ASTCT Talks

ASTCT
  • 4.9 (9)
  • Medicine
  • Updated Bimonthly

ASTCT Talks is the official podcast of the American Society for Transplantation and Cellular Therapy (ASTCT). We chat with industry leaders from all areas of the blood and marrow transplantation and cellular therapy field, including doctors, physician assistants, pharmacists, nurses, administrators, social workers, and more. We hope you enjoy listening!

  1. 1d ago

    TIL Therapy in Sarcoma: From Tumor Procurement to Clinical Response

    In this episode of ASTCT Talks, host Daniel Olson, MD, medical oncologist and co-leader of the melanoma, sarcoma, and solid tumor cellular therapy programs at the University of Chicago, is joined by John Mullinax, MD, surgical oncologist at Moffitt Cancer Center, and Lauren Banks, MD, PhD, medical oncologist at Memorial Sloan Kettering Cancer Center, to discuss the emerging role of tumor-infiltrating lymphocyte (TIL) therapy in sarcoma. As TIL therapy expands beyond melanoma, investigators are exploring its potential in soft tissue sarcomas, including dedifferentiated liposarcoma and undifferentiated pleomorphic sarcoma. The conversation examines the scientific rationale for TIL therapy in sarcoma, early clinical results, and the unique surgical and operational considerations required to bring this cellular therapy approach to patients with solid tumors. The discussion covers: The unmet clinical need in sarcoma and why certain sarcoma subtypes may be particularly attractive candidates for TIL therapy.Early clinical experience with TIL therapy in sarcoma and what the initial results may mean for future treatment approaches.Practical considerations for tumor procurement, including lesion selection, surgical planning, and manufacturing success.The multidisciplinary collaboration required among surgery, medical oncology, pathology, radiology, and cellular therapy teams to successfully deliver TIL therapy.This episode provides clinical, translational, and operational perspectives on one of the most promising emerging applications of cellular therapy in solid tumors and explores what may be next for patients with sarcoma. Listen to the episode below or on your favorite app. Subscribe to ASTCT Talks and share this episode with your colleagues to keep the conversation going. This episode was made possible through support from Iovance. Disclaimer: The views and opinions expressed by the podcast participants are their own and do not necessarily reflect those of ASTCT. This episode is intended for educational purposes only and should not be construed as medical advice or treatment recommendations. Discussion of investigational therapies, clinical trial data, or emerging treatment approaches does not imply endorsement or establish a standard of care. Clinicians should consult current guidelines, prescribing information, and institutional protocols when making treatment decisions.

  2. Sep 21

    Understanding Immune Effector Cell-Associated Enterocolitis After CAR T-Cell Therapy

    In this episode of ASTCT Talks, host Terri Lynn Shigle, PharmD, BCOP, clinical pharmacy specialist with Stem Cell Transplantation and Cellular Therapy Department at The University of Texas MD Anderson Cancer Center and current ASTCT director of pharmacists (ex-officio) and Mark Hamilton, MD, of The University of Texas MD Anderson Cancer Center discuss immune effector cell-associated enterocolitis (IEC-EC), a rare but potentially severe late complication of BCMA-directed CAR T-cell therapy. As the use of CAR T-cell therapies continues to expand, understanding and managing delayed toxicities has become increasingly important. The discussion highlights: The clinical presentation, incidence, and risk factors associated with IEC-EC.Current approaches to diagnosis, including endoscopy, pathology evaluation, and detection of CAR T-cell infiltration in the gastrointestinal tract.Emerging insights into the biology of IEC-EC and the role of persistent CAR T cells.Treatment strategies, supportive care considerations, and areas of ongoing research.This episode provides valuable clinical and translational perspectives on a rare but important CAR T-cell-related toxicity and explores how ongoing research may help improve diagnosis, management, and patient outcomes. Listen to the episode below or on your favorite app. Subscribe to ASTCT Talks and share this episode with your colleagues to keep the conversation going. This episode was made possible through support from Johnson & Johnson.

  3. Aug 11

    Exploring CAR T Updates in Pediatric Acute Lymphoblastic Leukemia

    In a cobranded episode between Oncology On the Go, hosted by CancerNetwork®, and the American Society for Transplantation and Cellular Therapy’s (ASTCT) program ASTCT Talks, Terri Lynn Shigle, PharmD, BCOP hosted Vinita Pai, PharmD, MS, BCPPS, who spoke about the use of CAR T-cell therapy for pediatric patients, focusing on acute lymphoblastic leukemia (ALL). After a brief overview of progress in the cellular therapy field and pediatrics’ first and only FDA approved CAR T product since 2017, their discussion explored the following: Review of real-world practice and outcomes in ALLPediatric practical challenges including logistics, leukapheresis, and lymphodepletion chemotherapyStrategies for managing cell therapy toxicities in pediatricpatientsConsiderations for survivorship and long-term toxicitiesGaps in pediatric care and future directions Listen below or via your favorite podcast platform. Reference O'Leary MC, Lu X, Huang Y, et al. FDA approval summary: tisagenlecleucel for treatment of patients with relapsed or refractory B-cell precursor acute lymphoblastic leukemia. Clin Cancer Res. 2019;25(4):1142-1146. doi:10.1158/1078-0432.CCR-18-2035

  4. Aug 3

    Titans of Transplant Featuring Dr. Crystal Mackall

    In this episode of ASTCT Talks, Dr. Nirali Shah welcomes Crystal Mackall, MD, the Ernest and Amelia Gallo Family Professor at Stanford University and a pioneer in immuno-oncology and cellular therapy, for a conversation in the Titans of Transplant series. Dr. Mackall reflects on her journey into medicine, the mentors who shaped her career, and the evolution of immunotherapy from an emerging concept to a transformative treatment modality. She also shares her perspective on the future of cell and gene therapies, the challenges facing pediatric cancer drug development, and the importance of resilience, mentorship, and innovation in scientific careers. Tune in to hear about: Dr. Mackall's path to becoming a physician-scientist.Lessons learned from mentors and decades of leadership in the field.The evolution of immunotherapy and cellular therapy.Emerging opportunities in RNA-based therapeutics and next-generation treatments.Barriers to advancing pediatric cancer therapies.Advice for trainees and early-career investigators.The role of resilience, collaboration, and curiosity in a successful career.Listen to the episode below or on your favorite podcast app. Subscribe to ASTCT Talks to stay up to date on the latest conversations in transplantation and cellular therapy.

