The Reversing PKD Podcast

Felix Müller
  • 4.0 (4)
  • Health & Fitness

This Podcast is all about the ins and outs of reversing polycystic kidney disease with diet, supplements and lifestyle. More info on natural polycystic kidney disease treatment can be found at www.reversingpkd.com - Created by Felix S. Mueller

  1. May 14

    Can Patients Choose the Next PKD Research Targets? YES. Dr. Benjamin Freedman Explains

    In this episode, Felix welcomes Dr. Benjamin “Beno” Freedman, Director of the PKD Invent Center at the University of Washington and one of the leading researchers in the world of PKD organoids — tiny “mini-kidney” structures grown from stem cells that can form PKD-like cysts in a dish.Beno explains how kidney organoids are made, why they are different from simple cell cultures or animal models, and how they allow researchers to study human PKD biology in a way that was not possible before. Felix and Beno go deep into the strange and fascinating details: cysts that grow “inside out,” extracellular matrix changing cyst orientation, myosin acting like a contractile force that may help cysts keep their shape, and the possibility that PKD cells may be mechanically weaker than normal cells.They also discuss one of the most relevant findings for the Reversing PKD community: how PKD organoids can pull in glucose through SGLT transporters, creating an osmotic pull that brings water into cysts. This connects directly to the larger metabolic picture of PKD, glucose exposure, SGLT2 inhibitors, ketogenic nutrition, and why lowering the glucose pressure on PKD tissue may matter.The second half of the conversation focuses on the new PKD Research Resource Consortium center and the possibility of patient-centered research input. Beno explains how scientists, companies, and potentially even the wider PKD community may be able to suggest molecules, supplements, etc. for pilot testing in PKD organoid systems.Viewers will learn:• What kidney organoids are and why they matter for PKD• How scientists grow “mini kidneys” from stem cells• Why PKD cysts can form differently depending on their environment• How extracellular matrix may change cyst orientation• Why myosin and cell contractility could become a therapeutic target• How glucose transport may help PKD cysts pull in water and expand• What SGLT transporters have to do with PKD research• How the new PKD Invent Center and PKD-RRC may allow community-driven research ideas• Why patient input could help shape the future of PKD research🎙️ Guest & Research Links• PKD Research Resource Consortiumhttps://pkd-rrc.org/• PKD Invent Center / University of Washingtonhttps://pkd-rrc.org/centers/invent/• Dr. Benjamin Freedman / Freedman Labhttps://freedmanlab.org/• Plurexa — Organoid-based drug discovery and research serviceshttps://www.plurexa.com/📚 Topics Mentioned• Kidney organoids• PKD organoids• Polycystic Kidney Disease in a dish• Stem cells and organogenesis• Extracellular matrix• Inside-out cyst formation• Myosin and cell contractility• SGLT transporters• Glucose-driven cyst expansion• Osmosis and cyst fluid accumulation• SGLT2 inhibitors• Patient-centered PKD research• Community screening of compounds and molecules🧬 This is not medical advice.🎧 Don’t forget to like, comment, and subscribe if this episode brought value to your PKD journey.Go tohttps://www.reversingpkd.comto find more learning resources and get on the PKD health coaching program.Find my book Reversing Polycystic Kidney Disease here:https://reversingpkd.com/booklinks

  2. 06/23/2025

    Cancer’s Hidden Trigger: How Fungi Ignite ALL Tumors & What It Could Mean for PKD - Mark Lintern

