The Reason For Now

The Reason For Now By DrTheo

Humans flatter themselves with their complicated theories about themselves . Maybe it's a symptom of our craving for significance within the expanding universe. In reality we are cavemen and forgetting this is what complicates matters. Understand this and you can derive and predict the reason for now and the future. Enjoy.

  1. 08/21/2025

    What Makes You Happy

    Research shows that we are hard wired to generate our own happiness. We show that the prize is peace of mind rather than pleasure and what is stopping us getting there. Enjoy the journey with us.

    36 min

  2. 02/03/2024

    Episode 244: Childhood Trauma and Success in Life, Part 1

    After a lecture by my son's headmaster wherein children are regarded by the Catholic Church as divine we say that wonderfully influences expectations of our kids which moulds behaviour and self esteem which is one of the main determinants of success in life. Andy my co presenter related this to his own experiences with Attention Deficit Hyperactivity Disorder. We then segway onto social media which destroys self esteem, social skills , causes depression and dissolves concentration in its frenzy of instant gratification and dopamine hits making us all ADHD. We look at how trauma and behavioural shifts can be passed across generations by epigenetics. We discuss one of the fundamental differences in the thought processes between adults and children. Whereas children combine reality with their imagination and inner self so that anything may seem possible , adults close their minds to reality and stay with their limited set of beliefs and dreams. We summarise that true clarity of mind only exists at two points in life: once when you are born and after you have had good therapy. Enjoy .

    48 min

  3. 08/26/2023

    Episode 243 - Responsibility for progress , political correctness for stagnation and the end of civilization

