The Matt Walker Podcast

Dr. Matt Walker
  • 4.9 (892)
  • MEDICINE
  • UPDATED BIWEEKLY

The Matt Walker Podcast is all about sleep, the brain, and the body. Matt is a Professor of Neuroscience at the University of California, Berkeley. He is the author of the book, Why We Sleep and has given a few TED talks. Matt is an awkward British nerd who adores science and the communication of science to the public. 

  1. #123 - Sleep & the Microbiome

    3D AGO

    #123 - Sleep & the Microbiome

    Matt explores a revolutionary shift in sleep science, identifying the gut microbiome as a secondary control center for rest. He elucidates the bidirectional gut-brain axis, where the Vagus nerve connects trillions of microorganisms to the brainstem, and details how bacterial metabolites, specifically the short-chain fatty acid butyrate, trigger critical BDNF-TrkB signaling to orchestrate deep NREM sleep. Using Parkinson’s disease as a model, he demonstrates how gut dysbiosis undermines sleep architecture and ramps up neuroinflammation, proving our intestinal health is inextricably linked to nightly stability. Matt discusses how dietary choices and circadian regularity influence this microbial ecosystem, highlighting prebiotic fibers like beta-glucan, which provide the essential fuel for bacteria to produce sleep-promoting compounds. He also reviews probiotics' ability to modulate neurochemistry - reducing cortisol and increasing GABA - to facilitate a seamless transition into sleep. Ultimately, Matt argues that sleep is a collaborative effort between neurons and microbes, suggesting that precision interventions tailored to our microbial signatures are the future of optimal health. Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way. Podcast partner, David, is a revolutionary new protein bar developed with Dr. Peter Attia. It boasts an unbeatable ratio: 28g of protein and 0g of sugar in just 150 calories. Incredibly satiating with six amazing flavors, it’s perfect for muscle health. Visit davidprotein.com/mattwalker and buy 4 cartons to get a 5th FREE! Another sponsor this week, LMNT, offers a science-based electrolyte drink with no sugar or artificial ingredients. Try their new limited-time Lemonade Salt flavor, available May 20th! Get eight free sample packs with any order at drinklmnt.com/mattwalker. Stock up on this flavor while it lasts! In a supplement industry where trust is critical, Matt uses podcast supporter Puori. Their protein powders are free from hormones, GMOs, and pesticides, with every single batch third-party tested for over 200 contaminants. For protein you can trust, save 20% at puori.com/mattwalker. As always, if you have thoughts or feedback you’d like to share, please reach out to Matt: Matt: Instagram @drmattwalker, X @sleepdiplomat,  YouTube https://www.youtube.com/@sleepdiplomatmattwalker9299

    29 min
  2. #122 - Exercise vs. Insomnia

    JAN 26

    #122 - Exercise vs. Insomnia

    Examining the $107B burden of insomnia and its link to a 45% increase in cardiovascular risk, Matt dissects a landmark study of 1,348 participants proving that movement is a potent clinical tool. He also explains how yoga adds nearly two hours of sleep by boosting GABAergic activity, while Tai Chi provides sustained benefits for up to two years. Our host details how exercise facilitates the core temperature drop necessary for consciousness to power down. Matt discusses how movement increases brain-derived neurotrophic factor (BDNF) and turns down the volume on systemic inflammation. In the end, Matt reveals that intentional activity recalibrates the nervous system to help you obtain the best quantity and quality of sleep. Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way. Clean biological living requires precision. Podcast partner Caraway’s non-toxic ceramic cookware eliminates deleterious "forever chemicals" for a seamless, slide-off-the-pan cooking experience. Save $190 on sets plus 10% off at Carawayhome.com/mattwalker.  Caraway. Non-Toxic kitchenware made modern. Another of today’s partners is Pique. Their circadian hydration system features a morning BT Fountain for skin and cellular health, plus an evening RE Fountain with triple magnesium for recovery. No sugar or fillers. Get 20% off + a free gift at piquelife.com/mattwalker to start your daily hydration ritual. As always, if you have thoughts or feedback you’d like to share, please reach out to Matt or Eti: Matt: Instagram @drmattwalker, X @sleepdiplomat,  YouTube: https://www.youtube.com/@sleepdiplomat