    In this episode, Felix welcomes Author and citizen scientist Mark Lintern—the man who might finally have nailed what actually flips healthy cells into the Warburg Effect metabolism that Professor Thomas Seyfried made famous— and explained on the Reversing PKD Podcast. Mark lays out his “Cell Suppression Theory,” showing how fungi seize control of cells, and create the glucose-dependent breakdown of respiration that Seyfried’s metabolic theory describes by keeping cells stuck in the „Cell Danger Response“ (CDR). Not in error, but it an attempt to rescue the cell.The two swap notes on the parallels between malignant tumors and expanding kidney cysts: a terrain drenched in toxic triggers and suppressed E-cadherin, mirroring the endotoxin fingerprints Felix had already traced in Polycystic Kidney Disease prior. They explore how viewing both diseases as slow-motion reactions to infections and/or toxins reframes everything—from a ketogenic “first line of defense" to antifungals and antiparasitic tactics that could stop tumors and cysts at their microbial root.🎙️ Guest & Core Material• Mark Lintern – Cell Suppression Theory websitehttps://www.cellsuppression.com/ • Free 13-page synopsis (PDF)https://www.cellsuppression.com/marks-theory-synopsis-free-download • Book — The Cancer Resolution ? (Amazon)https://amzn.to/4jOnZhI • Facebook discussion grouphttps://www.facebook.com/groups/marklinterncancertheory/________________________________________💊 Supplements Mentioned• Salvestrols (Example, standard 2000 pt dosage): https://amzn.to/45gal3d • Glutamine https://amzn.to/43Z3gBV or https://de.iherb.com/pr/doctor-s-best-pure-l-glutamine-powder-10-6-oz-300-g/85597?utm_source=chatgpt.com&rcode=HLH837 • Colloidal Silver https://amzn.to/4l7YE3j or https://de.iherb.com/pr/sovereign-silver-bio-active-silver-hydrosol-10-ppm-16-fl-oz-473-ml/16056?utm_source=chatgpt.com&rcode=HLH837 ________________________________________📚 Theories, Books & Foundational Papers• Thomas N. Seyfried/Wiley e-text versionhttps://onlinelibrary.wiley.com/doi/book/10.1002/9781118310311 • Thomas N. Seyfried on the ReversingPKD Podcast: https://www.youtube.com/watch?v=xQhIJxatT1M • Robert K. Naviaux – Cell Danger Response overview (PDF)https://naviauxlab.ucsd.edu/wp-content/uploads/2020/02/Naviaux-CDR-Environmental-Health_2019.pdf ________________________________________🦠 Fungal & Microbiome-Cancer Links• Malassezia 3 000-fold enrichment in pancreatic cancer (Nature 2019)https://pubmed.ncbi.nlm.nih.gov/31578522/ pubmed.ncbi.nlm.nih.gov• Nature editorial – “Fungi promote pancreatic cancer”https://www.nature.com/articles/s41575-019-0231-x nature.com• Itraconazole case report — pancreatic tumor down-staginghttps://pubmed.ncbi.nlm.nih.gov/25670260/ pubmed.ncbi.nlm.nih.gov• ReDO review: itraconazole as an anti-cancer agenthttps://ecancer.org/en/journal/article/521-repurposing-drugs-in-oncology-redo-itraconazole-as-an-anti-cancer-agent ecancer.org• Candida → PD-L1 up-regulation (2022 study)https://pubmed.ncbi.nlm.nih.gov/35362187/ pubmed.ncbi.nlm.nih.gov• Vomocytosis – macrophage expulsion of fungihttps://onlinelibrary.wiley.com/doi/10.1111/cmi.13145 onlinelibrary.wiley.com________________________________________🧑‍🔬 Organisations Mentioned• Yes to Life (UK integrative cancer charity) – https://yestolife.org.uk/ ________________________________________🧑‍⚕️ Key Definitions / Background• Warburg Effect (overview) – https://pmc.ncbi.nlm.nih.gov/articles/PMC4783224/ pmc.ncbi.nlm.nih.gov• Cell Danger Response explainer – https://aonm.org/wp-content/uploads/2021/07/Cell-Danger-Response-IHCAN.pdf aonm.org• E-cadherin / CDH1 gene factsheet – https://www.ncbi.nlm.nih.gov/gene/999 ncbi.nlm.nih.gov

  3. 06/06/2025

    I Listened To The PKD Foundation's New Podcast So You Don't Have To

    Felix checked out the PKD Foundation’s brand-new podcast "PKD Chronicles", sat through every sponsor tag and heartfelt story, and is coming back with questions no one on the show seems to be willing to ask. In this episode he talks about what really drives the conversation, why some topics stay off-limits, and how that silence impacts anyone taking their kidney health into their own hands. Stick around to the end for a preview of next week’s interview on the Cell Suppression Theory, actual info that moves the needle and adds to the metabolic understanding of uncontrolled growth - which might just matter for PKD.Ready to hear what Felix heard—and what he didn’t? Press play.---Go tohttps://www.reversingpkd.com to find more learning resources and get on the PKD health coaching program.

