GlycanHub Podcast

GlycanAge
  • 5.0 (1)
  • MEDICINE
  • UPDATED BIMONTHLY

Interested in learning more about glycobiology? You’ve come to the right place. Welcome to GlycanHub, the first podcast to explore health, disease and longevity through the lens of glycobiology.Glycans have been described as the third alphabet of biology alongside nucleic acid and proteins. Using this alphabet, our cells are able to communicate and interact with each other in health and disease. Meaning that once we truly understand the glycan language, we will gain a better understanding of ourselves.Every episode features an interview with a scientist or expert giving us a glimpse into what glycobiology research has uncovered about the human body to date and the potential applications of these findings in the medicine of tomorrow.Make sure to subscribe so you don’t miss out on new GlycanHub episodes.

  1. 08/30/2023

    The Role of Glycans in the Medicine of Tomorrow: Insights from 11 Leading Scientists

    Is the future of medicine sweetened by the study of glycans? As GlycanHub rounds off its season, we've brought back the insights of 11 eminent scientists spanning from neuroscience to nanotechnology. Each guest delves into their vision of how glycans could shape medical advancements in their respective fields. Join Rina, our host, for a grand finale that paints a holistic picture of the promising horizon glycobiology is steering us towards. Answers to the question: What role do you think glycans will play in the future of medicine relevant to your area of study?  Salome Pinho [01:21]  Olga Zaytseva [03:04]     Peter Joshi [03:51]    Hudson Freeze [05:11]   Samia Mora [06:11]      Anna Halama and Karsten Suhre [08:09]      Ronald Schnaar [12:03]      Gordon Lauc [14:49]    Louise Newson [17:35]      Vered Padler-Karavani [18:47]View the Show Notes Page for this Episode  Engage with us on social media: Instagram LinkedIn Facebook Twitter  Please be advised that this show is for information only and should not be considered as a replacement or equal to medical advice.

    22 min

  2. 08/09/2023

    Should You Stop Eating Red Meat? Glycans, Inflammation, and Cancer with Prof. Vered Padler-Karavani

    Could your steak dinner be tricking your immune system? In this episode we shed light on the connection between specific foods and colorectal cancer. Explore xeno-autoantigens, grasp the nuances of immunotherapy, and question the reliability of animal-derived heart valves. Vered Padler-Karavani is the principal investigator in the Department of Cell Research and Immunology at Tel Aviv University. Her research combines glycobiology, immunology, bio-nanotechnology, cancer research and xenotransplantation. Tune in to uncover the hidden connections between glycans, our diet, and the potential health repercussions. We discuss:  Why study Glycobiology [01:35]Xeno-autoantigens & Xenosialitis [03:16]Where Does Neu5Gc Accumulate? [06:33]Red Meat & Colorectal Cancer [10:28]Tumor-associated Carbohydrate Antigens [11:54]Immunotherapy: Potential & Limitations [13:22]Animal-derived Heart Valves: Safety & Efficacy [20:02]Navigating Safety Regulations for Biologic Therapies [31:27] Neu5Gc in Foods: The Gcemic Index [34:14]Does Prof. Vered Padler-Karavani Still Eat Red Meat? [37:23]Neu5Gc as Biomarkers [38:08] Follow Vered on social media: LinkedIn Twitter  View the Show Notes Page for this Episode Engage with us on social media: Instagram LinkedIn Facebook Twitter  Please be advised that this show is for information only and should not be considered as a replacement or equal to medical advice.