    30 min
  3. #121 - A Practical Guide To Insomnia

    JAN 19

    #121 - A Practical Guide To Insomnia

    Matt delves into insomnia, defining it as a persistent struggle to sleep despite having the opportunity. He presents "Cognitive Behavioral Therapy for Insomnia" (CBTI) as the scientifically validated gold standard, and details the five pillars: stimulus control to rebuild the bed-sleep association, time-in-bed restriction to boost efficiency, sleep hygiene, cognitive restructuring, and relaxation. These strategies retrain the brain to treat the bed as a sanctuary, deactivating the psychological triggers of wakefulness. The episode also addresses the physiological impacts of caffeine, alcohol, and nighttime rumination. Walker contrasts traditional "Z-drugs," which may hinder glymphatic housekeeping, with newer "DORAs" that target the orexin system like a dimmer switch. While discussing tools like Trazodone, he emphasizes that CBTI’s aim is to restore the body’s innate sleep signals. These evidence-based interventions offer a lasting payoff by aligning behavior with our deep biological needs. Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way. Clean biological living requires precision. Podcast partner Caraway’s non-toxic ceramic cookware eliminates deleterious "forever chemicals" for a seamless, slide-off-the-pan cooking experience. Save $190 on sets plus 10% off at Carawayhome.com/mattwalker.  Caraway. Non-Toxic kitchenware made modern. In a supplement industry where trust is critical, Matt uses podcast supporter Puori. Their protein powders are free from hormones, GMOs, and pesticides, with every single batch third-party tested for over 200 contaminants. For protein you can trust, save 20% at puori.com/mattwalker. As always, if you have thoughts or feedback you’d like to share, please reach out to Matt: Matt: Instagram @drmattwalker, X @sleepdiplomat,  YouTube: https://www.youtube.com/channel/UCA3FB1fOtY4Vd8yqLaUvolg

    24 min
  4. Ask Me Anything Part 24: Tinnitus, SAD, Sleep Divorce, and Vaccines

    JAN 12

    Ask Me Anything Part 24: Tinnitus, SAD, Sleep Divorce, and Vaccines

    Matt and Dr. Eti Ben Simon return with another AMA episode where they answer such listener questions as how sleep loss amplifies tinnitus and how Seasonal Affective Disorder impacts circadian rhythm. They also reveal that sleep restriction slashes vaccine-induced antibody production by 50%, and highlight deep NREM sleep as the vital soil for immunological memory. The hosts go on to analyze somniloquy, address long COVID’s inflammatory sleep fragmentation, and critique the fading efficacy of CBD/CBN. They also blueprint an optimal bedroom, and ultimately, emphasize that consistent regularity remains the primary architect of biological restoration. Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way. Another sponsor this week, LMNT, offers a science-based electrolyte drink with no sugar or artificial ingredients. Try their Lemonade Salt flavor, available May 20th! Get eight free sample packs with any order at drinklmnt.com/mattwalker. Another partner, AG1, is one that Matt relies upon for his foundational nutrition. Their new science-backed Next Gen formula features upgraded probiotics, vitamins, and minerals. Start your subscription today to get a FREE bottle of Vitamin D3+K2 and 5 free travel packs with your first order at drinkag1.com/mattwalker. As always, if you have thoughts or feedback you’d like to share, please reach out to Matt: Matt: Instagram @drmattwalker, X @sleepdiplomat,  YouTube: https://www.youtube.com/channel/UCA3FB1fOtY4Vd8yqLaUvolg Eti: X @etoosh,  LinkedIn https://www.linkedin.com/in/eti-ben-simon-b4578013/, Website https://www.sleepingeti.com/, Instagram https://www.instagram.com/etoosh/, or email at etoosh@gmail.com

    50 min
  5. #120 - How Sleep Deprivation Hijacks Your Genetic Code

    JAN 5

    #120 - How Sleep Deprivation Hijacks Your Genetic Code

    Putting sleep deprivation under the microscope yet again, Matt explores our "genetic workforce" of 20,000 genes operating on a precise 24-hour cycle. He details 2013 research showing that just one week of six-hour nights alters 711 genes - three percent of the human genome. This shift disrupts the circadian clock’s coordination, moving the body away from essential repair toward cellular stress and inflammatory markers. Matt also examines the tissue-specific damage of sleep loss, explaining how deprivation triggers muscle breakdown while fat tissue hoards calories. From stalled lung genes to a hippocampus "closed for business", he maps the molecular discord of exhaustion. Citing recent data on alternative splicing, Matt confirms sleep is a biological necessity and Mother Nature’s best effort yet at "contra-death." Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way. Podcast partner, David, is a revolutionary new protein bar developed with Dr. Peter Attia. It boasts an unbeatable ratio: 28g of protein and 0g of sugar in just 150 calories. Incredibly satiating with six amazing flavors, it’s perfect for muscle health. Visit davidprotein.com/mattwalker and buy 4 cartons to get a 5th FREE! Another sponsor this week, LMNT, offers a science-based electrolyte drink with no sugar or artificial ingredients. Try their new limited-time Lemonade Salt flavor, available May 20th! Get eight free sample packs with any order at drinklmnt.com/mattwalker. Stock up on this flavor while it lasts! In a supplement industry where trust is critical, Matt uses podcast supporter Puori. Their protein powders are free from hormones, GMOs, and pesticides, with every single batch third-party tested for over 200 contaminants. For protein you can trust, save 20% at puori.com/mattwalker. As always, if you have thoughts or feedback you’d like to share, please reach out to Matt: Matt: Instagram @drmattwalker, X @sleepdiplomat,  YouTube https://www.youtube.com/@sleepdiplomatmattwalker9299