  4. 05/19/2025

    Heavily Meditated: How Dave Asprey Turns Off the PKD Cell-Danger Response

    In this episode, Felix finally welcomes bio-hacking pioneer Dave Asprey—the man whose Bulletproof ideas we quote in almost every show—to the Reversing PKD Podcast. Dave explains why his new book Heavily Meditated puts mindset first, showing how switching off the “cell danger response” can unlock the healing potential of ketogenic eating, smart supplements and targeted fasting for people with Polycystic Kidney Disease. They dig into kidney-protective tactics—from boosting Klotho and strengthening cell membranes with Calcium AEP to tightening the gut barrier against endotoxin—and explore whether fungi or LPS keep cysts growing in some patients.________________________________________Viewers will learn• How calming the nervous system lowers the cell-danger response that blocks kidney repair• Practical ways to raise Klotho for kidney protection now and in the future• How Calcium AEP and targeted probiotics & fiber help seal cell membranes and the gut lining• Importance of cutting fungal toxins and endotoxin load, including when an antifungal trial makes sense• The BICEP method of brief, controlled stress to reset dopamine and cortisol📚 Resources & Mentions from the Episode with Dave AspreySupport the show by using the links below—some are affiliate links with no extra cost to you.________________________________________🧠 Dave Asprey's New Book – Heavily Meditated📘 Amazon: https://www.amazon.com/dp/0063204762?tag=pkdprotocol-20🧬 Viome Gut Intelligence Test🔬 Amazon: https://www.amazon.com/dp/B07HBFM8LS?tag=pkdprotocol-20🌐 Official Viome store (10% off): https://www.viome.com — use code 10DAVE at checkout💊 Calcium AEP (Ca-2-AEP)Amazon: https://www.amazon.com/dp/B003VLENHQ?tag=pkdprotocol-20 🦠 OMNi-BiOTiC® HETOX ProbioticAmazon: https://www.amazon.com/dp/B08PMY3973?tag=pkdprotocol-20Official Store: https://shop.omni-biotic.com/en-eu/products/omni-biotic-hetox-int-99107⚖️ Potassium BicarbonateAmazon: https://www.amazon.com/dp/B07YNXRM76?tag=pkdprotocol-20iHerb: https://www.iherb.com/pr/nutricost-potassium-bicarbonate-unflavored-16-oz-454-g/132299?rcode=HLH837🌿 Boswellia Serrata Extract (with 5-LOXIN – Swanson)40mg AKBA per capsule, so 4-5 capsules/day would be efficient for humans as per study to double Klotho, extrapolated via HED calculation from mouse models.Amazon: https://www.amazon.com/dp/B00A8FCFEQ?tag=pkdprotocol-20iHerb: https://www.iherb.com/pr/swanson-boswellia-serrata-extract-125-mg-60-veggie-caps/118170?rcode=HLH837🎧 Don’t forget to like, comment, and subscribe if this episode brought value to your PKD journey.🧬 This is not medical advice.---Go tohttps://www.reversingpkd.com to find more learning resources and get on the PKD health coaching program.

  5. 12/01/2024

    Mitochondria, Gut, and Detox: A Deep Dive into PKD Healing | Chris Shade, PhD

    Use Code REVERSINGPKD at https://www.quicksilverscientific.com/ (I don't make commission on this, it is just for your benefit.) In this episode, Felix interviews detoxification expert Dr. Chris Shade on the pivotal role of endotoxins and mitochondrial function in reversing Polycystic Kidney Disease (PKD). Learn how endotoxins drive chronic inflammation and cyst growth and explore the connection between mitochondrial health, autophagy and kidney function. Learn how activating AMPK and sirtuins can enhance cellular repair mechanisms, and discover actionable strategies involving ketogenic dieting, fasting and supplements to reduce endotoxin load. Dr. Shade also delves into optimizing detox pathways through improved bile flow and liver support to protect your kidneys. Viewers will learn: - How endotoxins contribute to PKD progression and cyst formation. - The importance of mitochondrial health and autophagy in reversing PKD. - How activating AMPK and sirtuins enhances cellular repair and function. - The benefits of ketogenic diets and fasting in reducing endotoxin levels. - Strategies to improve bile flow and liver detoxification pathways. - Ways to strengthen gut barriers to minimize endotoxin absorption. --- Go to https://www.reversingpkd.com to find more learning resources and get on the PKD health coaching program.

  6. 11/18/2024

    The Fiber Fix: Is Something in Your Gut Secretly Worsening Your PKD?

