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Dr Sean Kassen, PhD DIC
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  • PERSONAL JOURNALS

Join in on my journey of life as it happens as a biomedical science, research and education enthusiast. I am passionate about proactive health management; mentoring; coaching; and believe that knowledge is power and we need to seek out data and information that enhances our lives holistically, i.e. body, mind, and soul to find true balance across these elements for a healthy, prosperous, and fulfilling life.

  1. The Sugar Spike Solution: Balanced Eating for Stable Blood Glucose

    07/02/2025

    The Sugar Spike Solution: Balanced Eating for Stable Blood Glucose

    In today's episode we summarise key themes and important facts regarding blood sugar levels and how to manage spikes, drawing from a provided "Surrey Live" article and input from health coach Steve Bennett and my own lived experience and journey as a prediabetic (currently reversed). Here is a link to the article: https://www.getsurrey.co.uk/news/health/health-coach-says-foods-cause-31539332 For those interested, especially new listeners, I have a few podcast episodes on my channel discussing my health journey over the last 12 months. Earlier podcast episodes tracking my journey: ⁠https://open.spotify.com/episode/2FWiwJRAUoteP4vtk4ZyqL?si=Hsz_3NxCTrSLFUTE3yb8qA⁠ ⁠⁠https://open.spotify.com/episode/7u7unjCGGzRXDi4s87hZAT?si=suLCz3UqT7qtx7JSUXH_0A⁠⁠ ⁠⁠https://open.spotify.com/episode/289MS2NC4VzXsAoql4aob8?si=yvuxNUnaRoaOjaJJo3ncXg⁠⁠ Other resources and information utilised: ⁠⁠https://open.spotify.com/episode/4vjlss7hUSkwirKi8yt2qb?si=ALwthR9sSX6NODZMdGwqyg⁠⁠ ⁠⁠https://open.spotify.com/episode/2vvCYVmeGBVSRdKJhhfwTE?si=0g_0JnezTBKNnts6GnnfCw⁠⁠ ⁠⁠https://open.spotify.com/episode/6aVCgxHNETUvZ9IbQt2d96?si=GMrrVYGRSmWwOM1AQbG2rA⁠⁠ ⁠⁠https://open.spotify.com/episode/7nNusqCPho4wBsWmz9En82?si=jInmSqgiQUSje6J14MpPRw⁠⁠ Disclaimer The information presented in this podcast is for informational and educational purposes only and not as medical advice. While every effort has been made to ensure accuracy and relevance, the content is not exhaustive nor guaranteed to remain current beyond the date of recording. The perspectives shared reflect research and opinions as of the time of production. Listeners are encouraged to conduct their own independent research into these topics, where necessary, and if concerned or distressed by anything discussed in this episode, please consult your Dr or Healthcare Team. The creator of this podcast assumes no liability for any actions taken based on the content presented.

    25 min
  2. Dr Kassen's 8-month Blood Sugar and Lipid Profile Snapshot

    05/08/2025

    Dr Kassen's 8-month Blood Sugar and Lipid Profile Snapshot

    This episode continues discussing my personal health journey and data from August 2024 to May 2025 (including limited data from March 2024), focusing on my prediabetes and associated lipid profile changes as updated on 7 May 2025. The analysis reveals a successful reversal of prediabetes within three months (September to December 2024) through significant lifestyle and dietary modifications, primarily intermittent fasting (IF) and a low-carbohydrate diet (Low-carb). While blood glucose control remained stable within the normal range even with some dietary liberalisation and a cessation of intermittent fasting (IF), the lipid profile showed some increases in total and LDL cholesterol between September 2024 and December 2024, but did drop back down into the normal ranges for May 2025. Thus, to date, key lipid ratios are indicative of a very favourable cardiovascular risk (QRisk2 score). Taken together, this highlights the close interplay between insulin resistance (IR), blood sugar control, and lipid metabolism, and underscore the importance of continued monitoring and a sustainable healthy lifestyle. Earlier podcast episodes tracking my journey: https://open.spotify.com/episode/2FWiwJRAUoteP4vtk4ZyqL?si=Hsz_3NxCTrSLFUTE3yb8qA ⁠https://open.spotify.com/episode/7u7unjCGGzRXDi4s87hZAT?si=suLCz3UqT7qtx7JSUXH_0A⁠ ⁠https://open.spotify.com/episode/289MS2NC4VzXsAoql4aob8?si=yvuxNUnaRoaOjaJJo3ncXg⁠ Other resources and information utilised: ⁠https://open.spotify.com/episode/4vjlss7hUSkwirKi8yt2qb?si=ALwthR9sSX6NODZMdGwqyg⁠ ⁠https://open.spotify.com/episode/2vvCYVmeGBVSRdKJhhfwTE?si=0g_0JnezTBKNnts6GnnfCw⁠ ⁠https://open.spotify.com/episode/6aVCgxHNETUvZ9IbQt2d96?si=GMrrVYGRSmWwOM1AQbG2rA⁠ ⁠https://open.spotify.com/episode/7nNusqCPho4wBsWmz9En82?si=jInmSqgiQUSje6J14MpPRw⁠ Disclaimer The information presented in this podcast is for informational and educational purposes only and not as medical advice. While every effort has been made to ensure accuracy and relevance, the content is not exhaustive nor guaranteed to remain current beyond the date of recording. The perspectives shared reflect research and opinions as of the time of production. Listeners are encouraged to conduct their own independent research into these topics, where necessary, and if concerned or distressed by anything discussed in this episode, please consult your Dr or Healthcare Team. The creator of this podcast assumes no liability for any actions taken based on the content presented.

