considered a whole plant food, which is generally healthy when prepared without added oils or animal fats. C. BETTER WAYS TO PREPARE POTATOES Healthier options include:• Boiled potatoes• Baked potatoes (without butter or cheese)• Mashed potatoes using vegetable broth instead of butter/cream• Potato soups made with vegetables instead of dairy• Cold boiled potatoes (see “resistant starch” below) Try pairing potatoes with vegetables and beans instead of meat, cheese, or oils. D. WHAT IS “RESISTANT STARCH”? If you cook potatoes and then cool them in the refrigerator, they form something called resistant starch. Resistant starch:• Lowers the blood sugar response• Helps the gut (acts like fiber)• May help with weight-control Fun tip: Even if you reheat the cooled potatoes, the benefits stay. E. HOW POTATOES FIT INTO DIABETES AND WEIGHT LOSS Research on plant-based diets shows:• People can include potatoes without restricting them• A low-fat, whole-food diet helps the body use sugar

    24 min

  7. JAN 17

    Microplastics: Health Effects on the Brain and Vascular Systems, Food and Environmental Sources, Prevention and Reducing Your "Plastic Load"

    Hana Kahleova, MD, PhD Physicians Committee for Responsible Medicine5100 Wisconsin Ave NW, Ste 400Washington, DC 20016 hkahleova@pcrm.org; hana.kahleova@gmail.com Microplastic’s Effects on Human Health, Food and Environmental Sources and How to Reduce Your Intake and Body Burden. (Summary of interview transcript generated by otter.AI and ChatGPT edited by Kirk Hamilton PA / Slide presentation follows Summary, Key Points and Outline Below) SUMMARY In this interview, Kirk Hamilton hosts Dr. Hana Kahleova—an endocrinologist and Director of Clinical Research at the Physicians Committee for Responsible Medicine (PCRM)—to discuss the emerging problem of microplastics and their human health implications. Dr. Kahleova outlines her medical background, research credentials in diabetes and plant-based nutrition, and then details recent scientific findings on the presence of microplastics in human tissues, associations with chronic disease, primary exposure pathways (with marine food sources being predominant), and potential dietary strategies to mitigate absorption or toxicity of microplastics. Key research highlighted includes autopsy studies showing microplastic accumulation in human brain tissue (with higher levels observed in dementia cases), vascular studies linking microplastics in atherosclerotic plaque elevating cardiovascular risk, and laboratory findings suggesting fiber and plant compounds may help reduce microplastic bioavailability and enhance removal. Dr. Kahleova emphasizes that microplastics are ubiquitous in the environment but exposure can be reduced by limiting seafood intake, avoiding hot food contact with plastics, and using non-plastic storage and cooking materials. Dr. Kahleova further discusses evidence that plant-derived fibers and anthocyanin-rich foods may bind or block microplastic activity, potentially reducing endocrine disruption and metabolic effects. The interview concludes with practical recommendations: reduce direct sources (especially contaminated seafood and heated plastic contact), consume high-fiber and colorful plant foods, and adopt glass or stainless-steel food storage strategies. OUTLINE - KEY POINTS I. Participant BackgroundsA. Host: Kirk Hamilton, PA- Focus on lifestyle, preventative, integrative medicine topics.B. Guest: Hana Kahleova, MD, PhD * Medical training in former Czechoslovakia * Specialty: Endocrinology * PhD in Human Physiology & Pathophysiology * Clinical research focus: plant-based nutrition & diabetes reversal * Director of Clinical Research at PCRM II. Context of Topic: Microplastics and HealthA. Definition and relevanceB. Rising scientific and public health interestC. Dr. Kahleova’s entry point into topic via key autopsy study III. Evidence of Microplastic Accumulation in HumansA. Autopsy study results (University of New Mexico) * Sample: 24 human brains * Major findings: * Average ~7 grams of microplastics per brain (≈ plastic spoon) * Polyethylene and polypropylene most common * Trend data: * Microplastic content increasing over time in human tissues * Dementia association: * Brains of dementia patients contained higher amounts * Association only; causality not established IV. Cardiovascular Disease AssociationsA. Study of 300+ patients undergoing carotid endarterectomy * Microplastics detected in ~50% of plaques * Outcomes during 3-year follow-up: * Those with microplastics had 4.5× greater risk of stroke, MI, or death * Mechanistic considerations: * Microplastics may carry toxins * Potential inflammatory or vascular injury pathways V. Endocrine Disruption and ObesityA. Microplastics as endocrine disruptorsB. Debate regarding causal role in weight gain and metabolic diseaseC. Hypothesized mechanisms: * Hormone receptor interactions * Transport of