    Responsibility: Progress in any system is by trial and error. This is how nature works in evolution and how our children grow up through experiences and teaching. Models only work for specific unique situations. Eg laws of gravity , motion etc. in fact many scientific concepts. In fact even those only stay valid until they are disproven or someone comes up with a better concept. The idea that models can be produced for complex systems is not realistic. Yet this is what ‘experts’ are constantly doing in the search for certainty about future predictions of risk or growth. They are almost always invariably wrong. In order to make progress with trial and error there must be room for and consideration of disparate views in order to reach a consensus for going forwards to see if the idea worked or not . Trial and error. It has been known for a long time in the business world that large companies stop being creative. The reason is that they get so large that centralised control from head office is all about homogeneity within the company to maintain its identity and integrity. Anything challenging that is expelled rapidly. At this point the only way they can do more business without new products is to increase market share by monopolisation and by marketing. This is why all companies have a sine wave life. A slow start, an exponential rise , a tailing off and sudden decline as the ‘new idea’ company takes off.  Coca cola , Amazon , Tesla, Apple have no new ideas but are experts at monopolisation and marketing. They also lobby to suppress competition for  new ideas. There has been research looking at the decline of civilisations in the past and all of them collapse after they reach a point of maximal communication within the empire. Ie at their equivalent of globalisation. Wherever there is no progress and suppression of new and or better ideas there is always regress. Now we have social media where the crowd narrative expels, vilifies and suppresses anything that disagrees with that narrative. Unfortunately social media is often manipulated by the powers that be to create a crowd narrative . Additionally, fake news, which is usually more shocking  and more likely to spike the pleasure hormone dopamine, travels through social media six times more rapidly than real news. Humans are hard wired to respond to structure hierarchy and leadership and crowd opinion and to respond to fear stimuli automatically without thinking. Therefore any tool of mass manipulation such as social media in the wrong hands can and has had disastrous consequences . Indeed the psych ops teams used by individual governments to get their citizens to comply with useless and at worst highly damaging measures during the  ‘covid epidemic’  have been legally termed a military weapon. In other words governments used a military weapon against their own people. This was only necessary as the measures used were dictatorial, illogical, inconsistent and dangerous.  Wherever you hear the term ‘we are following the science’ combined with suppression of alternative views -especially suppression of the truth- you know its a scam. For sure.  Of course this is also an example of our leaders not taking any responsibility at all.  Political correctness is another mass media crowd narrative driven by the powers that be to destroy structure within society. It demands compliance no matter how illogical the requirement. It demands equal outcome for all which is often damaging as we are not all the same. We have the same rights but all of us are different.  Compliance is usually effortless and gains approval of the mass media and carries with it no responsibility. This is called virtue signalling. Eg I am wearing a mask. Aren’t I a good citizen? Worse than that is virtue signalling of the minorities which carries with it entitlement eg I am gay or I am LGBT aren't I special just for existing and everyone can and should recognise this talk about me and celebrate me. For doing nothing. Therefore virtue signalling and the entitlement associated with it is the opposite of responsibility and in fact carries something else dangerous which is blame and fault. Eg : You are not complying , you have not employed more gay people , you have not converted half your toilets to LGBT even though we are a tiny minority and the rest of you will have to queue up to use the rest. It is your fault and you must be punished. Being gender fluid is virtue signalling instead of taking responsibility for being the sex that you are.  Men, you are all bad. It is your fault. Take no responsibility and be punished or vilified.  Women: don’t take responsibility for being women, you can now be men so you can sleep with lots of men and women  and you must all be having careers and employers must preferentially employ you even if you are less qualified than your male counterpart. The result? Women who go to university have a 50% chance of hitting their 40s childless and often single or in dysfunctional relationships. Birth rates in the West have dropped off a cliff and now the birth rate is 80% that of the death rate. IIn Norway adult diapers are outselling baby diapers. In developing countries not hit by mass media and political correctness the birth rate is much higher than the death rate.  People confuse fault and responsibility and they are totally different. Fault looks at the past and usually requires punishment. Progress is usually a casualty of this process and in the rare cases there is progress it is accidental. Responsibility is being self aware and admitting when something goes wrong and taking steps to rectify the consequences and to improve future endeavours.. Now you can see that the mass narrative by global communication is purely set up to run on mindless compliance and blame and punishment if you do not comply . Responsibility taking is the trial and error approach in a complicated system which is the only way to progress. It is also the only way to be tribal or what I call tribe compatible behaviour. We are hardwired to be tribal. Our health, both mental and physical, even depends on it.  We take responsibility to function better within the tribe and to collaborate and help others which we are hard wired to do. You can imagine a tribe run by blind compliance and punishment and expulsion of original thinkers would quickly wither and die. This is what is happening to us right now.  Our leaders for decades have been reversing  their leadership style from command and control where everything is centralised and produced and implemented by the government  for the good of the people and has now changed to one of  abrogating all responsibility through the implementation of commissioned and or imported policies and models . In the vacuum which is left comes the chaos of political correctness and global mass media and social media narrative.  It also causes far more corruption amongst politicians. Since they have no responsibility and everything they do is responsibility avoidance it encourages self serving behaviour and entitlement.  Taking responsibility is core to the mental and physical health of the individual . It is a commitment on a daily basis to algorithmically be better than the previous day. As a society it is the same . If our leaders do not go back to this and if social media is not severely restricted and controlled we are being led off the cliff face of our existence virtue signalling as we do so. GetBlueMail for Android

    42 min

  4. 08/12/2023

    Episode 242: How to enjoy the pain and hard work necessary to succeed in life

    All the great minds including religion tell us that if we are to progress in life we need to shoulder responsibility which involves hard work and pain. They don't make life sound too appetising with the partial exception of religion in which faith is innate . We argue that they miss out one of the key secrets of life which is self esteem. Thanks to Angela who made this a lovely Podcast touching on many issues affecting our lives including narcissism , the universal wage, Dave Mustaine and Socrates.