    10 min
  3. Dr Kassen Blood Sugar & Lipid Trends: Aug 2024 - Apr 2025

    04/28/2025

    Dr Kassen Blood Sugar & Lipid Trends: Aug 2024 - Apr 2025

    This episode continues discussing my personal health journey and data from August 2024 to April 2025, focusing on my prediabetes and associated lipid profile changes. The analysis reveals a successful reversal of prediabetes within three months (September to December 2024) through significant lifestyle and dietary modifications, primarily intermittent fasting and a low-carbohydrate diet. While blood glucose control remained stable within the normal range even with some dietary liberalisation and a cessation of intermittent fasting (IF), the lipid profile showed some increases in total and LDL cholesterol between September and December 2024. Despite these increases, key lipid ratios indicative of cardiovascular risk (QRisk2 score) remained favourable. This highlights the close interplay between insulin resistance, blood sugar control, and lipid metabolism, and underscore the importance of continued monitoring and a sustainable healthy lifestyle. Earlier podcast episodes tracking my journey: https://open.spotify.com/episode/7u7unjCGGzRXDi4s87hZAT?si=suLCz3UqT7qtx7JSUXH_0A https://open.spotify.com/episode/289MS2NC4VzXsAoql4aob8?si=yvuxNUnaRoaOjaJJo3ncXg Other resources and information utilised: https://open.spotify.com/episode/4vjlss7hUSkwirKi8yt2qb?si=ALwthR9sSX6NODZMdGwqyg https://open.spotify.com/episode/2vvCYVmeGBVSRdKJhhfwTE?si=0g_0JnezTBKNnts6GnnfCw https://open.spotify.com/episode/6aVCgxHNETUvZ9IbQt2d96?si=GMrrVYGRSmWwOM1AQbG2rA https://open.spotify.com/episode/7nNusqCPho4wBsWmz9En82?si=jInmSqgiQUSje6J14MpPRw Disclaimer The information presented in this podcast is for informational and educational purposes only and not as medical advice. While every effort has been made to ensure accuracy and relevance, the content is not exhaustive nor guaranteed to remain current beyond the date of recording. The perspectives shared reflect research and opinions as of the time of production. Listeners are encouraged to conduct their own independent research into these topics, where necessary, and if concerned or distressed by anything discussed in this episode, please consult your Dr or Healthcare Team. The creator of this podcast assumes no liability for any actions taken based on the content presented.

    9 min
  4. Healthspan, Lifespan, Disease Trends, and Economics: A Global Overview