environmental toxins * Inflammatory and oxidative stress signaling VI. Primary Exposure PathwaysA. Environmental ubiquity * Air, soil, freshwater, oceansB. Dietary vectors * Seafood/fish (highest dietary source) * Bioaccumulation via food chain (plankton → fish → humans) * In a single ~3 oz serving: ~0.24 g microplastics(~½ a plastic straw) * Plant foods * Contain microplastics via soil/water exposure * Much lower concentrations: ~1–3 particles per 100 gC. Other non-food exposures * Water supplies * Household dust * Plastic consumer products VII. Mitigation Through DietA. Fiber binding effects * Lab study: groundwater with microplastics + complex carbs * Fenugreek carbs removed ~89% of microplastics * Okra carbs removed ~80% * Implication: soluble fibers may bind microplastics in GI tractB. Anthocyanins & receptor blockade * Compounds in purple/dark red fruits & vegetables (blueberries, blackberries, cherries, strawberries, purple potatoes) * Mechanism: block microplastics from attaching to sex hormone receptors * Potentially reduces endocrine-disrupting activity VIII. Practical Lifestyle and Food Handling Recommendations * Limit seafood (especially large or bottom-dwelling fish) * Prefer wild-caught small fish if consumed * Avoid microwaving plastics * Avoid placing hot food into plastic containers * Prefer glass and stainless steel * Plastic lids acceptable if not contacting food * Increase dietary fiber intake * Increase anthocyanin-rich plant foods * Emphasize whole-food plant-based eating IX. Concluding PointsA. Microplastics cannot be completely avoidedB. Major exposures can be substantially reducedC. Dietary countermeasures may offer biological protectionD. Further human causal research is needed (Slide presentation with permission from Hana Kahleova, MD, PhD / References, Key Takeaways and Bottom Line follow slide presentation) REFERENCESBioaccumulation of microplastics in decedent human brains. Nihart AJ et al. Nat Med 2025; 31:1114–1119.Microplastics and Nanoplastics in Atheromas and Cardiovascular Events. Marfella R et al. N Engl J Med 2024;390:900-910Freshwater and airborne textile fibre populations are dominated by ‘natural’, not microplastic, fibres. Stanton T et al. Sci. Total Environ. 2019, 666, 377–389.Quantitative Analysis of Selected Plastics in High-Commercial-Value Australian Seafood by Pyrolysis Gas Chromatography Mass Spectrometry. Ribeiro F et al. Environ. Sci. Technol. 2020, 54, 9408–9417.Fenugreek and Okra Polymers as Treatment Agents for the Removal of Microplastics from Water Sources. Srinivasan R et al. ACS Omega. 2025 Apr 10;10(15):14640-14656.Exploring the potential protective role of anthocyanins in mitigating micro/nanoplastic-induced reproductive toxicity: A steroid receptor perspective. Zhang J et al. J Pharm Anal. 2025 Feb;15(2):101148. KEY TAKEAWAYS * Microplastics are now measurable in human tissues, including brain and vascular plaque. * Epidemiologic findings link microplastics with higher cardiovascular and neurodegenerative risk, though causality remains unproven. * Fish and seafood are significant dietary sources. * Plant foods contain lower levels and may provide protective compounds. * Fiber and anthocyanin-rich foods may bind microplastics or block endocrine actions. * Avoiding heated contact between plastics and food reduces immediate exposure. BOTTOM LINEMicroplastic exposure is an emerging environmental health issue with early evidence linking tissue accumulation to adverse cardiovascular and neurocognitive outcomes. While causality is not established, clinicians can apply practical exposure-reduction counseling and dietary strategies that carry low risk and broader metabolic benefit. Dr. Joe Dispenza’s Website * Practice, Persistence and Patience - My Favorite. The first story of transformation that “jumped out” at me before my cancer and then the first one “sent” to me after my cancer diagnosis. A physician cures herself of a rare, life threatening sarcoma after chemo, radiation and alternative therapies had been tried. * ”Source” the Documentary - The Science behind the practice. Highly recommended. * Proof - Stories of Transformation (listen to a few stories of transformation from serious health problems) * Stories of Transformation - YouTube Channel * Research: The Science Behind Mind/Body Healing and Meditation * Dr. Joe Dispenza’s Book: Becoming Supernatural Falun Dafa – Truthfulness, Compassion and Forbearance Brief Introduction to Falun Dafa Books & Recent Writings of Mr. Li HongzhiVideo & Audio MaterialsTake an Online Class Kirk Hamilton PA-CHealth Associates Medical Group3301 Alta Arden, Suite 3Sacramento, CA 95825(916) 489-4400 (w)krhammer@surewest.netwww.StayingHealthyToday.comwww.HealthyLivingforBusypeople.com www.KwikerMedical.com Staying Healthy Today is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Get full access to Staying Healthy Today at stayinghealthytoday.substack.com/subscribe