    44 min

  5. 03/24/2023

    Episode 241 Processing Blocks And Post Traumatic Stress Disorder

    PTSD first defined in soldiers returning from the Vietnam War and officially recognised since 1980. The distilled essence which you won't find anywhere else is as follows: Similar to phobias there is a processing block causing an emotion logic gap: I know I should not feel like this but I can't help it. This is because we are hard wired to avoid or reduce anxiety so the brain actively suppresses anything causing anxiety so you can't think about it long enough to bring the emotion down to the logic. No amount of sense or education helps here which is in contrast to a real danger where you need tools and education without which just thinking about it will not help at all. There can be minor and major processing blocks. There can also be a processing block from a misperception of an event so here the processing needs to overcome the discomfort of having got it wrong and the consequences of that. It's easy to see how we all have various degrees of emotion logic gap. For instance have you found that no matter how well you explain something to someone they won't change their minds? Even if you know they have understood the logic? It is because it is too painful to do so and they have no reason to go through that pain. Or how many times have you done something knowing it is wrong just because you want to for various reasons? Here again there is a type of processing I teach bit it needs self awareness and motivation. Yet the harm from chronically raised cortisol from even mild processing gaps can be measured by improvement in all aspects of mental and physical health when it is dealt with. It is why I say you only have clarity of mind at two points in your life: 1 when you are borne, 2 after you have had good therapy by a true expert which you pay for. (The payment indicates your motivation versus just turning up). Life time prevalence of PTSD 8% of the population, about 90% are exposed to trauma including unexpected death of a loved one, equating to a lifetime occurrence of 5 separate traumas in men and 4 in females. Women are less likely to be exposed to traumas than men but the traumas they are exposed to are more likely to cause PTSD such as rape and sexual molestation where as males are more likely to be exposed to combat and witnessing trauma to others. About 30% of women view their child birth as traumatic with 30% of those developing PTSD hence about 10% of all mothers have PTSD. About 25% of acute medical problems including ITU have PTSD. Psycholgical sequalae of PTSD: Clinical depression , alchol and drug abuse. Predisoping factor: Clinical depression. Self report questionnaire: PCL-5 Post traumatic stress disorder Check List for DSM 5 20 questions scored 0-4 relating to the previous month. DSM 5:  SIACAD Stressor Intrusion Avoidance Cognition Arousal Distress More than 1 month Can specify whether dissociation or delayed onset. Routine debriefing re living trauma may make it worse CBT 4-5 sessions, EMDR, Reprocessing Live Exposure SSRI SNRI Psychedelics FDA approval pending Transcranial Magnetic Stimulation Atypical Antipsychotic , ECT Important nuances: Chronic loss of control eg bullying or lock-down = Prolonged Duress Stress Disorder Minor trauma still causes processing blocks or impaired processing which needs to be properly processed either with self journaling or with reprocessing therapy. In fact Professor Pennebaker showed that in Yale University students self journaling difficult events reduced cortisol and improved mental and physical health and exam results. Naomi Breslau The Epidemiology of Postraumatic Stress Disorder Jounral of clinical psychology 2001

