Freely Filtered, a NephJC Podcast

NephJC
NephJC
  • 4.9 (178)
  • Medicine
  • Biweekly

Twice monthly (aspirational) recap of the NephJC journal club. NephJC reviews the most important manuscripts which are driving nephrology forward and improving our understanding of the kidney.

  1. Oct 22

    Pregnancy Outcomes after Kidney Donation

    This is our second time releasing a podcast simultaneous with presentation and publication. Super exciting. This podcast covers a retrospective trial study on pregnancy complications in kidney donors. The Filtrate Joel Topf @kidney_boy Swapnil Hiremath @hswapnil.medsky.social Anna Gaddy @GaddyAnnaR Nayan Arora @captainchloride Sophia Ambruso @sophia_kidney Special Guests Amit Garg @AmitXGarg, Nephrologist at Western University, London and PI of the current study Editing Joel Topf The Kidney Connection written and performed by Timothy Yau Show Notes Previous appearances by Dr Garg: Episode 56 MyTEMP Episode 63 Enhance Access to Kidney Transplantation and Living Kidney Donation (EnAKT LKD) (Late breaking and High impact clinical trial session at KidneyWeek 2023 in Philadelphia Our last attempt to podcast about preeclampsia did not go so well: Episode 70: Predicting Preeclampsia, the PRAECIS trial and Episode 70b Do Over: Predicting Preeclampsia, the PRAECIS trial (https://www.nephjc.com/freelyfiltered/2024/freely-filtered-70b-do-over-preeclampsia) The use of the words “men” and “women” in scientific papers, an editorial The Big Ask, The Big Gift Garg’s prior work on male donors and scrotal surgery: Risk for Scrotal Surgery After Laparoscopic Donor Nephrectomy : A Population-Based Cohort Study PubMed Garg’s prior work on donor and pregnancy outcomes: Gestational Hypertension and Preeclampsia in Living Kidney Donors NEJM The Consensus Statement of the Amsterdam Forum on the Care of the Live Kidney Donor 2004 Transplantation KDIGO 2017 Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors KDIGO Tubular Secretion Swapnil Babylon 5 on AmazonPrime Wikipedia Sophia The Gentleman, the series on NetFlix Wikipedia and Gentleman, the film Wikipedia Anna and her boat, Freshwater Deficit. Heavy Weather Sailing by Adlard Coles Amazon Nayan William Osler: A Life in Medicine Amazon Amit Law and Order ethics Joel All the NephJC activities at Kidney Week: The Run | The other run | The Party

