The Cancer SIGNAL

GRAIL
  • 4.7 (26)
  • HEALTH & FITNESS

Host Susanna Quinn explores topics relating to early cancer detection testing, including multi-cancer early detection testing, cancer genomics and risk, barriers to cancer screening, and much more.

  1. 12/03/2025

    31 – When a Firefighter's Cancer Is Detected Early

    Kevin McFarland, a lieutenant with his local fire department, and Dr. Robert Merritt, a thoracic surgeon who helped diagnose and treat Kevin, share how the Galleri multi-cancer early detection (MCED) test unexpectedly revealed that Kevin had a signal for esophageal cancer—despite having no symptoms. The test, offered by the fire department where Kevin works, led to further medical exams that identified his specific type of cancer. Kevin reflects on the emotional, mental, and physical impact of his diagnosis and treatment, the importance of early detection, and how the experience renewed his appreciation for his health and family and gave him "a new lease on life." Dr. Merritt credits the Galleri test and early detection for Kevin's positive prognosis and recovery. Their story highlights the critical role of accessibility, awareness, and advocacy in cancer detection.   Watch the full episode on YouTube: https://www.youtube.com/watch?v=BVOJXdWUkCo  Help shape future episodes by taking our survey: https://bit.ly/3sQkbrN  Transcripts: https://grail.com/podcast/  Sign up for GRAIL's newsletter: https://grail.com/newsletter-signup/    The Galleri test does not detect a signal for all cancers. Not all cancers can be detected in the blood. False positive and false negative results do occur. Galleri is a screening test and does not diagnose cancer. Diagnostic testing is needed to confirm cancer. The Galleri test should be used in addition to healthcare provider recommended screening tests.    See Important Safety Information: http://bit.ly/33m8pFa    The overall sensitivity in study participants with esophageal cancer was 85.0% (12.5% for stage I, 64.7% stage II, 94.1% stage III, 100% stage IV).   Based on a clinical study of people ages 50 to 79, around 1% are expected to receive a Cancer Signal Detected result. After diagnostic evaluation, around 40% of these people are expected to have a confirmed cancer diagnosis.

    26 min

  2. 10/22/2025

    30 - PATHFINDER 2 study results from ESMO 2025 with principal investigator Nima Nabavizadeh, MD

    In this episode of The Cancer SIGNAL, Nima Nabavizadeh, MD, an associate professor of radiation medicine at Oregon Health & Science University (OHSU) and the chief medical officer at the Cancer Early Detection Advanced Research Center (CEDAR) at OHSU, joins host Susanna Quinn to share the results from the groundbreaking GRAIL PATHFINDER 2 clinical trial unveiled at the European Society for Medical Oncology (ESMO 2025) Congress. As the principal investigator for the trial, which examined the safety and performance of the Galleri multi-cancer early detection test, Dr. Nabavizadeh discusses why the findings are pivotal for patients and could potentially redefine early cancer detection.   Watch the full episode on YouTube: https://youtu.be/owhDC8vH1hw Help shape future episodes by taking our survey: https://bit.ly/3sQkbrN  Transcripts: https://grail.com/podcast/  Sign up for GRAIL's newsletter: https://grail.com/newsletter-signup/    The Galleri test does not detect a signal for all cancers. Not all cancers can be detected in the blood. False positive and false negative results do occur. Galleri is a screening test and does not diagnose cancer. Diagnostic testing is needed to confirm cancer. The Galleri test should be used in addition to healthcare provider recommended screening tests.    See Important Safety Information: http://bit.ly/33m8pFa    Based on a clinical study of people ages 50 to 79, around 1% are expected to receive a Cancer Signal Detected result. After diagnostic evaluation, around 40% of these people are expected to have a confirmed cancer diagnosis.