    35 min

  6. 12/23/2022

    Episode 240 - An Appraisal Of Jonah Hill's Stutz By Dr Theo

    Stutz Dr Theo I would be fine if I knew what direction to go in I would fly instead I become lazy . We also discussed the first step in therapy which is connecting with your internal energy You do that in 3 steps: 1: Diet exercise and sleep  2: Connecting with others as we are tribal 3: Connecting with yourself your underlying feelings which is self awareness most effectively done by self journaling. The Part X is  that part of you stopping forward progress which could include the Shadow self or the Maze or the Snap Shot or simply the judgmental antisocial part of you. Eg you’ll never be good at that, or who wants to do that , or you are wasting your time trying this. Radical acceptance is a tool to help you get over something bad. Grateful Flow helps deal with negative thoughts and Loss processing deals with loss The key is to understand that for forward progress  and overcome Part X you need to go through a life time of: Uncertainty pain and constant work. It is this process you need to enjoy ie the journey rather than the destination.It is overcoming Part X that leads to growth. Failure pain embarrassment connects you to the universe you are saying I need your help I cannot do this without you. Stutz says confidence is an appetite for uncertainty . I say this is not true because confidence is knowing how to do something which by definition is being certain. Rather self esteem is an appetite for uncertainty because  self esteem is the degree of positivity with which you view yourself and therefore an expectation of positive outcome . If things do not go well self esteem protects you from the negative effects and instead helps you learn and move on and  apply those lessons in your next steps. I am the one who gets to decide and take the next step. It will almost certainly be imperfect but progress is made by taking the steps  aka string of pearls each with a turd in them Indeed research shows that dopamine hits come from achievement and reward in general but it is much greater if the reward is unexpected. Hence watching sport has an element of unpredictability which is why so many people enjoy it.  . Indeed when Formula 1 became too predictable the audience ratings fell so they changed the rules to make it more unpredictable. It is a positive expectation of an outcome that raises dopamine rather than the known outcome itself. The positive outcome will raise dopamine only if is unexpected. This explains how you can enjoy the journey of uncertainty pain and constant work. Your self esteem gives you an expectation of a positive outcome. It is the positive anticipation raising dopamine that makes this process enjoyable. This is especially important because it helps with sense of achievement and growth. The greater the effort the more meaningful the achievement. This then enables the parallel step of balance : Effort and reward must be balanced. Since more of life is effort rather than the result then the mechanism of being able to tolerate the effort is a  positive expectation of success. Once you put in the effort the sense of achievement is fulfilling and makes you grow. Positive self esteem also helps us use failure as a growing opportunity and simply includes  lessons learnt as part of the effort to  the next step all under the umbrella of positive expectation of overall outcome. Snap Shot relates to setting of a goal  eg the perfect wife, the perfect success , the perfect amount of money in the bank which is static concept and has  no depth and does not allow for ongoing progress with pain uncertainty and constant work. There is no perfect nirvana. Goals are illusionary needs and living life like this is one of the worst inventions of the Western World.  When the snap shot does not give you nirvana and cure your inner unhappiness you get much more depressed. The Shadow is the part of yourself you are ashamed of.: This is how I see myself and I felt so much shame that I was denying myself and  and others would no longer see this if i got more successful Visualist a time in your life you felt inferior embarrassed ,rejected, despondent ashamed its a part of yourself that you that you wish you were not and you cannot get rid of How does he feel about you, how you have dealt with him how you have treated him and see what he says Denying and being ashamed of it THe shadow feels hurt angry and upset The shadow wants attention not from the world -does not need an academy award-  but from you The shadow wants to be acknowledged and included and celebrated as a beautiful part of you So in high pressure high stakes situations the goal is not create a faultless performance but to include the shadow self and tolerate whatever happens. Because if I cam content with my true self then other peoples opinions affect him less Ignore the shadow self and he will make you do destructive things. Connecting with your shadow self and having a sense of wholeness means you are happy the way you are, you don’t need to anything else to make you feel better.itis very freeing Maze refers to when someone does an injustice to you and you remain angry seeking or hoping for restitution which usually never comes. Stutz says instead take the love you wanted from the world around you  Active Love - you are unlikely to be paid back by the person so you may as well take it from the universe around you.  by closing your eyes and imagining this is happening then concentrating it in your heart and then sending it and physically feeling it go into the other person so that you become one with love. This is not for their good it is for your own good to free you from the maze. In terms of my coaching this reflects forgiveness but is not as powerful as understanding. For instance you can understand why something happens because it is in someone's nature. That does not need forgiveness.  It requires understanding of reality and what is possible and what you can then do about it. You understand their nature and have expectations according to their nature and act accordingly. For instance you dont put your hand in the mouth of a tiger. You now it will probably bite and you certainly dont get angry. Ask yourself do you want to be right or do you want to create something. Radical acceptance: when something bad happens you don't just think that you will sooner or later recover from it, or stay stuck in a cycle of self pity ,you have to squeeze the juice out of it. Learn your lessons in whatever happens First: dont tell yourself anything negative Second: find something that is positive about it So squeezing the juice out of it suggests that not only do you have the will but also the faith that there is something valuable there If you see all events as having value you are in the zone of tremendous opportunity The Grateful Flow wants to choose the positives. Every thought will affect your mood whether positive or negative.  Part X wants you to have the negative thoughts to just see clouds even though sun is behind the clouds and coming. The grateful flow is not the grateful thoughts but the process. You name 4 things that you are grateful for, the smaller the better as you can connect better then continue in your head. After a while you feel you will create another grateful thought but you dont you block it  so all you feel is the force that would create a grateful thought and as it gets stronger and stronger you  feel taken over by it. You don't just repeat the same grateful thoughts you look for new ones and that process of creating grateful thoughts will change your mood. Gratefulness is a state you want to be in as much as possible. It helps you break through the cloud, What you don't do is argue with negative thoughts. You cant reason with emotion. Loss Processing: The potency of Non attachment . You want to pursue it  and pursue it hard but you are willing not to have it, you are willing to lose Think of something you don't want to lose and imagine grasping it like you are hanging onto the branch of a tree. Then visualise letting go but its not a bad sensation.Its slow and gentle to your surprise. Then you say silently I am willing to lose everything but really feel the intent behind that. Then you imagine you fall into the sun and burn up losing your body (so you lose everything) and instead become part of the suns rays radiating out a very loving giving outflowing sensation and that sun is surrounded by other sons doing the same thing as part of the sun world all saying we are everywhere. All you can do is give you cant take. You cant grasp onto anything. If you have difficulty with that then think of yourself as moving towards non attached. In fact as a human it would not be good if you were totally non attached. If you are moving towards non attachment then no one thing or person leaving you can take away your sense of wholeness. Happiness depends on how you accept that  you cannot completely figure things out and what you do about it.  RAGL The Active Love, Grateful Flow , Loss Acceptance,Radical Acceptance

