Aging Reversing Blueprint Podcast

Dr Joel Rosen
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  • ALTERNATIVE HEALTH
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Age Reversing Tips For The Modern Day Men and Women, Search For The Fountain Of Youth That Resides In Their Own Bodies, So That They Can Be The Best Version Of Their Selves.

  1. 06/19/2024

    [EP.17]Mastering Your Genetic Code for Optimal Health: Dr. Bob Miller’s Latest Insights

    Dr. Joel Rosen:I would like to welcome Bayou Ck. I believe this is our third interview with Bob. Yeah, he is a traditional naturopath specializing in the field of genetics-specific nutrition. Bob is also an educator. He lectures nationally and internationally at seminars to educate health practitioners about genetic variants and nutritional supplementation for obtaining optimal health. Bob is also a researcher. He’s expanding his genetic research efforts. He founded and personally funded the NutriGenetic Research Institute to study the relationship between genetic variants and presenting symptoms. He’s also a nutritional supplement formulator and a genetic analysis software creator. Bob here is going to help us learn about cracking the code. So, Bob, welcome once again to another edition of helping people get their health back. Dr. Bob Miller:Oh, it was a pleasure to be with you. It’s um, I always enjoy these interviews because we’ve, we always have a good time, we kind of geek out a little bit on some of the deep dives on biochemistry, and it was a lot of fun. So yeah, do the same thing today. Dr. Joel Rosen:Excellent. So okay, so Bob, go ahead and share your screen and give our listeners what’s the latest and greatest, in what you’re researching. Dr. Bob Miller:Already? Well, our subject today is going to be superoxide. Now, you know, the traditional naturopathic philosophy has always been that most problems we see come from inflammation, from excess free radicals. We’ve been on that path for all of our time working: what is creating extra free radicals, and then what is causing us to not be able to break those free radicals down. Now, on the other hand, free radicals are bad if they’re in excess, but they can be our friend. One of my favorite sayings has been, you know, they can be your friend unless they’re not. So we need free radicals to kill viruses and bacteria. And even if we have bad cells inside the body, we need inflammation to kill them. But on the other hand, if it goes to the extreme, that’s when we have a problem. So we tend to villainize free radicals, and rightfully so. But on the other hand, we have to be careful that we don’t eradicate all free radicals, that they do play a role for us. Our subject again is superoxide. And again, we always mention that we’re not treating any disease here. This is for educational purposes only and informational. So our learning objectives today are what superoxides, and random superoxide, and then we’re going to delve into how excess superoxide impacts. We’re going to look at pathways of how we make superoxide and pathways of how we reduce it. And then we’re going to dig into something called ferroptosis, where superoxide causes iron to do some really bad things. So, you’ll see here it’s all about balance. Superoxide plays a role in the body at times, but in excess, it can cause all kinds of problems for us. Now, this little chart here that you see. You’ll see on the left there it says oxygen o2 and unfortunately, that too got knocked off. But as you know, oxygen is o2. So what you’re seeing and by the way, do you see my little love? Okay, good. So the oxygen is two oxygen atoms, and you see these two little dots there. That’s electrons. So we all remember even from high school that, you know, you’ve got the neutron-proton and the electron, and they need to be paired. So here’s two together, here’s two together, here’s two together, they’re all paired up. This superoxide occurs when an extra electron comes on here that shouldn’t be there, and that makes it very unstable. And I’m going to show you in a little bit why this can be the root cause of a lot of our problems. Now, the body is pretty amazing. There are multiple ways here, but I’m going to show you one of the main ways. There’s an enzyme called superoxide dismutase. Number two, so this is superoxide. Dismutase means to break it down. And it takes the mineral manganese, not magnesium, manganese. And I’ll show you a better chart later, but it turns it into oxygen. But it also turns it into hydrogen peroxide. And hydrogen peroxide again, is not all bad. Sometimes we use hydrogen peroxide to kill pathogens. But if we have too much of it and we have dysregulated iron, we’ll make what are called hydroxyl radicals that damage the DNA and just wreak havoc throughout the body. However, we do have other mechanisms. If we have enough catalase, that’ll turn that hydrogen peroxide into water and oxygen. And there’s something called glutathione that we’ll dig into a little bit later. And there’s an enzyme called glutathione peroxidase that takes that glutathione and turns it into two water molecules. So there’s a lot that can go wrong here; we can overproduce superoxide. We’re going to show you how you can have less than optimal production, less than optimal catalase glutathione, where you can have iron dysregulation. So this is a rather complex, sometimes we call it Joel, the 3d chess game played underwater, multiple factors going together. And I believe in the past, we’ve done live on podcasts on iron, haven’t we? Dr. Joel Rosen:Yeah, what I’ll do, Bob is I’ll put a link to those two other podcasts that we’ve done so the listeners can go deep dive deep into there, but yes, we’ve talked about that as well. And I Dr. Bob Miller:believe we did we do a podcast on Lyme disease? No, Dr. Joel Rosen:I don’t think we did. We talked about it at some level, I think we did G six PD. Right. And I think we also did just NADPH Dr. Bob Miller: Right. Right. Okay, so this is the crux of what we’re going to be talking about today. Now, I’d like to introduce you to a biochemist named Erwin Friedovitch. He went to Duke University as a student and then returned as a biochemist. He was there for a total of 60 years. If anyone you know, a researcher, goes on PubMed, this name will come up quite often because he published more than 500 academic papers that have been cited more than 51,000 times. When you look at a lot of research papers today, they refer to who did the work, and you’ll see this name come up. One of his papers was published in the Journal of Biological Chemistry all the way back in 1969 and has been cited 9,300 times. Now, here’s this gentleman at the age of 85, back in 2014, still lecturing. By the way, Joel, I’d like to still be able to lecture at 85. We’ll see if I can do that. He identified the two forms of superoxide dismutase. That’s what breaks down superoxide. There’s one that’s based on copper and zinc and another one on manganese. Our topic today is going to be the manganese one. He proposed the superoxide theory, that superoxide is the origin—the beginning of most reactive oxygen species, which is inflammation. It undergoes a chain reaction in a cell, playing a central role in that inflammation. That damages the cells and can lead to all kinds of things—Alzheimer’s, Parkinson’s, ALS, all kinds of things. I’m going to show a couple of slides of things related to excess superoxide. He said superoxide is the major factor in oxygen toxicity. Inside your mitochondria, as you all know, you’re made up of 60 to 100 trillion cells—amazing. There are mitochondria in there that make energy, and manganese superoxide dismutase is what degrades superoxide. Manganese is a mineral, not magnesium, manganese. It’s your essential defense against superoxide. So, how many people do you see that are just dead tired, and no matter what they do, no matter what kind of things they take for energy, they just can’t get on top of it? How many people do you see that are dead tired and can barely function, and no matter what you try, it doesn’t seem to work? How common is that in your practice? Dr. Joel Rosen:Yeah, I mean, I think everyone that we see comes in with a chief complaint of being exhausted and tired. They are the toughest of the tough, like you. They’ve been to so many other practitioners, and now they’re just throwing their hands up in the air. I think that what you’ve mentioned in the past is that one day we’ll look back at all of the environmental triggers we put in place and say, “Oops,” because we’ve created this perfect storm. But yes, I think probably everyone that we work with, to one extent or another, has had very little success and is completely exhausted and burnt out. Dr. Bob Miller: Absolutely. Now, I’m not going to say this is the case in every one of those who are, that would be a little too optimistic, but this is probably a factor in many of the people who are experiencing exhaustion. Now, let’s look at what this mitochondrial superoxide does—a key player in Alzheimer’s disease. So, this is a peer-reviewed study. For people who are not familiar, this is on PubMed, not somebody blathering on the internet. Our findings have reinforced the idea that mitochondrial superoxide plays a critical role in Alzheimer’s disease. That’s one of the things that people are so scared of. We were able to show that increasing the expression of the mitochondrial antioxidant, SOD2, prevents memory deficits and amyloid plaque deposition associated. Wow, that’s pretty astonishing there because that’s one of the things that seems to be on the rise. You know, people know that they’re going to leave this earth someday and they’re pretty much okay with that. What really scares them is if they don’t know who they are and there’s a burden to their family. That’s a real, that’s a real realistic fear. Right here is diabetic complications. Oxidative stress plays a pivotal role in the development of diabetes complications, both microvascular and cardiovascular. The metabolic abnormalities of diabetes cause mitochondrial superoxide overproduction in endothelial ce