    19 min

  3. 09/24/2025

    29 – The Dallas Cowboys Are Detecting Cancer Early

    In this episode of The Cancer SIGNAL, Tad Carper, Senior VP of Communications for the Dallas Cowboys, shares how a multi-cancer early detection (MCED) screening unexpectedly revealed a cancer signal for head and neck cancer—despite experiencing no symptoms. The test, sponsored for the team's assistant coaches by quarterback Dak Prescott's foundation, Faith Fight Finish, was the first step toward Tad's stage two cancer diagnosis. Tad reflects on the emotional and mental impact of his diagnosis, the importance of early detection, and how the experience reshaped his values—deepening his appreciation for life, relationships, and the power of proactive health care. His story highlights the critical role of accessibility, awareness, and advocacy in cancer detection, and his commitment to "paying it forward" by helping others take early action in their own health journeys.    Watch the full episode on YouTube: https://www.youtube.com/watch?v=WuManHvHtS4  Help shape future episodes by taking our survey: https://bit.ly/3sQkbrN  Transcripts: https://grail.com/podcast/  Sign up for GRAIL's newsletter: https://grail.com/newsletter-signup/    The Galleri test does not detect a signal for all cancers. Not all cancers can be detected in the blood. False positive and false negative results do occur. The Galleri is a screening test and does not diagnose cancer. Diagnostic testing is needed to confirm cancer. The Galleri test should be used in addition to healthcare provider–recommended screening tests.    See Important Safety Information: http://bit.ly/33m8pFa    The overall sensitivity in study participants with head and neck cancer was 85.7% (63.2% for stage I, 82.4% stage II, 84.2% stage III, 96.0% stage IV).   Based on a clinical study of people ages 50 to 79, around 1% are expected to receive a Cancer Signal Detected result. After diagnostic evaluation, around 40% of these people are expected to have a confirmed cancer diagnosis.

    40 min

  4. 06/06/2025

    28 – Jack's Journey with Multi-Cancer Early Detection

    At a semiannual primary care visit, Jack's doctor mentioned multi-cancer early detection (MCED) testing. Though Jack wasn't experiencing symptoms, and has no family history of cancer, he decided to take the test. Two Cancer Signal Detected results from MCED screening tests taken six months apart helped his care team determine the necessary diagnostics that confirmed an early-stage cancer diagnosis. Listen to Jack's story to learn more about the impact early cancer detection had on his life.     Watch the full episode on YouTube: https://youtu.be/p8fFVshFWJk Help shape future episodes by taking our survey: https://bit.ly/3sQkbrN  Transcripts: https://grail.com/podcast/  Sign up for GRAIL's newsletter: https://grail.com/newsletter-signup/    The Galleri test does not detect a signal for all cancers. Not all cancers can be detected in the blood. False positive and false negative results do occur. The Galleri is a screening test and does not diagnose cancer. Diagnostic testing is needed to confirm cancer. The Galleri test should be used in addition to healthcare provider recommended screening tests.    See Important Safety Information: http://bit.ly/33m8pFa    Based on a clinical study of people ages 50 to 79, around 1% are expected to receive a Cancer Signal Detected result. After diagnostic evaluation, around 40% of these people are expected to have a confirmed cancer diagnosis.

    16 min

  5. 03/20/2025

    27 – Multi-Cancer Early Cancer Detection at the Doctor's Office

    Dr. Patrick McGill was instrumental in introducing Community Health Network to multi-cancer early detection (MCED) testing and integrating it into routine screenings offered to patients. Dr. McGill is Executive Vice President and Chief Transformation Officer at Community Health Network, and as a practicing primary care physician he believes strongly in the importance of catching cancer as early as possible to improve outcomes for patients. In this episode he shares how MCED has made an impact at Community Health Network.    Watch the full episode on YouTube: https://youtu.be/X9PyQeiO0HM  Help shape future episodes by taking our survey: https://bit.ly/3sQkbrN  Transcripts: https://grail.com/podcast/  Sign up for GRAIL's newsletter: https://grail.com/newsletter-signup/    The Galleri test does not detect a signal for all cancers. Not all cancers can be detected in the blood. False positive and false negative results do occur. Galleri is a screening test and does not diagnose cancer. Diagnostic testing is needed to confirm cancer. The Galleri test should be used in addition to healthcare provider recommended screening tests.    Rx only. See Important Safety Information: http://bit.ly/33m8pFa    Based on a clinical study of people ages 50 to 79, around 1% are expected to receive a Cancer Signal Detected result. After diagnostic evaluation, around 40% of these people are expected to have a confirmed cancer diagnosis.