    20 min
  6. The Midnight Bookshop: A Sleep Story Read by Matt Walker

    12/29/2025

    The Midnight Bookshop: A Sleep Story Read by Matt Walker

    Join Matt to leave the day’s rush behind. After a brief breathing exercise to settle the mind and body, you will find yourself on a quiet street in a British village. Matt leads you across a small stone bridge to a cozy bookshop nestled between two old brick buildings. This sanctuary is filled with the faint scent of aged paper and polished wood, providing a peaceful haven where time slows down and the stresses of the day are left behind. Once you are inside the shop, you can wander through the quiet aisles and run your fingers along the spines of books that have waited years to be opened. You'll eventually settle into a plush armchair by a window, wrapped in a soft woolen blanket while looking out at the gently rippling water of a canal. There's no urgency here and no need to worry about the stories within the pages. Simply allow the tranquility of "The Midnight Bookshop" to envelop you as you release all tension and drift into a deep, restorative sleep. Craving more energy, better metabolism, and immunity? Discover Pique's Nandaka, a ceremonial cacao superfood blend for calm, sustained energy without the crash. Thanks to this wonderful podcast partner, you can now get 20% off for life at pique.com/mattwalker using code MattWalker. As always, if you have thoughts or feedback you’d like to share, please reach out to Matt or Eti: Matt: Instagram @drmattwalker, X @sleepdiplomat,  YouTube https://www.youtube.com/@sleepdiplomatmattwalker9299

    25 min
  7. #119 - Your Brain On GLP-1s

    12/22/2025

    #119 - Your Brain On GLP-1s

    Exploring GLP-1 agonists in a new light, Matt examines a review that positions these metabolic hormones as potential brain defenders. He details their surprising presence in memory centers and their capacity to combat the "biological rust" of oxidative stress and neuroinflammation. Matt critically evaluates the gap between robust animal models and the unwritten chapter of human trials, while highlighting the vital link between metabolic health and sleep. He argues that biology is not siloed; supporting the body’s metabolic "power grid" through sleep provides the integrated care the brain needs to withstand complex insults. Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way. In a supplement industry where trust is critical, Matt uses podcast supporter Puori. Their protein powders are free from hormones, GMOs, and pesticides, with every single batch third-party tested for over 200 contaminants. For protein you can trust, save 20% at puori.com/mattwalker. Another sponsor is UPLIFT Desk whose V3 Standing Desk helps boost circulation and concentration with a sturdy, customizable design that gets you moving while you work. Visit upliftdesk.com/walker and use code WALKER for 4 free accessories and a 15-year warranty. As always, if you have thoughts or feedback you’d like to share, please reach out to Matt: Matt: Instagram @drmattwalker, X @sleepdiplomat,  YouTube: https://www.youtube.com/channel/UCA3FB1fOtY4Vd8yqLaUvolg

    20 min
  8. #118 - A Sleep Medication to Lower the Risk of Alzheimer's

    12/15/2025

    #118 - A Sleep Medication to Lower the Risk of Alzheimer's

    Matt examines the critical link between sleep quality and Alzheimer’s pathology. He details the brain's "night shift" - the glymphatic system - which actively flushes out toxins like amyloid beta during deep sleep. Listeners learn how even a single night of deprivation can spike harmful tau levels by 50%, effectively accelerating brain aging. The discussion pivots to dual orexin receptor antagonists (DORAs), a drug class that quiets wakefulness rather than forcing sedation. Matt highlights research from Dr. Brendan Lucey and Dr. David Holtzman showing these agents may lower toxic proteins and preserve the hippocampus. Despite this therapeutic promise, he emphasizes that natural sleep remains the ultimate gold standard for neuroprotection. Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way. One of this week's sponsors, LMNT, offers a science-based electrolyte drink with no sugar or artificial ingredients. Try their new limited-time Lemonade Salt flavor, available May 20th! Get eight free sample packs with any order at drinklmnt.com/mattwalker. Stock up on this summer flavor while it lasts! Another sponsor, Shopify, made launching Matt's merchandise incredibly smooth with its integrated sales system. Shopify simplifies everything from online stores to in-person sales. Start your exclusive trial and see for yourself at shopify.com/mattwalker. Craving more energy, better metabolism, and immunity? Discover Pique's Nandaka, a ceremonial cacao superfood blend for calm, sustained energy without the crash. Thanks to this wonderful podcast partner, you can now get 20% off for life at piquelife.com/mattwalker using code MattWalker. As always, if you have thoughts or feedback you’d like to share, please reach out to Matt: Matt: Instagram @drmattwalker, X @sleepdiplomat,  YouTube: https://www.youtube.com/channel/UCA3FB1fOtY4Vd8yqLaUvolg

    19 min
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4.9
out of 5
892 Ratings

About

The Matt Walker Podcast is all about sleep, the brain, and the body. Matt is a Professor of Neuroscience at the University of California, Berkeley. He is the author of the book, Why We Sleep and has given a few TED talks. Matt is an awkward British nerd who adores science and the communication of science to the public. 

Information

  • Creator
    Dr. Matt Walker
  • Years Active
    2021 - 2026
  • Episodes
    157
  • Rating
    Clean
  • Copyright
    © 2026 The Matt Walker Podcast
  • Show Website
    The Matt Walker Podcast

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