  2. 05/01/2024

    [EP.16]Enzyme Secrets Unlocking the Key to a Longer, Healthier Life

    Dr. Joel Rosen:All right, so today I’m joined by Jeff Owen. He has been an ASD enzyme US retail private label practitioner educator trainer since 2021. He’s worked in the natural industry for over three decades and I’m really interested to know Ask him about his experiences. And he represented a number of large supplement supplement manufacturers. And I told Jeff before we get started, we’d want to hear about sort of The Good, the Bad, and the Ugly if he’s willing to tell us about all that. But without further ado, Jeff, thank you so much for being here today. Jeff Owen:Dr. Rosen, thank you so much for having me as your guest. I really feel privileged. Oh, good. Well, listen, Dr. Joel Rosen:I’ve had some guests in the past where their same position as you and I, and I’m always interested to hear about your experiences, and most importantly, what the listener can glean from that to help their own health journey and feel younger at heart and younger physically, mentally, emotionally. So Jeff, what tell me just give us sort of an overview of, why you got into this industry, you were telling me you have a sort of a unique background in your health journey. Jeff Owen:So in terms, in terms of the chronology, of how the company makes the enzyme and probiotic products, the raw materials themselves were made in Mumbai, India, and then they’re shipped to Chino, California, where there are four NS-certified manufacturing facilities, the first of which opened in 1985. And as you can imagine, what our company is committed to is rigorous rigorous testing. So the products are tested, tested, tested, and set at a GMP-certified facility. And then the fermentation, the extraction, the blending, the formulating all that is done at in Chino, California. And what I like about this company, Dr. Rosen is that they’re not trying to be all things to all people. In other words, this company, their, their, the mission of this company, is to be a pre-eminent science manufacturing company. And of course, the challenge for any company that’s involved with nutritional manufacturing, supply manufacturing, is to get the science, if you will, the pure science and apply it, you know, commercially, if you will, so that they’re linked together. And they were aligned. And I feel like of all the companies that I’ve had the opportunity to work with, in 30 plus years in the natural products industry, this company does it as well as anybody. Dr. Joel Rosen:Yeah, well, there, you said a lot there, which is, which is interesting. So a couple of things that I would want to touch upon is obviously enzymology. And that’s the purpose of our call today, and what that is and what enzymes are and how they differ from digestive purposes and systemic, like breaking down the purposes which we’ll get to in a second, I have seen that I’ve had another interview with the guests and talking about how some of these companies that were privately got sold to pharmaceutical companies and the concern with the I guess the goal of the company, does it change in terms of providing the best quality or are they trying to cut corners and get the cheapest product and make a higher profit. Also, the concern is that he did the other guests talked about how you get a trade-off, you can be darn sure that the the cleanliness of the lab and making sure that they are getting quality control in there is going to be top-notch, but at the same time is the products going to be top notch. So thank you for sharing your insight with your new company. Just before we get into the enzymes, and what they are one of the questions I like to ask guests is that we talk about supplements and the the purity of their products and the the emphasis that goes into the quality right from sourcing it themselves. I had the privilege of going through a lab and I liked that they teach this or they emphasize this to their sales reps because they need to know that their quality of the product that they’re representing is of the highest quality so that you feel good about what you’re promoting to other people. So with that being said, I had a chance to walk through a lab that is a supplement company that does the same thing or has the same emphasis. I guess the question to you Jeff is the they use the what’s the name of the just last off the top of my head but they will it is a way that they scan the products to fo photometry or how they Jeff Owen:Go to liquid chromatography or HPLC. Yes. Dr. Joel Rosen:So thank you. So maybe I’m sure they use that to tell our listeners what that is and how that’s able to discern the quality of the product with purities, or impurities if that’s being used or not, or also with another concern that I typically have is they’ll use a lot of flow through agents that will have some excipients in there that are told, Well, it’s not that much of a problem, or you shouldn’t worry about it, but in the reality is, if you’re taking a supplement over and over and over and over again, could it be more of a problem than something that’s just benign and not problematic? So sort of twofold question. Does the company use that? And how about excipients in the products Jeff Owen:in terms of the company’s, like you said, commitment to following you know, the highest, you know, regulatory analytical protocols. I, you know, I’ve been to the facility in Chino, California, on two occasions, I wish had, if I lived closer, obviously, I wouldn’t have more access to the facility, I would probably have more of an intimate, you know, knowledge about this, but what I can say is this, with respect to the in the analytical protocols, you know, that the company follows, they are always using the most advanced protocols, including high photo liquid chromatography. You know, enzymes are, are precision-based manufacturing, and it does take a real deep understanding, to make enzymes. The interesting thing is often, when you, you know if you’re a consumer and you’re in a health food store, trying to discern, you know, what is a high-quality enzyme supplement. One of the things like you said, you look at is not just the active ingredients, but the excipients that are used or flow agents, with ASP enzymes as much as possible. The formulas use minimal, minimal amounts of excipients or flow agents. So typically, if you’re looking at any one of our products, you know, one thing you will see, of course, is that the capsules themselves are made from vegetarian cellulose. And we use in some occasions, you know, just Manute really, the finished product is nearly undetectable. You know, flow agents such as, um, actually, we don’t eat at one time, I think we were using silicon dioxide, but we don’t use that anymore. In the last year, though, we did list it on the label. And because we want to be a transparent company, that we do use as a medium, you know, to grow the bacterium that makes the enzymes that we do use maltodextrin. But now that put them out of dextran that we use from wood is a corn source, but it is non-GMO. And the finished product of the resulting product, the amount of maltodextrin that’s in there is minute, minuscule, nearly undetectable. The interesting thing is that every company that is involved in the enzyme Manufacturing Practice has to use some type of a medium, a growth factor to make the bacterium. And when they don’t list it, it’s somewhat disingenuous. But this is something as a company that we made a decision, you know, make sure that the labels indicated that because we want to also be fully compliant with the law, the dietary supplement Health and Education Act. And of course, you know, like with anything else, you know, science, I would like to say it’s not dogmatic, it’s ever-changing. And we, as a company, always look to make, you know, changes. I’ll give you one other example, too. From a manufacturing perspective. Dr. Rosen, I think truly, truly distinguishes us. with ASD enzymes, we actually are the preeminent serrapeptase manufacturer, we manufacture 80% of serrapeptase. And we’ll maybe have the opportunity to talk about that later. But one of the things that we understand about serrapeptase enzyme is that it’s extremely hydrophilic and various, very susceptible to the low stomach acid environment. So when you take it the question is always how much ultimately are you absorbing through the small intestine through the small intestine? And we understand because it’s very, very sensitive nature, that you have to have some type of a protect, you know, protection. And it’s this, you know, series of ways to protect serrapeptase you could use you could use a moat. In, our case, we use an enteric coating, other companies might use micronized. Features, but, when you pick up a product of serrapeptase, and it’s and it doesn’t say that it’s enteric coated, it really is an open question of how much of it the body is actually utilizing absorbing. So in our case, we use a trademarked enteric coating that is free of phthalates, polymers acrylics, we actually spray the serrapeptase material, not the capsule itself, so that therefore you’re getting, you know, the full activity when it gets into the small intestine. then. And that’s important too, because obviously when people are taking an enzyme such as that, for a variety of health conditions, people want to obviously get the intended benefits associated with this. So that’s the thing that not trying to play that fast and loose with the manufacturing or trying to maybe give people a misleading impression that something, you know, maybe unsafe when the reality is that it is safe. Dr. Joel Rosen:Yeah, well, the liquid spectrometer, I think, is really important that I don’t know how many companies actually use it. But I think that it’s able to give you

