The Lead Podcast presented by Heart Rhythm Society

The Lead Podcast presented by Heart Rhythm Society
  • 5.0 (7)
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The Lead – a weekly journal review podcast that is designed to keep you up to date and informed on the latest publications and hottest topics in electrophysiology. Key takeaways, in-depth interpretations, and informative interviews are all fitted into 15 minute time slots, so that they fit easily into your busy schedule. Click the link below to learn more!

  1. 3d ago

    The Lead Episode 168: A Discussion of Weight Loss in Older Patients With Persistent Atrial Fibrillation, The LOSE-AF Randomized Clinical Trial

    Description: In this episode of The Lead, host Jenelle Dziano, PhD candidate, is joined by Roopinder Sandu, MD, MPH, FHRS and Louise Segan, MBBS, MPH, PhD to discuss the journal article, Weight Loss in Older Patients With Persistent Atrial Fibrillation, The LOSE-AF Randomized Clinical Trial. Together, they review the findings of the LOSE-AF randomized clinical trial examining weight loss in older patients with persistent atrial fibrillation. Learning Objectives Review the key findings of the LOSE-AF randomized clinical trial examining weight loss in older patients with persistent atrial fibrillation. Discuss the role of weight loss in the management of older patients with persistent atrial fibrillation. Examine the clinical implications of the study findings for patients with persistent atrial fibrillation. Host: Jenelle Dziano, PhD candidate   Guests: Roopinder Sandu, MD, MPH, FHRS and Louise Segan, MBBS, MPH, PhD   Disclosures: J. Dziano No relevant disclosures R. Sandu No relevant disclosures L. Segan No relevant disclosures

  2. Sep 3

    The Lead Episode 167: A Discussion of The Long-Term Outcomes of Left Bundle-Branch Pacing vs Biventricular Pacing in Heart Failure (The HeartSync-LBBP Randomized Clinical Trial)

    In this episode of The Lead, host Deepak Pasupula, MD, MPH, FHRS, is joined by Zaniar Ghazizadeh, MD, and Pugazhendhi Vijayaraman, MD, FHRS, to discuss the journal article, The Long-Term Outcomes of Left Bundle-Branch Pacing vs Biventricular Pacing in Heart Failure (The HeartSync-LBBP Randomized Clinical Trial). Together, they review the long-term outcomes of left bundle-branch pacing compared with biventricular pacing in patients with heart failure and discuss the findings of the HeartSync-LBBP randomized clinical trial. Learning Objectives Review the long-term outcomes of left bundle-branch pacing compared with biventricular pacing in patients with heart failure. Discuss the findings of the HeartSync-LBBP randomized clinical trial. Examine the clinical implications of comparing left bundle-branch pacing with biventricular pacing in heart failure. Host: Deepak Pasupula, MD, MPH, FHRS   Guests: Zaniar Ghazizadeh, MD and Pugazhendhi Vijayaraman, MD, FHRS   Disclosures: D. Pasupula No relevant disclosures   Z. Ghazizadeh No relevant disclosures   P. Vijayaraman Honoraria/Speaking/Consulting Fee: Biotronik, Boston Scientific, Abbott, Medtronic Research: Medtronic Fellowship Support: Medtronic

  3. Aug 27

    The Lead Episode 166: A Discussion of Relationship Between Time-to-First Atrial Tachyarrhythmia Recurrence and Atrial Fibrillation Burden: Implications for Trial Design

    In this episode of The Lead recorded at EHRA, host Christopher Kowalewski, MD, is joined by Tina Baykaner, MD, MPH, and Sanjiv M. Narayan, MD, PhD, FHRS, to discuss the journal article, Relationship Between Time-to-First Atrial Tachyarrhythmia Recurrence and Atrial Fibrillation Burden: Implications for Trial Design. Together, they examine the relationship between time to first atrial tachyarrhythmia recurrence and atrial fibrillation burden and discuss the implications of these measures for clinical trial design. Learning Objectives Review the relationship between time-to-first atrial tachyarrhythmia recurrence and atrial fibrillation burden. Discuss how different measures of atrial fibrillation recurrence and burden may influence the interpretation of clinical trial outcomes. Examine the implications of atrial fibrillation burden and time-to-first recurrence for the design of future atrial fibrillation trials.   Host: Christopher Kowalewski, MD   Guests: Tina Baykaner, MD, MPH and Sanjiv M. Narayan, MD, PhD, FHRS   Disclosures:   C. Kowalewski No relevant disclosures   T. Baykaner Honoraria/Speaking/Consulting Fee: Volta Medical, Medtronic, Pacemate, Johnson & Johnson, Abbott Medical, Boston Scientific Research: NIH, Boston Scientific   S. Narayan Honoraria/Speaking/Consulting Fee: UpToDate, Inc, LifeSignals, Abbott Medical, TDK Inc. Research: National Institutes for Health Intellectual Property Rights: University of California Regents Stocks – Privately Held: Physcade