    25 min

  6. 01/27/2025

    26 – The Role of Cancer Screening in Longevity

    How does cancer screening fit into one's longevity goals? Dr. Ummat, a preventative medicine physician dedicated to changing the approach to aging, shares insights on the role of preventative care in maintaining long-term health, why proactive screening matters, and how new technologies like multi-cancer early detection testing can change the way we screen for cancer. Watch the full episode on YouTube: https://youtu.be/D0Hi4NLC-qo Help shape future episodes by taking our survey: https://bit.ly/3sQkbrN  Transcripts: https://grail.com/podcast/  Sign up for GRAIL's newsletter: https://grail.com/newsletter-signup/  The Galleri test does not detect a signal for all cancers. Not all cancers can be detected in the blood. False positive and false negative results do occur. Galleri is a screening test and does not diagnose cancer. Diagnostic testing is needed to confirm cancer. The Galleri test should be used in addition to healthcare provider recommended screening tests.  See Important Safety Information: http://bit.ly/33m8pFa  Based on a clinical study of people ages 50 to 79, around 1% are expected to receive a Cancer Signal Detected result. After diagnostic evaluation, around 40% of these people are expected to have a confirmed cancer diagnosis.

    32 min

  7. 12/09/2024

    25 – Research Update on Multi-Cancer Early Detection with Dr. Eric Klein

    Dr. Eric Klein, Distinguished Scientist at GRAIL, provides a research update from GRAIL's 2024 findings on multi-cancer early detection (MCED) testing, presented at ASCO, ESMO, AACR and more. He explores insights from the first real-world evaluation of repeat multi-cancer early detection testing, data on how multi-cancer early detection (MCED) testing is helping cancer survivors by detecting recurrence and new cancers, and findings on using MCED to detect high grade, clinically significant prostate cancer over indolent cases. Plus, the economic and emotional impacts of cancer screening, and three insightful case studies.    Watch the full episode on YouTube: https://youtu.be/QU6s3P1B5Bo  Help shape future episodes by taking our survey: https://bit.ly/3sQkbrN  Transcripts: https://grail.com/podcast/  Sign up for GRAIL's newsletter: https://grail.com/newsletter-signup/    The Galleri test does not detect a signal for all cancers and not all cancers can be detected in the blood. False positive and false negative results do occur. Galleri is a screening test and does not diagnose cancer. Diagnostic testing is needed to confirm cancer. The Galleri test should be used in addition to healthcare provider recommended screening tests.    Rx only. See Important Safety Information: https://www.galleri.com/safety-information    Based on a clinical study of people ages 50 to 79, around 1% are expected to receive a Cancer Signal Detected result. After diagnostic evaluation, around 40% of these people are expected to have a confirmed cancer diagnosis.

    26 min

  8. 10/29/2024

    24 – Rich and Staci's Story with Multi-Cancer Early Detection

    At their doctor's recommendation, Rich and Staci each took a multi-cancer early detection test during a routine checkup. Despite having no symptoms, Rich received a Cancer Signal Detected result, while Staci, who had a strong family history of cancer, did not. Listen to their story and learn about the impact of early cancer detection. Watch the full episode on YouTube: https://youtu.be/NKY3lX9PGYs   View Rich and Staci's story: https://youtu.be/z7M_ebq4Tj4?si=-C9cGsmx7MFzcKzc  Help shape future episodes by taking our survey: https://bit.ly/3sQkbrN  Transcripts: https://grail.com/podcast/  Sign up for GRAIL's newsletter: https://grail.com/newsletter-signup/  The Galleri test does not detect a signal for all cancers. Not all cancers can be detected in the blood. False positive and false negative results do occur. Galleri is a screening test and does not diagnose cancer. Diagnostic testing is needed to confirm cancer. The Galleri test should be used in addition to healthcare provider recommended screening tests.  See Important Safety Information: http://bit.ly/33m8pFa  Based on a clinical study of people ages 50 to 79, around 1% are expected to receive a Cancer Signal Detected result. After diagnostic evaluation, around 40% of these people are expected to have a confirmed cancer diagnosis.

    16 min
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4.7
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26 Ratings

About

Host Susanna Quinn explores topics relating to early cancer detection testing, including multi-cancer early detection testing, cancer genomics and risk, barriers to cancer screening, and much more.

Information

  • Creator
    GRAIL
  • Years Active
    2022 - 2025
  • Episodes
    32
  • Rating
    Clean
  • Copyright
    © 2024
  • Show Website
    The Cancer SIGNAL