    58 min

  3. 03/27/2024

    [EP.15]TOXIC SUPERFOODS  With Sally K Norton MPH

    Dr. Joel Rosen:Right Hello, everyone, and welcome back to another edition of the age-reversing blueprint podcast. And I’m excited to talk to our next guest. She is Sally Norton, who is an Ivy League nutritionist and author of her new book Toxic Superfoods How Opposite Overload Is Making You Sick, and How to Get Better. Today we will be talking about genetic testing oxalates and identifying foods that may be making you worse or better. And ultimately, in the overall clinical picture, Sally recovered from her health issues by lowering her oxygen intake and burden. And she’s here to talk to us about that today. So thank you so much for being here today, Sally. Sally K. Norton, MPH:Thanks for having me. You’re gonna enjoy it. Dr. Joel Rosen:So yeah, we were talking a little bit beforehand before we got started. And but I always like to ask my guests you know, tell us your story. Because your story is usually yours is why you’re doing what you’re doing. So maybe give us the listeners a little bit about what you’re dealing with I know, when you were younger you were planting a farmer. And you’re, I’ve heard some of the stuff that you’ve talked about in the past. So maybe take us through a cliff notes version of your health challenges. Sally K. Norton, MPH:Well, I got committed to learning about what I teach and what I’ve written about with the book. Because when I did finally figure out what had been dogging my health since I was a kid, particularly at age 12, but probably very much earlier in life. You know, I was 49, about to turn 50 When I figured this out. And, because in my career, I’ve worked in medical schools, multiple ones, and been in the public health field my entire life. And I had all these great connections with doctors who do integrative medicine, functional medicine, all the complementary and alternative therapists, I’ve seen them all, I’ve spent tons of money on it, and no one can help me. I couldn’t help myself, I have a degree from Cornell Nutrition and a public health degree from a major Institute here in the US. And nobody could help me. Despite my, you know, affluence of connections, and knowledge and information, I was ignorant, and we all were ignorant about what was messing up my health. And I realized that I couldn’t be the only person who was sick because of sweet potatoes, swiss chard, and healthy eating, which is ultimately what I found out, which is heartbreaking. Because yeah, I have this big organic garden. And a lifetime of being a goody two shoes at the dinner table, to you know, my siblings didn’t like that I was a bad example at the table who would eat her vegetables. You know, so it’s all worked against me doing the right thing. And it turns out that many other people have this problem of being sick because of stuff that we eat all the time that we think is fine to eat. And that’s a pretty shocking message to run into. Luckily, I live long enough to figure it out. But it takes a while to recover from it. So where I am now with my health is I no longer have the arthritis, but I no longer have a uterus or ovaries. I mean, you lose things along the way of being sick and not knowing why I still have back problems. I have all kinds of problems in my spine, which include pits and holes and the bones and stenosis and, bone spurs and for set joint arthritis up and down, very flattened and bulging discs, all kinds of degeneration of the tissues in here and year 11. I’ve started my 11th year without a high oxalate diet, I feel like my body’s still working on and proof spine, how much of that tissue can recover? I don’t know. Eating a high oxalate diet causes calcifications and fascia and connective tissue, it turns on all kinds of genetic weirdnesses in the body where suddenly perfectly innocent cells become aberrant cells and you get this calcification and so on. So, you know, a lifetime of healthy eating led to a lot of oxidative stress, connective tissue damage, hormonal damage, thyroid damage, brain damage, digestive problems, rheumatoid rheumatism, and so on. So I had the whole gamut. For the most part, I spent years in crutches and wheelchairs, I had to leave Cornell for four years of medical leave because my feet were so bad. And it was after I changed my diet at age 49, that my feet finally started working. Dr. Joel Rosen:Well, yeah, you know, and it’s you met going back to having the wealth of practitioners and competent people around, you would suggest that it’s new, and relatively for myself speaking oxalates up until maybe 656 years ago, was like, what is that? But the research goes back, you know, 100 years, maybe talk about the early research that shed light on what oxalates are and how deleterious they are, and maybe give us an idea as to why you think it’s usually it’s 17 years behind the research before the field generals catch up with the ivory towers, but we’re talking about hundreds of years. So at least 100 years. Well, maybe you can give us some ideas as to why you think that Sally K. Norton, MPH:is? Well, you know, the first significant study on Oxley damaging human beings, was published in 1823. By the new, it was a new position of a forensic toxicologist for Edinburgh. And what was happening at the time, especially during the 18 teens was a lot of people were dying of oxalic acid poisoning by accidental ingestion of oxalic acid. This is because it was a household cleaner, just like Barkeeper’s friend which has oxalic acid didn’t clean oxalic acid was a standard cleaner that was used in the industry starting in the 1700s. To prepare cotton for dying for bleaching all kinds of materials including wood and, cotton, and taking the rust out of engines and just it’s an incredible cleaner, you can use oxalic acid, which comes from Spanish that’s naturally made, it’s managed to clean the rust out of your patio. You know how your metal furniture leaves, so you can do that. And so it turns out that in the household, there was a lot of illiteracy in the early 1800s. So your household staff who would go to the druggist to get your Epsom salts for your stomach issue, could pick up a product from another illiterate person who’s at the desk of the druggist and bring home something and put it somewhere in the wrong place in the house. And you think it’s Epsom salts, and it’s oxalic acid. So you take a spoonful of oxalic acid by mistake and you’re dead in two hours. And what they realized is that people were using something that was called salts of lemon at the time, and they they could put a little pinch of it in the water with a lemonade and make your lemonade more tart and stretch out your lemons. Right. So they would use it for all kinds of things. And it was clear to them that this was the perfect murder weapon. So the forensic guy, you know, working for the state, we wanted to be able to tell when a body of a dead cadaver came into the morgue was this murder. So he he grabbed like 50 different animals, I don’t know if they were stray dogs and cats and bunnies and all this and he forced various dilutions of oxalic acid down them watched how they died, and then immediately autopsy them to see what was going on. So they could study the tissues and see if you could see this in human cadavers as well. So you’d be more able to identify a murder victim. And it turns out, it’s very hard to do that even when you’re looking for it. Okay. Now, when people come into the morgue, we should look and see if there’s oxalate poisoning. But still, to this day, we can’t do that when the same thing can occur with ethylene glycol ingestion, which is antifreeze. People will do that on purpose to commit suicide or you can use that to kill your lover or your husband and get the insurance a lady tried to do that, and that was written up in a TV show in England. She tried to do this to her husband on their seventh wedding anniversary. And she, they he ended up in the hospital in a coma pretty quickly, like four or five days later. They stayed in a coma for was it four months, and survived it, and the whole time, they never knew what was wrong with him that he had oxalate poisoning, they could not tell in the case of a man who nearly died when he woke up, he was blind and deaf had liver damage, other forms of damage and brain damage as well. But he lived, luckily. And the other good part was that the neighbor was told by the wife that she was going to do this and the neighbor tasted the wine ahead of time to see if you could taste the ethylene glycol and the wine. And there’s no you can’t taste that’s okay. Like so she did when she realized that that guy was an a*****e. She went and told the police and that’s how they found out what nearly killed the man, not because clinically, they know how to recognize it. So here we are. We went from 1823 to like 2008 or something. And we do not know clinically how to identify franc poisoning when a person is about to die. We can’t recognize it, let alone the more subtle day-to-day version where you have arthritis and aging and aches and pains and anxiety. Yeah. Dr. Joel Rosen:Right. So okay, so as far as thank you for sharing that. So as far as identifying 100 years ago as a toxic compound, but yet not know how to identify it. And mentioning also it’s the same, same ingredient that’s found in vegetables, so maybe we can start from that or specific vegetables, and why they’re in there. And I think that the people who listen to this podcast are sophisticated, but yet can use brush up on what is oxalates. And why is it so rampant in our food source or our food bill? Yeah, Sally K. Norton, MPH:so it’s a tiny compound. oxalic acid becomes oxalates when it binds with a mineral. So when you take in the rest of your patio, you’re turning a soluble oxalic acid into iron oxalate, so we call t

    58 min

  4. 01/03/2024

    [EP.14] Why Omega 3 Accomplishes Longevity & Why Omega 6 isn’t the Almighty Devil?