    41 min

  3. 07/19/2023

    Rebranding Menopause: Glycans, Hormones and Inflammation with Dr. Louise Newson

    Does menopause hold implications beyond reproductive health? This episode reveals that the shift in hormonal balance affects inflammatory patterns, mediated by complex carbohydrates called glycans. We unravel the overlooked role of perimenopause in chronic disease onset and debunk common myths. Exploring hormone replacement therapy, we discuss its wider health impact, beyond mere symptom management. Louise Newson, a distinguished GP and Menopause Specialist, is the founder of the Balance App, The Menopause Charity, and the Newson Health Menopause Society. An active member of the UK Government Menopause Taskforce, she continually works to elevate menopause understanding and care. Listen in as we discuss the potential of glycans as biomarkers for menopause, surpassing existing diagnostic tests in their predictive capacity.   We discuss:  Menopause Specialisation: Why Choose It? [02:11]Menopause: Myths vs. Facts [04:12]What Exactly Is Menopause? [05:33]Testosterone's Role in Female Health [08:04]Sex Hormones and Immune Regulation [09:18]Menopause and the Rise of Chronic Illness [12:36]Viewing Menopause as a Hormone Deficiency [15:22]Menopause and Metabolic Syndrome [16:57]Menopause and the Gut Microbiome [18:20]Oestrogen's Role in the Cardiovascular System [24:03]Is Perimenopause Contributing to Chronic Disease? [26:59]Limitations of Current Menopause Tests [30:53]Introducing the Balance App [32:00]Glycan-Based Menopause Tests [34:05]Addressing the Lack of Menopause Education in Medicine [35:36]Common Questions About Hormone Replacement Therapy [38:50]A Look at the Newson Clinic [41:26]Follow Louise on social media: Instagram Twitter LinkedIn View the Show Notes Page for this Episode  Engage with us on social media: Instagram LinkedIn Facebook Twitter  Please be advised that this show is for information only and should not be considered as a replacement or equal to medical advice.

    45 min

  4. 07/05/2023

    Navigating the COVID-19 Pandemic: Glycans, Biological Age and Inflammation with Prof. Gordan Lauc

    In an era defined by COVID-19, understanding the intricacies of our immune response and the profound role our lifestyle choices play in shaping our resilience or vulnerability to future pandemics is of great importance. In this episode, we unravel the influence of glycans, complex carbohydrates instrumental in immune response regulation, on our understanding of COVID-19 susceptibility and severity. We explore the role of lifestyle in disease prevention, particularly focusing on diet and obesity. Gordan Lauc is a Professor of Biochemistry and Molecular Biology at the University of Zagreb Faculty of Pharmacy and Biochemistry and founder and CEO of Genos Ltd. Listen in as he shares valuable insights into pandemic regulations, the spread of misinformation, and vital lessons for the future.    We Discuss: The Role of Glycans in Promoting and Suppressing Inflammation [03:11]Biological Age as a Predictor of COVID-19 Severity [09:48]Behind the Scenes of Study Design: Stratifying COVID-19 Patients [12:17]The Role of Proinflammatory Glycans in COVID-19 Severity [16:24]Impact of Lifestyle Choices on Disease Risk [22:22]Glycan Biomarkers in Disease Prediction [28:58]Biobanking: A Vital Tool in Pandemic Preparedness [41:39]COVID-19 Regulations and Responses: A Croatian Perspective [43:48]Vaccine Mandates and Universal Masking: Is It Too Much? [50:13]Lessons for Future Pandemics [53:51]Follow Gordan on Social Media: LinkedIn Twitter Facebook   View the Show Notes Page for This Episode  Engage with us on social media: Instagram LinkedIn Facebook Twitter  Please be advised that this show is for information only and should not be considered as a replacement or equal to medical advice

    59 min

  5. 06/14/2023

    Glycans and Neurodegenerative Diseases: A New Perspective on Alzheimer's with Prof. Ronald Schnaar

