The Synthesis of Wellness

Chloe Porter
  • 4.8 (61)
  • ALTERNATIVE HEALTH
  • UPDATED DAILY
The Synthesis of Wellness

Your host and biohacker, Chloe Porter, has a background in engineering, innovation, and research. Her analytical background coupled with her journey in overcoming a brain tumor and defeating several chronic illnesses enables her to approach health and wellness in an innovative way, and now more than ever, she is ready to share her biohacking secrets and expose cutting-edge research.

  1. 5 DAYS AGO

    165. Hydrogen Sulfide Dominant Small Intestinal Bacterial Overgrowth & Gastrointestinal Motility | Contributing Factors, Symptoms, and More

    In this episode, we go through the pathophysiology of hydrogen sulfide (H₂S)-dominant small intestinal bacterial overgrowth (SIBO), focusing on its role in intestinal motility disruption, microbial dysbiosis, and epithelial barrier dysfunction. We detail the interplay between the enteric nervous system (ENS), interstitial cells of Cajal (ICCs), and migrating motor complex (MMC) in regulating small intestinal transit and how excess H₂S modulates smooth muscle activity, inflammatory signaling, and gastrointestinal transit time. Lastly, we detail symptoms and related SIBO subtypes. Topics: 1. Introduction to Hydrogen Sulfide Dominant SIBO     - Overview of hydrogen sulfide (H₂S) SIBO    - Sulfate as an electron acceptor     - H₂S production, sulfur-containing amino acids    - Physiological roles of H₂S vs. in excess    2. Hydrogen Sulfide and Gastrointestinal Motility     - Impact on transit time    - Association with IBS-like symptoms, diarrhea    3. Intestinal Motility and Regulation     - Role of the ENS, ICCs, smooth muscle cells, and neurotransmitters in motility    4. The Enteric Nervous System (ENS) and Gut Motility     - ENS as the "second brain" and its control over digestion     - Myenteric and submucosal plexuses: regulation of peristalsis, secretion, blood flow     - Gut-brain axis involvement via vagus nerve signaling     - ICCs as pacemaker cells generating slow-wave electrical activity     - MMC’s role in clearing debris and bacteria   5. Dysregulated Motility and SIBO Development  6. Overlapping Symptoms Across SIBO Subtypes     - Shared symptoms    - Hydrogen and H₂S-dominant SIBO vs. IMO   7. Gastric Acid and Its Role    - HCl secretion by parietal cells and its role in digestion and microbial defense     - Hypochlorhydria and bacterial overgrowth    8. Conclusion    - Root cause approach. Thank you to our episode sponsors: 1. Check out ⁠⁠⁠⁠⁠⁠Ulyana Organics'⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Tallow Wild Yam Cream⁠⁠⁠⁠⁠⁠ and ⁠⁠⁠⁠⁠⁠Healing Facial Oil⁠⁠⁠⁠⁠⁠, and use code ⁠⁠⁠⁠⁠⁠CHLOE10⁠⁠⁠⁠⁠⁠ 10% off your order. 2. Shop the Scalp Cleanser and Scalp Essence from T Stem Care. Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

    18 min

  2. FEB 7

    164. Intestinal Dysbiosis and The Roles of Gastrointestinal Mucus and Secretory Immunoglobulin A | High and Low Levels of SIgA, and More