    Dr. Joel Rosen:Hey guys, welcome back to another edition where I’m excited to announce our amazing guest Dr. Bill Harris as he’s been a leader and leading researcher in the omega-3 three fatty acid field for over 40 years. He has over 300 scientific papers on fatty acids and health, the vast majority on omega threes. He has been on the faculty of three medical schools and has received five NIH grants to study omega threes. He was the co-author of three h A statements on fatty acid and heart health as the CO inventor of the Omega three index, which we’ll be getting into, and the Omega three blood tests and founder of mega quant analytics, Dr. Harris has been ranked among the top 2% of scientists worldwide based on the impact that he’s had with his research. Dr. Bill, thank you so much for being here today. Dr. Bill Harris:Great to be here. Yes. Dr. Joel Rosen:So I always like to do some research so that I can ask intelligent questions before we get here. I know that initially in the 70s, you were asked to study dietary fat and its effects on cholesterol. At that time, we knew that animal fats raised cholesterol, or at least now we know triglycerides and vegetable oils lowered cholesterol or triglycerides. But as you mentioned there we weren’t sure why. So potentially over the 40 years, I guess that’s a good starting point to know where we started from and where we are now. You know. Dr. Bill Harris:And so do we know why liquid oils, lower cholesterol, and saturated fats raise cholesterol? I think we know better. I think we know now that you’re changing membrane fatty acid composition with the different fats that we’re eating. and a high saturated fat diet does change the the way that the liver and liver cells process or remove LDL cholesterol LDL particles from the blood that’s of course, that’s the way statins work they upregulate the LDL receptors and remove more LDL from the blood. And if you’re getting more saturated fat versus polyunsaturated fat, those LDL receptors are not as efficient at moving LDL out of circulation. So LDL levels go up. That’s kind of shorthand of what we know now but there is a physical selling biochemical reason for why different fats have different effects on cholesterol outs. Dr. Joel Rosen:Okay, great. So So then as far as springing forward from that we know so much about the Omega threes and the longevity studies and why they’re so important for human health. Maybe we can get into that. Dr. Bill Harris:Sure. Yeah. We’ve been interested in, of course, Omega Three for a lot of time. And until now, I don’t know maybe 10 or 15 years ago, nobody looked at total mortality or effects. They’ve looked and looked at people with cardiovascular disease and the effects of Omega three on those people typically lower the risk for cardiovascular events, which should translate into a longer lifespan. You have fewer events. More recently we’ve been part of a group called Force fo RCE, which stands for Fatty Acid Outcomes Research Consortium, it’s a group that started at Tufts University in Boston. And it’s a collaboration of multiple individuals who have access to different research cohorts like the Framingham cohort, or like epic, or Mesa, or Eric, are these acronyms that we throw around the most people don’t know, but they’re fundamentally groups of people that have volunteered to be in a lifetime study. You know, like in Framingham, they took like 4000 people out of the town of Framingham, Massachusetts, in the 1940s, when they started, and they did every test known to man in on these people, they’re all healthy people, you know, middle-aged people. And then they just followed him for years and looked for the relationship between some something, they measured either a sum, they developed the term risk factor, the Framingham group, there’s nobody used that term before. And nobody knew it that nobody knew that smoking was related to a high risk for cancer or heart disease, they didn’t know high blood pressure was they didn’t know high cholesterol. So that’s how they discovered these risk factors. And so they’re like Framingham, there are cohorts like that all around the world. And so we have a collaboration with many of those cohorts, and the ones that have measured fatty acids in the blood and the ones we work together. And we found when we asked the question, of all these cohorts and several, several 1000 people together, is there a relationship between the blood Omega three-level and your risk for dying over time? And of course, you know, the window, the average window of time between blood drawing and when we stopped following up on people, it’s like 16 years, 1316 years, something like that. So it’s a, you know if you study Omega three levels and 10-year-olds, and ask, what’s the mortality in the next 10 years, you’re not going to find anything because nobody’s gonna die. You’ve got to study people toward the end of life, if you’re gonna look about look at prolonging life. We found that the higher the Omega three level, the lower the risk for death from not just total mortality, which was everything all in, but for cardiovascular disease, for cancer, and for non-cardiovascular, noncancer, whatever else is in that bucket, the whole thing. So omega three, high omega three was associated with just a generalized slowing of the aging process. And we had been part of a study some years ago, where they looked at omega-three levels and how they predicted the rate of telomere shrinkage. And that was another study where we found that people who had the highest Omega three levels had the slowest rate of change over time in their telomeres, which is an anti-aging outcome. And then the final one would be, look, just look at what we call ecological studies, or studies of this country versus that country, or this culture in that culture. And you look at Japan, which is a very high omega-three intake country, they also have, what a surprise, one of the longest lifespans on the planet, about four years longer than Americans on average. So we think we’re so great. Well, you know, so that’s, that’s also kind of a consistent story with the high omega three length with longer outcomes, longer excuse me lifespans, Dr. Joel Rosen:right. So mentioning risk risk factors, and the studies and the longevity studies that you’ve done. And have pretty clear consensus data that higher levels are correlated with longevity yet any any speculation as to when the FDA or whoever deems a risk factor variable to be a risk factor that omega three will become one as it isn’t at this time? Dr. Bill Harris:Yeah, that’s a great question. I’m not sure I’ll live to see it. I’d love to live longer than I would otherwise, because I’m taking all my omega threes might not be long enough, you know. So yeah, it’s not the FDA that determines that it would be medical societies. So like, a joint consensus conference by the American Heart Association and the American College of Cardiology, for example, that those guys get together periodically, and say, Hey, here’s a here’s a new risk factor. Let’s have a consensus conference on it and let’s make a decision and then advise our community that this is important. So that’s The way it would happen, that someone would have to bang on the door loud enough to get their attention. And the Omega three I mean, it’s, I know we’ve got 45 minutes here, but you Dr. Joel Rosen:no longer if we need it. Okay. Right, right. Dr. Bill Harris:I mean, it’s complicated because there have been many randomized trials with Omega three, many successful, but not, not a few that have been neutral, no, no benefit. And they’re, of course, they’re the when these studies are done, they’re done with the drug model in mind, you know, take people in their mid-60s, give them either a placebo, or give them Omega three, just like you’ve given them a placebo, or you give them a statin, and then wait 234 years and see if you’ve had any effect on heart disease rates. Well, sometimes that doesn’t work with Omega three, and I would not expect it to work with Omega three, but the medical, because it’s on the Omega three benefits of life’s lifetime thing. It’s not a start when you’re already old and sick and on a bunch of drugs and trying to turn that battleship around with the nutrient. They didn’t want it to happen. And so I’m not surprised, but the medical community doesn’t think that way. They think if you do what studies like that, and you don’t get an effective Omega three then Omega threes don’t work. And that’s the message that goes out to the community. They don’t work without any caveats without an A Yeah, but they don’t work. Well. They do work if you test them in the right way. But nobody’s going to do a 40-year randomized trial, with a placebo and Omega Three to prove that they do have these effects. You can’t do it. So anyway, that’s because of that mindset in the cardiology community, particularly, most of them dismiss Omega three, as irrelevant. So back to your point about when are we going to get this test approved by the cardiovascular community? It’s gonna be a while because they have this idea that they don’t work. Dr. Joel Rosen:Right, gotcha. Yeah, thanks for sharing your insight on that. So as far as the mega Quan company and the company you founded, maybe tell us about exactly what an Omega quant test is? How would differ from an Omega three test that is being done through a different company, I know both tests aren’t necessarily created equal. So it’s a two-part question. No. Dr. Bill Harris:This raises yet another reason why testing is going to be hard to get into routine medical tests because there are different ways to do it. Right? There’s onl