  5. Jul 23

    The Role of the Social Worker in CAR T Care

    In this episode of ASTCT Talks, host Terri Lynn Shigle, PharmD, BCOP, Clinical Pharmacy Specialist in the Stem Cell Transplantation and Cellular Therapy Department at The University of Texas MD Anderson Cancer Center, sits down with Lauren Campasano, MSW, LCSW, OSW-C, a licensed clinical social worker in New Jersey at Robert Wood Johnson Barnabas Health, to discuss the vital role social workers play throughout the CAR T therapy journey. Together, they explore how social workers help patients and caregivers navigate the complex medical, emotional, financial, and logistical challenges associated with CAR T therapy. From pre-treatment evaluation through post-treatment recovery, the conversation highlights the importance of multidisciplinary support in improving the patient experience and optimizing outcomes.The discussion covers: The role of social workers in CAR T patient assessment, caregiver support, and treatment readiness.Common psychosocial, financial, and logistical barriers patients face during CAR T therapy.Best practices for integrating social work into the multidisciplinary cellular therapy team. This episode offers valuable insights for clinicians seeking to better understand the critical contributions of social work to CAR T care and patient-centered cellular therapy programs. Listen to the episode below or on your favorite app. Subscribe to ASTCT Talks and share this episode with your colleagues to keep the conversation going.This episode was made possible through support from Johnson & Johnson.

  6. Jul 21

    TIL Therapy for Solid Tumors

    In this episode of ASTCT Talks, host Daniel Olson, MD, of the University of Chicago, is joined by Stephanie Goff, MD, of the National Cancer Institute (NCI), and Allison Betof, MD, PhD, of Stanford Medicine to discuss the evolution and expanding role of tumor-infiltrating lymphocyte (TIL) therapy in solid tumors. From its early development at the NCI to its recent FDA approval in melanoma, the conversation explores how TIL therapy is reshaping treatment options for patients with advanced solid tumors. The discussion highlights: The history and key milestones that led to the development and approval of TIL therapy. The role of TIL therapy in the current melanoma treatment landscape. Practical considerations for treatment delivery, including lymphodepleting chemotherapy and IL-2 administration.This episode provides valuable clinical and operational perspectives on one of the most promising cellular therapy approaches for solid tumors and what’s next for the field. Listen to the episode below or on your favorite app. Subscribe to ASTCT Talks and share this episode with your colleagues to keep the conversation going. This episode was made possible through support fromIovance.

  7. Jul 6

    Titans of Transplant: Catherine Bollard, MBChB, MD

    In this episode of ASTCT Talks, Dr. Nirali Shah talks with Dr. Catherine Bollard as part of the Titans of Transplant series to explore her remarkable career journey and lasting impact on the field of transplantation and cellular therapy. From early inspirations rooted in personal experience to her leadership in advancing cell therapy, Dr. Bollard reflects on her decades of experience across research, clinical care, and mentorship. The conversation highlights both the scientific progress in cellular therapies and the human stories that continue to drive innovation. Dr. Bollard also shares insights into the challenges of building a career as a physician-scientist and the importance of passion, resilience, and collaboration in advancing the field. Tune in for a conversation that covers: Dr. Bollard's path into pediatric hematology/oncology and the personal experiences that shaped her focus on immunotherapy.Key milestones in the evolution of cell therapy, including early translational work and the path to broader adoption.Ongoing challenges in treating diseases like AML and pediatric solid tumors.The importance of mentorship, team science, and developing the next generation of leaders.Reflections on balancing a demanding career with her personal life and staying grounded in purpose.Listen to the episode below or on your favorite app. Subscribe to ASTCT Talks and share this episode with your colleagues to keep the conversation going.

  8. Jun 22

    Navigating the Dynamic Landscape of Stem Cell Transplantation

    In a cobranded episode between Oncology on the Go, hosted by CancerNetwork®, and the American Society for Transplantation and Cellular Therapy (ASTCT)’s program ASTCT Talks, Mitchell E. Horwitz, MD, highlighted key developments and ongoing initiatives related to allogeneic and cord blood transplantations among patients with different hematologic malignancies. The conversation touched upon the impact of omidubicel-onlv (Omisirge) on patient outcomes, current research on reducing the risk of graft-vs-host disease (GVHD) among transplantation recipients, and strategies for providing effective prophylaxis during treatment, among other topics.

See All (83)

Ratings & Reviews

4.9
out of 5
9 Ratings

About

ASTCT Talks is the official podcast of the American Society for Transplantation and Cellular Therapy (ASTCT). We chat with industry leaders from all areas of the blood and marrow transplantation and cellular therapy field, including doctors, physician assistants, pharmacists, nurses, administrators, social workers, and more. We hope you enjoy listening!

Information

  • Creator
    ASTCT
  • Years Active
    2020 - 2026
  • Episodes
    83
  • Rating
    Clean
  • Copyright
    © ASTCT
  • Show Website
    ASTCT Talks

You Might Also Like