The Synthesis of Wellness

Chloe Porter
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  • ALTERNATIVE HEALTH
  • UPDATED DAILY
The Synthesis of Wellness

Your host and biohacker, Chloe Porter, has a background in engineering, innovation, and research. Her analytical background coupled with her journey in overcoming a brain tumor and defeating several chronic illnesses enables her to approach health and wellness in an innovative way, and now more than ever, she is ready to share her biohacking secrets and expose cutting-edge research.

  1. 5D AGO

    172. Hypochlorhydria & Small Intestinal Bacterial Overgrowth | Low Stomach Acid, Microbial Dysbiosis, & a Brief Conversation on the Oral Microbiome

    In this episode, we detail the cellular make-up of the gastric lining, highlighting hydrochloric acid (HCl) secretion and its role in digestion, micronutrient absorption, and microbial defense. We discuss potential pathophysiological consequences of hypochlorhydria, including impaired digestive signaling, bacterial overgrowth in the small intestine (SIBO), and more. Lastly, we detail upstream microbial control, focusing on the influence of the oral microbiome and oral dysbiosis. Topics: 1. Introduction - Highlighting the stomach and hypochlorhydria / low stomach acid, as well as microbial balance, dysbiosis, and overgrowth. - Discussion of intestinal microbiome and oral microbiome.   2. Gastric Anatomy and Mucosal Layers - The stomach: cardia, fundus, body, pylorus. - The gastric mucosa: epithelial lining, lamina propria, muscularis mucosae. - The epithelial layer: mucous cells, parietal cells, chief cells, enteroendocrine cells. - Beneath the mucosa: submucosa and muscular layers that contribute to gastric motility, mechanical digestion, and more.   3. Mucous Cells - The surface epithelium and gastric pits. - Secretion of thick, viscous mucus. - Protecting the epithelium. - The mucus traps bicarbonate ions: neutral microenvironment that protects against acid-induced damage.   4. Parietal Cells and Gastric Acid Secretion - Secretion of hydrochloric acid (HCl): denatures dietary proteins, sterilizes ingested food. - Parietal cells produce intrinsic factor: binds vitamin B12 to facilitate absorption in the ileum.   5. Chief Cells and Pepsinogen - Secretion of pepsinogen: activated by low pH into the proteolytic enzyme pepsin. - Pepsin and protein digestion. - Release of gastric lipase.   6. Hydrochloric Acid: Digestive and Protective Roles - Immune defense. - Pepsinogen activation. - Adequate gastric acidity essential for properly acidified chyme. - Priming release of bile and pancreatic enzymes.   7. The Small Intestine, Stomach, and Microbial Regulation - The pyloric sphincter. - The stomach supports minimal microbial diversity. - Acidic barrier aids in limiting the entry of opportunistic microbes into the small intestine.   8. Hypochlorhydria, Low Stomach Acid - Hypochlorhydria can compromise one of the body's defense mechanisms. - Colonization of the small intestine. - Insufficient pepsinogen activation and possible protein digestion impairment. - Suboptimal chyme formation and downstream digestive capacity. - Possible symptoms of hypochlorhydria. - Possible impaired absorption of micronutrients including vitamin B12, iron, calcium, magnesium. - H. pylori infection, autoimmunity, aging.   9. The Oral Microbiome, Intestinal Microbiome, and Dysbiosis - Oral and environmental microbes. - Altered gastric pH, bile, digestive enzymes, and more. - The oral cavity as the gateway to the GI tract. - Oral microbial species. - Oral hygiene and oral microbiome health.   10. Conclusion - Root-cause approach. Thank you to our episode sponsor: 1. Shop ⁠⁠⁠⁠⁠⁠Fresh Press Farms⁠⁠⁠'⁠⁠⁠⁠⁠⁠Peach Cider Vinegar⁠⁠⁠ at Sprouts locations nationwide, and check out their full collection ⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠. Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

    15 min

  2. MAR 26

    171. Combating Inflammation and Pain, Supporting Joint Health, Mobility, and More with Red Light Therapy | Forrest Smith, Founder & CEO of Kineon