    02/03/2025

    Healthspan, Lifespan, Disease Trends, and Economics: A Global Overview

    While global average lifespans are increasing, major disparities exist both in terms of lifespan and healthspan, and these disparities are likely to continue in the future, with major regional variations in life expectancy, healthcare access, disease burden, and its socio-economic impact. The modelling for the future requires caution given the modelling methods used, but nevertheless provides an overview of likely future scenarios. These findings point towards a need for both global efforts to reduce the health gap, and regional-specific interventions tailored to different challenges. A few sources for those interested in delving a bit deeper: Global Healthspan-Lifespan Gaps Among 183 World Health Organization Member States; https://www.healthdata.org/news-events/newsroom/news-releases/global-life-expectancy-increase-nearly-5-years-2050-despite; COVID-19 eliminated a decade of progress; World health statistics 2024; Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021; https://www.visualcapitalist.com/japans-aging-problem-in-one-chart/; Longevity leap: mind the healthspan gap Thanks again for tuning in. Follow for more. Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠sckvvv_drathome⁠⁠⁠⁠⁠⁠⁠⁠; YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠@DrSean-888.⁠⁠⁠⁠⁠ Disclaimer The information presented in this podcast is for informational and educational purposes only and not as general, financial, or medical advice. While every effort has been made to ensure accuracy and relevance, the content is not exhaustive nor guaranteed to remain current beyond the date of recording. The perspectives shared reflect research and opinions as of the time of production. Listeners are encouraged to conduct their own independent research into these topics, where necessary, and if concerned or distressed by anything discussed in this episode, please consult your Dr, Healthcare Team, or the relevant authorities, and agencies. The creator of this podcast assumes no liability for any actions taken based on the content presented.

    22 min
  5. My Prediabetes Journey: IR and T2DM - A Global Health Crisis_Part 4

    01/31/2025

    My Prediabetes Journey: IR and T2DM - A Global Health Crisis_Part 4

    Insulin resistance, type 2 diabetes, and metabolic syndrome are major and escalating global health problems. Key factors driving these issues include obesity, unhealthy lifestyles, and genetic predispositions. These conditions place a significant burden on individuals and healthcare systems due to morbidity, mortality, and healthcare costs. Effective prevention and management strategies rely on lifestyle modifications, early diagnosis and, in some cases, medication. The continued collection of data and further research on the underlying mechanisms will be essential to combat these complex challenges effectively. Sources and links: 1 PERSON DIES OF DIABETES EVERY 5 SECONDS; https://transmedcomms.biomedcentral.com/articles/10.1186/s41231-022-00124-6; National Diabetes Statistics Report; Metabolic Syndrome; Insulin Resistance; https://diabetesatlas.org/; https://www.visualcapitalist.com/cp/diabetes-rates-by-country/ Thanks again for tuning in. Follow for more. Instagram: ⁠⁠⁠⁠⁠⁠⁠sckvvv_drathome⁠⁠⁠⁠⁠⁠⁠; YouTube: ⁠⁠⁠⁠⁠⁠⁠@DrSean-888.⁠⁠⁠⁠ Disclaimer The information presented in this podcast is for informational and educational purposes only and not as medical advice. While every effort has been made to ensure accuracy and relevance, the content is not exhaustive nor guaranteed to remain current beyond the date of recording. The perspectives shared reflect research and opinions as of the time of production. Listeners are encouraged to conduct their own independent research into these topics, where necessary, and if concerned or distressed by anything discussed in this episode, please consult your Dr or Healthcare Team. The creator of this podcast assumes no liability for any actions taken based on the content presented.

    21 min
  6. My Prediabetes Journey: T1DRA Study_Part 3

    01/31/2025

    My Prediabetes Journey: T1DRA Study_Part 3

    Today we discuss an experience I had with an at-home blood sample collection process for the T1DRA study, a UK-based research initiative investigating type 1 diabetes risk factors in adults. The study aims to identify individuals at increased risk and improve understanding of the condition's development. Participants aged 18-70 provide blood samples, and those with multiple risk markers receive information on type 1 diabetes management and clinical trials. The accompanying video is available on YouTube here and details the sample collection procedure, offering timestamps for viewers' convenience. The study seeks diverse participation to ensure representative findings for the general UK adult population. An unboxing of the study material received can be accessed here. Although my concerns are about acquiring T2DM, I felt it necessary to partake in this T1DM study. Links available on my YouTube channel. Thanks again for tuning in. Follow for more. Instagram: ⁠⁠⁠⁠⁠⁠sckvvv_drathome⁠⁠⁠⁠⁠⁠; YouTube: ⁠⁠⁠⁠⁠⁠@DrSean-888.⁠⁠⁠ Disclaimer The information presented in this podcast is for informational and educational purposes only and not as medical advice. While every effort has been made to ensure accuracy and relevance, the content is not exhaustive nor guaranteed to remain current beyond the date of recording. The perspectives shared reflect research and opinions as of the time of production. Listeners are encouraged to conduct their own independent research into these topics, where necessary, and if concerned or distressed by anything discussed in this episode, please consult your Dr or Healthcare Team. The creator of this podcast assumes no liability for any actions taken based on the content presented.