    22 min
  8. "Count Your Blessings"...The "Gift" of My Colon Cancer Journey Using Repurposed Drugs, Nutraceuticals, IV Vit C, Diet, Meditation, and Yes Surgery, Working Daily to Create My Thoughts and Emotions...

    JAN 2

    "Count Your Blessings"...The "Gift" of My Colon Cancer Journey Using Repurposed Drugs, Nutraceuticals, IV Vit C, Diet, Meditation, and Yes Surgery, Working Daily to Create My Thoughts and Emotions...

    Highlights… MIND - BODY - ENERGY CENTERS - MEDITATION - Count Your Blessings: A Guided Practice With the Energy Centers, a series of eight audio lessons and eight guided meditations – one for each center. Count Your Blessings also includes detailed instructions and a thorough resource guide to help you personalize your practice. Kirk’s Comment: Over the last two years in my successful colon cancer journey, which really has been a gift for me to change, I have gone to several Dr. Joe Dispenza’s four to seven day intensives, done their health professional training, committed to hours of meditation daily and have worked very hard at re-framing my thoughts and emotions. This above 8 meditation series, along with 8 mini-lectures one for each energy center, and a very practical and usable workbook is a gift and truly worth every penny to help one with personal transformation. I highly recommend this for everyone who is not just trying to “get well” but also create a life of purpose and self-direction. EXCELLENT! (Listen to my interviews with lead U.C. San Diego researcher Hemal Patel, PhD on Dr. Joe’s work. There is considerable hard science behind the many “Stories of Transformation” 1) Scientific Proof That a Week-Long Intensive Meditation Retreat Can Change Brain Structure and Metabolism, Create Endogenous Drug-Like Compounds and Enhance Non-Touch Healing... 2) What is the Evidence and Possible Mechanisms of How Meditation Can Change Our Biology to Prevent or Reverse Serious Disease in the Individual & In Those Who Receive Intentional Meditation From Others.) MICROPLASTICS - HEALTH RISK - REMOVAL WITH FOOD. Best Ways to Remove Microplastics From Your System. By Physicians Committee for Responsible Medicine with Chuck Carroll, Hana Kahleova, MD, PhD, VUMEDI, December 16, 2025. Excellent, understandable and practical 23:52 min:sec video where Dr. Kahleova reviews the health risks of microplastics; how much we accumulate them in our bodies (ex. a plastic spoon full (7 gms) of microplastics in ones brain); food, cooking and storage sources of microplastics; clothing and microplastics; and reviews foods sources of compounds that are lower in microplastics and have compounds (like anthocyanins in berries ) in them that help remove microplastics from our bodies. COVID 19 - PANDEMIC - Five Year Pandemic Review and What to Expect in 2026. Dr McCullough on The Josh Axe Show. Peter A. McCullough, MD, MPH, Focal Points (Courageous Discourse), Peter McCullough, MD, Dec 28, 2025. Video 1:44:32. “A MUST WATCH INTERVIEW TO UNDERSTAND THE TOTALLY OF THE ‘PLANNED’ COVID PANDEMIC FROM TREATMENTS, TO HEALTH CONSEQUENCES AND "VACCINE RELIGION.”TOPICS IN THIS INTERVIEW1) Early Response and Medical Silence2) Creating the McCullough Protocol3) What the Autopsies Revealed4) Long COVID and the Engineered Spike Protein5) Heart Effects, Myocarditis, and Sudden Death6) The “Religion” of Vaccinology7) The Path Forward8) Summary MCCULLOUGH FOUNDATION HIGHLIGHTS - Worth the 1:53 min:sec watch highlights from the McCullough Foundation’s Work in 2025 on treating early Covid, Covid Long Haul, Vaccine Harm, Autism and Congressional and Senate Testimonies. VACCINE SCHEDULE - RESTRUCTURING - DENMARK - Comparing US CDC ACIP and Denmark