    In this episode, we discuss the relationship between the intestinal mucus layer and secretory immunoglobulin A (sIgA), highlighting both as key components of the gut's first line of defense against pathogens, toxins, and environmental stressors. We detail how dysbiosis and microbial overgrowths can impact sIgA levels and can disrupt mucus integrity and function, contributing to increased intestinal permeability and inflammation. We then examine several additional factors influencing sIgA production. Topics: 1. Introduction: Importance of Secretory IgA and Intestinal Mucus     - Intestinal epithelial lining and its protective mucus layer     - Focus on intestinal dysbiosis and sIgA   2. Anatomy of the Gastrointestinal Lining     - Intestinal lumen, microbiome, mucus layer, epithelial cells, tight junctions, lamina propria, and smooth muscle     - Role of goblet cells in mucus secretion and epithelial integrity    3. Role of the Protective Mucus Layer     - Dual function of the mucus layer as a physical and biochemical barrier     - Composition of mucus: mucins, antimicrobial peptides, immunoglobulins    4. Goblet Cells and Mucin Production     - Mechanisms of mucin secretion and hydration     - Variability in goblet cell density across the intestinal tract     - Dysfunctions linked to conditions like IBD and IBS    5. Microbial Interactions with Mucins     - Glycan structures in mucins    - Roles of commensal and pathogenic bacteria in mucin degradation and mucus turnover     - Importance of regulated mucus production for gut homeostasis    6. Dysbiosis and Mucus Degradation     - Excessive mucin degradation leading to thinning of the mucus layer     - Consequences of increased intestinal permeability and inflammation     - Role of dysbiosis in disrupting the mucus layer    7. Overview of Secretory IgA     - Introduction to secretory IgA (sIgA) and its role in mucosal immunity    - Mechanisms of immune exclusion and pathogen neutralization    8. Production and Function of Secretory IgA     - sIgA production by plasma cells in the lamina propria     - Translocation of IgA through epithelial cells into the gut lumen     - sIgA binding to mucins and its immunological role in the mucus layer    9. Factors Affecting Secretory IgA Levels     - Possible contributing factors to low sIgA levels    - Implications of low and high sIgA levels for immune defense and intestinal health    10. Interactions Between Secretory IgA and Dysbiosis     - Cyclical relationship between low sIgA, dysbiosis, and infections     - Examples of overgrowths, like candida, disrupting sIgA     - Importance of addressing immune dysregulation to break the cycle    11. Bioindividual Root Cause Approach  - Factors to consider Thank you to our episode sponsors: 1. Shop ⁠⁠Fresh Press Farms⁠⁠' Peach Cider Vinegar at Sprouts locations nationwide, and check out their full collection ⁠⁠here⁠⁠. 2. Check out ⁠Spectrum Sciences⁠' Serums and The Vitamin B12 Protocol ⁠here⁠, and use code CHLOE15 for 15% off. Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

    17 min

  3. JAN 31

    163. The Gut-Immune Axis & Mycobiome | Intestinal Fungal Overgrowth, The Importance of Secretory Immunoglobulin A, and More

    In this episode, we go through the gut-immune axis and mycobiome, focusing on the mechanisms underlying intestinal fungal overgrowth. We highlight the roles of the intestinal mucus layer, intestinal epithelial cells, lamina propria, and secretory immunoglobulin A (sIgA) in maintaining homeostasis and defending against fungal overgrowth. We also detail the pathogenic transition of Candida from its commensal yeast form to an invasive hyphal state, as well as the resulting disruptions to immune function. Topics 1. Introduction to the Gut-Immune Axis and Mycobiome    - The gut-immune axis and mycobiome.    - Exploring intestinal fungal overgrowth.   2. Overview of the Gastrointestinal Lining    - Anatomy of the intestinal lining: lumen and microbiome, mucus layer, epithelial monolayer, and lamina propria.    - The dual role of the mucus layer: physical and biochemical barrier.    - Composition of mucus.   3. Goblet Cells and Mucus Production    - Goblet cells as critical producers of mucin glycoproteins and their role in mucus barrier integrity.    - Signals for mucin release, such as mechanical stress.   4. The Lamina Propria and Gut-Associated Lymphoid Tissue (GALT)    - Layers beneath the epithelium    - Peyer’s patches, mesenteric lymph nodes, isolated lymphoid follicles, and intraepithelial lymphocytes.    - Immune tolerance and defense against pathogens.   5. Peyer’s Patches    - Positioning of Peyer’s patches.    - The transition of microbial density from the small intestine to the colon and its immune implications.   6. Immune Cells in the Lamina Propria    - Overview of macrophages, dendritic cells, mast cells, plasma cells, and lymphocytes.    - Their role in maintaining immunological equilibrium in the gut.   7. The Mycobiome and Pathogenic Transition of Candida    - Candida’s transition from yeast to hyphal form.    - Regulation of Candida by microbial competition and immune surveillance.    - Factors promoting pathogenicity: immune suppression, lacking beneficial microbes, more.   8. Virulence Factors of Candida    - Secretion of hydrolytic enzymes such as SAPs and phospholipases.    - Degradation of sIgA and its consequences for immune evasion.    - Adhesins that facilitate fungal binding.   9. Intestinal Barrier Disruption by Candida    - Penetration of the mucus layer and epithelial barrier by Candida hyphae.    - Disruption of tight junctions and the resulting increased intestinal permeability.    - Inflammatory cascade triggered by fungal antigens and microbial toxins entering the lamina propria.   10. Biofilm Formation     - The role of biofilms in shielding fungal cells from immune attack and antifungal treatments.   11. Small Intestinal Fungal Overgrowth (SIFO)     - Intestinal dysmotility, low stomach acid, immunocompromise.     - Possible symptoms of SIFO.     - Discussion of the overlap between SIFO, SIBO, histamine intolerance, and other gastrointestinal conditions. - Root cause. Thank you to our episode sponsors: 1. Shop ⁠Fresh Press Farms⁠' Peach Cider Vinegar at Sprouts locations nationwide, and check out their full collection ⁠here⁠. 2. Check out ⁠⁠⁠⁠⁠Ulyana Organics'⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠Tallow Wild Yam Cream⁠⁠⁠⁠⁠ and ⁠⁠⁠⁠⁠Healing Facial Oil⁠⁠⁠⁠⁠, and use code ⁠⁠⁠⁠⁠CHLOE10⁠⁠⁠⁠⁠ 10% off your order. 3. Check out Spectrum Sciences' Serums and The Vitamin B12 Protocol here, and use code CHLOE15 for 15% off. Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