    1h 9m

  5. 12/20/2023

    [EP.13] Why Extra Stem Cells Really Accomplishes A Slower Rate Of Aging

    Dr. Joel Rosen:Alright, so our next guest is Christian Drapeau. He is a stem cell scientist, author, and creator of this first stem cell supplement. He holds a graduate degree in neurophysiology, and he’s been involved in medical research for 30-plus years, of which the last 20 years have specifically been dedicated to stem cell research. He’s the author of five books, including the best-selling Cracking the Stem Cell Code, he has published dozens of scientific papers on brain research and biological process processes, which we’ll be asking about endogenous stem cell mobilization. He’s lectured over 50 countries on stem cell research. He is known by scientists, physicians, and biohackers alike as the expert and pioneer in this field. Thank you so much for being here today. Christian, I could go on but I want to get the good stuff here today. Christian Drapeau:Thank you. Thank you. My pleasure. Yeah, so Dr. Joel Rosen:I you know, I like to prepare for these, these interviews, and I’ve done some research I know that in 94, you started with your blue-green algae research, but it wasn’t really until 2001 Were the article that you read turned blood into the brain. And like you said, as well, a lot of these times these amazing research articles come out, but they don’t register a glitch in the radar. Why was it that that article turning blood into the brain was so profoundly changing for you? Christian Drapeau:Well, to tell the truth, this article was sent to me soon after it was published, and it sat on my desk for probably three, or four months. So I read it the first time and it did not register. And I was cleaning my desk, and that paper was still there on my desk, and I read it again. And then that’s when slowly the thoughts started to trickle, and we need to look at it in the context of where we were at the time. So we had published not long before, that polysaccharides from that blue-green algae, were stimulating NK cell migration in tissues. So in the back of my mind was that data that there was something it is blue-green algae that mobilized immune cells taken in very broadly, my background is brain research, I know, we know, we were told that we cannot make new neurons. So finally reading that paper, and reading that stem cells from the bone marrow, could go to the brain and become a brain cell, which is a type of cell that we were told in neurology, you cannot regenerate your brain. I knew from just my basic class of med class that stem cells are only known to be precursors to blood cells. And suddenly, I’m thinking about when we were talking about the release of stem cells migrating into a tissue, and we showed that blue-green algae were supporting the migration of NK cells. So this sort of amorphous idea started to shape itself in my brain thinking that what if that plant could support the migration of stem cells in tissues? So it’s just reading it? And it started to be an answer a potential answer to a question that, that we had for several years, we did not have a way of explaining how this plant was leading to benefits touching so many aspects of human health. Right? Dr. Joel Rosen:Okay, so going forward from there, because I want to get your insight on this, and how research continues to propel us forward. But there’s been a lot of skepticism about the landscape and the controversy of stem cells. So given that, that article just sort of planted the seed for you, Christian, to tell us about where we come from, or what the initial, I guess, the landscape was, in terms of how stem cells and even more plant-based support for stem cells has been was initially received and where it is now? You know, Christian Drapeau:I liked these questions, because, to me, everything that we’re facing, and we’re looking at right now, in terms of what we have done with plants, but also the whole landscape of stem cell research, is an amazing example of the real life of scientific discoveries and scientific development, the interaction of scientific development, with business development, with policy development. All of this was so complex that if we knew today, so if we knew then what we know today, I guarantee you, we would not have today, the landscape that we have, things would have evolved differently. So and I’ll come back to that in a second. So when the first observations were made, we’re in early 2000 and 2001, that stem cells known for decades to be precursors to blood cells, were finally known to have the ability to become cells of many different tissues. At first, the observation or the belief was that, Okay, we’re ready to accept that they can be more than just blood cells, but we’re not ready to accept that they can become everything, yet. The data was there, right there. When I’m talking about the process of scientific discovery, we can observe and document the only things that we can accept, if there’s something that we cannot accept, we can observe it but we’re blind to its observation to a degree. So my point is that in early 2000, already data was already clear stem cells could become everything in the body, but there was a reluctance to accept it. And then accepting that the stem cells in your bone marrow can do it very well. So pushed into the direction of Okay, then let’s go to the causes that we have to inbuilt to embryonic stem cells, which is umbilical stem cells. So now led to the development of all these banking of cells and everything that is done with umbilical stem cells, which I’m not saying is not good or does not have its place. But it did develop at a time when we did not fully accept stem cells from the bone marrow. Arrow at all the potential that we know today that they have, if we knew that and accepted that from from from first, like from the beginning, we probably would not have the incentive of going and collecting umbilical cord stem cells. So I’m giving snippets here of the whole development of this world if you want the stem cell world. Now, when all of this has been developed systems of collection system of banking, systems of multiplication, cryopreservation, and all of that, you just don’t say, well, let’s drop all of this. And let’s turn to bone marrow stem cells, because they’re just as good, which is not like 100%. True. All I’m saying is that the landscape would be different today. And we knew these things earlier on. So the knowledge developed, but essentially what emerged, and which is the area that I’ve pushed a lot is this understanding that if stem cells have enormous regenerative potential, they’re not better because we take them out of a source and put them back in, they have intrinsically this kinds of regenerative potential. So if they do have this, what is their role in the body? And when we discover that stem cells are the natural role, the natural repair system of the body, then the question is, is there anything stronger, to help you be healthy, or improve your health if you have a problem, than to tap into your body’s ability to repair. And that is where I have studied the most because we ended up discovering plants, the one that we talked about earlier, we discovered plants that triggered the release of stem cells from the bone marrow. So it created this old view of saying, okay, instead of removing stem cells and re-injecting them, which is increasing the number of stem cells in circulation through an injection, what if we increase the number of stem cells in circulation, simply by boosting the release of our stem cells, which is the whole field now of plant-based stem cell enhancers? Dr. Joel Rosen:Right? No, that’s great. And you know, the name of this podcast is The Reversing Blueprint. And I like the idea that you have shared in the sense that the real marker of age is how well our stem cells can be released to be this protective layer, of renewables. And with that being said, maybe just let’s kind of start from the beginning, where someone that might be listening to this where we do tend to go a little deeper and into the weeds, but are wondering, what are stem cells? And what do they do? And I’ve heard that there are different kinds, maybe just kind of give us an overview of their first question, and then we can kind of elaborate going forward. Christian Drapeau:Okay, without going too deep into the various types of stem cells. Let’s put it this way. The best way to define me stem cell is first to define what is not a stem cell, and then we exclude that every cell of the body is called a somatic cell, they’re cells that have one specific function, and they will never change their function. Like if you have an injury to your muscle because you went to the gym, the gym, and you sort of over-exercise, you want to have a cell of your skin, looking down to your bicep and just say, Gee, that muscle needs assistance. Let me go and become a muscle cell. It won’t happen. A somatic cell does one thing, it will never change to a large extent it will never multiply. This is a somatic cell. At the other end of the spectrum, you have stem cells, they are sort of blank cells, mother cells having the ability to become everything in the body, and not only do they have the ability, but they do so during the entire life of an individual. So these are stem cells. There is one type of stem sales. By more you’ll sales, if you want in your bone marrow when you’re born, your bone marrow as these stem cells, they are the remnant of what it was one day, your embryonic stem cell, when you were one cell on the day of your conception. So these evolve, you become the whole organism and you’re born with a bank of stem cells in your bone marrow, these stem cells and you also have stem cells in every single one of your tissue. They are tissue resident-specific stem cells specific for that tissue. N

