Sugar Crush: And Now, The Rest of the Story...

Richard Jacoby
  • 5.0 (9)
  • Medicine
  • Weekly

Do you want to get unglued? Do you have chronic illness, consume too much sugar, or think you're addicted.... Do you think you can trust everything you read from the medical industry? Then this is the show for you. Welcome to.... Sugar Crush: And Now, The Rest of the Story... Join Dr. Rick Jacoby, author of the best-selling book, Sugar Crush, and the upcoming book Unglued... as he has conversations with the leading authorities about topics ranging from: Autism... to Alzheimer’s.... and everything in between. Come along and see how Stem cells are leading the way to dissolve the effects of sugar... allowing you to get UNGLUED. Follow along on Apple Podcasts, Spotify or wherever you listen to your podcasts.

  1. 11h ago

    The Body’s Hidden Messages: Peptides, Stem Cells & the Proof Gap

    What if understanding how the body communicates could change how we approach healing? Dr. Jacoby explores the world of cellular signaling, connecting Pavlov’s experiments to peptides, nerve function, and the possibilities of regenerative medicine. From BPC-157 and GLP-1s to Wharton’s jelly, Muse cells, and exosomes, Jacoby shares the questions and personal experiences driving his interest in the field. Alongside his AI conversation partner Chat, he examines the gap between promising anecdotes and clinical evidence, debates FDA oversight and pharmaceutical influence, and makes the case for a registry tracking every outcome—good, bad, or unchanged. A spirited conversation about scientific curiosity, patient experiences, and what it takes to turn a promising idea into a proven treatment. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

  2. Oct 27

    Lost Signals: Muse Cells and the Nerve Repair Riddle

    What happens when a nerve loses its signal—and what would it take to restore it? Dr. Rick Jacoby explores that question through decades of surgical experience, the history of stem cell research, and the emerging study of Muse cells. In this episode, Dr. Jacoby connects nerve compression, sugar-related tissue changes, blood flow, and electrical signaling. He examines how Muse cells respond to injury signals, how living cells differ from exosomes, and why repairing a nerve’s environment may matter alongside relieving compression. Along the way, he revisits the researchers who shaped his thinking and presents his global compression theory as a hypothesis that needs testing. It’s an exploration of scientific possibilities, unanswered questions, and the distinction between promising research and proven treatments. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

  3. Oct 20

    The Body’s SOS: Can Repair Cells Solve the Riddle of ALS and MS?

    What if sending repair cells to an injury is only half the challenge - and the environment they arrive in matters just as much? Dr. Rick Jacoby joins his AI assistant, Chat, for a thought-provoking episode of Sugar Crush, connecting a mysterious discovery in 1884 to today’s research into cellular signaling and regenerative medicine. At the center of the conversation are MUSE cells: stress-tolerant cells being studied for their ability to respond to injury signals. Through his “estuary” metaphor, Dr. Jacoby explores how blood flow, oxygen availability, mitochondrial function, inflammation, and metabolic health might influence the conditions surrounding damaged nerves. The discussion examines ALS and MS, distinguishes their disease processes, and puts his theories about sugar, trauma, and nerve compression up against the limits of current evidence. Along the way, an imagined scientific roundtable brings historical discoveries into conversation with modern research—and asks what meaningful progress should look like for patients. An exploration of promising questions, unproven connections, and the difference between cells reaching an injury and delivering measurable repair. MUSE cells remain investigational, with no established cure for ALS or MS. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

  4. Sep 29

    The Food Fight: Carnivore, Plant-Based, and What’s Really on Our Plates

    Is the answer to better health less meat, fewer carbs, or less processed food? Dr. Rick Jacoby invites Chat to an “intermezzo” table for a spirited discussion of competing nutrition ideas. They examine red meat and diabetes research, ancestral diets, fermented foods, and the rise of ultra-processed products. The conversation also turns to GLP-1 medications: what they do, what they don’t do, and why the food choices behind appetite and satisfaction still deserve attention. It’s a lively episode about asking better questions amid conflicting nutrition advice. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

  5. Sep 22

    The Electric Estuary: Where Blood Flow, Metabolism, and Disease Collide

    What if disease isn’t driven by chemistry alone? Could blood flow, nerve compression, cellular metabolism, and electrical signaling all be connected? In this episode of Sugar Crush, Dr. Rick Jacoby revisits a remarkable surgical moment in which decompressing a damaged nerve restored its electrical response so dramatically that the patient’s leg lifted from the operating table. That “Frankenstein moment” helped inspire his estuary hypothesis: the idea that impaired circulation and nerve compression may create a stagnant biological environment where oxygen, chemistry, and electrical signaling fall out of balance. Joined by an AI assistant, Dr. Jacoby brings the ideas of A. Lee Dellon, Otto Warburg, Robert Becker, Thomas Seyfried, Michael Levin, and other pioneering thinkers to one table. Together, their work raises provocative questions about neuropathy, mitochondrial metabolism, bioelectricity, regenerative medicine, and the environments in which chronic diseases develop. Where does established science end and a new hypothesis begin? Dr. Jacoby proposes moving from metaphor to measurement by tracking blood flow, nerve activity, oxygenation, metabolic markers, and cellular signaling before and after intervention. It’s an ambitious conversation about challenging conventional thinking, connecting disciplines, and developing testable questions that could help shape the future of medicine. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    The Electric Estuary: Where Blood Flow, Metabolism, and Disease Collide