    19 min

  4. JAN 29

    162. Supporting Methylation and Optimizing Vitamin B12 Utilization Through the Vitamin B12 Protocol with Chris Soppet, Founder of Spectrum Sciences

    We are honored to be joined today by Chris Soppet.  Chris is the founder of Spectrum Sciences, a health and wellness brand with the vision of bringing the healing power of vitamin B12 to the greatest number of folks out there.  He received his inspiration from his son, who recovered from autism in large part due to the remarkable power of vitamin B12.  Chris shares this hope through a very tangible means – The Vitamin B12 Protocol.  After using various other B12 products on the market, he was disappointed by the inconsistency and lack of transparency.  As a chemist and certified health coach, he was uniquely positioned to take matters into his own hands.  Launched in the Fall of 2024, Spectrum Sciences aims to deliver the most effective, safe, and transparently labeled option in transdermal delivery of nutrients. Topics: 1. Chris' Journey and Developing Spectrum Sciences - Chris Soppet's background and the inspiration for founding Spectrum Sciences. 2. Brief Overview of The Vitamin B12 Protocol 3. Brief Overview of Methylation - The importance of methylation for cellular function and overall health. 4. Background - The role of the thyroid in supporting methylation and B12 utilization, including testing, nutrients, and understanding a basic thyroid panel. - The thyroid’s role in activating riboflavin (B2) and other cofactors, and how activated riboflavin is used. - How to support riboflavin status through dietary intake. - The folate cycle and how activated riboflavin supports the MTHFR enzyme to yield active folate. - The interaction of B12 and B9 in converting homocysteine to methionine and producing SAM, the universal methylator. 5. The Organic Acids Test - Explanation of the test and its insights. 6. Topical Serums - Benefits of topical delivery. - Spectrum Sciences' products that support thyroid function. - Spectrum Sciences' products that support riboflavin activation with thyroid assistance. - Spectrum Sciences' activated B12. - Remarkable transdermal delivery through microemulsion technology. - How to use the topicals. 7. Spectrum Sciences LLC - Resources for learning about Spectrum Sciences, The Vitamin B12 Protocol, and topical serums. 8. Connecting with Chris Soppet - Social media and website links to learn more about Chris and Spectrum Sciences. Check out Spectrum Sciences and The Vitamin B12 Protocol at spectrum-sciences.net, and use code CHLOE15 for 15% off. Follow Spectrum Sciences on Instagram @spectrumscience1

    56 min

  5. JAN 24

    161. Gastrointestinal Dysmotility | Motility in Intestinal Methanogen Overgrowth & Small Intestinal Bacterial Overgrowth, and a Brief Discussion of Low Stomach Acid, Hypochlorhydria