  2. Oct 15

    FF98 FIND-CKD

    The Filtrate Joel Topf @kidney_boy Swapnil Hiremath @hswapnil.medsky.social Anna Gaddy @annagaddy.bsky.social Natalie Freidin Program director at Medical University of South Carolina Special Guests Brendon “Brendo” Neuen The first Five-Time guest on Freely Filtered. Nephrologist and Director, Kidney Trials, Royal North Shore Hospital. Associate Professor of Medicine at the George Institute Editing Natalie Freidin The Kidney Connection written and performed by Timothy Yau Show Notes Donate to the fall pledge drive: https://www.nephjc.com/news/2026/9/8/nephjc-fall-pledge-drive Come to the ASN NephJC Night in Denver the Kidney Week: https://www.nephjc.com/news/2026/9/13/the-2026-nephjc-night FIND-CKD: Finerenone in Persons with Chronic Kidney Disease without Diabetes NEJM | NephJC 2-year GFR data on sibeprelimab‍ ‍ Incidence of ESRD in the US due to IgAN (estimate using USRDS data) Heinz 57 wikipedia Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy. The Lancet 1997. The REIN trial for people with nephrotic range proteinuria (>3 grams/day) Renoprotective properties of ACE-inhibition in non-diabetic nephropathies with non-nephrotic proteinuria, The Lancet 1999 REIN Stratum 1 for sub-nephrotic range proteinuria (1-3 grams/day) Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes FIDELIO in NephJC | NEJM Benefits of aldosterone receptor antagonism in chronic kidney disease BARACK-D RCT PubMed We discussed the run in. Importantly the run in for FIDELIO and FIGRO did not give finerenone. This is sometimes done to assure that participants in a trial will tolerate the study drug but this will over inflate data on tolerability. See NephJC’s discussion on run ins here: https://www.nephjc.com/news/run-in-period Sean Barbour on Freely Filtered talking about the TESTING Trial FINALITY-HF A randomized, double-blind, placebo-controlled pragmatic study to evaluate FINerenone on clinicAL effIcacy and safeTY in patients with Heart Failure and reduced ejection fraction who are intolerant of or not eligible for treatment with steroidal mineralocorticoid receptor antagonists. ClinicalTrials.gov Boehringer provides update on EASi-KIDNEY trial 😢  Pooled finerenone data INFINITY Pooled Analysis        Tubular Secretion Swapnil The Will of the Many by James Islington (Amazon) Anna The Art Thief: A True Story of Love, Crime, and a Dangerous Obsession by Michael Finkel (Amazon) Brendo John Mayer Electric Guitar (PRS Guitar) Natalie Great Big Beautiful Life by Emily Henry (Amazon) Joel Come to the NephJC party at Kidney Week!

  3. Sep 27

    FF97 MERCURI-2, Can a Flozin prevent AKI?

    Bypass surgery continues to be the laboratory where we test the most innovative ideas on the prevention of AKI The Filtrate Joel Topf @kidney_boy Swapnil Hiremath @hswapnil.medsky.social Vipin Varghese Sophia Ambruso Special Guests Rahul Ganatra Deputy Editor NEJM Clinician. https://clinician.nejm.org/editors/AU3406 Jay Koyner Professor of Medicine, University of Chicago. https://www.uchicagomedicine.org/find-a-physician/physician/jay-koyner Editing Vipin Varghese The Kidney Connection written and performed by Timothy Yau Show Notes Back to the Future: https://youtu.be/BDuZqYeNiOA?is=r-RE2DgIDBazRAlW Amino Acids for AKI: The PROTECTION Study NephJC: Trial by Combat: Do Amino Acids provide PROTECTION to the Kidneys? In 2016 the FDA posted a warning that SGLT2i could induce AKI. This Nature Reviews Nephrology explores possible mechanisms for the AKI: Acute kidney injury from SGLT2 inhibitors: potential mechanisms https://www.nature.com/articles/nrneph.2016.159 But by 2019 the SMART-C Collaboration was looking at the risk of AKI in the large RCTs and found Flozins to be protective: SGLT2 inhibitors for the prevention of kidney failure in patients with type 2 diabetes: a systematic review and meta-analysis. https://www.thelancet.com/journals/landia/article/PIIS2213-8587(19)30256-6/abstract If you are actually looking for the best data you should look at the updated meta-analysis from 2025 which extends the findings to patients with and without diabetes and to patients with and without CKD: SGLT2 Inhibitors and Kidney Outcomes by Glomerular Filtration Rate and Albuminuria https://pmc.ncbi.nlm.nih.gov/articles/PMC12595549/ 2012 KDIGO AKI Guidelines: https://kdigo.org/wp-content/uploads/2016/10/KDIGO-2012-AKI-Guideline-English.pdf The 2025/2026 AKI Draft guidelines: https://kdigo.org/wp-content/uploads/2026/03/KDIGO-2026-AKI-AKD-Guideline-Public-Review-Draft-March-2026.pdf Meta-analysis of frusemide to prevent or treat acute renal failure https://www.bmj.com/content/early/2005/12/31/bmj.38902.605347.7C Euglycemic Diabetic Ketoacidosis: A Potential Complication of Treatment With Sodium–Glucose Cotransporter 2 Inhibition https://diabetesjournals.org/care/article-abstract/38/9/1687/37246/Euglycemic-Diabetic-Ketoacidosis-A-Potential Topic of this podcast, the MERCURI-2 trial: Dapagliflozin and Acute Kidney Injury Following Cardiac Surgery https://jamanetwork.com/journals/jama/article-abstract/2852324 | NephJC: Too sweet to be true? Prophylactic SGLT2 inhibitors before cardiac surgery https://www.nephjc.com/news/2026/8/18/mercuri2 MERCURI-1 Pilot trial is described here. Looks like it was only published as a pre-print. The first link provides a glimpse at MERCURI-3 https://abrahamhulst.com/research/mercuri-1/ https://www.medrxiv.org/content/10.1101/2024.03.27.24304998v1.full.pdf Vipin Varghese used to believe in the urinalysis: Diagnostic Utility of Serial Microscopic Examination of the Urinary Sediment in Acute Kidney Injury https://pubmed.ncbi.nlm.nih.gov/35373012/ MERCURI-2 in ClinicalsTrials.gov: proMoting Effective Renoprotection in Cardiac sURgery Patients by Inhibition of SGLT-2 (MERCURI-2)   https://clinicaltrials.gov/study/NCT05590143 Roger Rodby’s 4 favortite equations in Nephrology from Channel Your Enthusioasm: https://pca.st/episode/abff985f-6a87-41f9-bcc9-80b8a85c2441?t=3257.0 IDEAL ICU Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis https://www.nejm.org/doi/full/10.1056/NEJMoa1803213?referrer=https%3A%2F%2Fwww.google.com%2F Rethinking the definition of oliguria: Identification of an optimal threshold to define oliguria in critically ill patients: an observational study https://pubmed.ncbi.nlm.nih.gov/37254158/ Editorial on MERCURI-2 in JAMA by Wolfgang Winkelmayer and  Glenn Chertow https://jamanetwork.com/journals/jama/fullarticle/2852331          Tubular Secretion Swapnil Spider Noire Amazon Prime Sophia Bernadoodle via Starlight Bernadoodle https://starlightbernedoodles.com Rahul Derry Girls on Netflix Vipin Tennis Cincinnati Open and the US Open. The death of the one handed backhand. Jay Slow Horses on Apple TV and Adults on Hulu Joel Silo season three. Mountain biking.

