Nucleate Podcast

Nucleate
  • 5.0 (7)
  • Technology

Nucleate is the new voice for next generation biotech leaders.

  1. 3d ago

    Refusing to give up on an Oncology Breakthrough | Dana T. Aftab, Exelixis

    Time Stamps: 0:45 Introduction to Dana Aftab and what sparked his passion for science 6:39 His Ph.D. experience at Yale that led to a breakthrough in compound screening 16:15 Why that soured him on biotech and what ultimately drew him back in 24:33 Navigating the transition into industry by trusting his gut 30:09 The Exelixis-MetaXen acquisition 37:18 Taking the lead as a helping guide to younger scientist 41:00 What does it take to be a good manager  48:45 Discovery and development of CABOMETYX® (cabozantinib) 57:15 How differentiating clinical data changed the trajectory of Exelixis  1:00:34 Navigating the restructuring process 1:07:13 Rebuilding the Exelixis team 1:11:26 His return to science  1:13:30 Advice for founders on what makes a strong potential partner 1:20:07 Quick fire questions

  2. Jul 23

    Using Philanthropy to Drive Cures for Multiple Myeloma | Stephanie Oestreich, PhD MMRF

    (0:53) Introduction to Stephanie’s passion for science and her career transition from research to business (8:40) Key foundational business development skills  (13:06) What investors look for when evaluating early stage technology (14:37) The story behind Gleevec and its commercialization journey  (19:36) Long term planning for early career scientists  (24:39) Differences between U.S. and European ecosystems across pharma and biotech  (30:30) Introduction to the Multiple Myeloma Research Foundation  (36:23) How in vivo CAR-T and cell therapy are advancing  multiple myeloma care (42:08) Advice for entrepreneurs interested  in the Nucleate Activator program   (54:18) How can startup founders best position themselves in a competitive landscape (1:03:10) Quick fire questions

  3. Jun 23

    Translating Science into Patient Impact with Kendra Rose

    Time Stamps: (2:37) Introduction to Kendra’s professional journey and how she found her path into science  (7:30) Understanding the consumer mindset and patient perspectives (13:05) Key parameters that shape important decisions  (17:45) Core lessons on bridging the gap between science and business  (25:30) Introduction to Bayer and Kendra’s  role as Senior Vice President of Business Development and Licensing  (29:46) Latest trends shaping healthcare research,  education, and innovation  (38:59) How to establish credibility as an entrepreneur in a competitive market (41:28) Inside the Bayer Co.Lab incubator ecosystem and the support it offers (50:37) Tips for early-career scientists interested in making a pivot from the lab to business (57:09) Do you really need a Ph.D. to break into pharma? (1:00:01) Quick fire questions

  4. Jun 4

    Leading Mission-Driven Biotechs | Jodie Morrison, CEO of Q32 Bio

    Time Stamps 01:42: Jodie’s early interest in science and the defining moment   03:31: Starting from the bottom in clinical research shaped her leadership style as a CEO 08:32: How she joined Q32 Bio and then took them public 10:11: Jodie’s inspiration to get involved with challenging companies 11:42: The emotional reward of biotech: the long hours are worthwhile to save lives   13:46: Navigating challenging situations 15:10: Q32 Bio's focus on autoimmune disorders 19:59: The origins of the CEO Forum 27:54: The "lonely" nature of being a CEO and the importance of community 30:54: Philosophy on female leadership: “lift while we climb” 34:54: How AI is involved in biotech 43:24: Navigating challenging capital markets: focus on “killer experiments” that investors want 46:47: Balancing "ethical obligation" to employees with their "fiduciary responsibility" to investors 49:56: How layoffs are “heartbreaking” but necessary to preserve capital for future drug development 56:30: The future of biotech is "cautious optimism" but needed 1:00:06: Initiatives among leaders to heal the misconception of science 01:05:01: Rapid Fire questions

  5. Mar 24

    From Genomics to Deal-Making: How Science Becomes a Company | Laurence Reid, Biotech Entrepreneur