    In this episode, we explore some of the neural and cellular mechanisms underlying gastrointestinal motility, emphasizing the roles of the enteric nervous system (ENS) and interstitial cells of Cajal (ICCs) in coordinating smooth muscle contractions throughout the digestive tract. We detail disruptions in motility seen in dysautonomia, intestinal methanogen overgrowth (IMO), and small intestinal bacterial overgrowth (SIBO). And, we finish with a brief discussion on the impacts of low stomach acid. Topics: 1. Introduction to Gastrointestinal Motility - Coordinated contractions of smooth muscle that move food, liquid, and waste through the gastrointestinal (GI) tract. - Neural, hormonal, and microbial factors. - Intestinal methanogen overgrowth (IMO) and small intestinal bacterial overgrowth (SIBO). 2. Neural Regulation of Gut Motility - The enteric nervous system (ENS) embedded in the walls of the GI tract. - The ENS, central nervous system (CNS), and vagus nerve. - The myenteric plexus governs motor control and peristalsis, while the submucosal plexus regulates secretion, absorption, and blood flow. - Stress and motility 3. Cellular Regulation of Gut Motility - Interstitial cells of Cajal (ICCs), pacemaker cells located near smooth muscle cells. - ICCs generate slow-wave electrical activity. - Acetylcholine enhances smooth muscle contraction. 4. Dysmotility and Potential Contributing Factors - Impaired ICC function, smooth muscle dysfunction, nervous system dysfunction. - Dysautonomia, a dysfunction of the autonomic nervous system. - External stressors, hormonal imbalances, and more. 5. Intestinal Methanogen Overgrowth (IMO) - Characterized by an overgrowth of methane-producing archaea in the intestines. - Excess methane production affects smooth muscle activity and can slow intestinal transit. - Symptoms such as bloating, abdominal discomfort, constipation. - Breath testing. 6. Small Intestinal Bacterial Overgrowth (SIBO) - Excessive bacterial colonization in the small intestine, disrupting normal gut function. - Protective mechanisms including stomach acid and intestinal motility. - Low stomach acid (hypochlorhydria) reduces the acidic environment needed to inhibit bacterial colonization. - Bloating, diarrhea/constipation, and more. 7. Overlap Between IMO and SIBO - Excess hydrogen produced in SIBO can serve as a substrate for methane production in IMO. - Can exacerbate each other, creating a loop that worsens symptoms. 8. Addressing Dysmotility and Overgrowth - Determining the root cause of dysmotility. - Dysmotility can involve multiple regions of the GI tract. Thank you to our episode sponsors: 1. Shop Fresh Press Farms' Peach Cider Vinegar at Sprouts locations nationwide, and check out their full collection here. 2. Check out ⁠⁠⁠⁠Ulyana Organics'⁠⁠⁠⁠ ⁠⁠⁠⁠Tallow Wild Yam Cream⁠⁠⁠⁠ and ⁠⁠⁠⁠Healing Facial Oil⁠⁠⁠⁠, and use code ⁠⁠⁠⁠CHLOE10⁠⁠⁠⁠ 10% off your order. Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more!

    18 min

  6. JAN 17

    160. The Gut-Immune Axis | Mast Cells & Small Intestinal Bacterial Overgrowth, and a Brief Discussion on Mast Cell Activation Syndrome

