Hope Lies in Dreams

Nature Biotechnology
  • 5.0 (30)
  • ENTREPRENEURSHIP
  • WEEKLY SERIES

Stan Crooke rose from poverty to found a company that pioneered antisense drugs. After decades of struggle and years of public doubt, the company created a treatment that has saved thousands of children from the brutal disease spinal muscular atrophy. Hosted on Acast. See acast.com/privacy for more information.

Episodes

  1. Chapter 1: an ugly place

    EPISODE 1

    Chapter 1: an ugly place

    Stan Crooke is born ⬩ A tenuous existence ⬩ Life with his mother ⬩ The Tech Corner ⬩ Arsenal Tech High School ⬩ Nancy ⬩ Hoodlum ways ⬩ Off to Purdue Hosted on Acast. See acast.com/privacy for more information.

    32 min
  2. Chapter 2: a winding path

    EPISODE 2

    Chapter 2: a winding path

    Quits Purdue ⬩ Pharmacy school ⬩ Off to Baylor ⬩ Harris Busch ⬩ Bristol Labs ⬩ SmithKline ⬩ The death of Nancy Crooke ⬩ The end of SmithKline Hosted on Acast. See acast.com/privacy for more information.

    47 min
  3. Chapter 3: San Diego restart

    EPISODE 3

    Chapter 3: San Diego restart

    Rosanne ⬩ An investor emerges ⬩ Founding Isis ⬩ The old garage ⬩ A proper space ⬩ A growing antisense scene ⬩ Starting a pipeline ⬩ Isis goes public Hosted on Acast. See acast.com/privacy for more information.

    48 min
  4. Chapter 4: three kinds of failure

    EPISODE 4

    Chapter 4: three kinds of failure

    Stumbling out of the gate ⬩ Launch of Vitravene ⬩ Questions about antisense ⬩ The field thins ⬩ Clinical failure ⬩ The darkest days Hosted on Acast. See acast.com/privacy for more information.

    44 min
  5. Chapter 5: valley of antisense

    EPISODE 5

    Chapter 5: valley of antisense

    The genomics bubble ⬩ Affinitak fails ⬩ Lynne saves the company ⬩ Hybridon pivots ⬩ New chemistries ⬩ Regulus formed ⬩ Isis as cult Hosted on Acast. See acast.com/privacy for more information.

    42 min
  6. Chapter 6: lone voice in the wilderness

    EPISODE 6

    Chapter 6: lone voice in the wilderness

    Rosanne saves the company ⬩ Ibis is sold ⬩ An approval ⬩ Souring on Genzyme ⬩ The end of Genta ⬩ The discovery of the SMA gene Hosted on Acast. See acast.com/privacy for more information.

    43 min
  7. Chapter 7: the SMA gang

    EPISODE 7

    Chapter 7: the SMA gang

    The Larsons ⬩ The skunkworks project ⬩ The most unmet need ⬩ Instant synergy ⬩ Another first for antisense ⬩ The clinic, again ⬩ The achievements of Kathie Bishop Hosted on Acast. See acast.com/privacy for more information.

    40 min
  8. Chapter 8: part of something big

    EPISODE 8

    Chapter 8: part of something big

    Ethics lessons ⬩ Biogen re-ups ⬩ The ultimate sacrifice ⬩ FDA as partner ⬩ Emma’s phase 3 ⬩ Doug Kerr’s bright idea ⬩ Isis to Ionis ⬩ Spinraza approval Hosted on Acast. See acast.com/privacy for more information.

    42 min
  9. Chapter 9: the last of his kind

    EPISODE 9

    Chapter 9: the last of his kind

    Award season ⬩ NURTURE, and Gabriel ⬩ Kyle Derkowski’s new future ⬩ The drugs of SMA ⬩ Piece of magic ⬩ Frank’s Super Bowl Hosted on Acast. See acast.com/privacy for more information.

    39 min
  10. Chapter 10: Dr. Crooke

    EPISODE 10

    Chapter 10: Dr. Crooke

    The biggest deal ⬩ In the black ⬩ End of an era ⬩ n of 1 ⬩ Small places ⬩ A life of control ⬩ The doctor will see you now Hosted on Acast. See acast.com/privacy for more information.

    51 min
  11. Hope Lies in Dreams trailer

    09/01/2021

    Hope Lies in Dreams trailer

    Trailer for upcoming 10-part series, Hope Lies in Dreams. Hosted on Acast. See acast.com/privacy for more information.

    2 min

Trailer

5
out of 5
30 Ratings

About

Stan Crooke rose from poverty to found a company that pioneered antisense drugs. After decades of struggle and years of public doubt, the company created a treatment that has saved thousands of children from the brutal disease spinal muscular atrophy. Hosted on Acast. See acast.com/privacy for more information.

Information