    We are honored to be joined by Forrest Smith, the CEO and Founder of Kineon. Forrest has a 20-year history of building successful startups in tech hardware. He is passionate about health, wellness, and advancing technology to help others, and he has spent his adult life building remarkable products around innovative supply chain. Aside from his founder position in multiple companies, Forrest has held several positions, from Director of Asian Operations for a Fortune 500 company to Director of Business Development. He also grew up playing competitive sports in Atlanta, regularly participates in rugby matches, and trains CrossFit, which ultimately led him to develop Kineon Lab’s Move+, a modular, targeted laser therapy device for neuromuscular pain and inflammation. Topics: 1. Forrest's Personal Experience with Red Light Therapy - The creation of Kineon and the MOVE+ Pro.    2. Cellular Health - Supporting healthy mitochondrial function.  - ATP production and oxidative stress. - The role of oxidative stress in impairing mitochondrial output.  - Balancing ROS production and cellular repair.   3. Red and Infrared Light Therapy - Photoacceptors including cytochrome c oxidase. - Nitric oxide. - Comparing wavelengths and their tissue penetration.  - Clinical research on red light therapy. - Joint health, mobility, and blood flow. - Skin and hair scientific literature.  - Technical specifications. - Importance of dose control. - LEDs vs. Lasers in light therapy devices. - Including laser technology in the MOVE+ Pro.    4. Kineon Lab’s MOVE+ Pro - Remarkable engineering and performance. - Modular design for targeting joints and soft tissue.  - Joint pain, inflammation, and recovery.  - How often and how long to use the MOVE+ Pro.  - Sample protocols for joint pain and performance recovery.  Shop the Kineon Move+ Pro and save $100 during Kineon's Spring Amazon Sale running from March 25th to March 31st Check out Kineon's website here Check out Kineon's Instagram @kineon_labs Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

    55 min

  3. MAR 21

    170. Intestinal Mycobiome | The Role of Beneficial Microbes in Regulating Opportunistic Fungal Species, Candida Overgrowth, and a Brief Discussion on Mast Cell Activation Syndrome

    In this episode, we detail the intestinal mycobiome and the mechanisms by which beneficial microbes aid in regulating opportunistic fungal species: Candida albicans. We discuss Candida overgrowth virulence and how disruptions in microbial balance, immune function, and epithelial integrity impact Candida's pathogenicity. Additionally, we discuss the role of mast cells in the lamina propria, their involvement in mucosal immunity, and how Mast Cell Activation Syndrome (MCAS) can be exacerbated by fungal dysbiosis / microbial imbalances. Topics: 1. Introduction - The intestinal mycobiome and its role in intestinal health.  - Regulating populations of opportunistic fungal species like Candida albicans. - Mast cell activation syndrome (MCAS) intro.    2. Structure of the Intestinal Barrier - The microbiome and mucus layer: microbes, mucins, antimicrobial peptides, sIgA. - The epithelial monolayer: enterocytes, goblet cells, Paneth cells, enteroendocrine cells… - Tight junction proteins and paracellular transport. - The lamina propria beneath the epithelium: immune cells and more.   3. Candida’s Pathogenicity and Barrier Disruption - Exists primarily in its yeast form, regulated by microbial competition, host immune defenses, antifungal peptides.  - Secretory IgA (sIgA) and immune surveillance mechanisms help regulate fungal populations. - Chronic stress, immune suppression, and dysbiosis can deplete sIgA, increasing susceptibility to Candida proliferation.  - Environmental triggers such as immune suppression, microbial depletion, inflammatory cytokines. - Yeast-to-hyphal transition, deeper tissue invasion.  - Secreted aspartyl proteinases (SAPs), phospholipases, candidalysin: epithelial damage. - Pattern recognition receptors (PRRs) and overgrowth detection.   4. Impact of Beneficial Bacteria on Candida Overgrowth  - Beneficial bacteria compete with Candida for nutrients and epithelial adhesion sites.  - Short-chain fatty acids (SCFAs) produced by beneficial bacteria. - Depletion of beneficial bacteria removes ecological resistance, allowing Candida to proliferate unchecked.    5. Mast Cells in the Lamina Propria and Their Role in Intestinal Immunity - Mast cell location - Upon activation, mast cells release histamine, cytokines, proteases, and more that regulate gut immune responses.  - Histamine can increase gut permeability and modulate local immune activation.  - Tryptase and chymase. - Pro-inflammatory cytokines.   6. Mast Cell Activation Syndrome (MCAS) - Mast cell hyperactivation. - Environmental triggers, toxins, chronic infections, and stress. - Candida overgrowth and mast cell activation. - Addressing microbial imbalances and reducing the body’s total microbial, chemical, and toxin burden. - A diverse microbiome.    7. Conclusion - Candida overgrowth and regulation via immune defenses and beneficial bacterial competition. - MCAS, root cause approach. Thank you to our episode sponsor: 1. Shop ⁠⁠⁠⁠⁠Fresh Press Farms⁠⁠⁠'⁠⁠⁠⁠Peach Cider Vinegar⁠⁠ at Sprouts locations nationwide, and check out their full collection ⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠. Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