    16 min
  7. Cystic Fibrosis (CF): Metabolic Adaptations of Pseudomonas Aeruginosa_Part 2

    01/29/2025

    Cystic Fibrosis (CF): Metabolic Adaptations of Pseudomonas Aeruginosa_Part 2

    Cystic fibrosis (CF) is a complex genetic disorder with significant implications for those affected. While there is currently no cure, advancements in our understanding of the disease, its genetic underpinnings, and the development of targeted therapies are improving both life expectancy and quality of life for those affected. Yet, many challenges remain especially on the metabolic adaptations of Pseudomonas aeruginosa (P. aeruginosa) during chronic infections in the lungs of individuals with Cystic Fibrosis (CF). These adaptations are not simply a consequence of the environment, but an active process driven by specific mutations and metabolic shifts that impact virulence, immune evasion and interactions within the CF lung. A key finding is that mutations in the PDHc, causing shifts in pyruvate metabolism, play a central role in driving this adaption. Further research into these metabolic changes is essential for developing more effective treatment strategies for CF-related infections. The use of advanced metabolomics, proteomics, and in vitro models is essential to understanding this dynamic process. A few sources: https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002781⁠; https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2021.617784/full⁠⁠; ⁠https://www.sciencedirect.com/science/article/pii/S0966842X16000214⁠; https://pmc.ncbi.nlm.nih.gov/articles/PMC6835255/ Thanks for tuning in. Follow for more. Instagram: ⁠⁠⁠⁠⁠sckvvv_drathome⁠⁠⁠⁠⁠; YouTube: ⁠⁠⁠⁠⁠@DrSean-888.⁠⁠ Disclaimer The information presented in this podcast is for informational and educational purposes only and not as medical advice. While every effort has been made to ensure accuracy and relevance, the content is not exhaustive nor guaranteed to remain current beyond the date of recording. The perspectives shared reflect research and opinions as of the time of production. Listeners are encouraged to conduct their own independent research into these topics, where necessary, and if concerned or distressed by anything discussed in this episode, please consult your Dr or Healthcare Team. The creator of this podcast assumes no liability for any actions taken based on the content presented.

    26 min
  8. Cystic Fibrosis (CF): Genetics, Mutations, and Gene Therapy_Part 1

    01/29/2025

    Cystic Fibrosis (CF): Genetics, Mutations, and Gene Therapy_Part 1

    Cystic fibrosis (CF) is a complex genetic disorder with significant implications for those affected. While there is currently no cure, advancements in our understanding of the disease, its genetic underpinnings, and the development of targeted therapies like CFTR modulators are improving both life expectancy and quality of life for those affected. Ongoing research into gene therapy, modifier genes and personalized medicine holds much promise for the future management of CF. A few sources: https://www.nhs.uk/conditions/cystic-fibrosis/; https://my.clevelandclinic.org/health/diseases/9358-cystic-fibrosis; https://www.nhlbi.nih.gov/health/cystic-fibrosis/living-with; https://pmc.ncbi.nlm.nih.gov/articles/PMC4364438/ Thanks for tuning in. Follow for more. Instagram: ⁠⁠⁠⁠sckvvv_drathome⁠⁠⁠⁠; YouTube: ⁠⁠⁠⁠@DrSean-888.⁠ Disclaimer The information presented in this podcast is for informational and educational purposes only and not as medical advice. While every effort has been made to ensure accuracy and relevance, the content is not exhaustive nor guaranteed to remain current beyond the date of recording. The perspectives shared reflect research and opinions as of the time of production. Listeners are encouraged to conduct their own independent research into these topics, where necessary, and if concerned or distressed by anything discussed in this episode, please consult your Dr or Healthcare Team. The creator of this podcast assumes no liability for any actions taken based on the content presented.

    20 min
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About

Join in on my journey of life as it happens as a biomedical science, research and education enthusiast. I am passionate about proactive health management; mentoring; coaching; and believe that knowledge is power and we need to seek out data and information that enhances our lives holistically, i.e. body, mind, and soul to find true balance across these elements for a healthy, prosperous, and fulfilling life.

Information

  • Creator
    Dr Sean Kassen, PhD DIC
  • Years Active
    2020 - 2025
  • Episodes
    18
  • Rating
    Clean
  • Copyright
    © Dr Sean Kassen, PhD DIC
  • Show Website
    Dr@Home