  6. Sep 15

    The Estuary Effect: Where Sugar, Electricity & Disease Collide

    What if you could put some of history’s greatest scientific minds around one table—and ask them what modern medicine might still be missing? On this fascinating episode of Sugar Crush: The Rest of the Story, Dr. Rick Jacoby takes an unconventional trip through medical history, imagining an “intermezzo” with Benjamin Franklin, Nikola Tesla, Robert Becker, Otto Warburg, Thomas Seyfried, and other pioneering thinkers to explore one provocative question: What happens when metabolic stress, impaired flow, nerve dysfunction, and the body’s electrical signaling intersect?  At the center of the conversation is Dr. Jacoby’s developing “estuary” hypothesis—his idea that areas downstream from compression or impaired physiological flow may develop an altered local environment, much like polluted water collecting at the end of a river. Could sugar-driven glycation, hypoxia, changes in pH, impaired circulation, and electrical signaling help create conditions associated with chronic disease? And, importantly, how could that hypothesis actually be tested?  The discussion moves from Franklin’s experiments with electricity to Becker’s work on the body’s electrical properties, Warburg and cancer metabolism, nerve compression, regenerative signaling, nitric oxide, biomarkers, and the possibility of moving promising observations from anecdote to measurable mechanism.  It’s a different kind of Sugar Crush—part history, part thought experiment, and part scientific challenge—with one principle keeping everyone at the imaginary table honest: Don’t just tell the story. Measure it. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

  7. Sep 8

    The Dead Zone: Parasites, Pericytes & the Mystery of the Nerve

    What if some of the biggest mysteries surrounding nerve damage and neurodegenerative disease could be better understood by looking at an estuary? In this episode of Sugar Crush, Dr. Rick Jacoby brings AI back into the conversation as he dives deeper into his “estuary” metaphor—an environment where oxygen, blood flow, sugar, inflammation, and cellular function collide. From the origins of the word parasite to the very different role of pericytes, Dr. Jacoby explores his theory about what may be happening in the vulnerable transition zones of our nervous system. Could excess sugar and impaired circulation create a biological “dead zone” where unwanted organisms thrive and healthy nerve function begins to break down? And could pericytes, stem-cell science, improved blood flow, and regenerative medicine offer clues to reversing that process? The conversation ventures into peripheral neuropathy, the vagus nerve, MS, ALS, Lyme disease, trauma, glycation, hypoxia, and the potential relationship between diet and nerve degeneration—all through the lens of Dr. Jacoby's evolving Global Compression Theory. It's a provocative exploration of established biology, emerging research, and Dr. Jacoby's own hypotheses about one central question: What if changing the environment around the nerve changes the disease itself? The parasite takes. The pericyte repairs. And somewhere between the two may be an important clue to understanding the nervous system. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    The Dead Zone: Parasites, Pericytes & the Mystery of the Nerve

  8. Sep 1

    The NFL Brain Crisis: Is Sugar the Missing Link?

    Football’s connection to repetitive head trauma is well documented - but what if the hits themselves are only part of the story? On this episode of Sugar Crush, Dr. Rick Jacoby takes on the growing concerns surrounding chronic brain injury, CTE, ALS, and former NFL players through the lens of his Global Compression Theory and an idea he has been exploring for more than two decades: “Trauma + Sugar = Nerve Dysfunction.” Dr. Jacoby examines whether metabolic stress—including glycation, inflammation, vascular dysfunction, and impaired nitric oxide biology—could potentially influence how nerves respond to repeated physical trauma. The conversation travels from the football field to the microscopic anatomy of nerves, exploring Schwann cells, oligodendrocytes, the Obersteiner-Redlich transition zone, and the tightly packed cranial nerves at the base of the skull. The discussion also explores the significantly elevated incidence of ALS reported among former NFL players and asks an important question: Could metabolic health be an overlooked variable in understanding why some athletes develop devastating neurological disease? From carpal tunnel and diabetic neuropathy to ALS, atrial fibrillation, regenerative medicine, and stem-cell research, Dr. Jacoby lays out his argument that seemingly unrelated conditions may share common biological mechanisms—and explains why he believes medicine should be looking more closely at the intersection of trauma, metabolism, nerve compression, and repair. It’s a provocative exploration of what we know, what remains unproven, and where the next generation of neurological research might need to look. Could protecting the brain begin with understanding what happens to the nerves before, during, and after the hit? See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

    The NFL Brain Crisis: Is Sugar the Missing Link?
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About

Do you want to get unglued? Do you have chronic illness, consume too much sugar, or think you're addicted.... Do you think you can trust everything you read from the medical industry? Then this is the show for you. Welcome to.... Sugar Crush: And Now, The Rest of the Story... Join Dr. Rick Jacoby, author of the best-selling book, Sugar Crush, and the upcoming book Unglued... as he has conversations with the leading authorities about topics ranging from: Autism... to Alzheimer’s.... and everything in between. Come along and see how Stem cells are leading the way to dissolve the effects of sugar... allowing you to get UNGLUED. Follow along on Apple Podcasts, Spotify or wherever you listen to your podcasts.

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