    16 min

  4. MAR 14

    169. Immunoglobulins in Intestinal Health and Immune Function | Immunoglobulin G, Immunoglobulin M, Secretory Immunoglobulin A, and Supporting the Gut-Immune Axis

    In this episode, we detail the role of immunoglobulins in gut-immune function, examining their involvement in mucosal defense, microbial regulation, and immune homeostasis within the intestines. We discuss the mechanisms of antibody production, highlighting how secretory IgA (sIgA) contributes to intestinal barrier integrity and pathogen neutralization. We also detail low secretory immunoglobulin A levels and Candida overgrowth. Lastly, we go through tools to support the gut-immune axis including oral immunoglobulin supplementation. 1. Introduction    - Overview of immunoglobulins, roles in gut-immune health     - The gut as a constant interface with antigens, microbes, and potential pathogens     - Adequate but balanced immunoglobulin levels; preventing opportunistic pathogen overgrowth    2. Immunoglobulins     - Immunoglobulins (Ig) as glycoproteins, fundamental role in immune defense     - Five major immunoglobulin isotypes and their distinct roles     - How immunoglobulins recognize and neutralize pathogens / toxins / foreign antigens    3. Antibody Production in the Intestines    - Naïve B cells originate in the bone marrow, migrate to secondary lymphoid tissues     - Antigen-presenting cells (APCs) facilitate antigen processing and B cell activation     - Plasma cells and mucosal immunity    4. The Intestinal Barrier and Immune Components    - Layers of the gut barrier and their functions     - The role of gut-associated lymphoid tissue (GALT) in immune surveillance     - Immune cells within the lamina propria and their contributions to gut homeostasis    5. Secretory IgA (sIgA) and Its Role in Gut Immunity    - sIgA production and transport across the intestinal epithelium     - Role of sIgA in immune exclusion and pathogen neutralization    6. Factors That Can Influence sIgA Levels    - Chronic stress, infections, and gut inflammation as contributors to low sIgA     - Consequences of low sIgA, including increased susceptibility to pathogens     - Nutrients essential for supporting optimal sIgA levels     7. Other Key Immunoglobulins in Gut Immunity    - Immunoglobulin G’s role in immune responses / pathogen neutralization    - Immunoglobulin M’s location and function as an early immune responder in mucosal defense    8. Supplemental Immunoglobulins    - Oral immunoglobulin supplementation and its benefits     - Bovine colostrum as a source of immunoglobulins for intestinal and immune support    9. Conclusion     - Recap of immunoglobulins’ role in gut-immune function     - The importance of balanced IgA, IgG, and IgM levels     - Strategies to support gut immunity Thank you to our episode sponsor: 1. Shop ⁠⁠CYLN's⁠⁠ full skincare line ⁠⁠here⁠⁠. Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

    15 min

  5. MAR 7

    168. Intestinal Motility and Overlap Among Intestinal Methanogen Overgrowth (IMO), Hydrogen-Dominant Small Intestinal Bacterial Overgrowth, and Hydrogen Sulfide-Dominant SIBO