    The longer lifespans we enjoy come shadowed by age-related diseases, notably Alzheimer's. This episode shines a light on the often-overlooked glycans, complex carbohydrates that play a pivotal role in healthy brain function. Our understanding of Alzheimer's causation has evolved, moving beyond just 'trash accumulation' to include problems with 'trash clearance.' Discover the potential of glycans in healing spinal cord injuries, the hurdles in identifying early biomarkers and delivering drugs to the brain. We delve into the essential role of gangliosides, a unique class of glycolipids, and separate science from media hype around Alzheimer's prevention. Ronald Schnaar is the Professor and Interim Director of the Department of Pharmacology and Molecular Sciences and a Professor of Neuroscience at Johns Hopkins University School of Medicine. Listen in as he unpacks his extensive research in neuro glycobiology and the practical hurdles in the path of Alzheimer's research and prevention. We Discuss: Why Study Glycobiology? What Drew Ronald to Glycobiology [02:41]Understanding the Crucial Role of Glycans in Cell-to-Cell Interaction [05:18]Study on Gangliosides in Context of Nerve Cell Insulation [06:29]Congenital Disorders of Ganglioside Biosynthesis: Symptoms and Treatment Options [12:03]The Potential Role of Glycans in Repairing Spinal Cord Injuries [18:17]The Evolution in Our Understanding of Alzheimer's Disease [20:45]Challenges of Studying Alzheimer’s Disease [27:23]International Research Collaboration for Study of Alzheimer’s Disease [31:09]Dual Causes of Alzheimer's: A New Perspective [32:37]Are Mice Good Models for Neurodegenerative Diseases? [34:42]The Challenge of Translating Research into Clinical Application [38:40]Challenges of Drug Delivery to the Brain [40:45]The Future of Glycan Biomarkers of Alzheimer's Disease [42:23]Alzheimer’s Prevention: Sifting Fact from Fiction in Media Coverage [45:58]Ronald’s Future Research Plans and Focus [51:27]Ronald’s Final Message to Our Listeners [54:44]Follow Ronald on Social Media: LinkedIn View the Show Notes Page for this Episode Engage with us on social media:  Instagram  LinkedIn Facebook Twitter  Please be advised that this show is for information only and should not be considered as a replacement or equal to medical advice.

    58 min

  6. 05/31/2023

    Molecular Human and the Multi-Omics Revolution: with Dr. Karsten Suhre and Dr. Anna Halama

    Are you ready to journey through the intricate layers of Omics, a rapidly developing field that's reshaping our understanding of biological systems? From genomics to proteomics and metabolomics, the multi-omics approach intertwines these layers, offering a rich, multidimensional view of human biology. Today's conversation unravels the fascinating complexity within our bodies, spotlighting the current advancements in multi-omics research and its transformative potential in disease diagnosis and treatment. You'll also discover why glycans, despite often being overlooked in multi-omics studies, are in fact promising biomarkers due to their role as intermediate phenotypes. In this conversation, we are joined by two scientists from Weill Cornell Medicine in Qatar. Karsten Suhre, the Professor of Physiology and Biophysics and the Director of Bioinformatics Core and Dr. Ania Halama, who is an Assistant Professor in Research of Physiology and Biophysics. Tune in, as we unravel the enigmas of this complex and transformative field of research. We Discuss: Anna and Karsten's Collaborative Journey [02:27]Metabolism and Metabolomics [04:40]Linking the Dots: The Interconnected Nature of Omics Layers [07:44]Glycomics: The Underrated Player in Multi-Omics Research [09:26]Qatar Metabolomics Study on Diabetes and the Molecular Human [11:52]Unveiling a New Platform: An Introduction to the Comics Server [23:41]Intermediate Phenotypes [28:04]The advantages of a multi-omic approach to research [33:12]Overcoming the Hurdles: Current Challenges in the Multi-Omics Landscape [36:18]How Much Can Genomic Sequencing Inform Prevention and Diagnosis? [45:17]From Lab to Clinic: Karsten and Anna's Pursuit of Translating Research into Practice [50:21] Follow Anna on Social Media: LinkedIn Twitter   Follow Karsten on Social Media: LinkedIn Twitter View the Show Notes Page for This Episode   Engage with us on social media:  Instagram LinkedIn Facebook Twitter  Please be advised that this show is for information only and should not be considered as a replacement or equal to medical advice.

    56 min

  7. 05/17/2023

    Glycans and Cardiovascular Disease: Understanding Modifiable Risk Factors and the Power of Lifestyle Choices with Prof. Samia Mora