    In this episode, we detail the gut’s intricate immune defenses, emphasizing the role of mast cells in inflammation and immune signaling. We extend this conversation to Mast Cell Activation Syndrome briefly going through potential triggers, tests, and symptoms. Finally, we examine the bidirectional relationship between MCAS and Small Intestinal Bacterial Overgrowth (SIBO), illustrating how mast cell mediators and microbial byproducts can drive a cycle of chronic inflammation and increased intestinal permeability. Topics: 1. Introduction to the Gut-Immune Axis - Focus: mast cells, small intestinal bacterial overgrowth (SIBO), and mast cell activation syndrome (MCAS). 2. Anatomy of the Gastrointestinal Lining - Intestinal lumen, microbiome, mucus layer, epithelial monolayer, tight junctions, and lamina propria. - Role of the smooth muscle and deeper layers supporting the mucosal structures. 3. Gut-Associated Lymphoid Tissue (GALT) - Peyer’s patches, mesenteric lymph nodes (MLNs), isolated lymphoid follicles (ILFs), intraepithelial lymphocytes (IELs), and dispersed immune cells in the lamina propria. - Function of GALT. 4. Peyer’s Patches and Antigen Exposure - Location and function of Peyer’s patches. - Role in antigen sampling and processing. 5. Immune Cells in the Lamina Propria - Overview of interspersed immune cell populations. 6. Focus on Mast Cells - Key roles of mast cells in the gut’s innate immune system. - Locations with a focus on the lamina propria. 7. Mast Cell Mediators - Histamine - Tryptase: tissue remodeling, impact on intestinal permeability. - Cytokines, prostaglandins, and leukotrienes. 8. Mast Cell Activation Syndrome (MCAS) - Overactivation of mast cells and excessive release of inflammatory mediators. - Effects on gut barrier function. - Pathological behavior due to altered activation thresholds, receptor expression, and tissue environment changes (not resulting from an increased number of mast cells). 9. MCAS Symptoms and Systemic Effects - Abdominal pain, cramping, bloating, diarrhea, and nausea. - Systemic symptoms: skin reactions, respiratory and cardiovascular effects, neurological impacts. 10. Triggers and Conditions Associated with MCAS - Environmental toxins, infections, stress, chemical exposures. - Hypermobile Ehlers-Danlos syndrome (hEDS), dysautonomia (e.g., POTS). 11. MCAS Testing - Testing limitations: variability in mediator release and transient nature of mast cell degranulation. - Serum tryptase, urinary N-methylhistamine, plasma heparin levels, specific cytokines like IL-6, and more. 12. Small Intestinal Bacterial Overgrowth (SIBO) - Overview of SIBO. - Slow motility, low stomach acid. 13. Interaction Between SIBO and Mast Cells - SIBO-induced mast cell activation. - Cycle of inflammation, increased intestinal permeability, and gut dysfunction. 14. Conclusion - Recap of the intestinal anatomy and immune cell focus. - MCAS triggers, symptoms, and testing. - Connections between SIBO and MCAS, emphasizing an inflammatory cycle. Thank you to our episode sponsor: 1. Check out ⁠⁠⁠Ulyana Organics'⁠⁠⁠ ⁠⁠⁠Tallow Wild Yam Cream⁠⁠⁠ and ⁠⁠⁠Healing Facial Oil⁠⁠⁠, and use code ⁠⁠⁠CHLOE10⁠⁠⁠ 10% off your order. Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more!

    17 min

  7. JAN 10

    159. Connections Between Intestinal Dysbiosis, Impaired Intestinal Barrier Function & Histamine Intolerance, Diamine Oxidase Enzyme Production, and a Brief Discussion on SIBO

    In this episode, we go through the role of histamine within the gastrointestinal tract, exploring its regulation of gastric acid secretion and impact on intestinal motility. We examine how histamine-producing enterochromaffin-like (ECL) cells, mast cells, and gut microbiota contribute to histaminergic signaling, and how enzymatic degradation via diamine oxidase (DAO) maintains homeostasis. Additionally, we discuss histamine intolerance, highlighting the impacts of dysbiosis (as well as SIBO or small intestinal bacterial overgrowth) and intestinal barrier dysfunction on DAO insufficiency and histamine accumulation. Topics: 1. Introduction to Histamine & the Gastrointestinal Tract Role in digestion and motility Impact of intestinal conditions such as SIBO 2. Histamine as a Biogenic Amine Definition and classification L-histidine and histidine decarboxylase (HDC) Presence in various tissues, including the GI tract 3. Sources of Histamine in the Gut Enterochromaffin-like (ECL) cells in the stomach Mast cells in the lamina propria Histamine-producing gut bacteria 4. Histamine’s Role in Digestion & Gastric Acid Secretion Interaction with parietal cells in the stomach Activation of proton pumps via H₂ receptor binding Maintenance of acidic pH for digestion Importance of proper pH within the stomach for protecting against pathogenic microbes Impact on downstream gut microbiota balance (e.g., SIBO) 5. Histamine & Intestinal Motility Modulation of gut motility via H₁ and H₃ receptors H₁ receptor activation leading to contractions (diarrhea, cramping) H₃ receptor-mediated inhibition of neurotransmitter release (bloating, slow motility) 6. Histamine Intolerance: Definition & Mechanisms Diamine Oxidase and histamine breakdown DAO secretion by enterocytes (intestinal epithelial cells) Enzymatic breakdown of histamine before absorption 7. Factors That Can Affect DAO Activity Genetic Polymorphisms: AOC1 gene, reduced DAO expression Cofactor Deficiencies: Copper, vitamin B6, and vitamin C as essential DAO cofactors Importance of intestinal lining integrity for DAO production Conditions leading to or associated with enterocyte damage Intestinal dysbiosis and histamine accumulation Intestinal dysbiosis & epithelial/enterocyte damage Suppression of DAO production due to epithelial dysfunction Small Intestinal Bacterial Overgrowth (SIBO) & Histamine 8. Symptoms of Histamine Intolerance Gastrointestinal symptoms (bloating, gas, constipation, diarrhea, acid reflux...) Systemic symptoms (dizziness, flushing, migraines...) 9. Identifying Potential Root Causes Tools and supplements Bioindividual approach Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more!