    1h 9m

  6. 12/13/2023

    [EP.12]Powerful Genetic Testing: Learn the Effects of Genes On Your Longevity

    Dr. Joel Rosen:Right welcome back to another edition guys. And I’m excited to interview Alan Robinson. He is the founder of Genetic Insights and founder of Feel Younger. His goal is to empower committed and self-responsible people with the science-based tools they need to feel younger and improve their health. I first became interested in health and anti-aging because of his own experiences and the many health challenges throughout his own life, including chronic fatigue, chronic pain, malnutrition, hypothyroidism, IBS, and reoccurring infections, such as SIBO, Candida, and sinusitis, which made him feel way older than he was. And when conventional medicine practitioners weren’t able to help him set all of this out in desperation, he had to look within and figure it out on his own. So that’s what we’re going to be talking to him about today his health journey, how he improved his health and eventually resolved his issues, and lifelong interest in health, energy, and wellness, and the companies that he’s founded to help other people with the same problems. Oh, and thank you so much for being here today. Elwin Robinson:Thank you so much for having me, Joe. It’s a pleasure. Dr. Joel Rosen:Yeah. So you know, I’m excited to compare your journey and my journey, as it relates to what you do now with the genetic insights and how to feel younger. Perhaps you can just give us the Cliff Notes version of at worst what it was like for you when you were suffering from your health challenges. Elwin Robinson:Yeah, sure. So, you know, most recently, and that’s really what led to the founding of those two companies that you mentioned. So I’ll start at that point. I’ve been doing well for a long time after having health issues earlier, and I thought I’d been doing great. So long as I avoided certain foods, I was on top of the world, you know, plenty of energy. And I’d gone from, you know, kind of doing minimum wage jobs in my 20s to be able to start several businesses and travel the world and all that kind of cool stuff, right? I was enjoying life. And then suddenly, I got struck down with this pain condition where I kept having pain around my midsection, and no one was able to work out what it was. I had, you know, CT scan, MRI, blood tests, all of that kind of, you know, typical stuff, and then all kinds of other practitioners as well. Functional Medicine naturopath, acupuncturist chiropractor, osteopath, I mean, you know, the list goes on and on and on. All trying to work out what was going on. I had a few different theories, but no one was able to help. Along with that the constant pain and discomfort this, these digestive issues went along with it. And it got so bad that I wasn’t that I could list on one hand the food I can eat without having some kind of really unpleasant reaction. Even those foods I didn’t do very well on and I just started wasting away. I mean, I’m six foot three, and I think I got down to one 20 pounds, something like that, so I was really, I wouldn’t be emaciated might be a bit far. But for someone who’s trying to eat as much as possible, I was, you know, seriously wasting away. Along with that came extreme fatigue, extreme anxiety, you know, like being emotionally all over the place, as I said constant pain, and I wasn’t able to function. And I tried all the usual kinds of things, things I already knew to do to be healthy, because I already lived from the surface, maybe not to someone as sophisticated as yourself. But to any normal person, I would seem to live an extremely healthy lifestyle. And yet, you know, it wasn’t working I as I said, tried every practitioner under the sun, and none of them were able to help either. And eventually, I just, I realized that, you know, I was going to have to work this out for myself. The first breakthrough came through doing a kind of genetic testing. That was where I first got, maybe not all the answers, but the first clues as to what might be going on and helped me to work it out. Dr. Joel Rosen:Well, I’m glad that you did. And now you’re here to help other people. An interesting question is, I had contact with the patient the other day, and she’s dealing with, you know, right upper quadrant pain. And I was getting just sort of background information on what she’s been dealing with and what she’s done. And I asked her about the genetic test. And she looked at me like, that was the most craziest question, why would she want to look at genetics? What does that have to do with anything? So I guess the question would be, how did you go from learning all the things that you did with what didn’t work and having to take, the ball in your own hands and figure this out on your own? And how did that get into the world genetics is the next option. Elwin Robinson:It’s pretty random, to be honest, I mean, you know, I guess the kind of person who watches this kind of podcast is similar in that they become a little bit obsessed, right, and you know, you’re watching everything you can reading everything you can, you know, I’m sure I read hundreds of books over that year, literally, because I wasn’t working much as much else to do, let alone watching and listening and all the rest of it, and signed up for lots of people’s newsletters, and just got a random email and decided, you know, let’s give it a go from, you know, a particular company. And I had never heard of it, as you said, like, a lot of people had never occurred to me. But I’ve done a lot of testing, and it tends to be very expensive and inconvenient. And also, you have to wait a long time to get results. And so, you know, the cost seemed reasonable. And I was especially impressed that I could get results within a few hours, I was like, Well, that’s pretty awesome, right? When you normally have to wait weeks. So I just did it. And like I said, the insights came thick and fast, not just about what was going on with me at the time, but also about really things that had been plaguing me about the way I was and also the way I was about other people my whole life. Like, you know, one example is I, I had felt like I had always had a very low resilience to stress. Not necessarily that, you know, like, I’m not the kind of person who always avoids confrontation and stuff like that. But it’s more like, once I got stressed, it would take me a long time to calm down, it would be very, very difficult. And so I always felt very inferior to the kind of person who could, you know, get involved in some kind of conflict or confrontation or challenging situation. And then, you know, not long after a few minutes later, they’re laughing and joking and all relaxed. And I’m like, oh my god, it’s gonna take me days to, you know, overcome something like that. And so understanding her in that case about the comp gene and the MOBO gene, both of which I had slow and how that meant that you know, I struggled to break down stress chemicals, and in fact, all the lifestyle things that I was doing at the time exacerbated that tendency, you know, I hadn’t realized they were slowing down that gene even more. And so that helped me to understand, first of all, you know, that I can improve my situation. But second of all, I’m never going to be like a fast comps person, I’m never going to be that kind of person who, you know, can be in a warzone. And then minutes later, is relaxed and laughing and joking, because that’s just not me. But I do have the ability to stay focused for a long period in a peaceful environment, with someone with a fast calm Jean would never be able to do so seeing the kind of benefits and drawbacks was very helpful. And the other big thing was, you know, I, my raw genetic data come from 2013 2013. I was feeling great. My wife and I both did, you know, 23andme just to see the ancestry thing, and I didn’t have any of these problems back then. So I was just blown away, that I could take my data from them when I didn’t have any of the problems uploaded to the system. And it tells me about all these problems I now have but that I didn’t have back then. I was like, wow, if only I’d have known, you know like I could have prevented all of this stuff happening in the first place probably, or at least to a large degree. And that made me feel like, this is my mission to help other people to have that same realization, right to help to find and address the issues they already have, but especially to help prevent the perhaps more serious ones that they could have if they are not aware that they have that risk. Dr. Joel Rosen:Yeah, that’s, that’s very interesting, I find that a lot. I wish I always said if I had the investment dollars, after you see a 23andme commercial to find out about your ancestry and your heritage, you know, to have a commercial that comes on immediately afterward, and say, and once you find that out, you don’t want to know about your potentials for autoimmune diseases, mood disorders, immunological issues, you know, cardiovascular issues, behavioral issues, then you may want to use the raw data that no one ever tells you about that you can upload into software and learn about that. So a lot of people that do the ancestry don’t realize they have, they’re sitting on this goldmine of information, that they didn’t have a clue that was there. And that I was going to ask you about that because you said you could upload it when you first found it. Within a couple of hours or even shorter my thought process is Oh, you must have already had your raw data. So for people who are listening to this, you just can’t upload a file if you don’t have the raw data. So you have to have the actual raw data first. But with that being said, how, how did that I mean, ultimately, your main concern? When was your was your GI health? Rig