  4. Aug 20

    The Lead Episode 165: A Discussion of Left Atrial Appendage Closure or Medical Therapy in Atrial Fibrillation (The CLOSURE-AF Trial)

    In this episode of The Lead recorded at HRS2026, host Danesh Kella, MBBS, FHRS is joined by Jeffrey S. Healey, MD, FHRS and Fred M. Kusumoto, MD, FHRS to discuss the journal article, Left Atrial Appendage Closure or Medical Therapy in Atrial Fibrillation (The CLOSURE-AF Trial). Together, they review the study findings comparing left atrial appendage closure with medical therapy in patients with atrial fibrillation and discuss the potential implications for clinical practice. Learning Objectives Review the design and key findings of the CLOSURE-AF Trial comparing left atrial appendage closure with medical therapy in patients with atrial fibrillation. Discuss the comparative considerations of left atrial appendage closure and medical therapy for the management of atrial fibrillation. Examine the potential clinical implications of the CLOSURE-AF Trial for treatment decision-making in patients with atrial fibrillation.   Host: Danesh Kella, MBBS, FHRS Guests: Jeffrey S. Healey, MD, FHRS and Fred M. Kusumoto, MD, FHRS   Disclosures: D. Kella Honoraria/Speaking/Consulting Fee: Zoll Medical Corporation, MBW Spectrum   J. Healey Honoraria/Speaking/Consulting Fee: Boston Scientific, Servier Research: Pfizer, Boston Scientific, Medtronic, Inc. Speakers' Bureau: Bristol-Myers Squibb   F. Kusumoto No relevant disclosures

  5. Aug 13

    The Lead Episode 164: A Discussion of Digital Twin–Guided Ablation for Ventricular Tachycardia

    Recorded at HRS2026, this episode of The Lead features host Christopher Kowalewski, MD, in conversation with Junaid A.B. Zaman, MA, MD, PhD, CCDS, and Patrick Boyle, BS, PhD, FHRS, about the journal article, Digital Twin–Guided Ablation for Ventricular Tachycardia. Together, they discuss the study's findings and explore the use of digital twin technology to guide ventricular tachycardia ablation and its potential implications for clinical electrophysiology. Learning Objectives Review the design and key findings of the study evaluating digital twin–guided ablation for ventricular tachycardia. Discuss the use of digital twin technology as a tool to guide ventricular tachycardia ablation. Explore the potential clinical implications of digital twin–guided ablation for the management of ventricular tachycardia. Host: Christopher Kowalewski, MD   Guests: Junaid A.B. Zaman, MA, MD, PhD, CCDS  Patrick Boyle, BS, PhD, FHRS    Disclosures: C. Kowalewski No relevant disclosures   J Zaman Honoraria/Speaking/Consulting Fee: Acutus Medical Inc., Johnson and Johnson, American Medical Association, American College of Physicians, Bylis Medical Company Office/Trustee/Director/Other Fiduciary Role: Society of Bedside Medicine Travel/Entertainment: Boston Scientific   P Boyle Research: Seattle Foundation, Catherine Holmes Wilkins Charitable Foundation, NIH/NHLBI, American Heart Association Other Non-Financial Relationship: Cardiovascular Engineering and Technology Office/Trustee/Director/Other Fiduciary Role: The Cardiac Electrophysiology Society

  6. Aug 6

    The Lead Episode 163: A Discussion of Conduction System vs Biventricular Pacing in Heart Failure, The PhysioSync-HF Randomized Clinical Trial