    48 min

  7. 12/03/2022

    Episode 239 - Where Are You From? How Not To Be Offended And Why It Can Be Used For Offence

    "Where are you from" is considered a micro aggression. Of course in a harmonious society this is a reasonable question indicative of genuine interest. Indeed in a harmonious society to suggest any other motive would be nonsense. However it has become a problem for two reasons in this age of societal collapse where political correctness has been the latest disintegration stage. The first is people are easily offended because they are unhappy and are insecure about their own identity and feel they have no control apart from the politically correct right to offence for which there is no cost and no responsibility. Of course people should be proud of who they are and pride inspires respect and interest and education. Indeed who you are is simply reality and that is the healthiest thing to deal with. Not edging anxiously round political correctness. The second is that the indigenous population is also feeling unhappy and insecure about their identity as they see it collapsing around them manifested by discussions over whether Christmas should be cancelled or summer school exams moved due to Ramadan. As usual we are all too blinded by the symptom to really address the real problem which is something far more sinister. The real fault lies with our leaders. It is their responsibility to provide leadership including national identity. If someone wants to move to any country it should be clear to them that they will be respected for who they are and where they come from but the priority is to integrate and take on the identity of that country and it's customs. In evolutionary terms if something is familiar it's probably good as it has not already eaten you. If it's not familiar it could be a danger. Hence we dont like people who are different. Studies back this up by showing certain of our brain cells which respond to social queues -mirror neurones- either don't respond or respond less when observing someone of a different skin colour. It can be remedied by education. Hence the phenomenon of racism is a natural phenomenon but the fact it happens is a sign of a badly run society. People don't feel integrated and instead stay close to those they identify with which is why cities become mosaics of different cultures and religions with limited mixing. For instance we all know which cultural groups live in China town, Finchley, Hownslow, Walthamstow, Lambeth -or even large swathes of Birmingham.... Once you have coalescing of cultures each rubbing shoulders with each other then you have friction and strife. Add into that increased immigration recently with no effort or requirement of integration then you have a dry tinder box where small incidents can act as kindling for the underlying problem. For instance the UK is a Christian country. The King of England is the head of the Church of England. At citizenship ceremonies you have to swear allegiance to the King of England. Saudi Arabia is much clearer. It has strict requirements for cohesion to its own culture and religion and forbids public display of other religions. Do you think they would consider moving Ramadan to allow foreign students to study for exams? Who is the stronger more harmonious society? The problem with our leaders is that being a democracy they have to get elected hence they have to please the vast majority of the population who make decisions emotionally on top of which they are misinformed by the media. Therefore logical well infirmed voting is not only a pipe dream but those seeking election just make promises that sound good emotively for quick votes. This is nothing to do with firm fair leadership which will displease the politically correct mass media. Try enforcing British culture, identity, values let alone the Church of England. This general collapse is seeping into every fibre of our society including health, social services police. Everyone avoids responsibility behaves obstructively and destructively rather than constructively and takes offence. It is Marxism with the eradication of the middle and upper class -often and preferably unceremoniously- leaving only the elite and the vast mass of everyone else and this always ends in disaster and revolution.

