When Science Finds a Way

Wellcome

Science is always adding to our knowledge of health, but how do ideas become breakthroughs, and how can those breakthroughs bring about a better world? Could mosquitos help prevent disease? Will AI tools transform mental healthcare? How is a once-ignored drug now being used to save lives? And what can science do to keep us healthy as we age? Join botanist-turned-Hollywood actor Alisha Wainwright as she meets the scientists, innovators, and communities working together to solve our biggest health challenges. **** We want to hear from you! Our podcast is shaped by the people who listen to it. Please tell us a bit about your experience by filling out our short listener survey: https://www.surveymonkey.com/r/SX6X8X3 **** Brought to you by Wellcome, an independent global foundation that supports science to solve the urgent health challenges facing everyone. Please visit wellcome.org for more information.

  1. How can we respond to extreme heat and its effect on mental health?​

    8H AGO

    How can we respond to extreme heat and its effect on mental health?​

    We want to hear from you! Please tell us a bit about your experience by filling out our short listener survey. Everyone who completes it is entered into a draw for a £50 gift card. 👉  https://www.surveymonkey.com/r/SX6X8X3?source=shownotes Closes 28 May.  *** We know how extreme heat impacts us physically, but science is still uncovering its effects on mental health.  Professor Andrea Mechelli tells Alisha Wainwright what analysing millions of datapoints is teaching us, we hear from participants in his London-based research about their struggles with heat and mental health, and Mete Çoban, London's Deputy Mayor for Environment and Energy, talks about efforts to future-proof the city.    Looking beyond London, Dr Benedict Weobong explains why his research in Ghana and Zimbabwe shows that local context is crucial for dealing with heat-related mental health issues, and Alisha explores how reconnecting with nature - and each other - could also help us tackle the causes of rising heat.  *** Mentioned in this episode and further reading:    'People who live near green space are less likely to struggle with mental health issues' - Professor Andrea Mechelli (https://www.theguardian.com/science/article/2024/may/19/andrea-mechelli-urban-mind-green-space-mental-health)  The effects of extreme heat events on mental health in vulnerable urban communities: towards evidence-based policy and practice (https://www.kcl.ac.uk/research/the-effects-of-extreme-heat-events-on-mental-health-in-vulnerable-urban-communities-towards-evidence-based-policy-and-practice)  Urban Mind – an app that measures your experience of urban & rural living in the moment (https://urbanmind.info/)   Heat Exposure, Sleep, Cognition and Mental Health - HEATSCAPE-Africa (https://www.yorku.ca/dighr/project/heatscape-africa/)

    47 min
  2. Why was a life saving drug overlooked for half a century?

    APR 29

    Why was a life saving drug overlooked for half a century?

    Tranexamic acid (TXA) has enormous potential to prevent deaths from postpartum haemorrhage, but until very recently it's been overlooked. Professor Haleema Shakur Still tells Alisha Wainwright how she stumbled on TXA's untapped potential, and the drug's journey from being an undervalued discovery in post-war Japan to a groundbreaking treatment in modern-day Nigeria. Professor Nike Bellow and Dr Abiola Akiyode-Afolabi share their efforts to make TXA more accessible to communities, while Haleema explains how drug trials have revealed a hidden side to postpartum haemorrhage – one that could prevent cases before treatment is even needed.  **** We want to hear from you! Please tell us a bit about your experience by filling out our short listener survey. Everyone who completes it is entered into a draw for a £50 gift card. 👉 https://www.surveymonkey.com/r/SX6X8X3?source=shownotes Closes 28 May.  **** Mentioned in this episode and further reading:  WOMAN trials: looking at the effect of the drug tranexamic acid (TXA) on bleeding, and the best ways to give it (https://thebloodtrials.org/womens-health-trials/)  The missing evidence: anaemia, postpartum bleeding and maternal death, Blood Trials, LSHTM (https://thebloodtrials.org/the-missing-evidence/)  A word of thanks to all the WOMAN Trial collaborators, Professor Ian Roberts, who co-led the WOMAN Trials alongside Haleema, trial teams in London, Nigeria, Pakistan, Tanzania and Zambia and the women and families who make this work possible.

    41 min
  3. What happens when fungi find their way into our brains?

    APR 22

    What happens when fungi find their way into our brains?

