The AMR Studio

Uppsala Antibiotic Center

The AMR Studio is a podcast dedicated to the current multidiciplinary research on antimicrobial resistance, hosted by the Uppsala Antibiotic Center. The AMR Studio podcast is co-led by Eva Garmendia & Elin Fermér.

  1. 6d ago

    Ep 64: Stanley Maloy & a career in microbial genetics. Hybrid chromosomes & pandemic clones. Why E. coli needs its neighbors.

    Resistance usually comes down to two stories: either a mutation or a plasmid. But in this episode, we explore a third one. In this episode we feature an interview with Professor Stanley Maloy of San Diego State University, a microbial geneticist who was in Uppsala as faculty examiner at Talía Berruga-Fernández's PhD defense. We talk about a career built on bacterial genetics, how cheap sequencing turned evolution into something you can watch happening, and his own antibiotic-resistant infection treated with an experimental drug that did not yet have a name. In the news section, we bring you the two papers behind Talía Berruga-Fernández's thesis, published earlier this year. The first shows that nearly four in ten clinical E. coli isolates can mobilize large sections of their own chromosome, carrying resistance and virulence genes not selected for, while the second finds that E. coli keeps its ability to feed itself only by acquiring working genes from its neighbours. Taken together, these articles suggest that the spread of resistance could be a side effect of a process bacteria depend on for their evolution. Check relevant links in the show notes here ⁠https://www.uu.se/en/centre/uppsala-antibiotic-center/communication/the-amr-studio/episode-64. Follow our updates on social media with #theAMRstudio hashtag! Theme music by ⁠Henrik Niss⁠.

About

The AMR Studio is a podcast dedicated to the current multidiciplinary research on antimicrobial resistance, hosted by the Uppsala Antibiotic Center. The AMR Studio podcast is co-led by Eva Garmendia & Elin Fermér.