    36 min

  8. 08/19/2022

    Episode 238 - How Diet Fixes More Than You Could Possibly Imagine And Vice-versa

    Gut Immune Body Brain Axis. Dr Gundry: Leaky Gut, gut microbiome and diet Renowned Cardiovascular Surgeon who realised that all he was doing was treating the symptoms so he studied the underlying causes. The lining of the gut is one cell thick As bacteria break down the gut that is when ageing starts Ibuprofen or roundup disastrous the bacteria population Skin is a mirror of the lining of the gut Joints do not naturally wear out. Animal model C Elegans as bacteria begin to break down the wall of the gut that is when ageing starts 105 year old people have a diverse set of bugs identical to a healthy 30 year old. It is not attacking the wall of the gut. Ecermansia musinophilia. Lives in the mucous layer whose job is to trap lectins plant proteins looking for sugar molecules and to protect the wall of the gut from harmful bacteria. Ecermansia musinophilia eats mucus which in turn makes more mucus. Metformin works by increasing mucous and this change in bacteria makes some people have mild diarrhoea as the bacteria change. If we damage this lining eg ibuprofen or food with roundup destroys the bacteria population and gut lining. Glyocosade an antibacterial damages Ecermansia Musinophilia even though it does not directly affect human cells. Antibiotics in food or direct prescription eg ladies who take low dose for UTI have a higher incidence of heart disease. Heart disease is an autoimmune disease starting in the gut. Cholesterol is an innocent bystander which gets sucked into the inflamed wall of a blood vessel. Infants with heart transplants have coronary artery disease with pathology identical with typical coronary artery disease. Lectins which are a foreign protein which can stick to sugar molecules on the surface of blood vessels are the cause of atherosclerosis and removing lectins reduces those markers. Lectins are one of the plant defence systems. Sticky proteins that look for specific sugar molecules to stick to which insights an inflammtory response. Joints do not normally wear out. Usually you can find bacterial particles in the joint fluid of arthritis Because Lectins broke down the wall of the gut. 65% of the immune system is behind the wall of the gut because the gut is where the outside word gets through. A reason why we store fat in the gut is to provide energy to the immune system. Similarly fat on the outside of atherosclerotcic blood vessles correlates with the severity of inflammation. Fat is not the cause . It is there because of the inflammation and the inflammation is there due to the leaky gut. The immune system responds to antigens on bacteria of viruses. Lectins have antigens with cross reactivity with other proteins in the body. Eg thyroid. Nightshade vegetables or peanuts Lectins disrupt the microbiome and break up the lining of the gut allowing entry by lectins and by bacteria or bacterial particles. Hence if you inject a bacterial lipopolysaccharide into a person you can induce septic shock. Alzheimers Parkinsons is neuroinflammation. Most amyloid is produced by bacteria in the gut. Therefore 40 billion dollars invested in antiamyloid drugs has been a waste because amyloid is produced by the amyloid producing bacteria inthe gut fet by western diet. Then the amyloid has to get through the wall of the gut. Once they get through the gut wall and goto the brain it will produce more amyloid. Cholesterol and amyloid coexist in dementia in those with the apoE gene. The apo E gene codes for a carrier molecule because it is less efficient at transporting cholesterol. It cannot get out of the cell after it has been attracted by inflammation. Faecal microbial transplant: 1970s broad spectrum antibiotics came out which made it much quicker to treat infections but it also wiped out the gut bacteria. Normally 10000 species of bacteria. Pseudomembranous colitis was caused by Clostridium Difficile over growing. Initial study done from the faeces of medical students. Faecal enemas treated the pseudomembranous colitis. Meat with animals treated by antibiotics can also cause problems. 60% of faeces is bacteria Oral microbiome and cloud of bacteria around us –Holobiome . This defines our personal space. Kissing is a human and ape characteristic. Exchanging oral microbiome. Bacteria decide whether the other person's bacteria are compatible with them. Women have a gut feeling because they are more capable of listening to their microbiome. We inherit our microbiome from our mother. All of the mitochondria are involved with bacteria inherited from our mother. Bacteria communicate to their ‘sisters ’ie the body’s mitochondria. Autism: kids have a different microbiome than ‘normal’ The placental microbiome is important in educating the foetal immune system. Oral faecal transplants for 6 weeks in autistic kids. Almost immediately 50% autism symptoms reduced. Ecermansia like tubers, mushrooms, -study in Asia find 90% reduction in Alzheimers with two cups of mushrooms a week. Inulin containing compounds eg chicory, radicchio, jerusalem artichoke. Exercise women who exercise routinely from midlife have a 90% reduction in Alzheimers. In those who get AD it happens 11 years later. Housework can be important part of exercise. Meditation and yoga also changes the gut microbiome. Lymph system in the brain in deep sleep -early in the sleep cycle-shrinks by 20% and these bad proteins are squeezed out. You need a 3-4 hour window between sleep and dinner because blood flow diverts to the gut. Olive oil /walnuts / mediterranean low fat diet: first two groups improved memory after 5 years. 