Childhood Vaccine Schedules. Policy shift may lessen burden of vaccines on American children. Peter A. McCullough, MD, MPH, Focal Points (Courageous Discourse), Dec 26, 2025. “…The U.S. system prioritizes population‑wide immunologic saturation and corporate throughput, resulting in early and frequent exposures. Denmark’s model favors prudence—vaccinating later, less often, and focusing on diseases that pose proven, ongoing domestic threats…” Nutrition, Prevention and Integrative Medicine… ALZHEIMER’S DISEASE - BOSWELLIA SERRATA - 2022 (Canada-Iran) Clinical Trial with 85 patients with mild to moderate Alzheimer’s disease took Boswellia for 6 months and saw significant improvements! William Makis, MD, Covid Intel, Dec 29, 2025.1) Boswellic acids (K-Vie™) improves clinical cognitive scores and reduces systemic inflammation in patients with mild to moderate Alzheimer’s disease. “…The treatment doses were 400 mg K-Vie™ capsule, thrice a day (1200 mg/day), versus matching placebo…This study suggests that a reduction of systemic inflammatory biomarkerscorrelates with improvement in brain and cognitive function. Decreasing inflammation may represent a novel avenue to effectively treat AD…” ALZHEIMER’S DISEASE - GINKGO BILOBA - 2023 Systematic Review and Meta-analysis (China) - patients did better with Ginkgo + standard treatment than standard treatment alone! William Makis, MD, Covid Intel, Dec 29, 2025.1) Effectiveness and safety of ginkgo biloba preparations in the treatment of Alzheimer’s disease: A systematic review and meta-analysis. “…Conclusion: Ginkgo biloba preparations plus donepezil can improve clinical effectiveness rate and vocabulary memory outcomes…” BRAIN FUNCTION - CHOLINE - What Choline Does for Your Brain (Plus the Best Ways to Get It. By Molly Knudsen, M.S., RDN, MindBodyGreen, December 19, 2025.1) Improved Attentional Performance Following Citicoline Administration in Healthy Adult Women. “…After 28 days of daily citicoline supplementation, participants who were administered either the 250 mg or the 500 mg citicoline doses showed significantly better ability to produce correct responses on the CPT-II, likely due to improved cognitive inhibition…”2) The role of citicoline in cognitive impairment: pharmacological characteristics, possible advantages, and doubts for an old drug with new perspectives. “…Citicoline appears to be a promising agent to improve cognitive impairment, especially of vascular origin…”3) Neurocognitive effects of acute choline supplementation in low, medium and high performer healthy volunteers. “…behavioral performance in schizophrenia-relevant cognitive domains was assessed in 24 male participants following a single low (500mg) and moderate (1000mg) dose of CDP-choline. Relative to placebo, CDP-choline improved processing speed, working memory, verbal learning, verbal memory, and executive function in low baseline performers…” BRAIN FUNCTION - POTASSIUM - ULTRA PROCESSED FOODS - The Brain Nutrient You’re Not Getting Enough Of (But Really Should Be) By Dr. Drew Ramsey VUMEDI, October 22, 2025. ( high potassium foods, potato, sweet potato, spinach, greens, black beans, avocado, white beans, banana) CARDIOVASCULAR DISEASE - COLCHICINE - Should Colchicine Become Standard Therapy for CAD? The efficacy and safety of low-dose colchicine (0.5 mg daily) have been primarily demonstrated in two landmark, large-scale, randomized controlled trials (RCTs): * LoDoCo2 (Low-Dose Colchicine 2) Trial: Focused on patients with chronic stable CAD, this trial found that colchicine reduced the risk of MACE (a composite of cardiovascular death, spontaneous myocardial infarction, ischemic stroke, or urgent