    In this episode, we detail the pathophysiology of intestinal methanogen overgrowth (IMO), hydrogen-dominant small intestinal bacterial overgrowth (H₂-SIBO), and hydrogen sulfide-dominant SIBO (H₂S-SIBO), discussing their mechanistic interactions and overlap. We discuss methanogenic archaea, as well hydrogen sulfide- and hydrogen-producing microbes and their contributions to altered gastrointestinal motility, epithelial barrier function, and neuromuscular signaling. We detail host endogenous defense mechanisms, including gastric acid secretion, pancreatic enzymatic activity, bile flow, intestinal motility, and more. Topics: 1. Introduction - Overview of intestinal methanogen overgrowth (IMO), hydrogen sulfide-dominant SIBO, and hydrogen-dominant SIBO  - Discussion of overlap   2. Intestinal Methanogen Overgrowth (IMO) - Characterized by an overabundance of methane-producing archaea  - Methane and intestinal transit - Bloating, abdominal discomfort, constipation  - Associated with irritable bowel syndrome with constipation (IBS-C)    3. Overlap Between IMO and SIBO Subtypes - Hydrogen as a substrate for methane and/or hydrogen sulfide production - Shared potential root causes   4. Small Intestinal Bacterial Overgrowth (SIBO) and Protective Mechanisms - The small intestine remains relatively free of bacteria due to protective mechanisms  - Gastric acid secretion  - Pancreatic enzymes and bile - Intestinal motility - Structural abnormalities   5. Hydrogen-Dominant SIBO - Increased hydrogen and intestinal transit - Potential symptoms, diarrhea, postprandial bloating  - Different forms of SIBO can coexist   6. Hydrogen Sulfide-Dominant SIBO - H₂S and intestinal motility - H₂S and intestinal epithelial integrity - Symptoms, associations with IBS diarrhea      7. Host Defense Mechanisms Regulating Microbial Balance - Gastric acid secretion, pancreatic enzyme activity, bile flow, intestinal motility, and more   8. Gastric Acid and Its Role in Microbial Regulation - Parietal cells secrete hydrochloric acid (HCl) and intrinsic factor  - Chief cells secrete pepsinogen, conversion into pepsin in acidic conditions  - Gastric acid, digestion and antimicrobial defense    9. Hypochlorhydria - Low gastric acid impairs microbial defense - Reduced acidity disrupts digestion and downstream pancreatic enzyme and bile release    10. Pancreatic Enzymes and Their Role in Microbial Regulation - Pancreatic enzymes, digestion, antimicrobial activity - Enzymes modify chyme to limit fermentable substrates that fuel microbial proliferation    11. Intestinal Motility - Coordinated contractions propel food, microbes, and waste through the GI tract  - The enteric nervous system (ENS) and gut motility - The myenteric plexus controls peristalsis, while the submucosal plexus regulates secretion and absorption    12. Conclusion - Intestinal methanogen overgrowth (IMO), hydrogen-dominant SIBO, and hydrogen sulfide-dominant SIBO  - Overlap in symptoms and microbial interactions  - Host defense mechanisms, including gastric acid, pancreatic enzymes, and motility  - Intestinal motility and ENS function in microbial homeostasis  - Hydrogen sulfide as a gasotransmitter Thank you to our episode sponsors: 1. Shop ⁠⁠⁠⁠⁠Fresh Press Farms⁠⁠⁠'⁠⁠⁠⁠Peach Cider Vinegar⁠⁠ at Sprouts locations nationwide, and check out their full collection ⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠. 2. Shop ⁠CYLN's⁠ full skincare line ⁠here⁠. Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

    19 min

  6. FEB 28

    167. The Gut-Immune Axis | Gastrointestinal Mucus & Lactoferrin, Lactoferrin Levels, a Brief Discussion on Candida Overgrowth, & More