  4. Aug 30

    FF96 Majesty: Obi in membranous

    The Filtrate Joel Topf @kidney_boy Swapnil Hiremath @hswapnil.medsky.social Natalie Freidin Program director at Medical University of South Carolina AC @medpeedskidneys.bsky.social Special Guests Fernando Fervenza Professor of Medicine, The Mayo Clinic Editing Vip Vergues The Kidney Connection written and performed by Timothy Yau Show Notes MENTOR NephJC | NEJM | Freely Filtered episode 7 PLA2r in 2009 M-Type Phospholipase A2 Receptor as Target Antigen in Idiopathic Membranous Nephropathy NEJM MAJESTY NephJC | NEJM Obinutuzumab or Tacrolimus in Primary Membranous Nephropathy Giuseppe Remuzzi discovers rituximab works in primary membranous. Rituximab for idiopathic membranous nephropathy The Lancet 2002 Fervenza’s 15-person study of Rituximab treatment of idiopathic membranous nephropathy Kidney International 2008. Larry Beck’s NEJM PLA2r study M-Type Phospholipase A2 Receptor as Target Antigen in Idiopathic Membranous Nephropathy NEJM 2009 2011 (not 2010) JASN paper where using banked serum from two prior rituximab studies in membranous nephropathy, Beck and Fervenza showed that declines in anti-PLA2R antibodies preceded reductions in proteinuria and predicted subsequent clinical remission, establishing the concept that immunologic remission precedes clinical remission. Rituximab-Induced Depletion of Anti-PLA2R Autoantibodies Predicts Response in Membranous Nephropathy PubMed The National Institute of Animal Health…a Fervenza fiction Robert A. Star, M.D. NIH Daniel C. Cattran, M.D. NephCure Tubular Secretions Swap do not go to see Mandalorian and Grogu or Supergirl AC doing nothing Natalie The Wealth Ladder by Nick Maggiulli (amazon) Fernando South Portugal and GlomCon Hawaii Joel The Boundary Waters Canoe Area