    56 min

  7. 12/06/2023

    [EP.11]The Shocking Truth Why Cortisol Is The Rapid Aging Hormone

    Dr. Joel Rosen:All right, I am super excited to be interviewing Georgi Dinkov a second time. For those of you who know who he is, he doesn’t need a bio. But for those that may not know who Georgie didn’t cough, is, there’s so much to say and so much to get to today. I’m going to abbreviate his bio, but basically, he is a self-taught guy. His interest in health topics continued after he left his job. While researching aspirin and its effects on the brain circa 2011 11, he stumbled on Ray Pete’s website, and I think that’s what dug down into the bioenergetics field. His ideas on Bennett bioenergetics which is controlled by dietary and environmental factors as the ultimate causal factor in health disease and even aging immediately appealed to Georgia. And since then, he’s been doing research in that field. So Georgia, I’m super excited to get started. Thank you so much for joining us. Georgi Dinkov:Thanks for inviting me again. Hopefully, it will be I’ll be useful to your listeners. Oh, yes. Dr. Joel Rosen:Listen, I went through that interview several times. And I came up with some great questions for you today. So for those who want to hear the past interview, we got into metabolic flexibility. We’ll leave links there. And Georgie, as I was telling you, before we got started, I walked away with a lot of aha cars that were contrary to what’s being taught. And I’ve gone down the cortisol rabbit hole, if you will. And even just our conversation when we just had that amazing insight has shifted my perspective. And I wanted to share that. So cortisol is not what we thought it was the truth behind it is it’s a rapidly aging stress hormone. One of the sacred cows or the contrarian thinking is that cortisol is anti-inflammatory when in fact, it’s pro-inflammatory. So maybe in your in your amazing way of bringing difficult concepts into an easy, understandable way. Explain that to the person who thought, well, cortisol is anti-inflammatory, and I take prednisone hydrocortisone, for an anti-inflammatory immune response or suppression, but ultimately, it’s putting more oil on the fire perhaps. So maybe let’s go into that. Georgi Dinkov:I think probably the best comparison that I can give you is with opioids, which are widely used for pain management in the medical field, and a lot of people are abusing them for these pain-relieving properties. It’s very well known that basically, if you continue using opioids, you develop tolerance to them, and then it and not only that, you’re going to start needing higher and higher doses to be able to tamp down the same level of pain. But eventually, if you try to wean off or you stop the opioids, there will be a baseline of pain, that’s going to shoot up tremendously. In other words, you’re going to be in a worse position than you started. And the pathways for the opioids are fairly well known. They increase reluctant histamine and serotonin, and they also increase the expression of an endotoxin receptor known as TLR four. All of these are known to be involved in chronic pain. So while you’re taking opioids back activation of the opioid receptor, which is a receptor that our endogenous opioids known as the better endorphins also activate, yes, you are kind of inhibiting the signals, at least the peripheral signals from for pain to reach the brain and that are kind of registered as a pain signal. But it’s while you’re doing that you’re up-regulating the machinery that causes these pain signals to travel much more rapidly. So as soon as you stop the opioid, you’re in a worse position than where you started. So you kind of like, you know, in a catch-22 or, or actually, once you, once you start, you can stop unless you’re taking care of, you know, kind of like, unless you also take care of reducing these inflammatory mediators that were upregulated while using the opioids. And most people are not doing that simply because for a lot of, you know, whenever you prescribe opioids for pain, there’s there’s little concern, and now it’s starting to become a concern. However there was little concern about the long-term effects on pain. Now, doctors are starting to find out through various long-term studies that people who are using opioids long-term, end up being worse, right? Their pain starts to become unmanageable. And once they become resistant to the opioids, there’s very little you can do for them. And maybe the opioids aren’t the kind of like the end stage of pain treatment. In the hospital, they’re usually given to terminal cancer patients, or just in general terminal people just to kind of like ease the transition to them dying. But it’s really like a last resort step. So if patients stop responding to opioids, then there’s very little that the doctor can do for them, or at least that’s that’s what they think. So there wasn’t much of a thought to this process. But now they’re starting to find out that there’s this booming addiction to opioids, they’re saying, Well, what’s going on like, it’s just the pleasure response cannot explain the addiction and the need for using higher high doses. What explains this addiction and the need for higher doses, the development of tolerance, specifically, the tolerance to the pain, easing effects of the opioids, and you know, people keep using more, but the more you use, the more you upregulate, the machinery for inflammation and chronic pain in the future if you were to stop the opioids, and something similar turns out to be working with cortisol as well. So cortisol has an undisputed anti-inflammatory effect, while you’re using it inhibits the release of the inflammatory interleukins, one and six. It also inhibits the release of something called tumor necrosis factor alpha, and the activation of something called nuclear factor kappa B. And those are like them in combination, they’re basically the, the primary, the primary pathway towards chronic inflammation. Another thing that glucocorticoids do is while you’re taking them, they inhibit the activity of the enzyme cyclooxygenase and lipoxygenase, which are the IS is produce inflammatory mediators known as prostaglandins, or leukotrienes. From the polyunsaturated fatty acids. However, recent studies discovered that while causal or synthetic glucocorticoids are inhibiting the activity of those inflammatory enzymes, they’re simultaneously up-regulating their expression. So basically, just like the opioids, you’re developing tolerance, to the effects of the global credit coach, but the moment you stop using them, now, all of this machinery that responsible that was responsible for producing inflammatory signals, now he works in overdrive, because the cortisol, he’ll build more of that specific machinery. And I think the essential studies specifically say that cortisol regulates the genetic expression of the cyclooxygenase and lipoxygenase enzymes. And also, cortisol up-regulates the expression of the enzyme tryptophan hydroxylase. And also the history of decarboxylase. So the moment you stop taking the glucocorticoids, you’re gonna be producing more than before more than baseline of the prostaglandins leukotrienes histamine and serotonin and serotonin kind of has like a reputation of being a happy hormone, at least peripherally. Now it’s not a serotonin is anything but it’s a very dangerous profibrotic molecule. There are many drugs that are clinically in clinical currently clinical trials that are blocking one of the serotonin receptors, five HD, to be precise, that have been shown to prevent and even reverse peripheral fibrosis to conditions that were considered incurable. So taking glucocorticoids makes you feel good currently for you know, presently, in the background up-regulates the machinery that will make you a lot worse than you were before you started taking the glucocorticoids as soon as you stop them. So you know, you know, you know, you’re in this situation, we want to start taking the glucocorticoids you can’t stop unless you take measures to inhibit a lot of that machinery that cortisol started up-regulating while you’re taking the glucocorticoid. And of course, because this is kind of like disparate knowledge not put together politically, not that it isn’t known. I think specific doctors know that that there’s there’s this famous glucocorticoid rebound effect. So doctors are aware that this can happen. They’re just not digging, or at least connected the dots with preclinical research say, Hey, why are my patients becoming worse after I withdraw the corticoids? We don’t we don’t want them on call. recourse because we know, even aside from the APR agent effect of cortisol, we know that corticoids glucocorticoids, chronic use can cause osteoporosis, we know it can cause insulin resistance, we know it can cause diabetes, etc, etc. So I don’t want my patients to be taking glucocorticoids forever. But my immediate concern is that I gave them glucocorticoids for asthma or, you know, maybe COVID, or some other condition that is driven by inflammation. And now I want them to stop because, like I said, I don’t want him to take them forever. And now they present him with even higher inflammatory biomarkers than before, what’s going on here? What can we do to prevent that? And I think the answer is, well, don’t start using glucocorticoids. To start with, other anti-inflammatory steroids are there, specifically pregnenolone, progesterone, to a degree that dihydrate, and Rostro. But that one can be potentially dangerous because it could convert easily to estrogen. But yeah, really cortisol, just like the opioids, you’re going to pay a very heavy price for using it now, later on, to, you know, it’s like a circle. It’s like a power drill, you’re using the power drill to solve a problem that didn’t requi