    In this episode, we detail the gut-immune axis, focusing on the protective mucus layer, antimicrobial peptides, and the role of lactoferrin in intestinal health. We discuss endogenous secretions and how lactoferrin functions as an antimicrobial, immunomodulatory, and iron-regulating glycoprotein, influencing microbial balance and intestinal barrier integrity. Additionally, we highlight lactoferrin testing and levels. We finish by going through supplementation as a phenomenal tool. Topics: 1. The Intestinal Barrier & Mucus Layer - The intestinal lumen, microbiome, mucus layer, epithelial cells, and lamina propria. - The mucus layer: antimicrobial peptides (AMPs) and secretory IgA (sIgA). - Intestinal epithelial cells including goblet cells and enterocytes. 2. Immune Cells in the Gut - The lamina propria. - Macrophages, dendritic cells, neutrophils, B cells, T cells, mast cells, and more. 3. Antimicrobial Peptides & Secretory IgA - AMPs and sIgA in the mucus layer regulate microbial balance and prevent pathogen adhesion. 4. Lactoferrin: Functions & Sources - Iron-binding glycoprotein, antimicrobial and immunomodulatory properties. - Found in mucosal secretions, colostrum, and more. - Intestinal epithelial cells (IECs) and neutrophils. 5. Lactoferrin’s Role in Intestinal Health - Regulates iron absorption via lactoferrin receptors (LFR)on enterocytes. - Sequesters free iron, limiting bacterial growth, bacteriostatic. - Destabilizes bacterial membranes, cell lysis, bactericidal. 6. Lactoferrin Levels - Neutrophils release lactoferrin during infection,increasing its presence in the large intestine. - Fecal lactoferrin levels. - Fecal calprotectin levels. 7. Lactoferrin & Candida Overgrowth - Fungal membranes. - Aiding in the inhibition of biofilm formation. 8. Lactoferrin Supplementation & Benefits - Supports gut microbiota, epithelial integrity, and immunemodulation. - Bovine colostrum and as a supplement. 9. Conclusion - The intestinal mucus layer is key to gut barrier function. - Lactoferrin plays a central role in microbial regulationand immune defense. Thank you to our episode sponsors: 1. Shop ⁠⁠⁠⁠Fresh Press Farms⁠⁠⁠'⁠⁠Peach Cider Vinegar⁠ at Sprouts locations nationwide, and check out their full collection ⁠⁠⁠⁠here⁠⁠⁠⁠. 2. Shop CYLN's full skincare line here. Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

    16 min

  7. FEB 21

    166. Increased Intestinal Permeability & Hypothalamic-Pituitary-Adrenal (HPA) Axis Dysfunction | Cortisol & More

    In this episode, we detail the bidirectional relationship between the HPA axis and the intestinal barrier, illustrating how HPA axis dysfunction and cortisol dysregulation can impact intestinal permeability. We further discuss how intestinal dysbiosis can contribute to HPA axis overstimulation. Lastly, we detail some of the roles of short-chain fatty acids (SCFAs) and secretory IgA (sIgA) in this bidirectional relationship. Topics: 1. Overview of the HPA Axis and Gut Bidirectional Relationship - Chronic HPA activation, intestinal permeability, mucosalimmunity, and microbiome composition.    2. Components and Function of the HPA Axis - Hypothalamus, pituitary gland, and adrenal glands.  - Stress signals from the amygdala and prefrontal cortex, CRH release from the hypothalamus.  - CRH stimulates ACTH release from the pituitary. - Cortisol production and release.   3. Structure of the Intestinal Epithelial Barrier - The gut barrier consists of the intestinal lumen, microbiome, mucus layer, epithelial cells, and lamina propria.  - Specialized epithelial cells: goblet cells, enterocytes, enteroendocrine cells, and more. - The lamina propria contains immune cells, blood vessels, and lymphatics, supported by a smooth muscle layer.    4. Intestinal Permeability and Tight Junction Regulation - Transport across the intestinal epithelium: transcellular and paracellular pathways.  - Nutrient absorption and selective permeability.  - Tight junction proteins, such as occludin and claudins.    5. Cortisol’s Impact on Gut Barrier Integrity - Cortisol can cross the intestinal microvascular endothelium and enter the lamina propria.  - Chronic cortisol exposure and intestinal barrier function. - Increased permeability allows luminal antigens and bacterial endotoxins (e.g., LPS) to infiltrate the lamina propria.    6. Secretory IgA (sIgA) and Gut Immune Function  - Chronic cortisol exposure can reduce sIgA levels, weakening mucosal immunity.  - sIgA neutralizes pathogens, prevents microbial adhesion, and more.  - Lower sIgA levels increase susceptibility to dysbiosis and infections.    7. CRH and Its Role in Intestinal Permeability - CRH is produced in the hypothalamus and also peripherally. - CRH can stimulate mast cells, triggering histamine and inflammatory mediator release.  - Mast cell activation can increase gut permeability.   8. Microbiome’s Influence on HPA Axis Regulation - Dysbiosis can disrupt HPA axis function. - IBS and sustained HPA activation. - Dysbiosis reduces SCFA production.  - SCFAs, particularly butyrate, support colonocyte health, tight junction integrity, and anti-inflammatory pathways.  - Inflammation and HPA axis dysfunction.   9. Root Cause Approach & Closing - Chronic cortisol exposure, CRH signaling, and gut barrier dysfunction.  - The microbiome influences stress response and HPA axis activity.  - Roles of SCFAs, sIgA, and tight junction proteins. - Addressing gut dysbiosis and GI-derived inflammation can support HPA axis regulation.  - Root cause approach. Thank you to our episode sponsors: 1. Shop ⁠⁠⁠Fresh Press Farms⁠⁠⁠'Peach Cider Vinegar at Sprouts locations nationwide, and check out their full collection ⁠⁠⁠here⁠⁠⁠. 2. Shop the ⁠⁠Scalp Cleanser⁠⁠ and ⁠⁠Scalp Essence⁠⁠ from ⁠⁠T Stem Care. ⁠⁠ 3. Shop ⁠⁠⁠⁠⁠⁠⁠Ulyana Organics'⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Tallow Wild Yam Cream⁠⁠⁠⁠⁠⁠⁠, and use code ⁠⁠⁠⁠⁠⁠⁠CHLOE10⁠⁠⁠⁠⁠⁠⁠ 10% off your order. Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