  5. Aug 23

    FF95 The PUSH Trial

    The Filtrate Joel Topf@kidney_boy Vipin Verghese@vipvargh.bsky.social Nayan Arora @captainchloride Special Guests David Goldfarb Professor of Medicine, NYU (COI) Megan Prochaska Assistant professor of medicine at University of Chicago John Asplin Medical Director Consultant LithoLink (Twitter) Editing Anna Gaddy The Kidney Connection written and performed by Timothy Yau Show Notes Kidney Treks, University of Chicago. For medical students. The Push Trial: Prevention of urinary stones with hydration: a randomised clinical trial of an adherence intervention NephJC Short | The Lancet Charlie Pak trial showing increased urine volume reduced risk of kidney stones. Evidence justifying a high fluid intake in treatment of nephrolithiasis PubMed The Borghi Trial: Urinary volume, water and recurrences in idiopathic calcium nephrolithiasis: a 5-year randomized prospective study PubMed Medical Management of Kidney Stones: AUA Guideline (2026) Weird little trial Asplin mentioned with amlodipine. But it was actually verapami. By Kemal Sarical: The effect of calcium channel blockers on stone regrowth and recurrence after shock wave lithotripsy PubMed Borghi’s other giant study in kidney stones: Comparison of Two Diets for the Prevention of Recurrent Stones in Idiopathic Hypercalciuria NEJM The No Stone Trial: Hydrochlorothiazide and Prevention of Kidney-Stone Recurrence NephJC | NEJM Gary Curhan epidemiologic data from the Nurses Health Study and the Health Professionals Follow-up Study: Twenty-four-hour urine chemistries and the risk of kidney stones among women and men PubMed Gary Curhan epidemiologic data on sugar sweetened beverages and risk of kidney stones. Soda and other beverages and the risk of kidney stones PubMed Eric Topol’s tweet:NephJC in 2014 on the ACP Kidney Stone Guidelines NephJC Goldfarb’s scathing editorial on said guidelines, not on NephJC as I said but, on Fred Coe’s website at the University of Chicago. Link Tubular Secretions Nayan: Shrinking on Apple TV Wikipedia David: The deaths of Sonny Rollins (Wikipedia) and James Blood Ulmer (Wikipedia) Megan: Sri Lanka for travel (National Geographic) Vipin: Memory Eternal: Living with Grief as Orthodox Christians (Amazon) John: A History of Rock Music in 500 Songs (Link) Patty Smith’s memoir, Just Kids (Amazon) Joel: This is How You Lose The War by Amal El-Mohtar and Max Gladstone (Amazon) for the second time, and Acquired PodCast (Link)

  6. Jul 17

    FF94 C3 Glomerulopathy with Carla Nester

    The Filtrate Joel Topf kidneyboy.bsky.social Swapnil Hiremath @hswapnil.medsky.social Natalie Freidin Program director at Medical University of South Carolina Sophia Ambruso @sophia_kidney AC @medpeedskidneys.bsky.social Special Guests Carla Nester, Professor of Medicine, Professor of Pediatrics, University of Iowa. Senior author of Valiant Editing Natalie Freidin The Kidney Connection written and performed by Timothy Yau Show Notes Trial of Pegcetacoplan in C3 Glomerulopathy and Immune-Complex MPGN NEJM | NephJC Tubular Secretions Swapnil: City of Last Chances by Adrian Tchaikovsky (Amazon) Natalie: Heated Rivalry, the books by Rachel Reid Carla: Rowing and gold fiber embroidery AC: Audiobooks, that are appropriate for children: The Giver and Tuck Everlasting Sophia: Greeking Out podcast and the Wheel of Time by Robert Jordan (Wikipedia) Joel: This is How You Lose The War by Amal El-Mohtar and Max Gladstone (Amazon)

