The Simple Path To Health

Kevin Forey MD

Kevin Forey MD seeks to provide an educational resource for everyday individuals who are interested in learning more about food, nutrition, physical exercise, and other strategies for preventing common medical illnesses. Throughout this podcast, you will find an unbiased and evidence-based message that is easy to understand. https://www.kevinforeymd.com/

  1. 02/11/2025

    Episode 8. Why LDL-C, Hemoglobin A1c, and Continuous Glucose Monitors Are Not Optimal Tests For Longevity

    In today’s episode, we will be discussing the shortcomings and alternatives to some of the most commonly utilized tests for longevity and preventive medicine, including LDL cholesterol (LDL-C), Hemoglobin A1c (HbA1c), and Continuous Glucose Monitors (CGMs). With advancements in technology, there are now multiple laboratory tests that provide more accurate and useful information than LDL-C, HbA1c, or CGMs. Despite these improvements in testing, widespread awareness and adoption of these superior tests remain limited. The purpose of this podcast is to demonstrate the shortcomings of LDL-C, HbA1c, and CGMs. By examining alternative testing strategies, this podcast seeks to empower health conscious individuals and healthcare professionals in their ability to adopt more effective testing strategies for the prevention of disease and promotion of longevity. In summary,a normal LDL-C does not rule out the risk of cardiovascular disease, and thatnormal results from HbA1c and CGM data do not rule out the possibility of insulin resistance. Meanwhile, there are more effective testing strategies available to those who are seeking to optimize their health, likelihood of longevity, and ability to identify disease risk as early as possible. Link toOriginal Blog Post andReferences. Link toLPIR Score. Link toTriglyceride-Glucose Index (TyG Index). Link toHOMA-IR Calculator.

    39 min
  2. 09/13/2024

    Episode 6. Lipoprotein(a): Overcoming the Risk of Elevated Lp(a)

    In today’s episode, we will be discussing a very specific risk factor of cardiovascular disease known as Lipoprotein(a), abbreviated as Lp(a). Lp(a) is a distinct lipoprotein particle that is not routinely measured on the lipid panel, and is instead ordered as an additional test. For those seeking to promote longevity and optimize cardiovascular risk factors, it is reasonable to obtain a Lipoprotein(a) measurement at least once. Because if you have an elevated level, you want to know about this. References: Kamstrup PR. Lipoprotein(a) and Cardiovascular Disease. Clin Chem. 2021;67(1):154-166. doi:10.1093/clinchem/hvaa247. Ugovšek S, Šebeštjen M. Lipoprotein(a)-The Crossroads of Atherosclerosis, Atherothrombosis and Inflammation. Biomolecules. 2021;12(1):26. Published 2021 Dec 24. doi:10.3390/biom12010026. Romagnuolo I, Sticchi E, Attanasio M, et al. Searching for a common mechanism for placenta-mediated pregnancy complications and cardiovascular disease: role of lipoprotein(a). Fertil Steril. 2016;105(5):1287-1293.e3. doi:10.1016/j.fertnstert.2016.01.014. Manten GT, van der Hoek YY, Marko Sikkema J, et al. The role of lipoprotein (a) in pregnancies complicated by pre-eclampsia. Med Hypotheses. 2005;64(1):162-169. doi:10.1016/j.mehy.2004.04.026. Boerwinkle E, Leffert CC, Lin J, Lackner C, Chiesa G, Hobbs HH. Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations. J Clin Invest. 1992;90(1):52-60. doi:10.1172/JCI115855. Brandt EJ, Mani A, Spatz ES, Desai NR, Nasir K. Lipoprotein(a) levels and association with myocardial infarction and stroke in a nationally representative cross-sectional US cohort. J Clin Lipidol. 2020;14(5):695-706.e4. doi:10.1016/j.jacl.2020.06.010. Varvel S, McConnell JP, Tsimikas S. Prevalence of Elevated Lp(a) Mass Levels and Patient Thresholds in 532 359 Patients in the United States. Arterioscler Thromb Vasc Biol. 2016;36(11):2239-2245. doi:10.1161/ATVBAHA.116.308011. Bhatia HS, Hurst S, Desai P, Zhu W, Yeang C. Lipoprotein(a) Testing Trends in a Large Academic Health System in the United States. J Am Heart Assoc. 2023;12(18):e031255. doi:10.1161/JAHA.123.031255. Perrot N, Verbeek R, Sandhu M, et al. Ideal cardiovascular health influences cardiovascular disease risk associated with high lipoprotein(a) levels and genotype: The EPIC-Norfolk prospective population study. Atherosclerosis. 2017;256:47-52. doi:10.1016/j.atherosclerosis.2016.11.010. Tada H, Yamagami K, Sakata K, Usui S, Kawashiri MA, Takamura M. Healthy lifestyle, lipoprotein (a) levels and the risk of coronary artery disease. Eur J Clin Invest. 2024;54(1):e14093. doi:10.1111/eci.14093. Deshotels MR, Sun C, Nambi V, et al. Temporal Trends in Lipoprotein(a) Concentrations: The Atherosclerosis Risk in Communities Study. J Am Heart Assoc. 2022;11(21):e026762. doi:10.1161/JAHA.122.026762. Wong ND, Fan W, Hu X, et al. Lipoprotein(a) and Long-Term Cardiovascular Risk in a Multi-Ethnic Pooled Prospective Cohort. J Am Coll Cardiol. 2024;83(16):1511-1525. doi:10.1016/j.jacc.2024.02.031. Ebbeling CB, Knapp A, Johnson A, et al. Effects of a low-carbohydrate diet on insulin-resistant dyslipoproteinemia-a randomized controlled feeding trial [published correction appears in Am J Clin Nutr. 2022 Jan 11;115(1):310. doi: 10.1093/ajcn/nqab372]. Am J Clin Nutr. 2022;115(1):154-162. doi:10.1093/ajcn/nqab287. Björnson E, Adiels M, Taskinen MR, et al. Lipoprotein(a) Is Markedly More Atherogenic Than LDL: An Apolipoprotein B-Based Genetic Analysis. J Am Coll Cardiol. 2024;83(3):385-395. doi:10.1016/j.jacc.2023.10.039. Patel AP, Wang (汪敏先) M, Pirruccello JP, et al. Lp(a) (Lipoprotein[a]) Concentrations and Incident Atherosclerotic Cardiovascular Disease: New Insights From a Large National Biobank. Arterioscler Thromb Vasc Biol. 2021;41(1):465-474. doi:10.1161/ATVBAHA.120.315291. Character limit reached. Full references available at https://kevinforeymd.com/lpa

    53 min
4.8
out of 5
22 Ratings

About

Kevin Forey MD seeks to provide an educational resource for everyday individuals who are interested in learning more about food, nutrition, physical exercise, and other strategies for preventing common medical illnesses. Throughout this podcast, you will find an unbiased and evidence-based message that is easy to understand. https://www.kevinforeymd.com/

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