    Order my book "Reversing Polycystic Kidney Disease" here: https://reversingpkd.com/booklinks – send your receipt to bonus@reversingpkd.com to receive the free infographic to get started right away! -- In this episode, Felix interviews world-renowned Author and gut biome specialist Dr. William Davis on the role of gut health in improving PKD outcomes. Learn how fiber plays a critical role in reducing endotoxin that damages kidneys and how a balanced microbiome can lower inflammation and improve overall health. Discover the fascinating connection between SIBO, Leaky gut and fiber, and how it impacts PKD on the molecular level. You will get actionable strategies to fix your gut and protect your kidneys, including the importance of prebiotics, fermented foods, and Davis' special SIBO-fighting yogurt recipe. Viewers will learn: How endotoxins from the gut affect PKD progression. The role of fiber and prebiotics in maintaining a strong gut lining. How Dr. Davis's yogurt recipe combats SIBO and endotoxemia. Why carnivore and low-fiber keto can worsen blood glucose and endotoxemia. - Starters for Yogurt fermentation: Dr. Davis' brand for L.reuteri: https://www.oxiceutics.com/products/myreuteri Generic options: L.reuteri tablets Amazon US: https://amzn.to/3UWvEkr L.reuteri tablets iHerb US & Worldwide: https://www.iherb.com/pr/biogaia-gastrus-for-optimal-gut-health-mandarin-30-tablets/80974?rcode=HLH837 L.Gasseri Capsules Amazon US: https://amzn.to/4fvn2t3 L.Gasseri Capsules iHerb US & Worldwide: https://www.iherb.com/pr/swanson-lactobacillus-gasseri-3-billion-cfu-60-veggie-drcaps/109008?rcode=HLH837 B.Coagulans Capsules Amazon US: https://amzn.to/3UT1PBi B.Coagulans Capsules iHerb US & Worldwide: https://www.iherb.com/pr/swanson-bacillus-coagulans-6-billion-cfu-60-veggie-caps/118477?rcode=HLH837 W. Davis' Blog post on making L. reuteri yogurt: https://drdavisinfinitehealth.com/2019/07/how-to-make-l-reuteri-yogurt-step-by-step/ W. Davis' Video on making L. reuteri yogurt: https://youtu.be/la9yODLZizo

  7. 10/14/2024

    Beyond Glucose: How Glutamine Drives PKD and Cancer Growth

    In this special episode, Felix sits down with renowned researcher Professor Thomas Seyfried to discuss a groundbreaking revelation for Polycystic Kidney Disease (PKD) management: it's not just glucose that fuels PKD cell growth—glutamine is a major player, too. While many PKD patients have now started to focus on ketogenic diets to restrict glucose, this interview uncovers why glutamine might be just as crucial to take into account. Professor Seyfried explains how glutamine drives cancer cell fermentation and uncontrolled growth, drawing parallels to PKD research. Together, Felix and Professor Seyfried explore how combining a ketogenic diet with glutamine targeting could open new doors for slowing PKD progression. Key topics covered: Why glutamine is a second fuel source for PKD cells. The role of mitochondrial dysfunction in both PKD and cancer. Insights from Professor Seyfried’s decades of research into metabolic therapies. If you're already using a ketogenic diet for PKD, this interview offers a new perspective on your results. Learn from one of the leading experts in metabolic disease research and take your knowledge about PKD to the next level. For more insights and tools, visit reversingpkd.com and order Felix’s book, Reversing Polycystic Kidney Disease, to dive deeper into these innovative strategies: reversingpkd.com/booklinks --- Go to https://www.reversingpkd.com to find more learning resources and get on the PKD health coaching program.

  8. 10/12/2024

    Calculate Your Success: Optimal PKD Macros, VO₂Max, Protein fasting & Cystatin C GFR & More

    Try the tool here: https://reversingpkd.com/report In this episode, Felix introduces a new tool designed to help PKD patients estimate their daily calorie, protein, and fat intake, especially when adjusting for exercise and lab results. This tool also provides advanced options like protein fasting calculations and a VO₂ max estimation, which can assist in improving kidney health and starting autophagy. Viewers will learn: -How to calculate daily calorie and protein needs based on body fat and activity -The benefits of protein fasting over water fasting for PKD management -How VO₂ max and cardiovascular fitness impact autophagy and kidney health Order "Reversing Polycystic Kidney Disease: The PKD Proof Program" here: https://reversingpkd.com/booklinks – and send your receipt to bonus@reversingpkd.com to receive a free PKD infographic! --- Go to https://www.reversingpkd.com to find more learning resources and get on the PKD health coaching program.

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About

This Podcast is all about the ins and outs of reversing polycystic kidney disease with diet, supplements and lifestyle. More info on natural polycystic kidney disease treatment can be found at www.reversingpkd.com - Created by Felix S. Mueller

Information

  • Creator
    Felix Müller
  • Years Active
    2021 - 2026
  • Episodes
    24
  • Rating
    Clean
  • Copyright
    © Felix Müller
  • Show Website
    The Reversing PKD Podcast