    Recorded at EHRA 2026, this episode of The Lead features host Melissa Middeldorp, MPH, PhD, FHRS, in conversation with Sana Al-Khatib, MD, MHS, FHRS, and Wei Hua, MD, FHRS, about the journal article, Conduction System vs Biventricular Pacing in Heart Failure: The PhysioSync-HF Randomized Clinical Trial. Together, they discuss the findings of the PhysioSync-HF randomized clinical trial, comparing conduction system pacing with biventricular pacing in patients with heart failure and exploring the potential implications for clinical practice.   Learning Objectives: Review the design and key findings of the PhysioSync-HF randomized clinical trial comparing conduction system pacing and biventricular pacing in patients with heart failure. Discuss the differences between conduction system pacing and biventricular pacing as evaluated in the PhysioSync-HF trial. Examine the potential clinical implications of the trial findings for pacing strategies in patients with heart failure.   Host: Melissa Middeldorp, MPH, PhD, FHRS Guests: Sana Al-Khatib, MD, MHS, FHRS and Wei Hua, MD, FHRS   Disclosures: M. Middeldorp ·      No relevant disclosures   S. Al-Khatib ·      Other Financial Relationship: American Heart Association   W. Hua ·      No relevant disclosures

  7. Jul 30

    The Lead Episode 162: A Discussion of Atrial Fibrillation Screening According to Genetic Risk: A Secondary Analysis of the Randomized LOOP Study

    In this episode of The Lead, host Tina Baykaner, MD, MPH, is joined by Christopher Kowalewski, MD, and Marco Perez, MD, to discuss the journal article, Atrial Fibrillation Screening According to Genetic Risk: A Secondary Analysis of the Randomized LOOP Study. Together, they review findings from this secondary analysis of the LOOP Study and explore the relationship between genetic risk and atrial fibrillation screening. Learning Objectives Review the key findings from the secondary analysis of the randomized LOOP Study examining atrial fibrillation screening according to genetic risk. Discuss the relationship between genetic risk and atrial fibrillation screening as evaluated in the study. Explore the potential implications of incorporating genetic risk into atrial fibrillation screening strategies.   Host: Tina Baykaner, MD, MPH Guests: Christopher Kowalewski, MD and Marco Perez, MD   Disclosures: T. Baykaner Honoraria/Speaking/Consulting Fee: Volta Medical, Medtronic, Pacemate, Johnson & Johnson, Abbott Medical, Boston Scientific Research: NIH, Boston Scientific   C. Kowalewski No relevant disclosures   M. Perez Ownership/Partnership/Principal: QALY Honoraria/Speaking/Consulting Fee: Boston Scientific, Biotronik Research: Apple, Inc. Other/Stock Options Privately Held

  8. Jul 23

    The Lead Episode 161: A Discussion of 20 Years: Clinical Outcome After Pulmonary Vein Isolation in Patients With Symptomatic Drug-Refractory Paroxysmal Atrial Fibrillation

    Recorded at EHRA 2026, this episode of The Lead features host Christopher Kowalewski, MD, in conversation with Christian Sohns, MD, and Pierre Jaïs, MD, about the journal article, 20 Years: Clinical Outcome After Pulmonary Vein Isolation in Patients With Symptomatic Drug-Refractory Paroxysmal Atrial Fibrillation. Together, they discuss the study's long-term clinical outcomes following pulmonary vein isolation in patients with symptomatic drug-refractory paroxysmal atrial fibrillation and explore the implications of two decades of follow-up.   Learning Objectives: Review the long-term clinical outcomes reported after pulmonary vein isolation in patients with symptomatic drug-refractory paroxysmal atrial fibrillation. Discuss the implications of 20-year follow-up data for the treatment of patients undergoing pulmonary vein isolation. Examine how long-term outcome data may inform clinical decision-making for catheter ablation in paroxysmal atrial fibrillation.   Host: Christopher Kowalewski, MD   Guests: Christian Sohns, MD and Pierre Jaïs, MD   Disclosures: C. Kowalewski No relevant disclosures   C. Sohns No relevant disclosures   P. Jaïs Ownership/Partnership/Prinicipal: inHEART Honoraria/Speaking/Consulting Fee: Biosense Webster, Inc., Boston Scientific, Medtronic

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About

The Lead – a weekly journal review podcast that is designed to keep you up to date and informed on the latest publications and hottest topics in electrophysiology. Key takeaways, in-depth interpretations, and informative interviews are all fitted into 15 minute time slots, so that they fit easily into your busy schedule. Click the link below to learn more!

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