    19 min

  8. FEB 14

    165. Hydrogen Sulfide Dominant Small Intestinal Bacterial Overgrowth & Gastrointestinal Motility | Contributing Factors, Symptoms, and More

    In this episode, we go through the pathophysiology of hydrogen sulfide (H₂S)-dominant small intestinal bacterial overgrowth (SIBO), focusing on its role in intestinal motility disruption, microbial dysbiosis, and epithelial barrier dysfunction. We detail the interplay between the enteric nervous system (ENS), interstitial cells of Cajal (ICCs), and migrating motor complex (MMC) in regulating small intestinal transit and how excess H₂S modulates smooth muscle activity, inflammatory signaling, and gastrointestinal transit time. Lastly, we detail symptoms and related SIBO subtypes. Topics: 1. Introduction to Hydrogen Sulfide Dominant SIBO     - Overview of hydrogen sulfide (H₂S) SIBO    - Sulfate as an electron acceptor     - H₂S production, sulfur-containing amino acids    - Physiological roles of H₂S vs. in excess    2. Hydrogen Sulfide and Gastrointestinal Motility     - Impact on transit time    - Association with IBS-like symptoms, diarrhea    3. Intestinal Motility and Regulation     - Role of the ENS, ICCs, smooth muscle cells, and neurotransmitters in motility    4. The Enteric Nervous System (ENS) and Gut Motility     - ENS as the "second brain" and its control over digestion     - Myenteric and submucosal plexuses: regulation of peristalsis, secretion, blood flow     - Gut-brain axis involvement via vagus nerve signaling     - ICCs as pacemaker cells generating slow-wave electrical activity     - MMC’s role in clearing debris and bacteria   5. Dysregulated Motility and SIBO Development  6. Overlapping Symptoms Across SIBO Subtypes     - Shared symptoms    - Hydrogen and H₂S-dominant SIBO vs. IMO   7. Gastric Acid and Its Role    - HCl secretion by parietal cells and its role in digestion and microbial defense     - Hypochlorhydria and bacterial overgrowth    8. Conclusion    - Root cause approach. Thank you to our episode sponsors: 1. Check out ⁠⁠⁠⁠⁠⁠Ulyana Organics'⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Tallow Wild Yam Cream⁠⁠⁠⁠⁠⁠ and ⁠⁠⁠⁠⁠⁠Healing Facial Oil⁠⁠⁠⁠⁠⁠, and use code ⁠⁠⁠⁠⁠⁠CHLOE10⁠⁠⁠⁠⁠⁠ 10% off your order. 2. Shop the Scalp Cleanser and Scalp Essence from T Stem Care. Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

    18 min
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    4.8
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    61 Ratings

    About

    Your host and biohacker, Chloe Porter, has a background in engineering, innovation, and research. Her analytical background coupled with her journey in overcoming a brain tumor and defeating several chronic illnesses enables her to approach health and wellness in an innovative way, and now more than ever, she is ready to share her biohacking secrets and expose cutting-edge research.

    Information

    • Creator
      Chloe Porter
    • Years Active
      2023 - 2025
    • Episodes
      172
    • Rating
      Clean
    • Copyright
      © Chloe Porter
    • Show Website
      The Synthesis of Wellness

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