    16 min

  8. JAN 3

    158. The Stomach & Small Intestines | H. Pylori Infection & Symptoms, Gastric Acid Regulation & Secretion, and a Brief Discussion on Small Intestinal Bacterial Overgrowth

    In this episode, we discuss the anatomy and physiology of the stomach and its unique epithelial structure. We dive into the pathophysiological implications of conditions such as Helicobacter pylori infection and hypochlorhydria, examining how they disrupt gastric function and microbial balance. Finally, we connect these concepts to the small intestine, discussing possible downstream effects of altered gastric acid secretion, focusing on microbial colonization and contributions to broader gastrointestinal health challenges, such as small intestinal bacterial overgrowth (SIBO). Topics: 1. Introduction Highlighting the stomach and anatomy. Discussion on H. pylori. Interplay between the stomach and small intestines, focusing on microbial balance and overgrowth. 2. Anatomy of the Stomach The stomach as a hollow, muscular organ located between the esophagus and small intestine. Anatomical regions: cardia, fundus, body, and pylorus. Layers of gastric mucosa: epithelial lining, lamina propria, and thin band of smooth muscle. 3. Epithelial Lining and Specialized Cells Mucous cells: Location within the surface epithelium and gastric pits. Secretion of viscous mucus containing mucins, forming a protective barrier. Role in shielding the epithelial lining from acidic gastric juices and creating a neutral microenvironment. Parietal cells: Location in the gastric glands, predominantly in the fundus and body. Secretion of hydrochloric acid (HCl) for digestion and defense. Production of intrinsic factor and vitamin B12 absorption. Chief cells: Secretion of pepsinogen, converted to pepsin for protein digestion. Production of gastric lipase for lipid digestion. Enteroendocrine cells: Hormone secretion. Gastrin, acid secretion and gastric motility. 4. Protection and Functionality of Gastric Mucosa Physical and chemical barriers. Acidic environment maintained by parietal cells for enzymatic activity and pathogen defense. Coordination of cell functions for efficient digestion and protection. 5. Transition from Stomach to Small Intestine Anatomical junction marked by the pyloric sphincter. Balancing the acidic environment of the stomach with the intestinal conditions. Differences between stomach and intestinal epithelial barriers. 6. Microbial Communities in the Stomach and Intestines Limited microbial diversity in the stomach due to its low pH. Acid-resistant populations such as H. pylori and their impact on microbial diversity. H. pylori , chronic gastritis, ulcers, and gastric lining atrophy. 7. H. Pylori Infection and Symptoms Symptoms, manifestations. 8. Low Stomach Acid (Hypochlorhydria) The role of stress, aging, and infections. Downstream effects, particularly in the development of small intestinal bacterial overgrowth (SIBO). 9. Small Intestinal Bacterial Overgrowth (SIBO) Definition and microbial population thresholds. Protective mechanisms regulating bacterial density in the small intestine. Role of low stomach acid in bacterial colonization and overgrowth. Consequences of SIBO, including symptoms and metabolic activity of overgrown bacteria. 10. Conclusion Root cause analysis. Thank you to our episode sponsor: 1. Check out ⁠⁠Ulyana Organics'⁠⁠ ⁠⁠Tallow Wild Yam Cream⁠⁠ and ⁠⁠Healing Facial Oil⁠⁠, and use code ⁠⁠CHLOE10⁠⁠ 10% off your order. Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more!

    18 min
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4.8
out of 5
61 Ratings

About

Your host and biohacker, Chloe Porter, has a background in engineering, innovation, and research. Her analytical background coupled with her journey in overcoming a brain tumor and defeating several chronic illnesses enables her to approach health and wellness in an innovative way, and now more than ever, she is ready to share her biohacking secrets and expose cutting-edge research.

Information

  • Creator
    Chloe Porter
  • Years Active
    2023 - 2025
  • Episodes
    165
  • Rating
    Clean
  • Copyright
    © Chloe Porter
  • Show Website
    The Synthesis of Wellness

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