  7. Jun 30

    FF93 The Hyponatremia Intervention Trial

    The Filtrate Joel Topf kidneyboy.bsky.social Swapnil Hiremath @hswapnil.medsky.social Pedro Teixeira @nephcrit.bsky.social Special Guests Ewout J. Hoorn, Professor of Medicine Erasmus MC, Netherlands. One of the primary authors. Harish Seethapathy, Assistant physician at Massachusetts General Hospital Editing Vipin Verghese The Kidney Connection written and performed by Timothy Yau Show Notes A Randomized Trial of Targeted Hyponatremia Correction in Hospitalized Patients in NEJM Evidence, in PubMed, in NephJC Seethapathy: Severe Hyponatremia Correction, Mortality, and Central Pontine Myelinolysis in NEJM Evidence MacMillan: Osmotic Demyelination Syndrome in Patients Hospitalized with Hyponatremia in NEJM Evidence SALSA: Risk of Overcorrection in Rapid Intermittent Bolus vs Slow Continuous Infusion Therapies of Hypertonic Saline for Patients With Symptomatic Hyponatremia: The SALSA Randomized Clinical Trial in JAMA Internal Medicine SALT 1 and 2: Tolvaptan, a Selective Oral Vasopressin V2-Receptor Antagonist, for Hyponatremia in NEJM Hyponatremia registry: Current treatment practice and outcomes. Report of the hyponatremia registry in Kidney International The Richard Sterns’ article on the lower mortality with more severe hyponatremia: Mortality and Serum Sodium: Do Patients Die from or with Hyponatremia? in CJASN The European Hyponatremia Guidelines: Clinical practice guideline on diagnosis and treatment of hyponatraemia in The European Journal of Endocrinology The American Hyponatremia Guidelines: Diagnosis, Evaluation, and Treatment of Hyponatremia: Expert Panel Recommendations in American Journal of Medicine Treating hyponatremia: damned if we do and damned if we don't by Tom Berl in Kidney International Prospective (clamp) versus reactive (rescue) DDAVP in hyponatremia: Safety and efficacy of proactive versus reactive administration of desmopressin in severe symptomatic hyponatremia: a randomized controlled trial in Nature Scientific Reports and as covered in PBFluids Helbert Rondon’s RCT of urea Urea for Chronic Hyponatremia on ClinicalTrials.gov Tubular Secretions Swapnil: Catfishing on CatNet: A Novel by Naomi Kritzer (Amazon) Harish: Disney Cruise Edward: Flesh: A Novel (Booker Prize Winner) by David Szalay (Amazon) Pedro: Scrubs reboot (IMDB) Joel: KIDNEYcon

    FF93 The Hyponatremia Intervention Trial

  8. Jun 9

    FF92 Live from Dublin

    The Filtrate Joel Topf kidneyboy.bsky.social Special Guests Dr. Samir Parikh, President of the American Society of Nephrology Prof. Donal Reddan, President, Irish Nephrology Society Prof. Catherine Godson Editing Joel Topf The Kidney Connection written and performed by Timothy Yau Show Notes Tubular Secretions Joel Topf, the Dublin Port Greenway Link Catherine Godson: never heard of the Dublin Port Greenway Samir Parikh: Trinity College Dublin and specifically the Eavan Boland Library, named after the Irish poet. Donal Reddan: Something about rugby

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Twice monthly (aspirational) recap of the NephJC journal club. NephJC reviews the most important manuscripts which are driving nephrology forward and improving our understanding of the kidney.

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