revascularization) by 31% over a median follow-up of 28.6 months when added to standard care, including statins. * COLCOT (Colchicine Cardiovascular Outcomes Trial) Trial: Enrolled patients within 30 days after a myocardial infarction (heart attack). It demonstrated a 23% lower incidence of the primary composite cardiovascular endpoint over a median follow-up of 23 months. Other studies and meta-analyses have largely supported these findings, though some recent trials, such as the CLEAR SYNERGY trial (published in late 2024), produced mixed results, leading researchers to conclude that optimal dosing, timing, and patient selection require further research. Colchicine Debate: Colchicine Surprise: No Help Post-MI, Large CLEAR SYNERGY Trial Shows. The study conflicts with two prior trials showing a benefit and may warrant colchicine’s reconsideration in the guidelines. Mechanism of Action Colchicine works as an anti-inflammatory drug, a key factor in treating atherosclerosis, which is recognized as an inflammation-driven disease. Its main actions include: * Inhibiting the assembly and activation of the NLRP3 inflammasome, which reduces pro-inflammatory cytokines like interleukin-1β and interleukin-18. * Disrupting microtubule polymerization, which hinders the migration and adhesion of neutrophils (a type of white blood cell involved in inflammation) to arterial walls. These effects help stabilize atherosclerotic plaques and prevent their rupture, which is a common cause of heart attacks and strokes. Clinical Use and Considerations * Indications: Low-dose colchicine (0.5 mg/day) is approved as an adjunct therapy for secondary prevention in adults with established atherosclerotic cardiovascular disease or multiple risk factors. * Safety Profile: Colchicine is generally well-tolerated at low doses. The most common side effects are gastrointestinal issues, such as diarrhea, which often resolve with continued use. * Contraindications & Interactions: It should be avoided in patients with significant renal or liver dysfunction and used with caution with other drugs that share its metabolic pathways (e.g., certain antibiotics, antifungals, and some statins) to avoid toxicity. Overall, studies confirm that for many high-risk patients on standard therapy (including statins), adding low-dose colchicine offers a significant, additional layer of protection against future cardiovascular events. BRUSSELS SPROUTS - HEALTH - Brussels Sprouts: The Tiny Veggie That Detoxes and Protects DNA—How to Maximize Benefits. By Emma Suttie D.Ac, AP, EPOCH Times, December 19, 2025.1) Consumption of Brussels sprouts results in elevated α-class glutathione S-transferase levels in human blood plasma. 2) Effects of consumption of Brussels sprouts on intestinal and lymphocytic glutathione S-transferases in humans. 3) Reduction of oxidative DNA-damage in humans by Brussels sprouts. “…300 g of cooked Brussels sprouts per da

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About

Practicing physician assistant in nutrition, prevention, integrative and lifestyle medicine since 1983 who will discuss practical guidelines and share links and research dealing with individual, community and societal health through personal commentary and interviews. stayinghealthytoday.substack.com

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  • Creator
    Information to keep the indivdiual, your community and the world society living healthfully and in peace
  • Years Active
    2015 - 2026
  • Episodes
    48
  • Rating
    Explicit
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    © Prescription 2000, Inc
  • Show Website
    Staying Healthy Today Show with Kirk Hamilton