    Time Stamps [00:00] Laurence explains biotech to a five-year-old  [01:55] Early life in the UK and first steps toward biotech  [02:47] How The Double Helix and Celltech shaped his path  [07:15] Moving from bench science to Cell and a wider view of research  [13:04] Learning business development at Millennium [15:30] Why relationships matter in biotech deals  [17:43] How Millennium changed from platform company to drug developer  [28:01] Joining Alnylam and building around RNAi  [39:19] Becoming a CEO at Warp Drive Bio  [44:36] Novel antibiotics, molecular glues, and the RevMed merger [52:07] What founders should know about building to make a lasting impact [54:50] Joining Decibel during restructuring and COVID  [58:55] Rebuilding culture and sharpening strategy  [1:09:49] Why Decibel focused on gene therapy for the inner ear [1:25:05] Advice for founders raising money in a hard market

  6. Mar 10

    Negotiating Intellectual Property, Staying Focused, and Making the Most of Mentors with Michal Preminger, Board Member at MassBio

    Time Stamps (0:55) Introduction to Michal’s background and her professional journey  (7:58) How Michal leveraged tech skills to break into computational biology  (13:15) Her experience at Compugen working on early AI-enabled drug discovery   (19:52) Challenges startup founders face and strategies to overcome them (25:19) Michal’s personal experience as a founder at Anima Biotech (32:52) Resources available at academic institutions to support startups  (40:15) How to successfully negotiate as a scientific founder (46:51) Michal’s role at Johnson & Johnson (53:13) Introduction to MassBio and their purpose (58:35) Advice on networking and how to form meaningful partnerships

  7. Feb 24

    How Turbine Accelerates Drug Discovery with AI Simulation | Szabi Nagy, CEO and Co-Founder of Turbine

    Time Stamps 1:37 Introduction to Szabi’s journey from economics to healthcare  3:23 Szabi’s early startup experience at Tresorit  5:27 Key takeaways from his first venture 11:46 What led Szabi to pivot into healthcare and how he managed that transition 14:37 Introduction to Turbine 17:10 Example of running large-scale experiments in collaboration with Merck  19:17 Explanation of the main phases of application of the model  22:32 What fundamental tenets were used to build Turbine’s model  29:16 How to form successful partnerships 38:53 Szabi’s experience with raising funds in a tight capital market  40:00 Advice for founders navigating this challenging market 49:20 How to find the right mentor and form a meaningful connection  51:07 Final words of wisdom

  8. Feb 10

    The Science of Stem Cells and Social Impact: Inside Ovelle with Merrick Smela and Travis Potter

    Time Stamps 1:58 Merrick Smela's Early Influence 03:36 Ovelle's Founding:  Travis Potter and Merrick Smela 05:07 Travis Potter's Motivation After Facing Fertility Struggles 06:44 Underfunding of IVG 07:48 Finance/Biotech Commonalities 09:15 Scientific Co-founder Role: Merrick Smela 09:56 Using Statistics in Design 12:25 Definition of IVG 12:54 Ovelle's Mission to Revolutionize Infertility Treatment 13:33 IVG vs. IVF 15:49 Ovelle's Unique Scientific Approach 16:39 Direct Activation vs. Natural Signaling:  18:17 Meiosis Paper Innovation: Identifying Regulatory Factors that can Activate Meiosis from Stem Cells 21:23 Team Building: Finding Dedicated Scientists 24:20 Culture Difference (Meaning vs. Money) 28:35 IVG Process Overview:  29:36 IVM is Achieved in Humans:  30:35 Quality Control and Safety of Eggs 32:35 Prioritization using Critical Path Analysis: 35:02 Investor Funding for IVG as a New Fertility Approach 41:21 Rapid Fire Questions

See All (47)

Ratings & Reviews

5
out of 5
7 Ratings

About

Nucleate is the new voice for next generation biotech leaders.

Information

  • Creator
    Nucleate
  • Years Active
    2023 - 2026
  • Episodes
    47
  • Rating
    Clean
  • Copyright
    © 2024 Nucleate Podcast
  • Show Website
    Nucleate Podcast

You Might Also Like