    1h 23m

  8. 11/22/2023

    [EP.10]Mastering Your Biohacker’s Dashboard: How To Track Your Hacks Like a Pro

    Dr. Joel Rosen:Welcome to the age-reversing blueprint podcast where we discuss tools and tips to help you reverse your age naturally. David Korsunsky:Let’s take a few of some of the more interesting ones that I’m working on right now. Okay, which would be hyperbaric oxygen, infrared sauna, cold plunge PEMF just down the street from my house, I can go in there and I pay 200 bucks a month. And they got everything I want unlimited. H BOD cold plunges. So I go in there, I do my 30 minutes in the sauna. I do five minutes in the cold water and I do a P E and F. I will see my aura HRV is close to double on those nights. Those technologies were not accessible to us the masses just a couple of years ago. There’s all these recovery lounges popping up. And here’s why I like these places. We’re in such a hyperstimulated world. We work ourselves like crazy. These are dedicated spaces. It’s like the spa. But with all these new health optimization technologies. So inside one of these recovery lounges, I’m going this afternoon it’s Friday. I’ve been busting ass all week. I blocked two hours on my calendar to go and do recovery work. I’m gonna go to two sessions Am I to two plunges of contrast therapy, but I’m creating space in my life. to specifically go and work on recovering my body Dr. Joel Rosen:right everyone, welcome back to another edition with my new guest Dave Korsunsky. He is the founder and CEO of Heads Up Health. He has a digital health analytics company based in Scottsdale Arizona, and avid health and Susie’s himself, David. He makes everyone’s life easier and helps them to control their health through effective data tracking. Before founding heads up, David worked at Cloud Physics as a data analyst company collecting and analyzing a bit of what the ADB David billion 80 billion 80 billion data points per day. He also spent seven years at V malware in director-level leadership roles where he built partnerships with the world’s largest software companies, including Oracle, IBM, SAP, epic Cerner, and more. David holds a Bachelor of Science degree in mathematics, a Master of Business Administration, and a Master of Science, and he is in the emerging field of neuroscience and based leadership. So David, thank you so much for being here. Thanks, David Korsunsky:brother. It’s good to reconnect with you. We just hung out a couple of weeks ago in Miami. And here we are again. Yeah, Dr. Joel Rosen:it’s weird to read the Bible and read it as David. I only know Dave. David Korsunsky:Well, you don’t even call me that. You call me the names of hockey players from the 70s to the 80s. That’s right. We have Dr. Joel Rosen:a little running joke on us Canadians, you know, the one with the obscure hockey players. So yeah, it was nice to reconnect and I did enjoy it wasn’t just blowing smoke up your skirt. I enjoyed your conversate you presented at the Biohacking Conference, which was entitled The Biohackers Dashboard, how to track your, your your hacks, I’ve asked you if we can expand that and not just the biohackers dashboard, how to track your hacks but how to track your five hacks. So why don’t we just kind of get into a brief overview of I know we had talked before how you got heads up health company to get into existence in the first place. David Korsunsky:Yeah, well, I was living in Silicon Valley at the time and working for a tech company out there and this was like, the early days of biohacking. So 2010 and 2011 None of this stuff was on anyone’s radar screen except for a very obscure group of people doing at that time what was called Quantified Self. Now we call it biohacking. But it was the same thing. I got into that community and realized that it was incredibly powerful. However, there were no accessible ways for people to figure out if their health was improving or not. So like there were all these cool things. You could try different diets, different exercise regimens, different supplements, different things to try to move the needle. But how do you know if it worked or not? And some of this stuff, you’re spending a lot of money on it. You’re spending a lot of money on nutrition and the gym, and supplementation and all these things to try to be, quote unquote healthier. So I saw that, despite all the amazing technology coming on the market, and all of the amazing new ways that we had available to us to improve our health, like, I don’t know, infrared sauna, for example, I needed to, to measure what was working, because what works for me is not necessarily going to work for you. And so, one therapy that works for a certain individual doesn’t work for the next. So the only way to know for yourself is to test if it works. So that was kind of the origin story for heads up. I’m like, Hey, there’s all this cool stuff out there. There’s all this data, and it sucks. There’s no way to just I just want to see all my numbers on one screen. These are the 10 or 15 numbers that I care about my blood pressure, my HRV, etc. I just need them on one screen. That was it. And I didn’t see anybody providing that to people who were trying to improve their health. And that’s why we started the company. Dr. Joel Rosen:Oh, that’s awesome. And as far as the how far how long ago was that now, Dave? David Korsunsky:Well, the idea came to me in 2011, I didn’t start developing it at that time, and I didn’t know how to start a company. Right? Hey, you get an idea. Right? It was it was a bad idea for a software program. How do you even start took me like two or three years of just asking around, hey, I got this idea for this new app. How do you even start? There’s no, there’s no instruction manual to figure out. So I had the idea in 2011, but we did not start writing code until 2016. Dr. Joel Rosen:Gotcha. And since then, I’m like, What I’m interested in alongside the biohackers dashboard and the evolution, you know, the iterations and what you’ve learned in the process of building this company and determining who’s your target market? And what do they want to know, even with that idea? So maybe let’s go through that evolution to how you came up with the biohackers dashboard. David Korsunsky:Do you mean, the presentation? Dr. Joel Rosen:That was so you know, initially, I guess, how much it’s evolved from cutting away the debris and pruning the bonsai tree? And what may kind of learn along the way? David Korsunsky:Yeah, well, what I presented at the conference a couple of weeks ago was seven years of building this company, and working with 10s of 1000s of people tracking their house, on our system, giving us feedback, telling us what they like telling us what they don’t like, punching us in the face when things don’t work as well as it should. So that was all that then for the last four or five years, we’ve been doing the same thing with practitioners like yourself, putting them through the system, what features are they using? What are they not using? What do they need in there to make this more usable, even before I was in the biohacking world for five or six years, even before I had a company in the space? So that what I presented a couple of weeks ago was closer to 12 years of living and breathing, health optimization. Whatever biohacking Quantified Self, whatever set of words you slap on it was 12 years in the making. And just if I could sum it up quickly, I would say a few things were my main takeaways. One is that every person has a unique equation. So that’s why the quantification becomes so important. It starts with genetics, environment, lifestyle, culture, society, community, everything. So every single person is a different equation. And therefore, you don’t have one prescription that works for everybody. So that’s why measurement becomes very important. So that’s the first thing is that we have to approach it all differently. The second thing is that what you’re measuring is constantly evolving. So I used to be big into the keto diet five years ago, and I was tracking my macronutrients protein, fat carbs, I was tracking ketone levels, I was into that, right? Then my understanding and my knowledge of health evolved, and I listen to shows like yours. I listen to other shows, the science evolves, and the information evolves. Okay, now I’m focusing on my heart rate variability. We didn’t even have ways to measure that five years ago, as consumers, right, the ordering didn’t exist. You know what I mean? So like, now I can measure things that there was no continuous glucose monitor, you know, 10 years ago. So like, now you can measure things you couldn’t even measure before. So the second key takeaway is that that as your health evolves, as you age, as you learn more as you get wiser, what you’re measuring will also change so that that whole process evolves. And then I guess, the last thing I would say is that it’s hard. And it requires persistence, and perseverance, and, and commitment, and you’re gonna get frustrated, and you’re gonna feel defeated. And then the next day, you’re going to be on top of the world. So you know, the last piece of it is just to approach it with with open mindset, and a mindset of humility, and being able to just step back once in a while and not take yourself too seriously. So I guess the third part would just be making sure that you’re taking care of yourself mentally, psycho spiritually, as well, you know, this, this, we’re so hyper bombarded with information, some of it really helpful, like these amazing podcasts, but some of it really, that intentionally is designed with fear. And, so I would say the last piece of it is just to keep an open mindset. And to really just take care of yourself, mentally, spiritually, there’s a million bio hacks out there a trillion a billio

    1h 17m
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Age Reversing Tips For The Modern Day Men and Women, Search For The Fountain Of Youth That Resides In Their Own Bodies, So That They Can Be The Best Version Of Their Selves.

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