    We want to hear from you!  Please tell us a bit about your experience by filling out our short listener survey. Everyone who completes it is entered into a draw for a £50 gift card. 👉 https://www.surveymonkey.com/r/SX6X8X3?source=shownotes Closes 28 May.  *** It might sound like something out of TV shows like The Last of Us, but brain-invading fungi are a real-world problem. Alisha Wainwright speaks to Drs. Rachael Dangarembizi and Rebecca Drummond, an immunologist and a neuroscientist collaborating across continents to tackle Cryptococcal Meningitis – the leading cause of fungal death worldwide. Dr Kyla Murphy also talks about the new tests and treatments saving lives from the disease, and Alisha shares the story of her own mother's brush with a dangerous fungal infection.  **** Mentioned in this episode and further reading:  Will climate change lead to more fungal infections? An explainer by Wellcome (wellcome.org/insights/articles/will-climate-change-lead-more-fungal-infections)  Wellcome Fungal Adaptation Call Awardees (wellcome.org/research-funding/funding-portfolio/funded-grants?f%5B0%5D=funding_scheme_grants_awarded%3ABiology%20of%20fungal%20adaptation  Global incidence and mortality of severe fungal disease, David W Denning, The Lancet Infectious Diseases (thelancet.com/journals/laninf/article/PIIS1473-3099(23)00692-8/fulltext)  The WHO fungal priority pathogens list as a gamechanger, Matthew C. Fisher & David W. Denning, Nature Reviews Microbiology (nature.com/articles/s41579-023-00861-x#citeas)  How fungi shape our world...and how the climate is shaping our fungi – The Naked Scientist Podcast in partnership with Wellcome (thenakedscientists.com/podcasts/naked-scientists-podcast/how-fungi-shape-our-world)  When Science Finds a Way is brought to you by Wellcome, an independent global foundation that supports science to solve the urgent health challenges facing everyone. For more information and podcast transcripts visit wellcome.org/podcast

    44 min
  4. AI and mental health: can we trust AI therapy?

    APR 15

    AI and mental health: can we trust AI therapy?

    We want to hear from you!  Please tell us a bit about your experience by filling out our short listener survey. Everyone who completes it is entered into a draw for a £50 gift card. 👉 https://www.surveymonkey.com/r/SX6X8X3?source=shownotes Closes 28 May.    ***   AI chatbots and apps are increasingly being used for mental health support. But could these new tools carry hidden risks?   In the second part of this special episode, Alisha Wainwright unpicks her own experiments with AI therapy, takes tips from Dr John Torous on staying safe when seeking help digitally, and hears about the risks of unregulated tools.    But there's hope with these tools too. Professor Miranda Wolpert reveals how AI could help scale mental health interventions in the globally and even inspire whole new forms of therapy.  **** Mentioned in this episode and further reading: AI and mental health: "it could help revolutionise treatments" - Miranda Wolpert, Director of Mental Health, Wellcome  (https://wellcome.org/insights/articles/ai-and-mental-health-help-revolutionise-treatments) Generating evidence for AI in health (EVAH) (https://wellcome.org/insights/articles/evah-new-initiative-generate-evidence-ai-health)   When Science Finds a Way is brought to you by Wellcome, an independent global foundation that supports science to solve the urgent health challenges facing everyone. For more information and podcast transcripts visit wellcome.org/podcast

    45 min
  5. AI and mental health: could AI transform access to care?

    APR 8

    AI and mental health: could AI transform access to care?

    We want to hear from you!  Please tell us a bit about your experience by filling out our short listener survey. Everyone who completes it is entered into a draw for a £50 gift card. 👉 https://www.surveymonkey.com/r/SX6X8X3?source=shownotes Closes 28 May.  *** Launching season 4 with a special two-part episode, Alisha Wainwright explores the potential revolution AI is sparking in mental healthcare, and how our phones could play a part.  Digital psychiatry specialist Dr John Torous explains how AI trained on data from our devices could help us diagnose people with mental health conditions, but that's only the beginning.  We hear from clinical psychiatrist Dr Andrea Cipriani about how AI could optimise patients' prescriptions. And digital mental health expert Dr Jana Alagarajah explains why innovation in the Global South could shape future care for the rest of the world. **** Mentioned in this episode + further reading: PETRUSHKA (Personalise anti depressant treatment for unipolar depression combining individual choices, risks and big data) - www.psych.ox.ac.uk/evidence-based-mental-health/petrushka-trial Trial finds that AI tool could transform antidepressant prescribing -  National Institute for Health and Care Research (NIHR) Oxford Health Biomedical Research Centre When Science Finds a Way is brought to you by Wellcome, an independent global foundation that supports science to solve the urgent health challenges facing everyone. For more information and podcast transcripts visit wellcome.org/podcast

    39 min
4.8
out of 5
45 Ratings

About

Science is always adding to our knowledge of health, but how do ideas become breakthroughs, and how can those breakthroughs bring about a better world? Could mosquitos help prevent disease? Will AI tools transform mental healthcare? How is a once-ignored drug now being used to save lives? And what can science do to keep us healthy as we age? Join botanist-turned-Hollywood actor Alisha Wainwright as she meets the scientists, innovators, and communities working together to solve our biggest health challenges. **** We want to hear from you! Our podcast is shaped by the people who listen to it. Please tell us a bit about your experience by filling out our short listener survey: https://www.surveymonkey.com/r/SX6X8X3 **** Brought to you by Wellcome, an independent global foundation that supports science to solve the urgent health challenges facing everyone. Please visit wellcome.org for more information.

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