    It is a widely known fact that cardiovascular diseases are the leading cause of mortality and morbidity in both men and women, which puts an urgency on gaining a better understanding of them. One interesting lens to look at CVDs is through glycans. However, in order to do so, we need to uncover the answer to which came first, the chicken or the egg? Do glycans change in response to the disease? Or are they actively involved in disease development?  To figure this out, we welcomed Prof. Samia Mora to the podcast. Samia is a Professor of Medicine at Harvard Medical School and Director of the Centre for Lipid Metabolomics at the Brigham and Women’s Hospital in Boston, Massachusetts. Her research focuses on risk factors and prevention of cardiovascular diseases (CVDs). Listen in as she introduces us to a number of modifiable risk factors and the cumulative effect both positive and negative behaviours have on future disease risk.    We Discuss: Introduction to Cardiovascular Diseases [01:15]The Key Role of Inflammation in Cardiovascular Disease Development [02:41]The 'Good vs Bad Cholesterol' Perspective: Is It Outdated? [04:05]Glycans: Their Role in Predicting Cardiovascular Disease Risk [08:09]A Look Back: What We Can Learn from the GlycA Biomarker from the 1980s [10:41]Unravelling the Impact of Obesity and Weight Loss on Cardiovascular Disease [15:03]The Glycan Dilemma: Do They Change in Response to Disease or Are They Partake in Disease Development? [21:47]Risk Factors for Cardiovascular Disease: Modifiable vs Non-Modifiable [25:55]Lifestyle Changes: A Proactive Approach to Prevention [31:38]The Effect of Weight Loss on Inflammation Levels [40:14]How Often Should Blood Lipid Levels Be Measured? [43:17]Glycans and Sex-Specific Cardiovascular Risk [48:18]Pregnancy and Menopause as Risk Factors for Cardiovascular Disease [50:02]Glycans: Effective Biomarkers of Cardiovascular Disease? [58:44]  Follow Samia on social media Twitter View the Show Notes Page for This Episode Purchase a GlycanAge Test  Engage with us on social media: Instagram LinkedIn Facebook Twitter  Please be advised that this show is for information only and should not be considered as a replacement or equal to medical advice.

    1h 7m

  8. 05/03/2023

    The Past, Present and Future of Congenital Disorders of Glycosylation with Prof. Hudson Freeze

    Glycosylation, a biological process vital to life, is likely something you’ve never heard of before. It involves the addition of sugar molecules, known as glycans, to proteins and lipids which enable a number of crucial physiological functions, from immune regulation to cell-to-cell communication. This episode explores what happens when genetic mutations disrupt the glycosylation pathway as well as the detective work and collaboration required to diagnose and treat the resulting conditions. Hudson Freeze is the Director of the Sanford Children’s Health Research Centre and the Human Genetics Programme at Sanford Burnham Prebys Medical Discovery Institute, his research focuses on Congenital Disorders of Glycosylation, or CDG for short. Listen in as he reflects on the adventurous road to discovery of these rare conditions, the unlikely therapeutic options, the knowledge gap within the medical and scientific communities, and how a single discovery at Yellowstone National Park changed the course of history. We Discuss: Hudson’s Background [02:11]Glycosylation vs. Glycation [03:37]Congenital Disorders of Glycosylation (CDG) [06:10]The Accelerating Pace of CDG Research [15:50]Hudson’s Groundbreaking Discovery [21:02]Utilising Animal Models for Glycosylation Research [25:36]Including Families and Patients in CDG Research [34:51]The Future of Diagnostic Options [40:55] The Role of Dietary Supplementation in CDG Treatment [45:37]Overcoming Funding Challenges [57:11]View the Show Notes Page for This Episode Purchase a GlycanAge Test Engage with us on social media: Instagram LinkedIn Facebook Twitter  Please be advised that this show is for information only and should not be considered as a replacement or equal to medical advice.

    1h 6m
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About

Interested in learning more about glycobiology? You’ve come to the right place. Welcome to GlycanHub, the first podcast to explore health, disease and longevity through the lens of glycobiology.Glycans have been described as the third alphabet of biology alongside nucleic acid and proteins. Using this alphabet, our cells are able to communicate and interact with each other in health and disease. Meaning that once we truly understand the glycan language, we will gain a better understanding of ourselves.Every episode features an interview with a scientist or expert giving us a glimpse into what glycobiology research has uncovered about the human body to date and the potential applications of these findings in the medicine of tomorrow.Make sure to subscribe so you don’t miss out on new GlycanHub episodes.

Information

  • Creator
    GlycanAge
  • Years Active
    2022 - 2023
  • Episodes
    17
  • Rating
    Clean
  • Copyright
    © 2023 GlycanHub Podcast
  • Show Website
    GlycanHub Podcast