3rd group lost memory Those with CVD had a 30% reduction in events, the low fat group continued CVS events. Polyphenos in olive oil grow proteins TMAO is made by gut bacteria primarily from animal protein especially choline eg egg yolk and carnitine . TMAO damages blood vessels. Polyphenols in certain olive oil and red wine balsamic vinegar that paralyse enzyme systems in the bacteria so they do not make TMAO. However the logical error here is that eggs which are high in choline are not associated with increased morbidity. Vitamin D at least 5000 units a day . Almost all cancer patietns and autoimmune pateitns have low vitamin D. HIgher your VItamin D the longer your telomere. Stem cells in the gut are simulated by vitamin D. VItamin C Lectins are present in most plant foods but especially high in: legumes, such as beans, lentils, peas, soybeans, and peanuts nightshade vegetables, such as tomatoes and eggplant dairy products, including milk grains, such as barley, quinoa, and rice The Roll of Inflammation in Depression and Fatigue Frontiers In Immunology: CH Lee 2019: Immune system link to depression first noticed with immunotherapy eg INFa (which activates an inflammatory antiviral response) for Hepatitis C : associated with raised pro inflammatory cytokines and depression and fatigue. 20% of patients treated with INFa developed depression which resolved on discontinuation but also increased the risk of depression in future. Also people with higher IL6 aged 9 were more likely to have depression aged 18 in a dose dependent manner. Innate immune system seems to be lower in depression eg NK cells and also less anti inflammatory regulatory T cells whereas inflammatory monocytes are activated. There is commonality in immune activation from autoimmune disorder such as multiple sclerosis or immune reactions in sepsis. Antidepressants reduce inflammation while a higher baseline level of inflammation predicts a poorer treatment response. People with depression have been shown to have higher inflammatory markers which can be used to predict treatment efficacy and future recurrences of depression. Elevated inflammatory markets eg TNFa after an MI disrupt the blood brain barrier causing depression. Inflammatory changes in the brain with raised TNFa in the hippocampus and striatum precede development of depressive symptoms. Neurogenesis is inhibited by the kynurenine pathway which is rescued by both inhibitors of this pathway and traditional antidepressants. TNFa also increases glutamate release causing exocytotic damage to surroundings neurones. Conditions associated with chronic immune activation such as asthma, atopy, diabetes m MS, RhA, SLE are all associated with raised levels of depression eg 36% of asthma have depression who also had higher TNFa than those who were not depressed. 75% in RhA MS up to 50% risk of depression. Acute inflammation with sepsis also causes depression and raises the risk of depression in future which in animal models can be reduced by using steroid during the acute sepsis. Antidepressants reduce inflammatory markers perhaps SNRI more effective than SSRI and also ECT adds in return to normal of NK activity. Directly reducing the immune response eg anti TNF a or Caspase Inhibitors have been shown to reduce depression. Rituximab which is an antibody that targets and depletes B cells in the treatment of RhA also reduces depression. Aspirin can reduce depression but can also reduce the effect of an SSRI.

    31 min
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About

Humans flatter themselves with their complicated theories about themselves . Maybe it's a symptom of our craving for significance within the expanding universe. In reality we are cavemen and forgetting this is what complicates matters. Understand this and you can derive and predict the reason for now and the future. Enjoy.

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  • Creator
    The Reason For Now By DrTheo
  • Years Active
    2017 - 2025
  • Episodes
    248
  • Rating
    Explicit
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    © Copyright The Reason For Now By DrTheo
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    The Reason For Now